TDR Targets

Basic information

Technical information

TDR Targets ID: 718175
Name: methyl 4-methyl-3-[(6-nitro-2-oxochromene-3-c arbonyl)amino]benzoate
MW: 382.324 | Formula: C19H14N2O7
H donors: 1 H acceptors: 5 LogP: 3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc(c(c1)NC(=O)c1cc2cc(ccc2oc1=O)[N+](=O)[O-])C
InChi: 1S/C19H14N2O7/c1-10-3-4-11(18(23)27-2)9-15(10)20-17(22)14-8-12-7-13(21(25)26)5-6-16(12)28-19(14)24/h3-9H,1-2H3,(H,20,22)
InChiKey: GBBOGWAXXTZGPH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 4-methyl-3-[(6-nitro-2-oxo-chromene-3-carbonyl)amino]benzoate
4-methyl-3-[[(6-nitro-2-oxo-3-chromenyl)-oxomethyl]amino]benzoic acid methyl ester
3-[(2-keto-6-nitro-chromene-3-carbonyl)amino]-4-methyl-benzoic acid methyl ester
methyl 4-methyl-3-[(6-nitro-2-oxo-chromen-3-yl)carbonylamino]benzoate
ZINC01055988
IVK/4006697

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.0129	0.0158
Echinococcus multilocularis		0.0038	0.0388	0.0721
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	cytochrome P450 reductase	0.0059	0.0771	0.1002
Echinococcus multilocularis	neuropeptide receptor A26	0.0263	0.4651	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0056	0.0073
Echinococcus granulosus	carboxylesterase 5A	0.0186	0.3192	0.6825
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0129	0.0167
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0056	0.0073
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0038	0.0388	0.0721
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0423	0.7692	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0031	0.0257	0.0334
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0056	0.0073
Plasmodium vivax	flavodoxin domain containing protein	0.0052	0.0645	0.8159
Schistosoma mansoni	amine GPCR	0.0021	0.0056	0.0073
Echinococcus multilocularis	acetylcholinesterase	0.0186	0.3192	0.6825
Brugia malayi	Serotonin receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus multilocularis	methionine synthase reductase	0.0036	0.0346	0.063
Trichomonas vaginalis	spcc417.12 protein, putative	0.0031	0.0257	0.2504
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0038	0.0388	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0158	0.0205
Entamoeba histolytica	type A flavoprotein, putative	0.0022	0.0085	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0059	0.0771	1
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0059	0.0771	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0056	0.0073
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0032	0.0266	0.2644
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Brugia malayi	flavodoxin family protein	0.0059	0.0771	0.1002
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus multilocularis	para nitrobenzyl esterase	0.0031	0.0257	0.0436
Echinococcus granulosus	neuroligin	0.0031	0.0257	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus multilocularis	neuroligin	0.0031	0.0257	0.0436
Brugia malayi	G protein-coupled receptor	0.0021	0.0056	0.0073
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0388	0.0146
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0038	0.0388	0.0504
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0038	0.0388	0.4417
Entamoeba histolytica	type A flavoprotein, putative	0.0022	0.0085	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Toxoplasma gondii	histone lysine-specific demethylase	0.0038	0.0388	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0423	0.7692	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Onchocerca volvulus		0.0031	0.0257	0.18
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0038	0.0388	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0056	0.0073
Brugia malayi	hypothetical protein	0.008	0.1169	0.152
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0056	0.0073
Brugia malayi	FAD binding domain containing protein	0.0059	0.0771	0.1002
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0056	0.0073
Onchocerca volvulus		0.0031	0.0257	0.18
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0031	0.0257	0.2504
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0056	0.0073
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0038	0.0388	0.0721
Loa Loa (eye worm)	carboxylesterase	0.0031	0.0257	0.0334
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus multilocularis	acetylcholinesterase	0.0186	0.3192	0.6825
Echinococcus granulosus	para nitrobenzyl esterase	0.0031	0.0257	0.0436
Toxoplasma gondii	aldehyde dehydrogenase	0.0032	0.0266	0.3116
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0059	0.0771	0.1555
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0056	0.0073
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0056	0.0073
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Brugia malayi	hypothetical protein	0.0031	0.0257	0.0334
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Schistosoma mansoni	aldehyde dehydrogenase	0.0032	0.0266	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Brugia malayi	putative neuropeptide receptor	0.0021	0.0056	0.0073
Brugia malayi	Carboxylesterase family protein	0.0186	0.3192	0.415
Schistosoma mansoni	amine GPCR	0.0021	0.0056	0.0073
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0056	0.0073
Brugia malayi	Serotonin receptor	0.0021	0.0056	0.0073
Brugia malayi	Carboxylesterase family protein	0.0031	0.0257	0.0334
