Detailed information for compound 719134

Basic information

Technical information
  • TDR Targets ID: 719134
  • Name: ZINC05013746
  • MW: 334.754 | Formula: C16H15ClN2O4
  • H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1OC)C(=O)ONC(=N)c1ccc(cc1)Cl
  • InChi: 1S/C16H15ClN2O4/c1-21-13-5-3-4-12(14(13)22-2)16(20)23-19-15(18)10-6-8-11(17)9-7-10/h3-9H,1-2H3,(H2,18,19)
  • InChiKey: HZTOUERDKMWUPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [[amino-(4-chlorophenyl)methylidene]amino] 2,3-dimethoxybenzoate
  • [[amino-(4-chlorophenyl)methylene]amino] 2,3-dimethoxybenzoate
  • 2,3-dimethoxybenzoic acid [[amino-(4-chlorophenyl)methylene]amino] ester
  • STK323024

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.007 0.1297 0.2812
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1297 0.2379
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1297 0.2812
Mycobacterium leprae conserved hypothetical protein 0.007 0.1297 0.2812
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0213 0.4578 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Loa Loa (eye worm) hypothetical protein 0.0127 0.2612 0.5996
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1297 0.2961
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0035 0.0068
Brugia malayi Pre-SET motif family protein 0.0203 0.4347 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0143 0.0401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0035 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Echinococcus multilocularis dna polymerase eta 0.002 0.0143 0.0401
Onchocerca volvulus 0.007 0.1297 0.2578
Loa Loa (eye worm) hypothetical protein 0.0127 0.2612 0.5996
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2358 0.541
Loa Loa (eye worm) hypothetical protein 0.0155 0.3255 0.7479
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1297 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0446 0.0998
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0143 0.1013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1297 0.7178
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1297 0.2379
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0143 0.1013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0143 0.0727
Loa Loa (eye worm) hypothetical protein 0.0155 0.3255 0.7479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0351 0.1888
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1297 0.2961
Onchocerca volvulus 0.0231 0.4992 1
Trypanosoma brucei oxidoreductase-like protein 0.0014 0.0013 0.0102
Schistosoma mansoni hypothetical protein 0.0033 0.0446 0.2418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1297 0.7178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1297 0.2812
Brugia malayi hypothetical protein 0.0127 0.2612 0.5996
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0213 0.4578 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0351 0.1042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0799 0.1813
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0123
Loa Loa (eye worm) beta-lactamase 0.007 0.1297 0.2961
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Leishmania major hypothetical protein, conserved 0.007 0.1297 1
Leishmania major DNA polymerase eta, putative 0.002 0.0143 0.1013
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0143 0.1013
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1297 0.1285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1801 0.4125
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0351 0.1042
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0014 0.0013 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.1105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0799 0.1813
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1297 0.2379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0351 0.1888
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1297 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0351 0.1888
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0143 0.03
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0143 0.0727
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0143 0.1013
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0143 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0035 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1801 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0351 0.074
Trichomonas vaginalis hypothetical protein 0.0213 0.4578 0.9146
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1297 0.2379
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0446 0.0998
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0213 0.4578 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0213 0.4578 1
Onchocerca volvulus 0.007 0.1297 0.2578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1297 0.1285
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1297 0.3959
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0351 0.074
Plasmodium vivax hypothetical protein, conserved 0.007 0.1297 0.2812
Mycobacterium tuberculosis Conserved protein 0.007 0.1297 0.1285
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1297 0.1285
Mycobacterium tuberculosis Conserved protein 0.007 0.1297 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0351 0.1888
Loa Loa (eye worm) hypothetical protein 0.0029 0.0351 0.0779
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0326 0.0966
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Brugia malayi beta-lactamase 0.007 0.1297 0.2961
Schistosoma mansoni DNA polymerase eta 0.002 0.0143 0.0727
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0213 0.4578 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0035 0.0051
Trichomonas vaginalis esterase, putative 0.007 0.1297 0.2379
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1297 0.1285
Brugia malayi Muscleblind-like protein 0.0155 0.3255 0.7479
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1297 0.1285
Mycobacterium ulcerans hypothetical protein 0.007 0.1297 0.2812
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1297 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0143 0.1013
Mycobacterium ulcerans lipase LipD 0.007 0.1297 0.2812
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.1105
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0143 0.1013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0143 0.0401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1801 0.5516
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0143 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1801 0.5516
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0213 0.4578 1
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3255 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4347 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1801 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0143 0.1013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0035 0.0051
Brugia malayi beta-lactamase family protein 0.007 0.1297 0.2961
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0123
Trypanosoma brucei pteridine reductase 1 0.0014 0.0013 0.0102
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1801 0.4125
Onchocerca volvulus 0.0029 0.0351 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Brugia malayi Pre-SET motif family protein 0.0029 0.0351 0.0779
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0123
Echinococcus granulosus muscleblind protein 0.0155 0.3255 1
Brugia malayi beta-lactamase family protein 0.007 0.1297 0.2961
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Mycobacterium leprae Probable lipase LipE 0.007 0.1297 0.2812
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0799 0.1813
Plasmodium falciparum enoyl-acyl carrier reductase 0.0213 0.4578 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0143 0.03
Brugia malayi MH2 domain containing protein 0.0116 0.2358 0.541
Onchocerca volvulus Huntingtin homolog 0.0127 0.2612 0.522
Echinococcus multilocularis GPCR, family 2 0.0015 0.0035 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1801 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0213 0.4578 0.4571
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Echinococcus granulosus GPCR family 2 0.0015 0.0035 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1297 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0143 0.0285
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4992 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1297 0.2961
Echinococcus multilocularis muscleblind protein 0.0155 0.3255 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Giardia lamblia DINP protein human, muc B family 0.002 0.0143 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0143 0.1105
Onchocerca volvulus 0.007 0.1297 0.2578
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.03
Trypanosoma brucei unspecified product 0.002 0.0143 0.1105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0035 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1801 0.5516
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0143 0.03
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1297 0.3959
Echinococcus multilocularis dna polymerase kappa 0.002 0.0143 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Onchocerca volvulus Huntingtin homolog 0.0127 0.2612 0.522
Echinococcus granulosus dna polymerase eta 0.002 0.0143 0.0401
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0143 0.0401
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0143 1
Mycobacterium ulcerans beta-lactamase 0.007 0.1297 0.2812
Mycobacterium tuberculosis Conserved protein 0.007 0.1297 0.1285
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1297 0.2379
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.1105
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.1105
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0035 0.0068
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0143 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1801 0.5516
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1297 0.1285
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0799 0.1813
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2358 0.541
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0351 0.1042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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