Detailed information for compound 717943

Basic information

Technical information
  • TDR Targets ID: 717943
  • Name: furan-2-yl-[4-(4-propylphenyl)sulfonylpiperaz in-1-yl]methanone
  • MW: 362.443 | Formula: C18H22N2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C18H22N2O4S/c1-2-4-15-6-8-16(9-7-15)25(22,23)20-12-10-19(11-13-20)18(21)17-5-3-14-24-17/h3,5-9,14H,2,4,10-13H2,1H3
  • InChiKey: DCMXJEHGHUUXPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-furyl-[4-(4-propylphenyl)sulfonylpiperazin-1-yl]methanone
  • 2-furyl-[4-(4-propylphenyl)sulfonyl-1-piperazinyl]methanone
  • IVK/0011264
  • Oprea1_597216

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0812 0.0773
Schistosoma mansoni polycystin 1-related 0.0022 0.0123 0.0058
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0194 0.0131
Schistosoma mansoni hypothetical protein 0.003 0.0238 0.0175
Brugia malayi Heterochromatin protein 1 0.0073 0.0802 0.1212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0054
Schistosoma mansoni lamin 0.0033 0.0267 0.0204
Giardia lamblia DINP protein human, muc B family 0.0021 0.0116 0.0011
Leishmania major glycosyl hydrolase-like protein 0.0015 0.003 0.0046
Echinococcus multilocularis GPCR, family 2 0.0017 0.0064 0.0022
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0123 0.0081
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0144 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0307 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0209
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0365 0.0881
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.0323
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0567 0.0853
Loa Loa (eye worm) beta-lactamase 0.0036 0.0307 0.0423
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0365 0.0881
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0237 0.3002 0.2972
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0208
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0272 0.0231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0144 0.0102
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0425 0.0647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0144 0.0102
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0066 0.0068
Schistosoma mansoni microtubule-associated protein tau 0.0761 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0307 0.0903
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0145 0.035
Leishmania major importin beta-1 subunit, putative 0.0023 0.014 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Mycobacterium leprae Probable lipase LipE 0.0036 0.0307 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0144 0.0209
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0145 0.0208
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0116 0.0226
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.1057 0.1601
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0425 0.0363
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0144 0.008
Schistosoma mansoni hypothetical protein 0.0043 0.0413 0.035
Onchocerca volvulus 0.0033 0.0267 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0425 0.1027
Loa Loa (eye worm) hypothetical protein 0.0286 0.3648 0.5534
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0144 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0417 0.1008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0365 0.0881
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0112 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0028 0.0043
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0177 0.044
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0194 0.0131
Onchocerca volvulus 0.0036 0.0307 0.0839
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0145 0.035
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0194 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0064 0.0022
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.003 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0145 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0144 0.0209
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0112 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.1999 0.1965
Loa Loa (eye worm) glutaminase 0.0301 0.386 0.5858
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0123 0.0081
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0123 0.0254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0194 0.0251
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0194 0.1093
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0425 0.0385
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0365 0.0881
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0144 0.0102
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0144 0.008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.017
Entamoeba histolytica hypothetical protein 0.0023 0.014 0.0339
Brugia malayi Pre-SET motif family protein 0.0033 0.0272 0.0404
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0144 0.0102
Mycobacterium tuberculosis Conserved protein 0.0036 0.0307 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0144 0.0209
Leishmania major GTP-binding protein, putative 0.0021 0.0112 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0028 0.0043
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.2233 0.22
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.0741
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.057 0.053
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1759 0.2644
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0141
Trichomonas vaginalis glutaminase, putative 0.0301 0.386 0.9327
Echinococcus granulosus amiloride sensitive amine oxidase 0.0237 0.3002 0.2972
Loa Loa (eye worm) hypothetical protein 0.0021 0.0116 0.0131
Loa Loa (eye worm) hypothetical protein 0.0092 0.1057 0.1571
Entamoeba histolytica hypothetical protein 0.0043 0.0413 0.0997
Brugia malayi ecdysteroid receptor 0.0023 0.0144 0.0209
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0395 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0525
Loa Loa (eye worm) glutaminase 2 0.0301 0.386 0.5858
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0307 0.0903
Brugia malayi Bromodomain containing protein 0.003 0.0238 0.0352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Brugia malayi follicle stimulating hormone receptor 0.028 0.357 0.5431
Schistosoma mansoni alpha-glucosidase 0.0155 0.1898 0.1846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Schistosoma mansoni hypothetical protein 0.0237 0.3002 0.2956
Onchocerca volvulus 0.0023 0.0145 0.0347
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.2233 0.3393
Echinococcus multilocularis lamin dm0 0.0033 0.0267 0.0226
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0194 0.0153
Echinococcus multilocularis dna polymerase eta 0.0021 0.0116 0.0075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0123 0.0081
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0805 0.1225
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.022
Echinococcus multilocularis peregrin 0.003 0.0238 0.0197
Schistosoma mansoni survival motor neuron protein 0.0058 0.061 0.0549
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0267 0.0397
