Detailed information for compound 71859

Basic information

Technical information
  • TDR Targets ID: 71859
  • Name: N-(3,4-dichlorophenyl)-4-methylbenzenesulfona mide
  • MW: 316.203 | Formula: C13H11Cl2NO2S
  • H donors: 1 H acceptors: 2 LogP: 4.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C13H11Cl2NO2S/c1-9-2-5-11(6-3-9)19(17,18)16-10-4-7-12(14)13(15)8-10/h2-8,16H,1H3
  • InChiKey: SXCHPSMRYXIEGD-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(3,4-dichlorophenyl)-4-methyl-benzenesulfonamide
  • 16964-21-9
  • ZINC00102662
  • ST010997
  • NSC35193

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide s receptor 0.013 0.6351 0.6351
Brugia malayi Serotonin/octopamine receptor family protein 7 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent transporter 0.02 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0145 0.7126 0.5
Schistosoma mansoni hypothetical protein 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptides capa receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus tachykinin peptides receptor 99D 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0145 0.7126 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0145 0.7126 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0145 0.7126 0.7126
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0145 0.7126 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptide FF receptor 2 0.013 0.6351 0.6351
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.013 0.6351 0.6351
Brugia malayi Dopamine receptor protein 2 0.013 0.6351 0.6351
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0145 0.7126 0.5
Brugia malayi Melatonin receptor type 1A 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.0035 0.142 0.142
Schistosoma mansoni adenoreceptor 0.013 0.6351 0.6351
Trypanosoma brucei cytochrome P450, putative 0.0145 0.7126 0.5
Echinococcus granulosus neuropeptide Y receptor 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine receptor 0.013 0.6351 0.6351
Schistosoma mansoni amine GPCR 0.013 0.6351 0.6351
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.1349 0.1349
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.02 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus g protein coupled receptor 0.013 0.6351 0.6351
Leishmania major cytochrome p450-like protein 0.0145 0.7126 0.5
Echinococcus granulosus serotonin receptor 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.1349 0.1349
Schistosoma mansoni hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptide receptor 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Echinococcus multilocularis g protein coupled receptor 0.013 0.6351 0.6351
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0145 0.7126 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0145 0.7126 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus peptide allatostatin:somatostatin 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0145 0.7126 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.013 0.6351 0.6351
Schistosoma mansoni opsin-like receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni histamine h1 receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0145 0.7126 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.6351 0.6351
Leishmania major cytochrome p450-like protein 0.0145 0.7126 0.5
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0145 0.7126 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.6351 0.6351
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.6351 0.6351
Trypanosoma cruzi cytochrome P450, putative 0.0145 0.7126 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1895 0.1895
Plasmodium vivax hypothetical protein, conserved 0.0034 0.1349 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Echinococcus multilocularis g-protein coupled receptor 0.013 0.6351 0.6351
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0145 0.7126 0.5
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.8657 0.8657
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0145 0.7126 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.6351 0.6351
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi RE15519p 0.013 0.6351 0.6351
Loa Loa (eye worm) melatonin receptor type 1A 0.013 0.6351 0.6351
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.6351 0.6351
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0145 0.7126 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Echinococcus multilocularis fmrfamide receptor 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptide receptor A26 0.013 0.6351 0.6351
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.1349 0.1349
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Brugia malayi cytochrome P450 0.0145 0.7126 0.7126
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) follicle stimulating hormone receptor 0.013 0.6351 0.6351
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0175 0.8657 0.8657
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.1349 0.1349
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Echinococcus multilocularis allatostatin A receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0145 0.7126 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus cytochrome P450 2K1 0.0145 0.7126 0.7126
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.8657 0.8657
Echinococcus multilocularis sex peptide receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0145 0.7126 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.013 0.6351 0.6351
Leishmania major cytochrome p450-like protein 0.0145 0.7126 0.5
Echinococcus multilocularis serotonin receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0034 0.1349 0.1349
Brugia malayi Cytochrome P450 family protein 0.0145 0.7126 0.7126
Onchocerca volvulus 0.02 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Echinococcus granulosus g-protein coupled receptor 0.013 0.6351 0.6351
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.013 0.6351 0.6351
Schistosoma mansoni hypothetical protein 0.0145 0.7126 0.7126
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0145 0.7126 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptide Y receptor 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0195 0.0195
Onchocerca volvulus 0.013 0.6351 0.5782
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0145 0.7126 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0195
