Detailed information for compound 719181

Basic information

Technical information
  • TDR Targets ID: 719181
  • Name: 1-(2,5-dimethoxyphenyl)-3-(3-methylphenyl)thi ourea
  • MW: 302.391 | Formula: C16H18N2O2S
  • H donors: 2 H acceptors: 0 LogP: 3.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)NC(=S)Nc1cccc(c1)C)OC
  • InChi: 1S/C16H18N2O2S/c1-11-5-4-6-12(9-11)17-16(21)18-14-10-13(19-2)7-8-15(14)20-3/h4-10H,1-3H3,(H2,17,18,21)
  • InChiKey: RBRDZJJVWIADRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK131150
  • ZINC00619605

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.2609 0.4199
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.6214 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Onchocerca volvulus 0.0035 0.1082 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2609 0.4199
Brugia malayi beta-lactamase 0.0035 0.1082 0.1742
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1082 0.1742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.153 0.254
Mycobacterium leprae Probable lipase LipE 0.0035 0.1082 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.153 0.2462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.153 0.2462
Loa Loa (eye worm) TAR-binding protein 0.0067 0.2609 0.4199
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.1423 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2609 0.4199
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.2609 0.4199
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.1423 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1082 0.5
Onchocerca volvulus 0.0035 0.1082 1
Loa Loa (eye worm) RNA binding protein 0.0067 0.2609 0.4199
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1082 0.1742
Leishmania major hypothetical protein, conserved 0.0035 0.1082 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.1423 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.6023 1
Brugia malayi TAR-binding protein 0.0067 0.2609 0.4199
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1257 0.5
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2609 0.4199
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.1423 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1082 0.1742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.153 0.254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.153 0.2462
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1082 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1082 0.5
Loa Loa (eye worm) acetyltransferase 0.0143 0.6214 1
Echinococcus granulosus tar DNA binding protein 0.0067 0.2609 0.4332
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.153 0.2462
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1082 0.5
Echinococcus multilocularis tar DNA binding protein 0.0067 0.2609 0.4199
Brugia malayi RNA binding protein 0.0067 0.2609 0.4199
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2609 0.4199
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1082 0.5
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.6214 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1257 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1082 0.5
Mycobacterium ulcerans hypothetical protein 0.0035 0.1082 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.153 0.2462
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Brugia malayi beta-lactamase family protein 0.0035 0.1082 0.1742
Brugia malayi beta-lactamase family protein 0.0035 0.1082 0.1742
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2609 0.4199
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.1423 1
Onchocerca volvulus 0.0035 0.1082 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1742
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.1423 0.2363
Mycobacterium ulcerans lipase LipD 0.0035 0.1082 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.153 0.2462
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.6214 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1082 0.1742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.153 0.2462
Mycobacterium ulcerans beta-lactamase 0.0035 0.1082 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.1082 0.1742
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1082 0.1797
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1082 0.1742
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1257 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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