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0802 0.1939
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0802 0.1939
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0194 0.0131
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0194 0.0296
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Brugia malayi intermediate filament protein 0.0033 0.0267 0.0397
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0144 0.0102
Loa Loa (eye worm) hypothetical protein 0.0055 0.0561 0.0811
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.0741
Entamoeba histolytica hypothetical protein 0.0026 0.0177 0.0427
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0177 0.0967
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.2233 0.3369
Echinococcus granulosus chromobox protein 1 0.0073 0.0802 0.0764
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0194 0.1093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0365 0.0555
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Brugia malayi Doublecortin family protein 0.0022 0.0123 0.0176
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0194 0.0251
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0425 0.0385
Trypanosoma brucei unspecified product 0.0015 0.0028 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0509
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0805 0.1225
Giardia lamblia PHD finger protein 15 0.003 0.0238 0.0313
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0425 0.0385
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0144 0.0102
Schistosoma mansoni alpha-glucosidase 0.0155 0.1898 0.1846
Brugia malayi hypothetical protein 0.0043 0.0413 0.0618
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0116 0.0281
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0307 0.0903
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0425 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0074
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0425 0.0647
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0365 0.0881
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0074
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0177 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0509
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0238 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0177 0.0178
Toxoplasma gondii ABC1 family protein 0.0036 0.0307 0.1903
Schistosoma mansoni lipoxygenase 0.0022 0.0123 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1809 0.5403
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0567 0.0853
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0194 0.0153
Brugia malayi jmjC domain containing protein 0.0027 0.0194 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.2899 0.4388
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0194 0.0251
Loa Loa (eye worm) hypothetical protein 0.0165 0.2033 0.3064
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0425 0.1027
Brugia malayi RNA, U transporter 1 0.0081 0.0913 0.1381
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0064 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0146 0.0354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0054
Echinococcus granulosus dna polymerase eta 0.0021 0.0116 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0504 0.6567 0.6553
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0397 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0376 0.0908
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.0467
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0144 0.008
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0504 0.6567 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.057 0.053
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0365 0.0881
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0395 0.0354
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0812 0.1967
Leishmania major DNA polymerase eta, putative 0.0021 0.0116 0.0177
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0194 0.0251
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.021
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.017
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.0741
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0177 0.0292
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1759 0.2644
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0177 0.0269
Schistosoma mansoni loxhd1 0.0022 0.0123 0.0058
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0245 0.3112 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.003 0.0036
Schistosoma mansoni hypothetical protein 0.0304 0.3891 0.3851
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0074
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0425 0.1027
Plasmodium vivax SET domain protein, putative 0.0033 0.0272 0.0741
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0116 0.0177
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0064 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0238 0.0318
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0123 0.0081
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0116 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0116 0.0167
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.1936 0.6695
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0064 0.0088
Onchocerca volvulus 0.0023 0.0144 0.0345
Leishmania major hypothetical protein, conserved 0.0027 0.0194 0.0296
Brugia malayi jmjC domain containing protein 0.0027 0.0194 0.0285
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0238 0.1409
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.061 0.092
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0144 0.0174
Leishmania major DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Brugia malayi jmjC domain containing protein 0.0027 0.0194 0.0285
Schistosoma mansoni ran 0.0021 0.0112 0.0048
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0307 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0144 0.0209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0144 0.008
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0504 0.6567 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0425 0.1027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0812 0.1967
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0413 0.035
Echinococcus granulosus tumor protein p63 0.0373 0.4811 0.4789
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0066 0.0045
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0805 0.0745
Mycobacterium ulcerans hypothetical protein 0.0023 0.0145 0.0208
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0144 0.008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0144 0.0209
Brugia malayi nuclear receptor NHR-88 0.0023 0.0144 0.0209
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3648 0.3621
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0212 0.1223
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0141
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0108 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0525
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0123 0.0081
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0194 0.0153
