Detailed information for compound 719361

Basic information

Technical information
  • TDR Targets ID: 719361
  • Name: 2-[(4-bromophenyl)sulfonyl-[(2-chlorophenyl)m ethyl]amino]-N-cyclopropylacetamide
  • MW: 457.769 | Formula: C18H18BrClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)Br)Cc1ccccc1Cl)NC1CC1
  • InChi: 1S/C18H18BrClN2O3S/c19-14-5-9-16(10-6-14)26(24,25)22(12-18(23)21-15-7-8-15)11-13-3-1-2-4-17(13)20/h1-6,9-10,15H,7-8,11-12H2,(H,21,23)
  • InChiKey: LJISOHPJVRUGSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-bromophenyl)sulfonyl-[(2-chlorophenyl)methyl]amino]-N-cyclopropyl-acetamide
  • 2-[(4-bromophenyl)sulfonyl-(2-chlorobenzyl)amino]-N-cyclopropyl-acetamide
  • 2-[(4-bromophenyl)sulfonyl-[(2-chlorophenyl)methyl]amino]-N-cyclopropyl-ethanamide
  • ZINC01108577

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0092 0.0092
Brugia malayi hypothetical protein 0.001 0.0092 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0019 0.04 0.0493
Toxoplasma gondii protease inhibitor PI2 0.0022 0.0519 0.2047
Schistosoma mansoni neprilysin-2 (M13 family) 0.0022 0.0501 0.0642
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0092 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0478 0.0478
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0019 0.04 0.0338
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0071 0.2199 0.3134
Brugia malayi SPARC precursor 0.0022 0.0519 0.0459
Schistosoma mansoni hypothetical protein 0.0014 0.025 0.0273
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0586 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.0047 0.1383 0.1383
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0013 0.0197 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Onchocerca volvulus 0.001 0.0085 0.0053
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.5934
Leishmania major cathepsin L-like protease 0.0037 0.1041 0.2799
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0009 0.0065 0.0002
Echinococcus granulosus lysine specific demethylase 5A 0.0024 0.0586 0.0526
Echinococcus multilocularis serotonin receptor 0.0075 0.2338 0.2289
Echinococcus granulosus single minded 2 0.001 0.0108 0.0045
Schistosoma mansoni hypothetical protein 0.0014 0.025 0.0273
Echinococcus granulosus histone acetyltransferase KAT2B 0.0121 0.3949 0.391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0949 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Schistosoma mansoni neprilysin 0.0011 0.0137 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Onchocerca volvulus Huntingtin homolog 0.0118 0.3826 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi acetyltransferase, GNAT family protein 0.0125 0.407 0.4032
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0112 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0478 0.0607
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0011 0.0111 0.007
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0586 0.0526
Loa Loa (eye worm) hypothetical protein 0.0016 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0071 0.2199 0.2149
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0092 0.0028
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0092 0.0041
Brugia malayi CHE-14 protein 0.0045 0.1313 0.1257
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.1041 0.2799
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0033 0.0878 0.082
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0133 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0019 0.04 0.0338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0092 0.0028
Giardia lamblia Synaptic glycoprotein SC2 0.0071 0.2199 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0071 0.2199 0.2149
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0478 0.0607
Onchocerca volvulus 0.001 0.0087 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0478 0.0417
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.011 0.355 0.3509
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0017 0.0327 0.0265
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0478 0.0417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0092 0.0028
Echinococcus multilocularis protein patched 0.0045 0.1313 0.1257
Echinococcus granulosus cathepsin L cysteine proteinase 0.001 0.0087 0.0023
Echinococcus granulosus transcription factor btf3 0.0014 0.0246 0.0184
Schistosoma mansoni coup transcription factor 0.0021 0.0478 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Onchocerca volvulus 0.001 0.0087 0.0057
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0092 0.0028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0034 0.0929 0.2477
Brugia malayi MH2 domain containing protein 0.0079 0.25 0.2452
Loa Loa (eye worm) peptidase family M13 containing protein 0.0032 0.0852 0.0852
Brugia malayi Nuclear hormone receptor E75 0.001 0.0092 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0305 0.0305
Brugia malayi hypothetical protein 0.0118 0.3826 0.3786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0019 0.04 0.0493
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.6124
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0073 0.2278 0.2228
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0071 0.2199 1
Echinococcus granulosus tar DNA binding protein 0.0016 0.0304 0.0242
