Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0951 | 0.2825 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0951 | 0.0951 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.2391 | 0.691 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3368 | 1 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.1552 | 0.4607 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0951 | 0.2825 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.3193 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0208 | 0.0089 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2471 | 0.238 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0919 | 0.0919 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0951 | 0.2825 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.1552 | 0.1449 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.3193 | 0.9482 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0951 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0025 | 0.0025 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.3193 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0025 | 0.0073 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3368 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0208 | 0.0617 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0208 | 0.0617 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2471 | 0.2471 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1424 | 0.3848 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0208 | 0.0617 |
Mycobacterium leprae | Possible regulatory protein | 0.0012 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3368 | 0.3287 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3368 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3368 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3193 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3368 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2471 | 0.2471 |
Brugia malayi | hypoxia-induced factor 1 | 0.0148 | 0.916 | 0.915 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0012 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0951 | 0.0842 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0208 | 0.0208 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.2391 | 0.2299 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0208 | 0.0208 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3368 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0951 | 0.2825 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0951 | 0.0842 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1424 | 0.132 |
Echinococcus granulosus | lamin | 0.0027 | 0.0951 | 0.2825 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0148 | 0.916 | 0.916 |
Onchocerca volvulus | 0.0027 | 0.0951 | 0.6132 | |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0951 | 0.2353 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0208 | 0.0617 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.012 | 0.012 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2471 | 0.238 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3193 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0208 | 0.0617 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3193 | 0.9448 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.3193 | 0.9482 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0025 | 0.0073 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3193 | 0.9448 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0208 | 0.0617 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0951 | 0.6132 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.3193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1424 | 0.1424 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.1552 | 0.4607 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | single-minded | 0.0048 | 0.2391 | 0.691 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0951 | 0.2825 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3368 | 0.3368 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0208 | 0.0089 |
Schistosoma mansoni | lamin | 0.0027 | 0.0951 | 0.2353 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3193 | 1 |
Onchocerca volvulus | 0.0035 | 0.1552 | 1 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3368 | 0.3368 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3368 | 0.3368 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3368 | 0.3287 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3368 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3368 | 0.3287 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0951 | 0.0951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.