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0144 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Echinococcus multilocularis tumor protein p63 0.0373 0.4811 0.4789
Schistosoma mansoni jumonji domain containing protein 0.0144 0.1755 0.1702
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.057 0.053
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0194 0.0296
Mycobacterium ulcerans glutaminase 0.0301 0.386 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0144 0.008
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0504 0.6567 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0362
Trypanosoma brucei unspecified product 0.0015 0.0028 0.0043
Trypanosoma brucei unspecified product 0.0021 0.0116 0.0177
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0065 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.119 0.1133
Schistosoma mansoni lamin 0.0033 0.0267 0.0204
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0145 0.035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0365 0.0881
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0194 0.0131
Loa Loa (eye worm) RecQ helicase 0.0024 0.0146 0.0177
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0504 0.6567 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0112 0.016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.0529
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0238 0.0197
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0123 0.0081
Brugia malayi jmjC domain containing protein 0.0102 0.119 0.1803
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0116 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0018
Schistosoma mansoni importin beta-1 0.0028 0.0212 0.0149
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0194 0.0131
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.022
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0805 0.1225
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0144 0.008
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0112 0.007
Echinococcus multilocularis muscleblind protein 1 0.0165 0.2033 0.1999
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0365 0.0555
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Echinococcus granulosus importin subunit beta 1 0.0028 0.0212 0.0171
Onchocerca volvulus 0.0058 0.061 0.1762
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0307 0.0266
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.1936 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.4139 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0307 0.0903
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3891 0.5906
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0212 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0365 0.0881
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0175
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0365 0.0511
Brugia malayi nuclear hormone receptor 0.0023 0.0144 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0144 0.0174
Schistosoma mansoni rab6-interacting 0.0022 0.0123 0.0058
Brugia malayi beta-lactamase 0.0036 0.0307 0.0457
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0144 0.0209
Loa Loa (eye worm) hypothetical protein 0.0028 0.0212 0.0278
Brugia malayi Muscleblind-like protein 0.0165 0.2033 0.3088
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0417 0.1175
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.003 0.0074
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0123 0.0187
Onchocerca volvulus Alhambra homolog 0.003 0.0238 0.0631
Schistosoma mansoni intermediate filament proteins 0.0033 0.0267 0.0204
Loa Loa (eye worm) hypothetical protein 0.0148 0.1809 0.2721
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0376 0.105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0307 0.0903
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0177 0.0269
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0238 0.1409
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0123 0.0141
Schistosoma mansoni alpha glucosidase 0.004 0.0365 0.0302
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0116 0.0177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0812 0.0773
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0116 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.003 0.0074
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0146 0.0354
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3648 0.3621
Brugia malayi jmjC domain containing protein 0.0164 0.2028 0.3081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.003 0.0074
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0307 0.0903
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0425 0.0385
Brugia malayi STAT protein, DNA binding domain containing protein 0.0156 0.1913 0.2906
Leishmania major S-adenosylmethionine decarboxylase 0.0504 0.6567 1
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.2233 0.22
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0064 0.0022
Loa Loa (eye worm) hypothetical protein 0.0055 0.0567 0.082
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0805 0.1944
Echinococcus multilocularis chromobox protein 1 0.0073 0.0802 0.0764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.057 0.0858
Mycobacterium ulcerans lipase LipD 0.0036 0.0307 0.0636
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0504 0.6567 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0413 0.0372
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0112 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0208
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.0741
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.0349
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0467 0.0669
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.1057 0.0999
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0144 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0209
Schistosoma mansoni glutaminase 0.0301 0.386 0.382
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1999 0.1947
Plasmodium vivax hypothetical protein, conserved 0.003 0.0238 0.0631
Loa Loa (eye worm) hypothetical protein 0.0148 0.1809 0.2721
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0146 0.0213
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0116 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0259 0.035
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0144 0.0102
Echinococcus granulosus bloom syndrome protein 0.0024 0.0146 0.0105
Onchocerca volvulus Huntingtin homolog 0.0148 0.1809 0.5403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.014 0.0339
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0112 0.007
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0177 0.0292
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0194 0.0153
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0116 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0567 0.082
Onchocerca volvulus 0.0261 0.3322 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0116 0.0167
Loa Loa (eye worm) hypothetical protein 0.0069 0.0759 0.1115
Brugia malayi hypothetical protein 0.0022 0.0123 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0028 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1999 0.1947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0144 0.0174