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0056	0.0073
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0545	1	1
Echinococcus granulosus	acetylcholinesterase	0.0186	0.3192	0.6825
Loa Loa (eye worm)	hypothetical protein	0.0373	0.6738	0.8759
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Giardia lamblia	Hypothetical protein	0.0052	0.0645	0.5
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0059	0.0771	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0026	0.0158	0.0205
Entamoeba histolytica	type A flavoprotein, putative	0.0022	0.0085	0.5
Brugia malayi	RE15519p	0.0021	0.0056	0.0073
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3192	0.415
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0036	0.0346	0.045
Onchocerca volvulus		0.0031	0.0257	0.18
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0029	0.0219	0.0285
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Plasmodium falciparum	protoporphyrinogen oxidase	0.0038	0.0388	0.4417
Brugia malayi	sulfakinin receptor protein	0.0021	0.0056	0.0073
Brugia malayi	flavodoxin family protein	0.0022	0.0085	0.011
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Onchocerca volvulus		0.008	0.1169	1
Treponema pallidum	flavodoxin	0.0022	0.0085	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0056	0.0073
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0059	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0056	0.0073
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0052	0.0645	0.8159
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0056	0.0073
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.0129	0.0158
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0038	0.0388	0.4417
Brugia malayi	larval opioid receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0038	0.0388	0.0721
Echinococcus granulosus	neuropeptide receptor A26	0.0263	0.4651	1
Mycobacterium ulcerans	oxidoreductase	0.0038	0.0388	0.0135
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0056	0.0073
Brugia malayi	FAD binding domain containing protein	0.0036	0.0346	0.045
Schistosoma mansoni	amine GPCR	0.0021	0.0056	0.0073
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0059	0.0771	0.1555
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0388	0.4417
Schistosoma mansoni	adenoreceptor	0.0021	0.0056	0.0073
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0038	0.0388	0.4417
Schistosoma mansoni	amine GPCR	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0423	0.7692	1
Schistosoma mansoni	opsin-like receptor	0.0021	0.0056	0.0073
Brugia malayi	amine oxidase, flavin-containing family protein	0.0038	0.0388	0.0504
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Trypanosoma cruzi	p450 reductase, putative	0.0059	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0059	0.0771	0.1002
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	acetylcholinesterase	0.0031	0.0257	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Mycobacterium ulcerans	dehydrogenase	0.0038	0.0388	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0056	0.0073
Entamoeba histolytica	type A flavoprotein, putative	0.0022	0.0085	0.5
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0056	0.0073
Echinococcus granulosus	methionine synthase reductase	0.0036	0.0346	0.063
Trichomonas vaginalis	sulfite reductase, putative	0.0059	0.0771	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0056	0.0073
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0059	0.0771	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0031	0.0257	0.0334
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0026	0.0158	0.0205
Brugia malayi	hypothetical protein	0.0038	0.0388	0.0504
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0032	0.0266	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0032	0.0266	0.0011
Loa Loa (eye worm)	hypothetical protein	0.008	0.1169	0.152
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Leishmania major	UDP-galactopyranose mutase	0.0038	0.0388	0.4417
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Leishmania major	cytochrome P450 reductase, putative	0.0052	0.0645	0.8159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0026	0.0158	0.0205
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0056	0.0073
Entamoeba histolytica	type A flavoprotein, putative	0.0022	0.0085	0.5
Schistosoma mansoni	opsin-like receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0056	0.0073
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0059	0.0771	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0056	0.0073
Schistosoma mansoni	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	carboxylesterase	0.0186	0.3192	0.415
Loa Loa (eye worm)	hypothetical protein	0.0423	0.7692	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3192	0.415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0025	0.0129	0.0167
Leishmania major	p450 reductase, putative	0.0059	0.0771	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Schistosoma mansoni	BC026374 protein (S09 family)	0.0031	0.0257	0.0334
Brugia malayi	Carboxylesterase family protein	0.0031	0.0257	0.0334
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0038	0.0388	0.0504
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	acetylcholinesterase 1	0.0186	0.3192	0.415
