Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3014 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3014 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3014 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.1241 | 0.4072 | 0.4072 |
Loa Loa (eye worm) | hypothetical protein | 0.3014 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3014 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1241 | 0.4072 | 0.4072 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1414 | 0.4651 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3014 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1241 | 0.4072 | 0.4072 |
Echinococcus multilocularis | protein patched | 0.1241 | 0.4072 | 0.4072 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1241 | 0.4072 | 0.4072 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1414 | 0.4651 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1241 | 0.4072 | 0.4072 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1241 | 0.4072 | 0.4072 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus multilocularis | protein dispatched 1 | 0.1241 | 0.4072 | 0.4072 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1414 | 0.4651 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1241 | 0.4072 | 0.4072 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1414 | 0.4651 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3014 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1241 | 0.4072 | 0.4072 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3014 | 1 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0023 | 0 | 0.5 |
Brugia malayi | CHE-14 protein | 0.1241 | 0.4072 | 0.4072 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1241 | 0.4072 | 0.4072 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.7 nM | Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes | ChEMBL. | 8568803 |
Ki (binding) | = 3.7 nM | Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes | ChEMBL. | 8568803 |
[35S] TBPS shift (binding) | = 0.88 | In vitro inhibition of [35S]-TBPS binding in rat brain membranes, activity expressed as [35S]-TBPS shift value | ChEMBL. | 8568803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.