Detailed information for compound 718324

Basic information

Technical information
  • TDR Targets ID: 718324
  • Name: ethyl 2-[2-(2-acetyl-5-thiophen-2-yl-3,4-dihy dropyrazol-3-yl)phenoxy]acetate
  • MW: 372.438 | Formula: C19H20N2O4S
  • H donors: 0 H acceptors: 2 LogP: 2.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1ccccc1C1CC(=NN1C(=O)C)c1cccs1
  • InChi: 1S/C19H20N2O4S/c1-3-24-19(23)12-25-17-8-5-4-7-14(17)16-11-15(18-9-6-10-26-18)20-21(16)13(2)22/h4-10,16H,3,11-12H2,1-2H3
  • InChiKey: FZJCPPBVECWRFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[2-[2-acetyl-5-(2-thienyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetate
  • 2-[2-[2-acetyl-5-(2-thienyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetic acid ethyl ester
  • ethyl 2-[2-(2-ethanoyl-5-thiophen-2-yl-3,4-dihydropyrazol-3-yl)phenoxy]ethanoate
  • STK214084

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0024 0.0403 0.1162
Trichomonas vaginalis helicase, putative 0.0007 0.0025 0.0081
Loa Loa (eye worm) DR-78 0.003 0.0551 0.0774
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.1321 0.3118
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0266 0.4916
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Brugia malayi hypothetical protein 0.0034 0.0634 0.1468
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0064 0.1321 0.1302
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0403 0.0914
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0895
Mycobacterium ulcerans hypothetical protein 0.0024 0.0403 0.106
Schistosoma mansoni retinoic acid receptor RXR 0.0064 0.1321 0.1302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0041 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0064 0.1321 0.1302
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0403 0.106
Schistosoma mansoni smad 0.0009 0.006 0.0038
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0022 0.0061
Onchocerca volvulus Bile acid receptor homolog 0.0064 0.1321 0.3965
Onchocerca volvulus 0.0064 0.1321 0.3965
Brugia malayi MH2 domain containing protein 0.0009 0.006 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Echinococcus granulosus importin subunit beta 1 0.0029 0.0519 0.0498
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0634 0.0613
Onchocerca volvulus 0.003 0.0551 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0403 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0488 0.9382
Echinococcus granulosus FTZ F1 alpha 0.0064 0.1321 0.1302
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0551 0.053
Onchocerca volvulus 0.0031 0.0575 0.1689
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0346 0.2723
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0041 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0403 1
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.6981 1
Schistosoma mansoni hypothetical protein 0.0189 0.4188 0.4175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0064 0.1321 0.3118
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0189 0.4188 0.4175
Plasmodium falciparum importin beta, putative 0.0029 0.0519 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0551 0.1615
Loa Loa (eye worm) hypothetical protein 0.0027 0.0488 0.0682
Echinococcus granulosus cpg binding protein 0.0033 0.0616 0.0595
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0551 0.053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0266 0.0681
Schistosoma mansoni nuclear hormone receptor 0.0064 0.1321 0.1302
Echinococcus multilocularis Smad4 0.0009 0.006 0.0038
Brugia malayi hypothetical protein 0.0189 0.4188 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0084 0.0091
Brugia malayi Nuclear hormone receptor E75 0.003 0.0551 0.127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0064 0.1321 0.19
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0346 0.0474
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0092
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0064 0.1321 0.1302
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1212 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0064 0.1321 0.1302
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.1083 0.1525
Entamoeba histolytica hypothetical protein 0.0023 0.0395 0.0896
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.3232 0.4613
Plasmodium vivax importin-beta 2, putative 0.0029 0.0519 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0346 0.0778
Brugia malayi ecdysteroid receptor 0.0064 0.1321 0.3118
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0403 0.0547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0064 0.1321 0.19
Brugia malayi nuclear receptor NHR-67 0.003 0.0551 0.127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0041 0.0019
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0551 0.053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0357
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0357
Trichomonas vaginalis ran, putative 0.0021 0.0346 0.8685
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1373 0.1354
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0519 0.0498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0519 0.0727
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0403 0.0557
Echinococcus multilocularis FTZ F1 alpha 0.0064 0.1321 0.1302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0634 0.0613
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0403 0.106
Onchocerca volvulus Protein ultraspiracle homolog 0.0064 0.1321 0.3965
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0084 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0064 0.1321 0.1302
Brugia malayi nuclear receptor RXR 0.0034 0.0634 0.1468
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0346 0.0466
Schistosoma mansoni cpg binding protein 0.0033 0.0616 0.0595
Schistosoma mansoni smad1 5 8 and 0.0009 0.006 0.0038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0064 0.1321 0.1302
Schistosoma mansoni coup transcription factor 0.0064 0.1321 0.1302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0064 0.1321 0.19
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0346 0.0778
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0403 0.106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0064 0.1321 0.3118
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0064 0.1321 0.1302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0403 0.1115
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Schistosoma mansoni hypothetical protein 0.0306 0.686 0.6853
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0266 0.4916
