Detailed information for compound 720860

Basic information

Technical information
  • TDR Targets ID: 720860
  • Name: 3-[(4-iodophenyl)methylsulfanyl]-4-methyl-5-( phenylmethyl)-1,2,4-triazole
  • MW: 421.299 | Formula: C17H16IN3S
  • H donors: 0 H acceptors: 2 LogP: 4.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)CSc1nnc(n1C)Cc1ccccc1
  • InChi: 1S/C17H16IN3S/c1-21-16(11-13-5-3-2-4-6-13)19-20-17(21)22-12-14-7-9-15(18)10-8-14/h2-10H,11-12H2,1H3
  • InChiKey: SRVFTGBRSSAMOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(4-iodophenyl)methylthio]-4-methyl-5-(phenylmethyl)-1,2,4-triazole
  • 3-(benzyl)-5-[(4-iodobenzyl)thio]-4-methyl-1,2,4-triazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0038 0.0038
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0125 1
Schistosoma mansoni inositol monophosphatase 0.0079 0.0302 0.0284
Echinococcus granulosus dna polymerase kappa 0.0021 0.0038 0.0038
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0038 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0249 0.8101
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0834 0.3714 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0038 0.0992
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0038 0.0087
Schistosoma mansoni chromobox protein 0.0076 0.0287 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0091
Echinococcus multilocularis microtubule associated protein 2 0.2224 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0091 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0091
Brugia malayi steroid hormone receptor 0.0021 0.0039 0.0091
Loa Loa (eye worm) ctsf protein 0.0018 0.0024 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0039 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0019 0.0366
Echinococcus granulosus peregrin 0.0035 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.0834 0.3714 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0302 0.0755
Schistosoma mansoni chromobox protein 0.0076 0.0287 0.0269
Echinococcus granulosus muscleblind protein 0.0321 0.1394 0.1394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Onchocerca volvulus 0.0018 0.0024 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0068
Brugia malayi nuclear hormone receptor 0.0021 0.0039 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0039 0.002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0142 0.032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0302 0.0755
Echinococcus multilocularis dna polymerase eta 0.0021 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0148 0.0614 0.161
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0024 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0039 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.06 0.1604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Loa Loa (eye worm) hypothetical protein 0.0043 0.0136 0.0317
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0038 0.0992
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0355 0.1547 0.4157
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0019 0.0019
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0125 0.0275
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0039 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0038 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.003 0.008 0.0153
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0142 0.032
Entamoeba histolytica hypothetical protein 0.0289 0.1253 0.333
Brugia malayi Inositol-1 0.0079 0.0302 0.0801
Schistosoma mansoni hypothetical protein 0.005 0.0168 0.0149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0136 0.1226
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0039 0.002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0142 0.0331
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0099
Onchocerca volvulus 0.0045 0.0147 0.1324
Loa Loa (eye worm) fibroinase 0.0018 0.0024 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.06 0.0582
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0142 0.0142
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0872 0.3889 0.3889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0144 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0039 0.0053
Onchocerca volvulus Huntingtin homolog 0.012 0.0487 0.4384
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0039 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0559 0.0541
Onchocerca volvulus 0.0018 0.0024 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0038 0.065
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0287 0.0714
Echinococcus multilocularis muscleblind protein 1 0.0321 0.1394 0.1394
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0289 0.1253 0.333
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0038 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0302 0.0755
Giardia lamblia PHD finger protein 15 0.0032 0.0088 0.5693
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Loa Loa (eye worm) hypothetical protein 0.0321 0.1394 0.3721
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Echinococcus multilocularis chromobox protein 1 0.0076 0.0287 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Leishmania major DNA polymerase eta, putative 0.0021 0.0038 0.065
Loa Loa (eye worm) RNA binding protein 0.0136 0.0559 0.146
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0559 0.0559
Onchocerca volvulus 0.0148 0.0614 0.5525
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0039 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0039 0.0351
Loa Loa (eye worm) hypothetical protein 0.012 0.0487 0.1267
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0302 1
Brugia malayi jmjC domain containing protein 0.0104 0.0415 0.1103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Onchocerca volvulus 0.005 0.0168 0.1509
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0236 0.0621
Schistosoma mansoni hypothetical protein 0.014 0.0575 0.0557
Brugia malayi Bromodomain containing protein 0.0035 0.0104 0.0266
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0183 0.5796
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0834 0.3714 1
Brugia malayi Muscleblind-like protein 0.0321 0.1394 0.3744
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0222 0.7166
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0834 0.3714 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0039 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Echinococcus multilocularis peregrin 0.0035 0.0104 0.0104
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0834 0.3714 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.06 0.06
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0091 0.0072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0215 0.0916 0.0916
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0834 0.3714 1
Schistosoma mansoni coup transcription factor 0.0021 0.0039 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0039
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0019 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0118 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.012 0.0487 0.1267
Trichomonas vaginalis conserved hypothetical protein 0.003 0.008 0.0153
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0289 0.1253 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0289 0.1253 0.333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Plasmodium vivax vivapain-2 0.0018 0.0024 0.0012
Brugia malayi nuclear receptor NHR-88 0.0021 0.0039 0.0091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0204
Schistosoma mansoni hypothetical protein 0.0065 0.0236 0.0217
Echinococcus granulosus tar DNA binding protein 0.0136 0.0559 0.0559
Schistosoma mansoni inositol monophosphatase 0.0079 0.0302 0.0284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Loa Loa (eye worm) hypothetical protein 0.014 0.0575 0.1504
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0142 0.0331
Brugia malayi hypothetical protein 0.0148 0.0614 0.1642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0053
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0144 0.0144
Echinococcus multilocularis cysteine protease 0.0018 0.0024 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0039 0.0039
Schistosoma mansoni survival motor neuron protein 0.005 0.0168 0.0149
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0038 0.065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0215 0.0916 0.0916
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0053
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0159
Echinococcus multilocularis muscleblind protein 0.0321 0.1394 0.1394
Brugia malayi Heterochromatin protein 1 0.0076 0.0287 0.076
Brugia malayi isocitrate dehydrogenase 0.0017 0.0019 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Onchocerca volvulus 0.0021 0.0039 0.0351
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0415 0.0415
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0598 0.0598
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Onchocerca volvulus 0.0258 0.1112 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0559 0.0541
