TDR Targets

Basic information

Technical information

TDR Targets ID: 717649
Name: N-(1,3-benzodioxol-5-yl)-3-(propanoylamino)be nzamide
MW: 312.32 | Formula: C17H16N2O4
H donors: 2 H acceptors: 2 LogP: 2.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc2c(c1)OCO2
InChi: 1S/C17H16N2O4/c1-2-16(20)18-12-5-3-4-11(8-12)17(21)19-13-6-7-14-15(9-13)23-10-22-14/h3-9H,2,10H2,1H3,(H,18,20)(H,19,21)
InChiKey: DSNICNNTVCUXCV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1,3-benzodioxol-5-yl)-3-(1-oxopropylamino)benzamide
N-(1,3-benzodioxol-5-yl)-3-propionamido-benzamide
ST067082
ZINC06703750

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0145	0.0737	0.5105
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.094	0.0888
Brugia malayi	hypothetical protein	0.0286	0.1761	0.1761
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.016	0.0848	0.0848
Echinococcus multilocularis	expressed conserved protein	0.0112	0.0496	0.0496
Schistosoma mansoni	carbonic anhydrase	0.016	0.0848	0.0848
Leishmania major	carbonic anhydrase-like protein	0.0268	0.1637	0.0769
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0139	0.0082
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0108	0.0108
Schistosoma mansoni	carbonic anhydrase-related	0.016	0.0848	0.0848
Mycobacterium ulcerans	hypothetical protein	0.0192	0.1082	0.0841
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0055	0.0055
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.2337	0.2293
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.0425	0.2773	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0268	0.1637	0.1637
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0118	0.0118
Schistosoma mansoni	glutathione synthetase	0.0425	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0262	0.0208
Mycobacterium tuberculosis	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)	0.0425	0.2773	0.2579
Loa Loa (eye worm)	hypothetical protein	0.016	0.0848	0.0798
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.092	0.092
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0425	0.2773	0.2732
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.1418	1	1
Giardia lamblia	Farnesyl diphosphate synthase	0.1418	1	0.5
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.0425	0.2773	0.2773
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.1719	0.1673
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.1082	0.0841
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0268	0.1637	0.1637
Echinococcus multilocularis	carbonic anhydrase	0.016	0.0848	0.0848
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.1761	0.1761
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.0425	0.2773	0.2773
Schistosoma mansoni	carbonic anhydrase-related	0.016	0.0848	0.0848
Schistosoma mansoni	hypothetical protein	0.0058	0.0108	0.0108
Mycobacterium tuberculosis	Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)	0.0519	0.3461	0.3285
Schistosoma mansoni	hypothetical protein	0.0049	0.0042	0.0042
Onchocerca volvulus		0.0093	0.0357	0.2024
Schistosoma mansoni	hypothetical protein	0.0049	0.0042	0.0042
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.1418	1	1
Echinococcus multilocularis	carbonic anhydrase	0.016	0.0848	0.0848
Mycobacterium ulcerans	polyprenyl diphosphate synthetase, GrcC1	0.0425	0.2773	0.2579
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.0425	0.2773	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0549	0.0497
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.0425	0.2773	0.2732
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.0608	0.4108	0.4108
Leishmania major	polyprenyl synthase, putative	0.0608	0.4108	0.3497
Echinococcus granulosus	carbonic anhydrase II	0.0268	0.1637	0.1637
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.2337	0.2293
Plasmodium falciparum	octaprenyl pyrophosphate synthase	0.0425	0.2773	0.2104
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.1418	1	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0268	0.1637	0.159
Schistosoma mansoni	hypothetical protein	0.016	0.0848	0.0848
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.0549	0.1979
Onchocerca volvulus	Matrilysin homolog	0.0228	0.134	1
Trypanosoma cruzi	polyprenyl synthase, putative	0.0608	0.4108	0.4074
Schistosoma mansoni	hypothetical protein	0.0049	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0159	0.0104
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.1418	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.2337	0.2293
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.1418	1	1
Brugia malayi	CHE-14 protein	0.0051	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.016	0.0848	0.0798
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.0425	0.2773	0.2732
Echinococcus multilocularis	tumor protein p63	0.0408	0.2652	0.2652
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.1418	1	1
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.0608	0.4108	0.4075
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.1418	1	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0268	0.1637	0.1589
Echinococcus granulosus	carbonic anhydrase	0.016	0.0848	0.0848
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0108	0.0108
Schistosoma mansoni	patched 1	0.0051	0.0055	0.0055
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.1761	0.1761
Leishmania major	solanesyl-diphosphate synthase, putative	0.0425	0.2773	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0139	0.0084
