TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.447 | Formula: C26H22O10
H donors: 5 H acceptors: 8 LogP: 4.42 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)OC1CCCC1OC(=O)c1cc(O)c(c(c1)O)C(=O)c1c(O)cccc1C(=O)O
InChi: 1S/C26H22O10/c27-14-7-9-15(10-8-14)35-20-5-2-6-21(20)36-26(34)13-11-18(29)23(19(30)12-13)24(31)22-16(25(32)33)3-1-4-17(22)28/h1,3-4,7-12,20-21,27-30H,2,5-6H2,(H,32,33)
InChiKey: NIUBYBAPAVVDMG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, eta	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, alpha		References
Homo sapiens	protein kinase C, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, beta		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium knowlesi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	protein kinase A catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Theileria parva	cAMP-dependent protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Cryptosporidium hominis	protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase DC2, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Leishmania braziliensis	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Cryptosporidium parvum	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium berghei	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Theileria parva	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma brucei gambiense	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania braziliensis	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Trypanosoma congolense	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania donovani	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	protein kinase, cAMP-dependent, catalytic, beta	358 aa	320 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.3326	0.3326
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.3326	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0143	0.3113	0.3113
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0147	0.3326	0.5
Echinococcus granulosus	protein kinase c iota type	0.0112	0.162	0.162
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0153	0.3625	0.3625
Onchocerca volvulus		0.0167	0.4258	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.3326	0.4009
Trypanosoma brucei	squalene synthase, putative	0.0251	0.8297	1
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0147	0.3326	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.8855	0.8855
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Brugia malayi	Protein kinase c protein 2	0.0199	0.5819	0.3735
Trypanosoma cruzi	squalene synthase, putative	0.0251	0.8297	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0286	1	1
Schistosoma mansoni	atypical protein kinase C	0.0112	0.162	0.162
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0147	0.3326	0.5
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.3113	0.3113
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0233	0.7441	0.7441
Echinococcus multilocularis	serine threonine protein kinase	0.0217	0.6661	0.6661
Loa Loa (eye worm)	hypothetical protein	0.0167	0.4258	0.4258
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0147	0.3326	0.4009
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.8855	0.8855
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.3326	0.3326
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0144	0.3179	0.3179
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0286	1	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.3113	0.3113
Loa Loa (eye worm)	hypothetical protein	0.0233	0.7441	0.7441
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0262	0.8855	0.8855
Entamoeba histolytica	PH domain containing protein kinase, putative	0.017	0.4405	1
Leishmania major	squalene synthase, putative	0.0251	0.8297	1
Giardia lamblia	Kinase, AGC PKA	0.0147	0.3326	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.4258	0.4258
Loa Loa (eye worm)	hypothetical protein	0.0167	0.4258	0.4258
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0144	0.3179	0.3179
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0212	0.6452	0.6452
Echinococcus granulosus	protein kinase C gamma type	0.0217	0.6661	0.6661
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0078	0	0.5
Echinococcus granulosus	serine:threonine protein kinase N2	0.017	0.4405	0.4405
Toxoplasma gondii	AGC kinase	0.0147	0.3326	0.5
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0188	0.5307	0.5307
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.3113	0.3113
Leishmania major	protein kinase A catalytic subunit	0.0147	0.3326	0.4009
Schistosoma mansoni	serine/threonine protein kinase	0.0286	1	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.3326	0.3326
Toxoplasma gondii	AGC kinase	0.0147	0.3326	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.3326	0.3326
Echinococcus granulosus	protein kinase c epsilon type	0.0286	1	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0147	0.3326	0.4009
Trypanosoma cruzi	squalene synthase, putative	0.0251	0.8297	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.3326	0.3326
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.3326	0.5
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0147	0.3326	0.4009
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.3326	0.4009
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0078	0	0.5
Echinococcus multilocularis	protein kinase c iota type	0.0112	0.162	0.162
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0147	0.3326	0.4009
Echinococcus granulosus	Protein kinase C brain isozyme	0.0262	0.8855	0.8855
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3326	0.3326

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.01 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.01 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 0.01 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.01 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C beta I	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C beta I	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	= 0.22 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 0.22 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	= 0.22 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 0.22 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	= 0.24 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850
IC50 (binding)	= 0.24 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference
IC50 (binding)	= 0.24 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850
IC50 (binding)	= 0.24 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference
IC50 (binding)	= 0.25 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	= 0.25 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	= 0.25 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	= 0.25 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	> 10 uM	Inhibition of Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (functional)	> 10 uM	Inhibitory activity in human neutrophil assay	ChEMBL.	8978850
IC50 (functional)	> 10 uM	Inhibition of cellular activity by neutrophil assay	ChEMBL.	No reference
IC50 (binding)	> 10 uM	Inhibition of Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (functional)	> 10 uM	Inhibitory activity in human neutrophil assay	ChEMBL.	8978850
IC50 (functional)	> 10 uM	Inhibition of cellular activity by neutrophil assay	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Evaluated against recombinant human Protein Kinase A (PKA)	ChEMBL.	8978850
IC50 (binding)	= 50 uM	Inhibition of protein kinase A.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	8978850

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL48988

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 71770