Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0047 | 0.0918 | 0.0918 |
Echinococcus multilocularis | acetylcholinesterase | 0.0193 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0047 | 0.0918 | 0.0918 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.0918 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.0918 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0047 | 0.0918 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0193 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0047 | 0.0918 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0047 | 0.0918 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0041 | 0.051 | 0.051 |
Echinococcus granulosus | carboxylesterase 5A | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0193 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0041 | 0.051 | 0.051 |
Echinococcus multilocularis | acetylcholinesterase | 0.0193 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.0918 | 0.0918 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.0918 | 0.0918 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0193 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.0918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0193 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0193 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0193 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.