Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0.0411 | 0.0411 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0019 | 0.0411 | 0.0411 |
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0.0411 | 0.0411 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0019 | 0.0411 | 0.0119 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0029 | 0.129 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0.0411 | 0.0131 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0126 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0019 | 0.0411 | 0.1157 |
Echinococcus granulosus | FTZ F1 alpha | 0.0019 | 0.0411 | 0.0119 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0019 | 0.0411 | 0.1157 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0029 | 0.129 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0019 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0029 | 0.129 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0019 | 0.0411 | 0.0411 |
Chlamydia trachomatis | sulfite reductase | 0.0018 | 0.0296 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0019 | 0.0411 | 0.0119 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0019 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0019 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0029 | 0.129 | 0.1025 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0029 | 0.129 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0029 | 0.129 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0029 | 0.129 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0029 | 0.129 | 0.1131 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0019 | 0.0411 | 0.0411 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0019 | 0.0411 | 0.0131 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0029 | 0.129 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0029 | 0.129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0019 | 0.0411 | 0.1157 |
Brugia malayi | ecdysteroid receptor | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0.0411 | 0.0131 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0019 | 0.0411 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0019 | 0.0411 | 0.1157 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0.0411 | 0.0119 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0019 | 0.0411 | 0.1157 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0026 | 0.0994 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0019 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.129 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.0411 | 0.1157 |
Trypanosoma cruzi | p450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0019 | 0.0411 | 0.0411 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0019 | 0.0411 | 0.0119 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0.0411 | 0.0131 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0019 | 0.0411 | 0.1157 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0029 | 0.129 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0019 | 0.0411 | 0.0131 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0019 | 0.0411 | 0.0411 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0019 | 0.0411 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0019 | 0.0411 | 0.1157 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0.0411 | 0.0119 |
Onchocerca volvulus | 0.0019 | 0.0411 | 0.5 | |
Schistosoma mansoni | coup transcription factor | 0.0019 | 0.0411 | 0.0411 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0.0411 | 0.0119 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0029 | 0.129 | 0.1131 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0029 | 0.129 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0019 | 0.0411 | 0.1157 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0029 | 0.129 | 0.1025 |
Giardia lamblia | Hypothetical protein | 0.0026 | 0.0994 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0029 | 0.129 | 0.129 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0029 | 0.129 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0019 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear hormone receptor | 0.0019 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0019 | 0.0411 | 0.0131 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0019 | 0.0411 | 0.1157 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0116 | 0.9091 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0018 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0019 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0411 | 0.1157 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0019 | 0.0411 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0019 | 0.0411 | 0.0131 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0.0411 | 0.0119 |
Brugia malayi | flavodoxin family protein | 0.0029 | 0.129 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0019 | 0.0411 | 0.1157 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = 0 day | Change in mean survival time of Trophozoite-induced P. berghei innoculated mice following 160 mg/kg s.c. administration; Survival 60 days postinfection. | ChEMBL. | 6227747 |
Delta MST (functional) | = 0 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 80 mg/kg. | ChEMBL. | 6227747 |
Delta MST (functional) | = 0 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 40 mg/kg. | ChEMBL. | 6227747 |
Delta MST (functional) | = 0 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice after subcutaneous administration dose of 20 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 0 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 20 mg/kg; 4 survived after 60 days of postinfection | ChEMBL. | 6227747 |
Delta MST (functional) | = 0 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 10 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 0.7 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 2.5 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 8.7 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 5 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 8.8 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 10 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 19.8 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 10 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 20.9 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice after subcutaneous administration dose of 20 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 21.8 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 40 mg/kg. | ChEMBL. | 6227747 |
Delta MST (functional) | = 25.9 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 10 mg/kg | ChEMBL. | 6227747 |
ID50 (functional) | = 0.0000000019 M | Molar concentration required to reduce the number of L1210 cells by 50% after incubation for 2 days | ChEMBL. | 6227747 |
SD90 (functional) | = 0.088 mg kg-1 day-1 | Daily dose required for 90% parasitaemia in trophozoite induced P. berghei in 21 mice | ChEMBL. | 6227747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.