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0116 0.0177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0812 0.1236
Loa Loa (eye worm) hypothetical protein 0.0038 0.0334 0.0465
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2865 1
Onchocerca volvulus 0.0045 0.0431 0.1216
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0504 0.6567 1
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0504 0.6567 0.6553
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0177 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0144 0.0209
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0365 0.2319
Onchocerca volvulus 0.0055 0.0561 0.1611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0244
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0144 0.0174
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0307 0.0905
Onchocerca volvulus 0.0092 0.1057 0.3119
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0457
Trichomonas vaginalis set domain proteins, putative 0.0261 0.3322 0.8028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.021
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0425 0.0778
Onchocerca volvulus 0.0022 0.0123 0.028
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0397 0.0357
Loa Loa (eye worm) hypothetical protein 0.0044 0.0425 0.0604
Schistosoma mansoni hypothetical protein 0.0058 0.061 0.0549
Onchocerca volvulus 0.0032 0.0258 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0307 0.0266
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.003 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0272 0.0231
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0116 0.0177
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0144 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0509
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.014 0.0214
Schistosoma mansoni lipoxygenase 0.0061 0.0645 0.0585
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0144 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0102 0.119 0.1774
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.0741
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0267 0.0362
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0244
Echinococcus multilocularis lamin 0.0033 0.0267 0.0226
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.003 0.0074
Plasmodium vivax importin-beta 2, putative 0.0028 0.0212 0.0546
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0145 0.0208
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0812 0.0752
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0645 0.0606
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0307 0.0855
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0144 0.0102
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0365 0.0324
Schistosoma mansoni DNA polymerase eta 0.0021 0.0116 0.0052
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0065 0.0053
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0238 0.0197
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0144 0.008
Echinococcus multilocularis RUN 0.0022 0.0123 0.0081
Echinococcus granulosus intermediate filament protein 0.0033 0.0267 0.0226
Echinococcus granulosus lysine specific demethylase 5A 0.0102 0.119 0.1153
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0805 0.1225
Toxoplasma gondii hypothetical protein 0.012 0.1433 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0175
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.1057 0.1019
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0376 0.0908
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0425 0.0385
Brugia malayi MH2 domain containing protein 0.0144 0.1759 0.267
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.008 0.0016
Echinococcus multilocularis muscleblind protein 0.0165 0.2033 0.1999
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.4139 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0144 0.0174
Entamoeba histolytica hypothetical protein 0.0043 0.0413 0.0997
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0365 0.0324
Loa Loa (eye worm) hypothetical protein 0.0165 0.2033 0.3064
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.022
Echinococcus granulosus RUN 0.0022 0.0123 0.0081
Schistosoma mansoni rab6-interacting 0.0022 0.0123 0.0058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0116 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0116 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0194 0.0153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0145 0.0326
Schistosoma mansoni chromobox protein 0.0073 0.0802 0.0743
Entamoeba histolytica Ran family GTPase 0.0021 0.0112 0.027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0272 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0245 0.3112 1
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0457
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0144 0.0102
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0112 0.0219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.057 0.0826
Schistosoma mansoni coup transcription factor 0.0023 0.0144 0.008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0307 0.0457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.357 0.5414
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.1057 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0144 0.0209
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0805 0.1184
Leishmania major hypothetical protein, conserved 0.0036 0.0307 0.0467
Onchocerca volvulus 0.0036 0.0307 0.0839
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Echinococcus multilocularis lysine specific demethylase 5A 0.0102 0.119 0.1153
Echinococcus granulosus lamin dm0 0.0033 0.0267 0.0226
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0334 0.0499
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0425 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0144 0.0174
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0116 0.0281
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0116 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.014 0.0339
Brugia malayi chromobox protein homolog 3 0.0041 0.0376 0.0562
Echinococcus multilocularis snurportin 1 0.0304 0.3891 0.3865
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0144 0.0209
Mycobacterium ulcerans beta-lactamase 0.0036 0.0307 0.0636
Brugia malayi PHD-finger family protein 0.003 0.0238 0.0352
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.067 0.0979
Brugia malayi hypothetical protein 0.0022 0.0123 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0307 0.0423
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.0323
Schistosoma mansoni copper/topaquinone oxidase 0.0237 0.3002 0.2956
Echinococcus granulosus muscleblind protein 0.0165 0.2033 0.1999
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.1936 0.4929
Plasmodium vivax JmjC domain containing protein 0.0027 0.0194 0.0487
Brugia malayi Pre-SET motif family protein 0.0229 0.2899 0.4408
Schistosoma mansoni chromobox protein 0.0073 0.0802 0.0743
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0144 0.008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0144 0.0102
Echinococcus granulosus snurportin 1 0.0304 0.3891 0.3865
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0144 0.008