Trypanosoma cruzi cytochrome P450, putative 0.0145 0.7126 0.5
Toxoplasma gondii cytochrome p450 superfamily protein 0.0145 0.7126 1
Brugia malayi ORL1-like opioid receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0145 0.7126 0.5
Onchocerca volvulus 0.013 0.6351 0.5782
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Echinococcus granulosus alpha 1A adrenergic receptor 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.013 0.6351 0.6351
Echinococcus multilocularis g protein coupled receptor 0.013 0.6351 0.6351
Brugia malayi GnHR receptor homolog 0.013 0.6351 0.6351
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0145 0.7126 0.5
Echinococcus granulosus neuropeptide s receptor 0.013 0.6351 0.6351
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.1349 0.1349
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.6351 0.6351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.6351 0.6351
Echinococcus granulosus G protein coupled receptor 139 0.013 0.6351 0.6351
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.6351 0.6351
Echinococcus multilocularis serotonin receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0145 0.7126 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0145 0.7126 0.5
Echinococcus multilocularis fmrfamide receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0145 0.7126 0.5
Loa Loa (eye worm) cytochrome P450 0.0145 0.7126 0.7126
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.6351 0.6351
Brugia malayi sulfakinin receptor protein 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.17 0.17
Brugia malayi AKH receptor 0.013 0.6351 0.6351
Brugia malayi Cytochrome P450 family protein 0.0145 0.7126 0.7126
Echinococcus multilocularis neuropeptide receptor A26 0.013 0.6351 0.6351
Schistosoma mansoni cytochrome P450 0.0145 0.7126 0.7126
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.1349 0.1349
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.013 0.6351 0.6351
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0034 0.1349 0.5
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Onchocerca volvulus 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus g protein coupled receptor 0.013 0.6351 0.6351
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0175 0.8657 0.8448
Brugia malayi Protein kinase domain containing protein 0.0175 0.8657 0.8657
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.013 0.6351 0.6351
Echinococcus multilocularis alpha 1A adrenergic receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus multilocularis serotonin transporter 0.02 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0145 0.7126 0.5
Schistosoma mansoni hypothetical protein 0.013 0.6351 0.6351
Brugia malayi Serotonin receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) cytochrome P450 family protein 0.0145 0.7126 0.7126
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.013 0.6351 0.6351
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) norepinephrine transporter 0.02 1 1
Brugia malayi Cytochrome P450 family protein 0.0145 0.7126 0.7126
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Echinococcus multilocularis orexin receptor type 2 0.013 0.6351 0.6351
Brugia malayi Dopamine receptor protein 1 0.013 0.6351 0.6351
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0145 0.7126 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0145 0.7126 0.5
Schistosoma mansoni amine GPCR 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0145 0.7126 0.5
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Schistosoma mansoni sodium-dependent amino acid transporter 0.0034 0.1349 0.1349
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni neuropeptide receptor 0.013 0.6351 0.6351
Schistosoma mansoni neuropeptide receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Schistosoma mansoni opsin-like receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Mycobacterium leprae putative cytochrome p450 0.0145 0.7126 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.013 0.6351 0.6351
Echinococcus multilocularis neuropeptide receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0145 0.7126 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.013 0.6351 0.6351
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0175 0.8657 0.8657
Echinococcus multilocularis g protein coupled receptor 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0145 0.7126 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.013 0.6351 0.6351
Brugia malayi G-protein coupled receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0145 0.7126 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0175 0.8657 0.8657
Loa Loa (eye worm) solute carrier family 6 member 4 0.02 1 1
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0145 0.7126 0.5
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0145 0.7126 0.5
Onchocerca volvulus 0.013 0.6351 0.5782
Echinococcus granulosus hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus g protein coupled receptor 0.013 0.6351 0.6351
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0034 0.1349 0.1349
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.6351 0.6351
Brugia malayi G protein-coupled receptor F59B2.13 0.013 0.6351 0.6351
Echinococcus multilocularis biogenic amine (5HT) receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0145 0.7126 0.5
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.02 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0034 0.1349 0.1349
Echinococcus multilocularis neuropeptide receptor 0.013 0.6351 0.6351
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.1561 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1895 0.1895
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0145 0.7126 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.1349 0.1349
Echinococcus granulosus orexin receptor type 2 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0145 0.7126 0.5
Schistosoma mansoni neuropeptide receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0145 0.7126 0.5
Onchocerca volvulus 0.013 0.6351 0.5782
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.1349 0.1349
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi G protein-coupled receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.013 0.6351 0.6351
