Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ATM serine/threonine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.2592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1923 | 0.1923 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.003 | 0.2592 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.003 | 0.2592 | 0.1493 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.003 | 0.2592 | 0.1493 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0022 | 0.1293 | 0.4987 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6613 | 0.6111 |
Giardia lamblia | GTOR | 0.0022 | 0.1293 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.003 | 0.2592 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.003 | 0.2592 | 0.1493 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6613 | 0.6111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.1293 | 0.1293 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.13 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Toxoplasma gondii | FATC domain-containing protein | 0.003 | 0.2592 | 1 |
Echinococcus granulosus | serine protein kinase ATM | 0.003 | 0.2592 | 0.1493 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.6613 | 0.6613 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.1293 | 0.1293 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.2592 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.13 | 0.0052 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0022 | 0.1293 | 0.4987 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.1923 | 0.4849 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0022 | 0.1293 | 0.4987 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.6613 | 0.6111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0022 | 0.1293 | 0.4987 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 89.315 uM | PUBCHEM_BIOASSAY: HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2118] | ChEMBL. | No reference |
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.