Detailed information for compound 71833

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.358 | Formula: C23H15FNNaO3
  • H donors: 0 H acceptors: 3 LogP: 6.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)c(C(=O)[O-])c(c(n2)Oc1ccc(cc1)c1ccccc1)C.[Na+]
  • InChi: 1S/C23H16FNO3.Na/c1-14-21(23(26)27)19-13-17(24)9-12-20(19)25-22(14)28-18-10-7-16(8-11-18)15-5-3-2-4-6-15;/h2-13H,1H3,(H,26,27);/q;+1/p-1
  • InChiKey: RETNDRKPKWGDTI-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dihydroorotate dehydrogenase (quinone) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP dihydroorotate dehydrogenase (quinone) 395 aa 361 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.1564 0.4098
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0173 0.0173
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.636 0.6307
Loa Loa (eye worm) acetyltransferase 0.0149 0.7299 0.9562
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0016 0.0316 0.0414
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.636 0.8293
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.1564 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0142 0.0399
Leishmania major P-type ATPase, putative 0.0013 0.0142 0.0142
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.02 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0173 0.0173
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0014 0.0173 0.0031
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0173 0.0173
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0142 0.0142
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 1 1
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.0922 0.0763
Schistosoma mansoni ATPase 0.0028 0.0922 0.0791
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0173 0.0173
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0014 0.0173 0.0173
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1756 0.1756
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.3568 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0078 0.3568 0.3568
Brugia malayi Na,K-ATPase alpha subunit 0.0016 0.0316 0.0316
Trypanosoma brucei oligopeptidase b 0.0052 0.2196 0.2196
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1756 0.4922
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0435
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0316 0.0316
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0173 0.0226
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.636 0.636
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0142 0.0142
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 1 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0422
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.2196 0.2196
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0173 0.0036
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.047 0.0616
Trypanosoma cruzi oligopeptidase b 0.0052 0.2196 0.2196
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0173 0.0226
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.7299 0.7299
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0749 0.0749
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0303 0.019
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0303 0.0303
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.636 0.636
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1756 0.1902
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0014 0.0173 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0922 0.1208
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.3568 0.4038
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0078 0.3568 1
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.0922 0.0922
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0016 0.0316 0.0316
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0316 0.0316
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.02 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0303 0.0133
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0885
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.3568 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0422
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0014 0.0173 0.0036
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.0922 0.0763
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0016 0.0316 0.0204
Leishmania major dihydroorotate dehydrogenase 0.02 1 1
Echinococcus granulosus calcium transporting atpase 0.0025 0.0749 0.0715
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0014 0.0173 0.0173
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.3568 0.4038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0303 0.0397
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0173 0.0031
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.3568 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0303 0.0303
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0016 0.0316 0.0279
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0749 0.0715
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0303 0.0303
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0303 0.0267
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.3568 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0303 0.019
Echinococcus multilocularis geminin 0.0174 0.8626 1
Trypanosoma brucei prolyl endopeptidase 0.0131 0.636 0.636
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0173 0.0484
Toxoplasma gondii P-type ATPase4, putative 0.0016 0.0316 0.0316
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0142 0.0142
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0922 0.2584
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0014 0.0173 0.0173
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0303 0.0303
Echinococcus granulosus Dipeptidyl peptidase 9 0.0014 0.0173 0.0036
Leishmania major oligopeptidase b 0.0052 0.2196 0.2196
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.0922 0.0919
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0885
Loa Loa (eye worm) hypothetical protein 0.0155 0.7633 1
Trypanosoma cruzi oligopeptidase b 0.0052 0.2196 0.2196
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0316 0.0316
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.7078 0.8176
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.3568 0.4038
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.02 1 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0922 0.0919
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.3568 0.4038
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0016 0.0316 0.1219
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.636 0.7328
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0303 0.0133
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.1564 0.1416
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0014 0.0173 0.0173