Schistosoma mansoni nuclear hormone receptor 0.001 0.0092 0.0041
Echinococcus multilocularis survival motor neuron protein 1 0.0296 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Onchocerca volvulus 0.006 0.1839 0.4715
Leishmania major cathepsin L-like protease 0.001 0.0087 0.0061
Echinococcus multilocularis GPCR, family 2 0.0014 0.025 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0087 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0016 0.0304 0.0353
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0092 0.0092
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0137 0.0108
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0112 0.0133
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0071 0.2199 0.5934
Brugia malayi ecdysteroid receptor 0.0021 0.0478 0.0417
Entamoeba histolytica transcription factor BTF3, putative 0.0014 0.0246 0.0854
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0092 0.007
Loa Loa (eye worm) glutaminase 2 0.0113 0.3647 0.3647
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.1313 0.1313
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0033 0.0878 0.0878
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Schistosoma mansoni transcription factor btf3 0.0014 0.0246 0.0268
Leishmania major basic transcription factor 3a, putative 0.0014 0.0246 0.0518
Loa Loa (eye worm) hypothetical protein 0.0032 0.0852 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0478 0.0417
Mycobacterium ulcerans putative regulatory protein 0.001 0.0108 0.0297
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0108
Schistosoma mansoni single-minded 0.0014 0.0235 0.0251
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0092 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0019 0.04 0.04
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0478 0.0417
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0478 0.0478
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0878 0.2161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0112 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Plasmodium falciparum basic transcription factor 3b, putative 0.0014 0.0246 0.1119
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0145 0.4782 0.4748
Brugia malayi nuclear hormone receptor 0.001 0.0092 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.2208 0.5959
Loa Loa (eye worm) RNA binding protein 0.0016 0.0304 0.0304
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0087 0.0023
Echinococcus multilocularis transcription factor btf3 0.0014 0.0246 0.0184
Onchocerca volvulus 0.0035 0.0949 0.235
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 1
Onchocerca volvulus 0.001 0.0087 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0478 0.0417
Brugia malayi peptidase family M13 containing protein 0.0011 0.0111 0.0048
Mycobacterium leprae probable zinc metalloprotease 0.0043 0.1242 1
Onchocerca volvulus 0.001 0.0087 0.0057
Echinococcus multilocularis Niemann Pick C1 protein 0.0045 0.1313 0.1257
Mycobacterium ulcerans hypothetical protein 0.0071 0.2199 0.6031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0478 0.0417
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Brugia malayi hypothetical protein 0.0047 0.1383 0.1328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0092 0.0028
Brugia malayi hypoxia-induced factor 1 0.0044 0.1257 0.1201
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0878 0.082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0085 0.0234
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0011 0.0111 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.1041 0.2799
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0051 0.1531 0.4808
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0011 0.0112 0.0899
Schistosoma mansoni cellular tumor antigen P53 0.0033 0.0902 0.1231
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0125 0.407 0.5879
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0071 0.2199 1
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0071 0.2199 0.2149
Schistosoma mansoni hypothetical protein 0.0206 0.6878 1
Schistosoma mansoni organic anion transporter 0.0033 0.0878 0.1195
Plasmodium falciparum cysteine proteinase falcipain 2a 0.001 0.0087 0.0395
Echinococcus multilocularis transfer RNA-Lys 0.001 0.0108 0.0045
Leishmania major cathepsin L-like protease 0.0037 0.1041 0.2799
Loa Loa (eye worm) glutaminase 0.0113 0.3647 0.3647
Loa Loa (eye worm) hypothetical protein 0.0145 0.4782 0.4782
Loa Loa (eye worm) hypothetical protein 0.0011 0.0133 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Echinococcus granulosus synaptic glycoprotein sc2 0.0071 0.2199 0.2149
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0051 0.1531 0.4057
Brugia malayi nuclear receptor NHR-67 0.001 0.0092 0.0028
Brugia malayi beta-NAC-like protein 0.0014 0.0246 0.0184
Plasmodium falciparum cysteine proteinase falcipain 3 0.001 0.0087 0.0395
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0478 0.0417
Echinococcus multilocularis lamin 0.0035 0.0949 0.0891
Loa Loa (eye worm) hypothetical protein 0.0296 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0085 0.0058
Onchocerca volvulus 0.001 0.0092 0.007
Echinococcus multilocularis musashi 0.0035 0.0949 0.0891