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	flavodoxin family protein	0.0022	0.0085	0.011
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0059	0.0771	0.1555
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0129	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0056	0.0073
Mycobacterium ulcerans	monoamine oxidase	0.0038	0.0388	0.0135
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0032	0.0266	0.0457
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0038	0.0388	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0032	0.0266	0.001
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0388	0.4417
Mycobacterium tuberculosis	Possible oxidoreductase	0.0038	0.0388	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0056	0.0073
Onchocerca volvulus		0.0031	0.0257	0.18
Schistosoma mansoni	diflavin oxidoreductase	0.0029	0.0211	0.0274
Brugia malayi	neuropeptide F receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Schistosoma mansoni	amine oxidase	0.0038	0.0388	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0257	0.0334
Brugia malayi	G-protein coupled receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0129	0.0167
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0059	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	AKH receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	carboxylesterase	0.0031	0.0257	0.0334
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0059	0.0771	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0056	0.0073
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0031	0.0257	0.0436
Brugia malayi	G-protein coupled receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0771	0.1002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0031	0.0257	0.0334
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0056	0.0073
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0056	0.0073
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0038	0.0388	0.4417
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0506	0.9272	1
Brugia malayi	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0059	0.0771	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0038	0.0388	0.4417
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0056	0.0073
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0031	0.0257	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0038	0.0388	0.0721
Brugia malayi	Dopamine receptor	0.0021	0.0056	0.0073
Echinococcus multilocularis	carboxylesterase 5A	0.0186	0.3192	0.6825
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0186	0.3192	0.415
Schistosoma mansoni	opsin-like receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0025	0.0129	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	amine GPCR	0.0021	0.0056	0.0073
Brugia malayi	GnHR receptor homolog	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	Carboxylesterase family protein	0.0186	0.3192	0.415
Brugia malayi	Carboxylesterase family protein	0.0031	0.0257	0.0334
Echinococcus granulosus	acetylcholinesterase	0.0186	0.3192	0.6825
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus granulosus	BC026374 protein S09 family	0.0031	0.0257	0.0436
Schistosoma mansoni	aldehyde dehydrogenase	0.0032	0.0266	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0056	0.0073
Plasmodium falciparum	nitric oxide synthase, putative	0.0059	0.0771	1
Onchocerca volvulus		0.0038	0.0388	0.298
Brugia malayi	neuropeptide F receptor	0.0021	0.0056	0.0073
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0056	0.0073
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0036	0.0346	0.045
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0059	0.0771	1
Schistosoma mansoni	myosin xvIII	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0388	0.0504
Echinococcus granulosus	neuropeptide s receptor	0.0263	0.4651	1
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0059	0.0771	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0056	0.0073
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0038	0.0388	0.4417
Echinococcus multilocularis	neuropeptide s receptor	0.0263	0.4651	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.0129	0.0158
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.0129	0.0158
Schistosoma mansoni	gliotactin	0.0031	0.0257	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0056	0.0073
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Brugia malayi	Carboxylesterase family protein	0.0031	0.0257	0.0334
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0032	0.0266	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0031	0.0257	0.0436
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0056	0.0073
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0032	0.0266	0.001
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0056	0.0073
Brugia malayi	SWIRM domain containing protein	0.0038	0.0388	0.0504
Onchocerca volvulus		0.0031	0.0257	0.18
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0056	0.0073
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0031	0.0257	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0038	0.0388	0.0135
Giardia lamblia	Nitric oxide synthase, inducible	0.0052	0.0645	0.5
Schistosoma mansoni	amine oxidase	0.0038	0.0388	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0073

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 718175