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0144 0.0122
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0488 0.067
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0061
Brugia malayi nuclear receptor NHR-88 0.0064 0.1321 0.3118
Echinococcus multilocularis snurportin 1 0.0306 0.686 0.6853
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0551 0.127
Brugia malayi conserved hypotetical protein 0.003 0.0551 0.127
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0022 0.0061
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0551 0.053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.006 0.0038
Brugia malayi hypothetical protein 0.003 0.0551 0.127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.006 0.0038
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0403 0.0914
Loa Loa (eye worm) hypothetical protein 0.015 0.3298 0.4791
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0403 0.0914
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0041 0.0019
Brugia malayi nuclear receptor RXR 0.003 0.0551 0.127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0244 0.0677
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0346 0.0466
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0061
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0403 0.106
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0519 0.0714
Schistosoma mansoni transcription factor LCR-F1 0.0189 0.4188 0.4175
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0551 0.0774
Onchocerca volvulus 0.015 0.3298 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0895
Toxoplasma gondii hypothetical protein 0.005 0.1012 0.8316
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.006 0.0038
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.1321 0.3118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.1321 0.3118
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0488 0.067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.1321 0.3118
Schistosoma mansoni hypothetical protein 0.0443 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.1321 0.1302
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0403 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0064 0.1321 0.3118
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0064 0.1321 0.1302
Brugia malayi hypothetical protein 0.003 0.0551 0.127
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0488 0.3919
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0041 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.1321 0.1302
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0395 1
Entamoeba histolytica hypothetical protein 0.0189 0.4188 1
Loa Loa (eye worm) Smad1 0.0009 0.006 0.0056
Brugia malayi Importin beta-1 subunit 0.0029 0.0519 0.1193
Mycobacterium ulcerans hypothetical protein 0.0164 0.3613 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0634 0.0613
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0865 0.1211
Brugia malayi RNA, U transporter 1 0.0081 0.1727 0.4094
Schistosoma mansoni cpg binding protein 0.0031 0.0575 0.0555
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.006 0.0038
Leishmania major importin beta-1 subunit, putative 0.0023 0.0395 0.0536
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0403 0.0547
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0551 0.053
Echinococcus granulosus Smad4 0.0009 0.006 0.0038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0346 0.0325
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0061
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0865 0.1211
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0575 0.0809
Schistosoma mansoni smad1 5 8 and 0.0009 0.006 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0189 0.4188 0.4175
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0346 0.652
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0395 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0346 0.652
Echinococcus multilocularis dnaJ subfamily B 0.0443 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0634 0.1468
Brugia malayi hypothetical protein 0.0027 0.0488 0.112
Schistosoma mansoni nuclear hormone receptor 0.003 0.0551 0.053
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0346 0.0466
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.3232 0.4613
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0403 0.106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0064 0.1321 0.19
Schistosoma mansoni nuclear receptor 0.003 0.0551 0.053
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0634 0.0895
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0081 0.0142
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0865 0.1211
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0346 0.5
Echinococcus granulosus smad 0.0009 0.006 0.0038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0064 0.1321 0.1302
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0064 0.1321 0.1302
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0551 0.053
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Schistosoma mansoni hypothetical protein 0.0012 0.0144 0.0122
Echinococcus granulosus ecdysone induced protein 78C 0.0064 0.1321 0.1302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0064 0.1321 0.19
Brugia malayi hypothetical protein 0.0034 0.0634 0.1468
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0403 0.0914
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0865 0.1211
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0395 1
Brugia malayi MH2 domain containing protein 0.0126 0.2748 0.6543
Brugia malayi MH2 domain containing protein 0.0009 0.006 0.0092
Schistosoma mansoni cpg binding protein 0.0033 0.0616 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0895
Echinococcus multilocularis cpg binding protein 0.0033 0.0616 0.0595
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0084 0.0062
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0244 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0064 0.1321 0.19
Echinococcus multilocularis ecdysone induced protein 78C 0.0064 0.1321 0.1302
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0551 0.053
Schistosoma mansoni smad1 5 8 and 0.0009 0.006 0.0038
Schistosoma mansoni nuclear hormone receptor 0.003 0.0551 0.053
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0551 0.127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0064 0.1321 0.1302
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0551 0.053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0551 0.0774
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0022 0.0061