Brugia malayi Latrophilin receptor protein 2 0.0014 0.025 0.0187
Brugia malayi intermediate filament protein 0.0035 0.0949 0.0891
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0478 0.1096
Brugia malayi bHLH-PAS transcription factor 0.001 0.0108 0.0045
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.5934
Echinococcus multilocularis expressed protein 0.0022 0.0519 0.0459
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0071 0.2199 0.3134
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0071 0.2199 0.6124
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0043 0.1242 0.1729
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0878 0.082
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.0225 0.0388
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0092 0.0028
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0092 0.0041
Mycobacterium ulcerans zinc metalloprotease 0.0043 0.1242 0.3405
Plasmodium vivax basic transcription factor 3b, putative 0.0014 0.0246 0.1119
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0071 0.2199 1
Loa Loa (eye worm) TAR-binding protein 0.0016 0.0304 0.0304
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0085 0.0234
Echinococcus multilocularis protein dispatched 1 0.0045 0.1313 0.1257
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0112 0.0048
Loa Loa (eye worm) hypothetical protein 0.0045 0.1313 0.1313
Plasmodium vivax vivapain-2 0.001 0.0087 0.0395
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.011 0.355 0.9734
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0035 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0032 0.0852 0.0852
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0022 0.0501 0.0642
Leishmania major cathepsin L-like protease 0.001 0.0087 0.0061
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Brugia malayi glutaminase DH11.1 0.0113 0.3647 0.3606
Echinococcus granulosus agrin 0.0022 0.0519 0.0459
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.025 0.0187
Plasmodium falciparum histone acetyltransferase GCN5 0.0034 0.0913 0.4149
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0014 0.025 0.025
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0478 0.0417
Brugia malayi hypothetical protein 0.001 0.0092 0.0028
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0024 0.0586 0.0526
Echinococcus granulosus survival motor neuron protein 1 0.0296 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.1313 0.1257
Loa Loa (eye worm) hypothetical protein 0.0022 0.0519 0.0519
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0478 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0478 0.0417
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0878 0.2161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0478 0.0417
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0519 0.0459
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0037 0.1018 0.441
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0586 0.0586
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0478 0.0607
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.011 0.355 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0112 0.0048
Brugia malayi hypothetical protein 0.0011 0.0133 0.007
Echinococcus granulosus Protein patched homolog 1 0.0045 0.1313 0.1257
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.1335 0.128
Onchocerca volvulus 0.0021 0.0488 0.1123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0246 0.0447
Schistosoma mansoni hypothetical protein 0.006 0.1839 0.2604
Brugia malayi nuclear hormone receptor 0.0021 0.0478 0.0417
Loa Loa (eye worm) zinc metallopeptidase 4 0.0011 0.0111 0.0111
Brugia malayi RNA binding protein 0.0016 0.0304 0.0242
Echinococcus multilocularis cysteine protease 0.001 0.0087 0.0023
Echinococcus granulosus choline O acetyltransferase 0.0009 0.0065 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0133 0.0133
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0125 0.407 0.4032
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.005 0.1482 0.4065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0478 0.0417
Plasmodium vivax polyprenol reductase, putative 0.0071 0.2199 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0037 0.1018 0.463
Brugia malayi Choline O-acetyltransferase 0.0009 0.0065 0.0002
Loa Loa (eye worm) choline O-acetyltransferase 0.0009 0.0065 0.0065
Onchocerca volvulus 0.0022 0.0519 0.1207
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0133 0.007
Schistosoma mansoni hypothetical protein 0.0206 0.6878 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0033 0.0878 0.082
Schistosoma mansoni hypothetical protein 0.0014 0.025 0.0273
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0071 0.2199 0.2199
Plasmodium vivax vivapain-2 0.001 0.0087 0.0395
Brugia malayi AMP-binding enzyme family protein 0.001 0.0085 0.0022
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0878 0.2161
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0478 0.0607
Echinococcus multilocularis synaptic glycoprotein sc2 0.0071 0.2199 0.2149
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Loa Loa (eye worm) ctsf protein 0.001 0.0087 0.0087
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0878 0.082
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0133 0.0102
