TDR Targets

Basic information

Technical information

TDR Targets ID: 718177
Name: 2-(3,4-dichlorophenyl)-N-(5-ethyl-1,3,4-thiad iazol-2-yl)acetamide
MW: 316.206 | Formula: C12H11Cl2N3OS
H donors: 1 H acceptors: 3 LogP: 3.56 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nnc(s1)NC(=O)Cc1ccc(c(c1)Cl)Cl
InChi: 1S/C12H11Cl2N3OS/c1-2-11-16-17-12(19-11)15-10(18)6-7-3-4-8(13)9(14)5-7/h3-5H,2,6H2,1H3,(H,15,17,18)
InChiKey: IASHGBRUDNIKOF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3,4-dichlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)ethanamide
ZINC01056110
IVK/4006800

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine oxidase	0.0042	0.042	0.0552
Plasmodium vivax	flavodoxin domain containing protein	0.0056	0.0676	0.8159
Echinococcus multilocularis	acetylcholinesterase	0.0202	0.3215	0.7021
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0034	0.0289	0.0631
Onchocerca volvulus		0.0034	0.0289	0.2413
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0063	0.0802	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0453	0.7611	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0033	0.0044
Onchocerca volvulus		0.0034	0.0289	0.2413
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0027	0.0162	0.0353
Echinococcus multilocularis	methionine synthase reductase	0.0039	0.0378	0.0826
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0063	0.0802	0.1751
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0027	0.0162	0.0353
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0118	0.5
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0042	0.042	0.5
Brugia malayi	hypothetical protein	0.0034	0.0289	0.038
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.042	0.0917
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0063	0.0802	0.0528
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0035	0.0299	0.0652
Brugia malayi	hypothetical protein	0.0042	0.042	0.0552
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0034	0.0289	0.0631
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0042	0.042	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0289	0.038
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0191	0.025
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0027	0.0162	0.0212
Echinococcus granulosus	carboxylesterase 5A	0.0202	0.3215	0.7021
Brugia malayi	amine oxidase, flavin-containing family protein	0.0042	0.042	0.0552
Toxoplasma gondii	histone lysine-specific demethylase	0.0042	0.042	1
Echinococcus multilocularis	neuropeptide s receptor	0.028	0.458	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0202	0.3215	0.4225
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Onchocerca volvulus		0.0034	0.0289	0.2413
Mycobacterium ulcerans	dehydrogenase	0.0042	0.042	0.0135
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0039	0.0378	0.0497
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0063	0.0802	0.1751
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0027	0.0162	0.0353
Echinococcus granulosus	BC026374 protein S09 family	0.0034	0.0289	0.0631
Trichomonas vaginalis	sulfite reductase, putative	0.0063	0.0802	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0028	0.0191	0.025
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0063	0.0802	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.3215	0.4225
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0035	0.0299	0.2644
Brugia malayi	FAD binding domain containing protein	0.0063	0.0802	0.1054
Brugia malayi	hypothetical protein	0.0086	0.1198	0.1575
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0028	0.0191	0.025
Echinococcus multilocularis		0.0042	0.042	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0033	0.0044
Echinococcus granulosus	acetylcholinesterase	0.0202	0.3215	0.7021
Brugia malayi	Carboxylesterase family protein	0.0034	0.0289	0.038
Brugia malayi	Carboxylesterase family protein	0.0034	0.0289	0.038
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0035	0.0299	0.0011
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0039	0.0378	0.0497
Brugia malayi	flavodoxin family protein	0.0024	0.0118	0.0155
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.042	0.4417
Schistosoma mansoni	aldehyde dehydrogenase	0.0035	0.0299	0.0392
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0549	0.9274	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0042	0.042	0.4417
Echinococcus multilocularis	acetylcholinesterase	0.0202	0.3215	0.7021
Echinococcus granulosus	neuroligin	0.0034	0.0289	0.0631
Brugia malayi	Carboxylesterase family protein	0.0034	0.0289	0.038
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0056	0.0676	0.8159
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0453	0.7611	1
Onchocerca volvulus		0.0042	0.042	0.3504
Brugia malayi	FAD binding domain containing protein	0.0039	0.0378	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.059	1	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0019	0.0025
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0034	0.0289	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0042	0.042	0.0917
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0299	0.001
Loa Loa (eye worm)	carboxylesterase	0.0202	0.3215	0.4225
Trypanosoma cruzi	p450 reductase, putative	0.0063	0.0802	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0042	0.042	0.4417
Echinococcus granulosus	neuropeptide s receptor	0.028	0.458	1
Echinococcus granulosus	acetylcholinesterase	0.0202	0.3215	0.7021
Schistosoma mansoni	acetylcholinesterase	0.0034	0.0289	0.038
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0042	0.042	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0118	0.5
Loa Loa (eye worm)	acetylcholinesterase 1	0.0202	0.3215	0.4225
