TDR Targets

Basic information

Technical information

TDR Targets ID: 718781
Name: 2-[(3-chloro-4-methylphenyl)-(4-methylphenyl) sulfonylamino]-N-cyclopropylacetamide
MW: 392.9 | Formula: C19H21ClN2O3S
H donors: 1 H acceptors: 3 LogP: 3.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)C)c1ccc(c(c1)Cl)C)NC1CC1
InChi: 1S/C19H21ClN2O3S/c1-13-3-9-17(10-4-13)26(24,25)22(12-19(23)21-15-6-7-15)16-8-5-14(2)18(20)11-16/h3-5,8-11,15H,6-7,12H2,1-2H3,(H,21,23)
InChiKey: BHKHZRQDRDOJCI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(3-chloro-4-methyl-phenyl)-(4-methylphenyl)sulfonyl-amino]-N-cyclopropyl-acetamide
2-[(3-chloro-4-methyl-phenyl)-(4-methylphenyl)sulfonyl-amino]-N-cyclopropyl-ethanamide
ZINC01110184

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	1
Brugia malayi	Probable ClpP-like protease	0.0094	0.5355	0.5355
Brugia malayi	hypothetical protein	0.0039	0.1596	0.1596
Echinococcus granulosus	tar DNA binding protein	0.0076	0.4134	0.3999
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.5355	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4134	0.762
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1729	0.1729
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4134	0.762
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.1596	0.1402
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0928	0.0928
Echinococcus granulosus	lamin dm0	0.0029	0.0928	0.0719
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.2319	0.2142
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.2319	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1729	0.1729
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0163	1	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1667	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0225	0.0225
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.2319	0.4082
Echinococcus granulosus	lamin	0.0029	0.0928	0.0719
Schistosoma mansoni	inositol monophosphatase	0.004	0.1667	0.281
Echinococcus granulosus	intermediate filament protein	0.0029	0.0928	0.0719
Brugia malayi	TAR-binding protein	0.0076	0.4134	0.4134
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0928	0.0928
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.5355	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.4134	0.4134
Onchocerca volvulus		0.0029	0.0928	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.4134	0.3999
Loa Loa (eye worm)	hypothetical protein	0.0094	0.5355	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0163	1	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.3141	0.2983
Brugia malayi	RNA binding protein	0.0076	0.4134	0.4134
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.5355	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.3025	0.3025
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.4134	0.4134
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.2319	0.2142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.2319	0.4082
Loa Loa (eye worm)	inositol-1	0.004	0.1667	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0891	0.0891
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1667	0.5
Schistosoma mansoni	lamin	0.0029	0.0928	0.137
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.5355	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4134	0.762
Schistosoma mansoni	lamin	0.0029	0.0928	0.137
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.3025	0.3025
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.1667	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.1667	0.5
Schistosoma mansoni	hypothetical protein	0.0039	0.1596	0.2671
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.5355	0.5248
Echinococcus multilocularis	muscleblind protein	0.0163	1	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.3141	1
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.1667	0.1475
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0225	0.0225
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.1667	0.5
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.1667	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0225	0.0225
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.3025	0.3025
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.1667	0.1475
Loa Loa (eye worm)	RNA binding protein	0.0076	0.4134	0.4134
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.138	0.0562
Onchocerca volvulus		0.0029	0.0928	0.5
Schistosoma mansoni	inositol monophosphatase	0.004	0.1667	0.281
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.2319	0.2319
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.1596	0.1402
Echinococcus multilocularis	lamin dm0	0.0029	0.0928	0.0719
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.5355	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.2319	0.2319
Echinococcus granulosus	muscleblind protein	0.0163	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4134	0.762
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0928	0.0928
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.2319	0.2142
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0928	0.0928
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4134	0.762
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.1667	0.1243
Brugia malayi	Inositol-1	0.004	0.1667	0.1667
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.1596	0.2671
Echinococcus multilocularis	musashi	0.0029	0.0928	0.0719
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.5355	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.4134	0.4134
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.3141	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1667	0.5
Brugia malayi	intermediate filament protein	0.0029	0.0928	0.0928
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0225	0.0225
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.3141	0.2983
Loa Loa (eye worm)	hypothetical protein	0.006	0.3025	0.3025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.2319	0.2142
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0928	0.137
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.5355	0.5248
Schistosoma mansoni	hypothetical protein	0.0041	0.1729	0.2932
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1667	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.3141	0.4744
Loa Loa (eye worm)	hypothetical protein	0.0163	1	1
Echinococcus multilocularis	lamin	0.0029	0.0928	0.0719

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1995 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1323242
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 718781