Brugia malayi follicle stimulating hormone receptor 0.013 0.6351 0.6351
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi gonadotropin-releasing hormone receptor 2 0.013 0.6351 0.6351
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0195 0.0195
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0034 0.1349 0.1349
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus fmrfamide receptor 0.013 0.6351 0.6351
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Echinococcus multilocularis somatostatin receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni biogenic amine receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Plasmodium vivax amine transporter, putative 0.0034 0.1349 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus dro:myosuppressin receptor 0.013 0.6351 0.6351
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.1349 0.1349
Plasmodium falciparum amino acid transporter, putative 0.0034 0.1349 0.5
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.1349 0.1349
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.17 0.17
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.6351 0.6351
Schistosoma mansoni peptide (allatostatin)-like receptor 0.013 0.6351 0.6351
Schistosoma mansoni amine GPCR 0.013 0.6351 0.6351
Mycobacterium leprae Conserved hypothetical protein 0.0145 0.7126 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.6351 0.6351
Schistosoma mansoni myosin xvIII 0.013 0.6351 0.6351
Schistosoma mansoni neuropeptide f receptor 76f 0.013 0.6351 0.6351
Plasmodium falciparum transporter, putative 0.0034 0.1349 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi Dopamine receptor 0.013 0.6351 0.6351
Echinococcus granulosus 7TM GPCR rhodopsin 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.8657 0.8657
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.6351 0.6351
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.013 0.6351 0.6351
Schistosoma mansoni amine GPCR 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0145 0.7126 0.5
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0145 0.7126 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.013 0.6351 0.6351
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.17 0.17
Schistosoma mansoni opsin-like receptor 0.013 0.6351 0.6351
Brugia malayi neuropeptide F receptor 0.013 0.6351 0.6351
Echinococcus multilocularis dro:myosuppressin receptor 0.013 0.6351 0.6351
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0145 0.7126 0.5
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0145 0.7126 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.6351 0.6351
Treponema pallidum sodium- and chloride- dependent transporter 0.02 1 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi putative neuropeptide receptor NPR1 0.013 0.6351 0.6351
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.013 0.6351 0.6351
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0034 0.1349 0.1349
Schistosoma mansoni biogenic amine receptor 0.013 0.6351 0.6351
Onchocerca volvulus 0.013 0.6351 0.5782
Onchocerca volvulus Neuropeptide F receptor homolog 0.013 0.6351 0.5782
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Loa Loa (eye worm) serotonin transporter b 0.02 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.6351 0.6351
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.1561 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.013 0.6351 0.6351
Schistosoma mansoni amine GPCR 0.013 0.6351 0.6351
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.1402 0.1402
Echinococcus granulosus allatostatin A receptor 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Brugia malayi putative neuropeptide receptor 0.013 0.6351 0.6351
Echinococcus multilocularis 0.0145 0.7126 0.7126
Echinococcus granulosus sex peptide receptor 0.013 0.6351 0.6351
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.6351 0.6351
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.02 1 1
Brugia malayi Serotonin receptor 0.013 0.6351 0.6351
Brugia malayi larval opioid receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0145 0.7126 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.013 0.6351 0.6351
Echinococcus granulosus somatostatin receptor 0.013 0.6351 0.6351
Brugia malayi neuropeptide F receptor 0.013 0.6351 0.6351
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0195 0.0195
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0195 0.0195
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0145 0.7126 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0145 0.7126 0.5
Echinococcus granulosus neuropeptides capa receptor 0.013 0.6351 0.6351
Schistosoma mansoni neuropeptide receptor 0.013 0.6351 0.6351
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.17 0.17
Echinococcus granulosus serotonin transporter 0.02 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0145 0.7126 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.013 0.6351 0.6351
Loa Loa (eye worm) cytochrome P450 family protein 0.0145 0.7126 0.7126
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.02 1 1
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.6351 0.6351
Loa Loa (eye worm) TYRA-2 protein 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.0034 0.1349 0.1349
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0145 0.7126 0.5
Loa Loa (eye worm) CYP4Cod1 0.0145 0.7126 0.7126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.6351 0.6351
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.013 0.6351 0.6351
Brugia malayi G-protein coupled receptor 0.013 0.6351 0.6351
Brugia malayi hypothetical protein 0.013 0.6351 0.6351
Echinococcus granulosus neuropeptide receptor 0.013 0.6351 0.6351
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0145 0.7126 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.6351 0.6351
Brugia malayi Cytochrome P450 family protein 0.0145 0.7126 0.7126
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0145 0.7126 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.013 0.6351 0.6351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.6351 0.6351

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 10 p.p.m. Minimum inhibitory concentration against staphylococcus aureus ATCC 6538 ChEMBL. 6644743

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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