Schistosoma mansoni agrin 0.0022 0.0519 0.0669
Echinococcus multilocularis serotonin receptor 0.0075 0.2338 0.2289
Echinococcus granulosus Niemann Pick C1 protein 0.0045 0.1313 0.1257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0478 0.0417
Mycobacterium ulcerans glutaminase 0.0113 0.3647 1
Schistosoma mansoni endothelin-converting enzyme-related 0.0011 0.0111 0.007
Brugia malayi secreted modular calcium-binding protein 1 0.0022 0.0519 0.0459
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0092 0.0092
Onchocerca volvulus Cathepsin L homolog 0.001 0.0087 0.0057
Echinococcus multilocularis choline O acetyltransferase 0.0009 0.0065 0.0002
Loa Loa (eye worm) cysteine protease 0.001 0.0087 0.0087
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0043 0.1242 0.1186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Schistosoma mansoni tar DNA-binding protein 0.0016 0.0304 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0478 0.0478
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.025 0.0187
Trypanosoma brucei transcription factor BTF3, putative 0.0014 0.0246 0.0518
Toxoplasma gondii NAC domain-containing protein 0.0014 0.0246 0.0754
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0586 0.0767
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0009 0.0065 0.0002
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0071 0.2199 0.6124
Brugia malayi nuclear receptor NHR-88 0.0021 0.0478 0.0417
Onchocerca volvulus 0.0033 0.0878 0.2161
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0519 0.2047
Onchocerca volvulus 0.0071 0.2199 0.5675
Loa Loa (eye worm) hypothetical protein 0.0075 0.2338 0.2338
Schistosoma mansoni tar DNA-binding protein 0.0016 0.0304 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.2199 0.5934
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0051 0.1531 0.4057
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0519 0.2047
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.6124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Schistosoma mansoni choline o-acyltransferase 0.0009 0.0065 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0085 0.0688
Brugia malayi hypothetical protein 0.0033 0.0878 0.082
Entamoeba histolytica hypothetical protein 0.0014 0.0246 0.0854
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0051 0.1531 0.4057
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0478 0.0417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.001 0.0087 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0085 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0478 0.0417
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.5934
Plasmodium falciparum polyprenol reductase, putative 0.0071 0.2199 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0092 0.0028
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0014 0.025 0.0187
Onchocerca volvulus 0.0033 0.0878 0.2161
Onchocerca volvulus 0.0033 0.0878 0.2161
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.011 0.355 1
Schistosoma mansoni zinc finger protein 0.001 0.0092 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0478 0.0607
Echinococcus multilocularis follistatin 0.0022 0.0519 0.0459
Brugia malayi Intermediate filament tail domain containing protein 0.0035 0.0949 0.0891
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0133 0.0133
Trichomonas vaginalis bromodomain-containing protein, putative 0.0037 0.1018 0.2617
Trypanosoma cruzi MFS transporter, putative 0.0033 0.0878 0.2332
Echinococcus granulosus cathepsin l cysteine peptidase 0.001 0.0087 0.0023
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0087 0.0087
Entamoeba histolytica hypothetical protein 0.0071 0.2199 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0019 0.04 0.0338
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0033 0.0878 0.082
Trichomonas vaginalis glutaminase, putative 0.0113 0.3647 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0111 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0019 0.04 0.0338
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0092 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.1335 0.1335
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0017 0.0327 0.0265
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0071 0.2199 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Brugia malayi AMP-binding enzyme family protein 0.001 0.0085 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0108
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.001 0.0087 0.0087
Brugia malayi steroid hormone receptor 0.0021 0.0478 0.0417
Schistosoma mansoni nuclear hormone receptor 0.001 0.0092 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0071 0.2199 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0501 0.0642
Loa Loa (eye worm) hypothetical protein 0.0043 0.1242 0.1242
Mycobacterium ulcerans hypothetical protein 0.001 0.0085 0.0234
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0092 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.001 0.0087 0.0023
Echinococcus multilocularis tumor protein p63 0.0228 0.7639 0.7624
Loa Loa (eye worm) hypothetical protein 0.0075 0.2338 0.2338
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Schistosoma mansoni choline o-acyltransferase 0.0009 0.0065 0.0003
