Detailed information for compound 71858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 545.136 | Formula: C28H37ClN4O3S
  • H donors: 2 H acceptors: 3 LogP: 7.45 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOc1cc(NCc2cc(Cl)cc(c2)NC(=O)OC(C)C)nc(c1)CCc1sc(c(n1)C)CC
  • InChi: 1S/C28H37ClN4O3S/c1-6-8-11-35-24-15-22(9-10-27-31-19(5)25(7-2)37-27)32-26(16-24)30-17-20-12-21(29)14-23(13-20)33-28(34)36-18(3)4/h12-16,18H,6-11,17H2,1-5H3,(H,30,32)(H,33,34)
  • InChiKey: LIMKMXRSWFOHST-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor neuropeptide Y receptor Y1 384 aa 345 aa 22.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 0.0146 0.6069 0.6069
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus fmrfamide receptor 0.0132 0.5326 0.5326
Echinococcus granulosus g protein coupled receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0146 0.6069 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.5326 0.5326
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.5326 0.5326
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis sex peptide receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni adenoreceptor 0.0132 0.5326 0.5326
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide s receptor 0.0132 0.5326 0.5326
Schistosoma mansoni hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus multilocularis somatostatin receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni growth hormone secretagogue receptor 0.0132 0.5326 0.5326
Trypanosoma cruzi cytochrome P450, putative 0.0146 0.6069 0.5
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0146 0.6069 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.5326 0.5326
Brugia malayi putative neuropeptide receptor NPR1 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Plasmodium vivax hypothetical protein, conserved 0.0037 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0146 0.6069 0.5
Onchocerca volvulus 0.0132 0.5326 0.5326
Echinococcus granulosus allatostatin A receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0146 0.6069 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis g protein coupled receptor 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine receptor 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0146 0.6069 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0146 0.6069 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0132 0.5326 0.5326
Schistosoma mansoni alpha-1 adrenergic receptor 0.0132 0.5326 0.5326
Schistosoma mansoni hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0146 0.6069 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0146 0.6069 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Schistosoma mansoni histamine h1 receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0146 0.6069 0.5
Schistosoma mansoni neuropeptide receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) cytochrome P450 family protein 0.0146 0.6069 0.6069
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.063 0.063
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0146 0.6069 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Mycobacterium leprae Conserved hypothetical protein 0.0146 0.6069 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0216 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0132 0.5326 0.5326
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0405 0.0405
Brugia malayi sulfakinin receptor protein 0.0132 0.5326 0.5326
Schistosoma mansoni amine GPCR 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Leishmania major cytochrome p450-like protein 0.0146 0.6069 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0146 0.6069 0.6069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus multilocularis orexin receptor type 2 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0146 0.6069 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0146 0.6069 0.5
Echinococcus granulosus neuropeptide receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus peptide allatostatin:somatostatin 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0146 0.6069 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.5326 0.5326
Brugia malayi Cytochrome P450 family protein 0.0146 0.6069 0.6069
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni amine GPCR 0.0132 0.5326 0.5326
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni hypothetical protein 0.0146 0.6069 0.6069
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.5326 0.5326
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus Neuropeptide F receptor homolog 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.5326 0.5326
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0146 0.6069 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0146 0.6069 0.5
Echinococcus multilocularis allatostatin A receptor 0.0132 0.5326 0.5326
Brugia malayi Serotonin receptor 0.0132 0.5326 0.5326
Echinococcus granulosus g-protein coupled receptor 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0082
Echinococcus multilocularis 0.0146 0.6069 0.6069
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Leishmania major cytochrome p450-like protein 0.0146 0.6069 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0132 0.5326 0.5326
Echinococcus multilocularis neuropeptide receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0146 0.6069 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0132 0.5326 0.5326
Brugia malayi G protein-coupled receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0146 0.6069 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0132 0.5326 0.5326
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.5326 0.5326
Leishmania major cytochrome p450-like protein 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) norepinephrine transporter 0.0216 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis g protein coupled receptor 0.0132 0.5326 0.5326
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.5326 0.5326
Echinococcus multilocularis fmrfamide receptor 0.0132 0.5326 0.5326
Echinococcus granulosus hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0146 0.6069 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0405 0.0405
Brugia malayi Cytochrome P450 family protein 0.0146 0.6069 0.6069
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0146 0.6069 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.5326 0.5326
Brugia malayi Cytochrome P450 family protein 0.0146 0.6069 0.6069
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi Serotonin receptor 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide receptor A26 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus g protein coupled receptor 0.0132 0.5326 0.5326
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0146 0.6069 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0244 0.5
Brugia malayi Cytochrome P450 family protein 0.0146 0.6069 0.6069
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus tachykinin peptides receptor 99D 0.0132 0.5326 0.5326
Brugia malayi ORL1-like opioid receptor 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) serotonin transporter b 0.0216 1 1
Onchocerca volvulus 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0244 0.5
Onchocerca volvulus 0.0132 0.5326 0.5326
Brugia malayi putative neuropeptide receptor 0.0132 0.5326 0.5326
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0132 0.5326 0.5326
Schistosoma mansoni opsin-like receptor 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus granulosus serotonin transporter 0.0216 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0132 0.5326 0.5326
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.5326 0.5326
Brugia malayi Dopamine receptor protein 1 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0146 0.6069 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.063 0.063
