Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0598 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.065 | 0.065 |
Brugia malayi | TAR-binding protein | 0.0125 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0598 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0598 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.6607 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.6607 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0598 | 0.0598 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.6607 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0598 | 0.0598 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.5611 | 0.8342 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0598 | 0.0598 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0598 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.5611 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0598 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0598 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.5611 | 0.8342 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0598 | 0.0598 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.5611 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.3848 | 0.3848 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.065 | 0.065 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.6607 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.7163 | 0.7163 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.5611 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3848 | 0.3848 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0598 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.7163 | 0.7163 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.5611 | 0.8342 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0598 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.