Brugia malayi replication factor A 73 kDa subunit 0.0014 0.025 0.0187
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0878 0.3745
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0009 0.0065 0.0065
Onchocerca volvulus 0.0038 0.1076 0.2688
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0043 0.1242 1
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0019 0.04 0.0338
Schistosoma mansoni hypothetical protein 0.0028 0.0731 0.098
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0014 0.025 0.0187
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.001 0.0085 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0478 0.0607
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0478 0.0417
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0478 0.1096
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.005 0.1482 0.1427
Brugia malayi jmjC domain containing protein 0.0024 0.0586 0.0526
Loa Loa (eye worm) hypoxia-induced factor 1 0.0044 0.1257 0.1257
Schistosoma mansoni hypothetical protein 0.0031 0.0833 0.1129
Loa Loa (eye worm) hypothetical protein 0.001 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0073 0.2278 0.2278
Loa Loa (eye worm) hypothetical protein 0.0031 0.0833 0.0833
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.1313 0.1257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.025 0.0187
Brugia malayi conserved hypotetical protein 0.001 0.0092 0.0028
Echinococcus multilocularis agrin 0.0022 0.0519 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Brugia malayi ecdysone receptor 0.001 0.0092 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0478 0.0478
Loa Loa (eye worm) fibroinase 0.001 0.0087 0.0087
Schistosoma mansoni nuclear receptor 0.001 0.0092 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0024 0.0586 0.0526
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0478 0.0417
Schistosoma mansoni organic anion transporter 0.0033 0.0878 0.1195
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0085 0.0102
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0092 0.0028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0902 0.0902
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0037 0.1018 0.441
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.025 0.0457
Loa Loa (eye worm) hypothetical protein 0.0071 0.2199 0.2199
Brugia malayi prostaglandin transporter 0.0033 0.0878 0.082
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0092 0.0041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0016 0.0304 0.0304
Brugia malayi isocitrate dehydrogenase 0.0011 0.0112 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0478 0.0417
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0079 0.25 0.25
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.001 0.0085 0.0234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0478 0.0417
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.1335 0.128
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0085 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0133 0.0102
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi tailless protein 0.001 0.0092 0.0028
Onchocerca volvulus 0.0021 0.0478 0.1096
Loa Loa (eye worm) acetyltransferase 0.0125 0.407 0.407
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.025 0.0457
Loa Loa (eye worm) hypothetical protein 0.0043 0.1242 0.1242
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0037 0.1018 0.2617
Loa Loa (eye worm) agrin synaptic family protein 0.0022 0.0519 0.0519
Schistosoma mansoni follistatin 0.0022 0.0519 0.0669
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0478 0.0607
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0478 0.0607
Loa Loa (eye worm) hypothetical protein 0.0014 0.025 0.025
Schistosoma mansoni glutaminase 0.0113 0.3647 0.5258
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0764 0.2005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0927 0.0927
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0478 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0246 0.0447
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.1041 0.2799
Leishmania major cathepsin L-like protease 0.0037 0.1041 0.2799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0478 0.0417
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.006 0.1839 0.1786
Echinococcus granulosus cathepsin l1 0.001 0.0087 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0478 0.0417
Echinococcus multilocularis geminin 0.0206 0.6878 0.6858
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0112 0.0048
Echinococcus multilocularis cysteine protease 0.001 0.0087 0.0023
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0501 0.0642
Loa Loa (eye worm) hypothetical protein 0.0022 0.0519 0.0519
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.2338 0.2289
Loa Loa (eye worm) hypothetical protein 0.0032 0.0852 0.0852
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.2338 0.3338
Loa Loa (eye worm) hypothetical protein 0.0017 0.0327 0.0327
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.005 0.1482 0.4065
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.6124
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0833 0.0774
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0519 0.2047
