Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 2.8 uM | The cytotoxic concentration of the compound against P388 leukemia cell | ChEMBL. | 2875185 |
Ki (binding) | = 17 uM | Compound was tested for inhibitory activity against Inosine-5'-monophosphate dehydrogenase, the type of inhibition in not competitive | ChEMBL. | 2875185 |
TAD (functional) | = 13 % | Compound was tested for its degradation by TAD-phosphodiesterase | ChEMBL. | 2875185 |
TAD (functional) | = 37.6 % | Compound was tested for its degradation by venom phosphodiesterase | ChEMBL. | 2875185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.