Brugia malayi CXXC zinc finger family protein 0.0031 0.0575 0.1329
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.6981 1
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0551 0.053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0064 0.1321 0.19
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0551 0.1615
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0519 0.4177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0064 0.1321 0.3118
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2748 0.3986
Entamoeba histolytica hypothetical protein 0.0189 0.4188 1
Brugia malayi hypothetical protein 0.015 0.3298 0.7864
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0403 0.1115
Brugia malayi Nuclear hormone receptor E75 0.003 0.0551 0.127
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.6981 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0403 0.106
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0519 0.0714
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0064 0.1321 0.1302
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0488 0.067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Entamoeba histolytica hypothetical protein 0.0189 0.4188 1
Brugia malayi tailless protein 0.003 0.0551 0.127
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Brugia malayi Smad1 0.0009 0.006 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.1321 0.3118
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0634 0.1468
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0064 0.1321 0.3118
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0081
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0551 0.053
Brugia malayi nuclear receptor NHR-88 0.003 0.0551 0.127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0357
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0551 0.053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.1321 0.3118
Schistosoma mansoni nuclear receptor 0.003 0.0551 0.053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.1321 0.1302
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0551 0.0774
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.006 0.0038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0551 0.053
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0346 0.0325
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.006 0.0056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0064 0.1321 0.1302
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0064 0.1321 0.3118
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0403 0.106
Brugia malayi steroid hormone receptor 0.0064 0.1321 0.3118
Schistosoma mansoni ran 0.0021 0.0346 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Schistosoma mansoni importin beta-1 0.0029 0.0519 0.0498
Schistosoma mansoni ran 0.0021 0.0346 0.0325
Brugia malayi ecdysone receptor 0.003 0.0551 0.127
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0022 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.1321 0.1302
Brugia malayi photoreceptor-specific nuclear receptor 0.0064 0.1321 0.3118
Brugia malayi nuclear hormone receptor 0.0064 0.1321 0.3118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0357
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0064 0.1321 0.1302
Schistosoma mansoni thyroid hormone receptor 0.0064 0.1321 0.1302
Brugia malayi hypothetical protein 0.0018 0.0267 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0064 0.1321 0.3118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0403 0.0557
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.6981 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0403 0.0557
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0022 0.0061
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Echinococcus multilocularis smad 0.0009 0.006 0.0038
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0022 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0064 0.1321 0.1302
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0634 0.0613
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2748 0.3986
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0266 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0244 0.0677
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.3232 0.4613
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0551 0.053
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0266 0.0737
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0895
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.1321 0.3118
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0488 0.9382
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0403 0.0547
Loa Loa (eye worm) hypothetical protein 0.0064 0.1321 0.19
Brugia malayi nuclear hormone receptor 0.003 0.0551 0.127
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0064 0.1321 0.1302
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0022 0.0061
Leishmania major GTP-binding protein, putative 0.0021 0.0346 0.0466
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.0774
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.1321 0.1302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.686 1
Schistosoma mansoni RAR-like nuclear receptor 0.0064 0.1321 0.1302
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0403 0.0914
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.3613 1
Echinococcus granulosus snurportin 1 0.0306 0.686 0.6853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0244 0.0677
Schistosoma mansoni thyroid hormone receptor 0.0064 0.1321 0.1302
Brugia malayi Steroid receptor seven-up type 2 0.0064 0.1321 0.3118
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0551 0.127
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0551 0.053
Schistosoma mansoni Smad4 0.0009 0.006 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0081
Leishmania major hypothetical protein, conserved 0.0027 0.0488 0.067
Entamoeba histolytica hypothetical protein 0.0189 0.4188 1
Loa Loa (eye worm) steroid hormone receptor 0.0064 0.1321 0.19
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0551 0.127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0551 0.053
Schistosoma mansoni zinc finger protein 0.003 0.0551 0.053
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0395 0.0536
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0064 0.1321 0.3965
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0144 0.0122
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0488 0.9382
Onchocerca volvulus 0.003 0.0551 0.1615

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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