Leishmania major cathepsin L-like protease 0.001 0.0087 0.0061
Onchocerca volvulus 0.001 0.0087 0.0057
Brugia malayi AMP-binding enzyme family protein 0.001 0.0085 0.0022
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0071 0.2199 1
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0112 0.0117
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0112 0.0117
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0519 0.0459
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0111 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi cytoplasmic intermediate filament protein 0.0019 0.0391 0.033
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0092 0.0028
Loa Loa (eye worm) ICD-1 protein 0.0014 0.0246 0.0246
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0478 0.0417
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.005 0.1482 0.4065
Brugia malayi hypothetical protein 0.0038 0.1076 0.1019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Echinococcus granulosus follistatin 0.0022 0.0519 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0478 0.0478
Schistosoma mansoni survival motor neuron protein 0.006 0.1839 0.2604
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0045 0.1313 0.1833
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0478 0.0417
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0133 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0085 0.0085
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0112 0.0048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.025 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0478 0.0478
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0085 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.0033 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0852 0.0852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0246 0.0447
Loa Loa (eye worm) peptidase family M13 containing protein 0.0032 0.0852 0.0852
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0112 0.007
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.011 0.355 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0009 0.0065 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0085 0.0234
Onchocerca volvulus 0.0033 0.0878 0.2161
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0011 0.0112 0.0507
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Brugia malayi Peptidase family M13 containing protein 0.0043 0.1242 0.1186
Loa Loa (eye worm) hypothetical protein 0.0071 0.2199 0.2199
Echinococcus granulosus lamin dm0 0.0035 0.0949 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0016 0.0304 0.0353
Onchocerca volvulus 0.0033 0.0878 0.2161
Echinococcus granulosus intermediate filament protein 0.0035 0.0949 0.0891
Echinococcus granulosus lamin 0.0035 0.0949 0.0891
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.0043 0.1242 0.1242
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.1313 0.3444
Loa Loa (eye worm) DR-78 0.001 0.0092 0.0092
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.011 0.355 0.355
Schistosoma mansoni patched 1 0.0045 0.1313 0.1833
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0586 0.0767
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.011 0.355 0.5116
Echinococcus granulosus endothelin converting enzyme 1 0.0043 0.1242 0.1186
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.011 0.355 0.3509
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0478 0.0417
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0478 0.0607
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0478 0.0607
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.6124
Leishmania major cathepsin L-like protease 0.001 0.0087 0.0061
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0092 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0478 0.0417
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0071 0.2199 0.5934
Loa Loa (eye worm) hypothetical protein 0.0022 0.0519 0.0519
Brugia malayi hypothetical protein 0.0011 0.0133 0.007
Onchocerca volvulus 0.001 0.0108 0.0114
Loa Loa (eye worm) intermediate filament protein 0.0035 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0478 0.0478
Schistosoma mansoni hypothetical protein 0.0011 0.0137 0.0108
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.001 0.0085 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0478 0.0417
Onchocerca volvulus 0.0033 0.0902 0.2226
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0112 0.0133
Echinococcus multilocularis tar DNA binding protein 0.0016 0.0304 0.0242
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0085 0.0102
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0519 0.0519
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0009 0.0065 0.0002
Loa Loa (eye worm) hypothetical protein 0.0118 0.3826 0.3826
Toxoplasma gondii peptidase family M13 protein 0.0043 0.1242 0.5467
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0112 0.0133
Loa Loa (eye worm) hypothetical protein 0.0046 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0133 0.0133
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0092 0.0028
Brugia malayi hypothetical protein 0.0033 0.0878 0.082
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0478 0.0417
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0092 0.0028