Onchocerca volvulus 0.0036 0.0307 0.0839
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Plasmodium falciparum importin beta, putative 0.0028 0.0212 0.0481
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0144 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0209
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0116 0.0052
Entamoeba histolytica hypothetical protein 0.0043 0.0413 0.0997
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0561 0.05
Echinococcus granulosus chromobox protein 1 0.0073 0.0802 0.0764
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0307 0.0903
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0177 1
Loa Loa (eye worm) STAT protein 0.0156 0.1913 0.288
Onchocerca volvulus 0.0104 0.122 0.3615
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0064 0.0022
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.1687 0.1652
Echinococcus multilocularis microtubule associated protein 2 0.0761 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0144 0.0102
Trichomonas vaginalis ran, putative 0.0021 0.0112 0.027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0144 0.0102
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0164 0.2028 0.1995
Mycobacterium tuberculosis Conserved protein 0.0036 0.0307 0.0903
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.017
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0238 0.0175
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0812 0.5534
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.1687 0.1652
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0144 0.0209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.0369
Brugia malayi Importin beta-1 subunit 0.0028 0.0212 0.0313
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.0467
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0144 0.0209
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0145 0.0208
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0194 0.0153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0116 0.0226
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0256 0.0215
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0144 0.0209
Trichomonas vaginalis esterase, putative 0.0036 0.0307 0.0741
Brugia malayi hypothetical protein 0.0148 0.1809 0.2747
Brugia malayi glutaminase DH11.1 0.0301 0.386 0.5873
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.2233 0.22
Echinococcus granulosus peregrin 0.003 0.0238 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0431 0.0369
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0144 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0365 0.0881
Echinococcus granulosus dna polymerase kappa 0.0021 0.0116 0.0075
Echinococcus granulosus phd:f box containing protein 0.0027 0.0194 0.0153
Trypanosoma brucei glucosidase, putative 0.004 0.0365 0.0555
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0307 0.0903
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0812 0.1967
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0144 0.0209
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0805 0.1216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.057 0.053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0174
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0805 0.0766
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0417 0.1008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0413 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0144 0.0174
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.003 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0812 0.2699
Schistosoma mansoni hypothetical protein 0.0022 0.0123 0.0058
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0425 0.0647
Echinococcus multilocularis musashi 0.0033 0.0267 0.0226
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0144 0.0345
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0365 0.0545
Echinococcus granulosus GPCR family 2 0.0017 0.0064 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0365 0.0881
Brugia malayi steroid hormone receptor 0.0023 0.0144 0.0209
Trichomonas vaginalis importin beta-1, putative 0.0023 0.014 0.0339
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0177 0.0364
Brugia malayi jmjC domain containing protein 0.0027 0.0194 0.0285
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0146 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0802 0.1181
Treponema pallidum fructose-bisphosphate aldolase 0.0322 0.4139 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0238 0.0566
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0365 0.0881
Schistosoma mansoni ran 0.0021 0.0112 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0145 0.0208
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0144 0.0345
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.119 0.1133
Onchocerca volvulus 0.0033 0.0267 0.0719
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0272 0.1652
Echinococcus multilocularis chromobox protein 1 0.0073 0.0802 0.0764
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0074
Brugia malayi hypothetical protein 0.0286 0.3648 0.555
Entamoeba histolytica hypothetical protein 0.0043 0.0413 0.0997
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0054
Brugia malayi Cytochrome P450 family protein 0.0048 0.0467 0.0702
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0425 0.0363
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0425 0.0385
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0194 0.0422
Schistosoma mansoni hypothetical protein 0.0038 0.0334 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0423
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0194 0.0153
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0164 0.2028 0.1995
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.4139 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0116 0.0131
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0194 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0208
Mycobacterium ulcerans hypothetical protein 0.0036 0.0307 0.0636
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0194 0.0153
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0194 0.0251
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0812 0.0752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0144 0.0174
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0805 0.0766
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0307 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0116 0.0177
Echinococcus granulosus lamin 0.0033 0.0267 0.0226
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0645 0.0606
Schistosoma mansoni hypothetical protein 0.0139 0.1687 0.1633
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0116 0.0281
Onchocerca volvulus 0.0022 0.0123 0.028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0144 0.0209
Giardia lamblia Fructose-bisphosphate aldolase 0.0322 0.4139 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0267 0.0362
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0177 0.0967
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0365 0.0555
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0504 0.6567 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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