Toxoplasma gondii	aldehyde dehydrogenase	0.0035	0.0299	0.3116
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0042	0.042	1
Echinococcus granulosus	methionine synthase reductase	0.0039	0.0378	0.0826
Giardia lamblia	Nitric oxide synthase, inducible	0.0056	0.0676	0.5
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0034	0.0289	0.038
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0063	0.0802	1
Brugia malayi	flavodoxin family protein	0.0063	0.0802	0.1054
Echinococcus multilocularis	para nitrobenzyl esterase	0.0034	0.0289	0.0631
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.042	0.4417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0162	0.0212
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0042	0.042	0.4417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Brugia malayi	Carboxylesterase family protein	0.0034	0.0289	0.038
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0063	0.0802	0.1751
Schistosoma mansoni	aldehyde dehydrogenase	0.0035	0.0299	0.0392
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0042	0.042	0.0552
Brugia malayi	Carboxylesterase family protein	0.0202	0.3215	0.4225
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0032	0.0252	0.0331
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0063	0.0802	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Loa Loa (eye worm)	carboxylesterase	0.0034	0.0289	0.038
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.042	0.0917
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0063	0.0802	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0034	0.0289	0.038
Loa Loa (eye worm)	hypothetical protein	0.0202	0.3215	0.4225
Brugia malayi	latrophilin 2 splice variant baaae	0.0019	0.0033	0.0044
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0063	0.0802	0.1751
Schistosoma mansoni	amine oxidase	0.0042	0.042	0.0552
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0027	0.0162	0.0353
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.042	0.0146
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0042	0.042	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0453	0.7611	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0162	0.0212
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0162	0.0212
Echinococcus granulosus	neuropeptide receptor A26	0.028	0.458	1
Plasmodium falciparum	nitric oxide synthase, putative	0.0063	0.0802	1
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0063	0.0802	1
Loa Loa (eye worm)	flavodoxin family protein	0.0024	0.0118	0.0155
Mycobacterium ulcerans	oxidoreductase	0.0042	0.042	0.0135
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0028	0.0191	0.025
Echinococcus multilocularis	neuropeptide receptor A26	0.028	0.458	1
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0063	0.0802	1
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0118	0.5
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0035	0.0299	0.0652
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0289	0.038
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0042	0.042	0.0135
Mycobacterium ulcerans	monoamine oxidase	0.0042	0.042	0.0135
Schistosoma mansoni	diflavin oxidoreductase	0.0031	0.0244	0.032
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0802	0.1054
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0118	0.5
Echinococcus multilocularis	carboxylesterase 5A	0.0202	0.3215	0.7021
Echinococcus multilocularis	neuroligin	0.0034	0.0289	0.0631
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0299	0.001
Brugia malayi	Carboxylesterase family protein	0.0202	0.3215	0.4225
Mycobacterium tuberculosis	Possible oxidoreductase	0.0042	0.042	0.0146
Leishmania major	cytochrome P450 reductase, putative	0.0056	0.0676	0.8159
Echinococcus granulosus	para nitrobenzyl esterase	0.0034	0.0289	0.0631
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0019	0.0025
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.042	0.4417
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1198	0.1575
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0299	0.001
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.042	0.4417
Onchocerca volvulus		0.0086	0.1198	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.042	0.0552
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0118	0.5
Loa Loa (eye worm)	carboxylesterase	0.0034	0.0289	0.038
Schistosoma mansoni	cytochrome P450 reductase	0.0063	0.0802	0.1054
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0063	0.0802	1
Brugia malayi	SWIRM domain containing protein	0.0042	0.042	0.0552
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0289	0.038
Loa Loa (eye worm)	hypothetical protein	0.0399	0.6659	0.875
Giardia lamblia	Hypothetical protein	0.0056	0.0676	0.5
Leishmania major	UDP-galactopyranose mutase	0.0042	0.042	0.4417
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0027	0.0162	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0453	0.7611	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0034	0.0289	0.2504
Leishmania major	p450 reductase, putative	0.0063	0.0802	1
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0063	0.0802	1
Treponema pallidum	flavodoxin	0.0024	0.0118	0.5
Onchocerca volvulus		0.0034	0.0289	0.2413
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.042	0.4417
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0063	0.0802	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0289	0.038
Trichomonas vaginalis	spcc417.12 protein, putative	0.0034	0.0289	0.2504
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0042	0.042	0.4417
Onchocerca volvulus		0.0034	0.0289	0.2413
Schistosoma mansoni	gliotactin	0.0034	0.0289	0.038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 718177