Echinococcus multilocularis endothelin converting enzyme 1 0.0043 0.1242 0.1186
Brugia malayi nuclear receptor RXR 0.001 0.0092 0.0028
Schistosoma mansoni nuclear receptor 0.001 0.0092 0.0041
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0009 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0118 0.3826 0.3826
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0033 0.0878 0.082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0133 0.0133
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.001 0.0085 0.0234
Schistosoma mansoni aryl hydrocarbon receptor 0.0014 0.0235 0.0251
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0133 0.007
Schistosoma mansoni hypothetical protein 0.0014 0.025 0.0273
Trypanosoma cruzi transcription factor btf3, putative 0.0014 0.0246 0.0518
Schistosoma mansoni intermediate filament proteins 0.0035 0.0949 0.1299
Entamoeba histolytica acyl-coA synthetase, putative 0.001 0.0085 0.0102
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Onchocerca volvulus 0.001 0.0087 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0016 0.0304 0.0353
Brugia malayi jmjC domain containing protein 0.0024 0.0586 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.1041 0.2799
Brugia malayi Choline O-acetyltransferase 0.0009 0.0065 0.0002
Entamoeba histolytica acetyltransferase, GNAT family 0.0034 0.0913 0.3975
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0478 0.0607
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0092 0.0028
Brugia malayi Synaptic glycoprotein SC2 0.0071 0.2199 0.2149
Echinococcus multilocularis cathepsin L cysteine protease 0.001 0.0087 0.0023
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0112 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0087 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.025 0.0187
Brugia malayi Nuclear hormone receptor E75 0.001 0.0092 0.0028
Onchocerca volvulus Huntingtin homolog 0.0118 0.3826 1
Onchocerca volvulus Cathepsin F homolog 0.001 0.0087 0.0057
Echinococcus granulosus GPCR family 2 0.0014 0.025 0.0187
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0071 0.2199 0.5934
Echinococcus granulosus geminin 0.0206 0.6878 0.6858
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0519 0.0459
Leishmania major cysteine peptidase A (CPA) 0.001 0.0087 0.0061
Brugia malayi PAS domain containing protein 0.0014 0.0235 0.0172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.001 0.0085 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0019 0.04 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.2199 0.5934
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0478 0.0417
Brugia malayi nuclear receptor NHR-88 0.001 0.0092 0.0028
Onchocerca volvulus 0.001 0.0092 0.007
Leishmania major cathepsin L-like protease 0.001 0.0087 0.0061
Schistosoma mansoni lamin 0.0035 0.0949 0.1299
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0501 0.0642
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0019 0.0391 0.0391
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0007 0 0.5
Onchocerca volvulus Cathepsin L homolog 0.001 0.0087 0.0057
Schistosoma mansoni replication factor A 1 rfa1 0.0014 0.025 0.0273
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.011 0.355 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0011 0.0112 0.0507
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0071 0.2199 0.5934
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0478 0.0417
Loa Loa (eye worm) hypothetical protein 0.0009 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0092 0.0092
Brugia malayi TAR-binding protein 0.0016 0.0304 0.0242
Echinococcus granulosus tumor protein p63 0.0228 0.7639 0.7624
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0087 0.0034
Echinococcus multilocularis cathepsin L cysteine protease 0.001 0.0087 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0478 0.0607
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.005 0.1482 0.1427
Brugia malayi Cathepsin L-like precursor 0.001 0.0087 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.025 0.0187
Plasmodium falciparum cysteine proteinase falcipain 2b 0.001 0.0087 0.0395
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0112 0.0133
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0519 0.2047
Brugia malayi RNA recognition motif domain containing protein 0.0016 0.0304 0.0242
Loa Loa (eye worm) transcription factor SMAD2 0.0079 0.25 0.25
Echinococcus granulosus histone acetyltransferase KAT2B 0.0037 0.1018 0.0961
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0519 0.0459
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.011 0.355 0.3509
Loa Loa (eye worm) hypothetical protein 0.0022 0.0519 0.0519
Schistosoma mansoni lamin 0.0035 0.0949 0.1299
Trypanosoma cruzi transcription factor btf3, putative 0.0014 0.0246 0.0518
Brugia malayi nuclear receptor RXR 0.0011 0.0133 0.007
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0111 0.007
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0112 0.0048
Onchocerca volvulus 0.0035 0.0949 0.235
Echinococcus multilocularis lamin dm0 0.0035 0.0949 0.0891
Onchocerca volvulus 0.001 0.0087 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.1041 0.2799

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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