Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, tissue | Starlite/ChEMBL | References |
Homo sapiens | protein C (inactivator of coagulation factors Va and VIIIa) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0106 | 0.0412 | 0.0629 | |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.65 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0003 | 0.004 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.0664 | 0.1018 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.0664 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0069 | 0.0003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0664 | 0.1018 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0069 | 0.0003 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.0664 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0664 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.2884 | 0.4434 |
Leishmania major | hypothetical protein, conserved | 0.0069 | 0.0003 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0661 | 0.65 | 1 |
Onchocerca volvulus | 0.0129 | 0.0664 | 0.1018 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0069 | 0.0003 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0069 | 0.0003 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0661 | 0.65 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0069 | 0.0003 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 nM | Inhibition of Coagulation factor Xa | ChEMBL. | 11958994 |
Ki (binding) | = 12 nM | Compound was evaluated for the inhibitory activity against Coagulation factor X | ChEMBL. | 10937736 |
Ki (binding) | = 12 nM | Inhibition of Coagulation factor Xa | ChEMBL. | 11958994 |
Ki (binding) | = 12 nM | Compound was evaluated for the inhibitory activity against Coagulation factor X | ChEMBL. | 10937736 |
Ki (binding) | > 2900 nM | Compound was evaluated for the inhibitory activity against trypsin. | ChEMBL. | 10937736 |
Ki (binding) | > 2900 nM | Compound was evaluated for the inhibitory activity against trypsin. | ChEMBL. | 10937736 |
Ki (binding) | > 4000 nM | Compound was evaluated for the inhibitory activity against thrombin | ChEMBL. | 10937736 |
Ki (binding) | > 4000 nM | Compound was evaluated for the inhibitory activity against thrombin | ChEMBL. | 10937736 |
Ki (binding) | > 7300 nM | Compound was evaluated for the inhibitory activity against plasmin | ChEMBL. | 10937736 |
Ki (binding) | > 7300 nM | Compound was evaluated for the inhibitory activity against plasmin | ChEMBL. | 10937736 |
Ki (binding) | > 8700 nM | Compound was evaluated for the inhibitory activity against t-PA. | ChEMBL. | 10937736 |
Ki (binding) | > 8700 nM | Compound was evaluated for the inhibitory activity against t-PA. | ChEMBL. | 10937736 |
Ki (binding) | > 18000 nM | Compound was evaluated for the inhibitory activity against Activated protein C | ChEMBL. | 10937736 |
Ki (binding) | > 18000 nM | Compound was evaluated for the inhibitory activity against Activated protein C | ChEMBL. | 10937736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.