Echinococcus granulosus prolyl endopeptidase 0.0131 0.636 0.7328
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.0922 0.0919
Trichomonas vaginalis cation-transporting ATPase, putative 0.0016 0.0316 0.0885
Plasmodium vivax P-type ATPase4, putative 0.0028 0.0922 0.0763
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0016 0.0316 0.0316
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0011 0.0054 0.0017
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.0922 0.0888
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.2196 0.2167
Echinococcus granulosus geminin 0.0174 0.8626 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0014 0.0173 0.0173
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0014 0.0173 0.0173
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0173 0.0173
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0303 0.0303
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1756 0.1756
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0174 0.8626 0.8606
Plasmodium falciparum dihydroorotate dehydrogenase 0.02 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1756 0.4922
Brugia malayi Zinc finger, C2H2 type family protein 0.0078 0.3568 0.3568
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0016 0.0316 0.0204
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0142 0.0142
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0173 0.0036
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.636 0.6307
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0749 0.0615
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1756 0.1612
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0016 0.0316 0.0885
Loa Loa (eye worm) hypothetical protein 0.0016 0.0316 0.0414
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.3568 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0303 0.019
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.02 1 1
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0922 0.0919
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.2196 0.2167
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0016 0.0316 0.0316
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0173 0.0484
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.02 1 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0014 0.0173 0.0212
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0749 0.0615
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.636 0.636
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0173 0.0173
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0014 0.0173 0.0036
Loa Loa (eye worm) hypothetical protein 0.0131 0.636 0.8332
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.2196 0.2196
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0303 0.0303
Toxoplasma gondii hypothetical protein 0.0014 0.0173 0.0173
Schistosoma mansoni ATPase 0.0028 0.0922 0.0791
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0173 0.0031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0173 0.0226
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0749 0.0615
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0303 0.0303
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.02 1 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.2196 0.2196
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0303 0.019
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0303 0.0163
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0014 0.0173 0.0173
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 1 1
Onchocerca volvulus 0.0016 0.0316 0.0192
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0749 0.0749
Onchocerca volvulus 0.0155 0.7633 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0303 0.019
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.2196 0.2196
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0422
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.0037 0.0037
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0303 0.0303
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.2196 0.2196
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0014 0.0173 0.0173
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0922 0.2584
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0885
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0142 0.0142
Schistosoma mansoni dihydroorotate dehydrogenase 0.02 1 1
Schistosoma mansoni hypothetical protein 0.0174 0.8626 0.8606
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.5635 0.5618
Leishmania major calcium-translocating P-type ATPase 0.0028 0.0922 0.0922
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.7299 0.8435
Toxoplasma gondii prolyl endopeptidase 0.0131 0.636 0.636
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0885
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.02 1 1
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0016 0.0316 0.0316
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0078 0.3568 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0142 0.0142
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.2196 0.2167
Giardia lamblia Alanyl dipeptidyl peptidase 0.0014 0.0173 0.0212
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0016 0.0316 0.0422
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0014 0.0173 0.0036
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0019 0.047 0.047
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0173 0.0226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0303 0.019
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0316 0.0316
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0016 0.0316 0.0176
Brugia malayi hypothetical protein 0.0155 0.7633 0.7633
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.7299 0.726
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0173 0.0484
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0303 0.0303
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.0922 0.0922
Mycobacterium tuberculosis Probable peptidase 0.0052 0.2196 0.2167
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 1 1
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0749 0.0586
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0316 0.0885
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.0037 0.0049

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10000 nM Ability to inhibit proliferation in a mixture of human lymphocytes from two unrelated donors in MLR (human mixed lymphocyte reaction) ChEMBL. 9873427
Ki (binding) > 1000 nM Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the formation of orotate from radiolabeled dihydroorotate ChEMBL. 9873427
Ki (binding) > 1000 nM Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the formation of orotate from radiolabeled dihydroorotate ChEMBL. 9873427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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