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.1418	1	1
Echinococcus multilocularis	carbonic anhydrase	0.016	0.0848	0.0848
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0425	0.2773	0.2692
Loa Loa (eye worm)	matrix metalloproteinase	0.0065	0.0159	0.0104
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0519	0.3461	1
Echinococcus granulosus	carbonic anhydrase	0.016	0.0848	0.0848
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0549	0.0549
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.0608	0.4108	0.4108
Brugia malayi	Hemopexin family protein	0.0093	0.0357	0.0357
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.1418	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0549	0.0549
Schistosoma mansoni	trans-prenyltransferase	0.0425	0.2773	0.2773
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.6808	0.6808
Brugia malayi	Matrixin family protein	0.0065	0.0159	0.0159
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0549	0.0549
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.016	0.0848	0.0848
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0425	0.2773	0.2732
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0762	0.0711
Onchocerca volvulus		0.006	0.0118	0.0087
Loa Loa (eye worm)	matrixin family protein	0.0145	0.0737	0.0686
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.0425	0.2773	0.2773
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.092	0.092
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0268	0.1637	0.1637
Trypanosoma cruzi	polyprenyl synthase, putative	0.0608	0.4108	0.4074
Toxoplasma gondii	hypothetical protein	0.016	0.0848	0.0745
Brugia malayi	Matrixin family protein	0.0065	0.0159	0.0159
Brugia malayi	Matrixin family protein	0.0065	0.0159	0.0159
Brugia malayi	Matrixin family protein	0.0065	0.0159	0.0159
Loa Loa (eye worm)	carbonic anhydrase 3	0.0268	0.1637	0.159
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.032	0.2014	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0286	0.1761	0.1716
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.016	0.0848	0.0848
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0055	0.0055
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0562	0.0562
Brugia malayi	Matrixin family protein	0.0241	0.1435	0.1435
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.032	0.2014	0.2014
Loa Loa (eye worm)	matrixin family protein	0.0241	0.1435	0.1388
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.2337	0.1543
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0079	0.0262	0.0262
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0108	0.0108
Echinococcus granulosus	expressed conserved protein	0.0112	0.0496	0.0496
Onchocerca volvulus		0.0065	0.0159	0.0414
Onchocerca volvulus	Matrilysin homolog	0.0065	0.0159	0.0414
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.0519	0.3461	0.5
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.016	0.0848	0.0848
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.1418	1	1
Schistosoma mansoni	hypothetical protein	0.0093	0.0357	0.0357
Mycobacterium tuberculosis	Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate	0.0519	0.3461	0.3285
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.0425	0.2773	0.2773
Leishmania major	farnesyl pyrophosphate synthase	0.1418	1	1
Brugia malayi	Polyprenyl synthetase family protein	0.0425	0.2773	0.2773
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.1418	1	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0268	0.1637	0.1589
Echinococcus granulosus	tumor protein p63	0.0408	0.2652	0.2652
Schistosoma mansoni	carbonic anhydrase-related	0.016	0.0848	0.0848
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.016	0.0848	0.0848
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.1418	1	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0159	0.0104
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0268	0.1637	0.1637
Brugia malayi	follicle stimulating hormone receptor	0.028	0.1719	0.1719
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0048	0.0031	0.0031
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.0425	0.2773	1
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.1418	1	1
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.1418	1	1
Echinococcus multilocularis	protein patched	0.0051	0.0055	0.0055
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.0425	0.2773	1
Loa Loa (eye worm)	polyprenyl synthetase	0.0425	0.2773	0.2733
Loa Loa (eye worm)	hypothetical protein	0.006	0.0118	0.0064
Echinococcus multilocularis	carbonic anhydrase II	0.0268	0.1637	0.1637
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.094	0.0888
Loa Loa (eye worm)	polyprenyl synthetase	0.1418	1	1
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.0608	0.4108	0.4108
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.0608	0.4108	0.4108
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.1418	1	1
Treponema pallidum	octaprenyl-diphosphate synthase	0.0608	0.4108	0.5
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0268	0.1637	0.1589
Echinococcus granulosus	carbonic anhydrase	0.016	0.0848	0.0848
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0055	0.0055
Mycobacterium ulcerans	polyprenyl synthetase IdsB	0.0519	0.3461	0.3285
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0148	0.0762	0.0762
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.016	0.0848	0.0798
Loa Loa (eye worm)	hypothetical protein	0.016	0.0848	0.0798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 717649