Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4055 | 0.3829 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0365 | 0.0123 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.182 | 0.1633 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2201 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.1709 | 0.1395 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4055 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.182 | 0.443 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4055 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.389 | 0.959 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4055 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2201 | 0.1911 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4055 | 0.3952 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2201 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.3449 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0247 | 0.0509 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0204 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2201 | 0.2028 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.182 | 0.443 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4055 | 0.3834 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2201 | 0.5379 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2201 | 0.2028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4055 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1709 | 0.4154 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.9883 | 0.9878 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.9883 | 0.9879 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.9883 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.9883 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.9883 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0365 | 0.0123 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.1709 | 0.1401 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4055 | 0.3829 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.9883 | 0.9878 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2201 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4055 | 0.3829 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.182 | 0.1633 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0204 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4055 | 0.3834 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0204 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0204 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4055 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2201 | 0.5379 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4055 | 0.3952 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2201 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4055 | 0.3834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.636 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.