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Brugia malayi Dopamine receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0216 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0146 0.6069 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0132 0.5326 0.5326
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0405 0.0405
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.5326 0.5326
Loa Loa (eye worm) cytochrome P450 family protein 0.0146 0.6069 0.6069
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0146 0.6069 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0146 0.6069 0.5
Echinococcus multilocularis serotonin transporter 0.0216 1 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0037 0 0.5
Brugia malayi RE15519p 0.0132 0.5326 0.5326
Echinococcus granulosus G protein coupled receptor 139 0.0132 0.5326 0.5326
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0405 0.0405
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0146 0.6069 0.5
Schistosoma mansoni opsin-like receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0216 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) CYP4Cod1 0.0146 0.6069 0.6069
Brugia malayi neuropeptide F receptor 0.0132 0.5326 0.5326
Brugia malayi larval opioid receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) melatonin receptor type 1A 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0146 0.6069 0.5
Brugia malayi follicle stimulating hormone receptor 0.0132 0.5326 0.5326
Mycobacterium leprae putative cytochrome p450 0.0146 0.6069 0.5
Brugia malayi cytochrome P450 0.0146 0.6069 0.6069
Echinococcus granulosus alpha 1A adrenergic receptor 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Plasmodium falciparum amino acid transporter, putative 0.0037 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0132 0.5326 0.5326
Echinococcus granulosus g protein coupled receptor 0.0132 0.5326 0.5326
Schistosoma mansoni cytochrome P450 0.0146 0.6069 0.6069
Brugia malayi G-protein coupled receptor 0.0132 0.5326 0.5326
Schistosoma mansoni amine GPCR 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.5326 0.5326
Echinococcus granulosus orexin receptor type 2 0.0132 0.5326 0.5326
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis G-protein coupled receptor, putative 0.0132 0.5326 0.5326
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0132 0.5326 0.5326
Echinococcus multilocularis g-protein coupled receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0146 0.6069 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0132 0.5326 0.5326
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus serotonin receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0146 0.6069 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0146 0.6069 0.5
Echinococcus granulosus sex peptide receptor 0.0132 0.5326 0.5326
Echinococcus granulosus 7TM GPCR rhodopsin 0.0132 0.5326 0.5326
Plasmodium vivax amine transporter, putative 0.0037 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Brugia malayi GnHR receptor homolog 0.0132 0.5326 0.5326
Brugia malayi Tachykinin-like peptides receptor 99D 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0146 0.6069 0.5
Schistosoma mansoni amine GPCR 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0216 1 1
Brugia malayi neuropeptide F receptor 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide FF receptor 2 0.0132 0.5326 0.5326
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine receptor 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni neuropeptide receptor 0.0132 0.5326 0.5326
Schistosoma mansoni amine GPCR 0.0132 0.5326 0.5326
Toxoplasma gondii cytochrome p450 superfamily protein 0.0146 0.6069 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0146 0.6069 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0146 0.6069 0.5
Brugia malayi Melatonin receptor type 1A 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Treponema pallidum sodium- and chloride- dependent transporter 0.0216 1 0.5
Echinococcus granulosus somatostatin receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus granulosus cytochrome P450 2K1 0.0146 0.6069 0.6069
Plasmodium falciparum transporter, putative 0.0037 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0132 0.5326 0.5326
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.5326 0.5326
Trypanosoma cruzi cytochrome P450, putative 0.0146 0.6069 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0132 0.5326 0.5326
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Echinococcus multilocularis serotonin receptor 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis g protein coupled receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.5326 0.5326
Brugia malayi AKH receptor 0.0132 0.5326 0.5326
Schistosoma mansoni neuropeptide receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.5326 0.5326
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus 7tm_1 domain containing protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni sodium/chloride dependent transporter 0.0216 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus granulosus neuropeptide receptor 0.0132 0.5326 0.5326
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni myosin xvIII 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0216 1 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Echinococcus multilocularis serotonin receptor 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0146 0.6069 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0146 0.6069 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0146 0.6069 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0132 0.5326 0.5326
Echinococcus multilocularis fmrfamide receptor 0.0132 0.5326 0.5326
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0146 0.6069 0.5
Brugia malayi hypothetical protein 0.0132 0.5326 0.5326
Brugia malayi G-protein coupled receptor 0.0132 0.5326 0.5326
Echinococcus multilocularis G protein coupled receptor 139 0.0132 0.5326 0.5326
Schistosoma mansoni neuropeptide receptor 0.0132 0.5326 0.5326
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.5326 0.5326
Loa Loa (eye worm) TYRA-2 protein 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0146 0.6069 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0146 0.6069 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0146 0.6069 0.5
Onchocerca volvulus 0.0132 0.5326 0.5326
Echinococcus multilocularis neuropeptide receptor A26 0.0132 0.5326 0.5326
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0132 0.5326 0.5326
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0146 0.6069 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0132 0.5326 0.5326
Onchocerca volvulus 0.0132 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0132 0.5326 0.5326
Schistosoma mansoni hypothetical protein 0.0132 0.5326 0.5326
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0132 0.5326 0.5326
Trypanosoma brucei cytochrome P450, putative 0.0146 0.6069 0.5
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0146 0.6069 0.5
Schistosoma mansoni opsin-like receptor 0.0132 0.5326 0.5326
Loa Loa (eye worm) solute carrier family 6 member 4 0.0216 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0132 0.5326 0.5326

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) nM Inhibitory concentration against 1 nM NPY induced [Ca2+] increase in CHO/dhFr- cells expressing recombinant human Y1 receptor; d=Not determined ChEMBL. 15026066
IC50 (functional) 0 nM Inhibitory concentration against 1 nM NPY induced [Ca2+] increase in CHO/dhFr- cells expressing recombinant human Y1 receptor; d=Not determined ChEMBL. 15026066
IC50 (binding) = 16 nM Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]-PYY ChEMBL. 15026066
IC50 (binding) = 16 nM Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]-PYY ChEMBL. 15026066

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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