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0038 0.0149
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0834 0.3714 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0088 0.0185
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0559 0.146
Echinococcus granulosus dna polymerase eta 0.0021 0.0038 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0039
Echinococcus multilocularis GPCR, family 2 0.0065 0.0236 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0559 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0091
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0038 0.005
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0125 0.0287
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0834 0.3714 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.06 0.06
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0019 0.0366
Loa Loa (eye worm) acetyltransferase 0.0149 0.0617 0.1618
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0088 0.0068
Onchocerca volvulus 0.0018 0.0024 0.0214
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0355 0.1547 0.4136
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0024 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0151 0.0345
Echinococcus granulosus chromobox protein 1 0.0076 0.0287 0.0287
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1042 0.1042
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Onchocerca volvulus 0.0018 0.0024 0.0214
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0088 0.0185
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0867 0.2294
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0088 0.0088
Onchocerca volvulus 0.0018 0.0024 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0305
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0318 0.0299
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0834 0.3714 0.3702
Leishmania major cathepsin L-like protease 0.0067 0.0249 0.8101
Plasmodium vivax vivapain-2 0.0018 0.0024 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0236 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0024 0.0159
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0039
Onchocerca volvulus Huntingtin homolog 0.012 0.0487 0.4384
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0185
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0151 0.0345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0834 0.3714 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0834 0.3714 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0039
Echinococcus multilocularis geminin 0.0182 0.0768 0.0768
Schistosoma mansoni hypothetical protein 0.0065 0.0236 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.097 0.2573
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0039 0.0091
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0168 0.0438
Trypanosoma brucei unspecified product 0.0021 0.0038 0.0992
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Loa Loa (eye worm) inositol-1 0.0079 0.0302 0.0766
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0024 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0091
Brugia malayi Pre-SET motif family protein 0.0227 0.097 0.2601
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0287 0.0714
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0024 0.0012
Onchocerca volvulus 0.0018 0.0024 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0091
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0289 0.1253 1
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0287 0.0725
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0039 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0039 0.0091
Brugia malayi chromobox protein homolog 3 0.0043 0.0136 0.0353
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0289 0.1253 0.2786
Schistosoma mansoni hypothetical protein 0.0065 0.0236 0.0217
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0039 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0039 0.0351
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0091 0.0194
Loa Loa (eye worm) hypothetical protein 0.0065 0.0236 0.0586
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0302 0.2178
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.002
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0024 0.0024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0038 0.0038
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0159
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0088 0.0088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0617 0.0599
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0249 0.8101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0091
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0159
Leishmania major cathepsin L-like protease 0.0067 0.0249 0.8101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0038 0.065
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0302 0.0766
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0024 0.0005
Brugia malayi RNA binding protein 0.0136 0.0559 0.1492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.06 0.0582
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0039 0.002
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0024 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0038 0.065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0147 0.0128
Entamoeba histolytica hypothetical protein 0.0834 0.3714 1
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0289 0.1253 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0038 0.0087
Schistosoma mansoni DNA polymerase eta 0.0021 0.0038 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0236 0.0236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.06 0.06
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0024 0.005
Schistosoma mansoni hypothetical protein 0.0182 0.0768 0.075
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0302 0.0302
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0024 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0039
Brugia malayi PHD-finger family protein 0.0032 0.0088 0.0221
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0834 0.3714 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.019 0.0463
Trichomonas vaginalis set domain proteins, putative 0.0258 0.1112 0.2948
Brugia malayi Pre-SET motif family protein 0.0033 0.0091 0.0231
Brugia malayi dUTP diphosphatase 0.0834 0.3714 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0834 0.3714 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0091 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0241 0.0599
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0249 0.8101
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0617 0.0617
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0039 0.0351
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0151 0.1358
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0038 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0038 0.065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0321 0.1394 0.3721
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0118 0.0267
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0024 0.0024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0038 0.065
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0302 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0024 0.0012
Onchocerca volvulus 0.0033 0.0095 0.0852
Entamoeba histolytica hypothetical protein 0.0544 0.2405 0.6453
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0559 0.0541
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0053
Schistosoma mansoni hypothetical protein 0.0182 0.0768 0.075
Onchocerca volvulus Alhambra homolog 0.0032 0.0088 0.0787
Echinococcus granulosus GPCR family 2 0.0065 0.0236 0.0236
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0024 0.0214
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0038 0.0038
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0265 0.199
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0559 0.1492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0867 0.2323
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0142 0.0331
Echinococcus granulosus geminin 0.0182 0.0768 0.0768
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0249 0.8101
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0302 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0088 0.0185
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0039 0.0091
Echinococcus multilocularis chromobox protein 1 0.0076 0.0287 0.0287
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0302 1
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0159
Plasmodium falciparum phd finger protein, putative 0.0032 0.0088 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0559 0.146
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0091 0.0072
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0039
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0834 0.3714 1
Loa Loa (eye worm) cysteine protease 0.0018 0.0024 0.0012
Brugia malayi hypothetical protein 0.012 0.0487 0.1299
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0038 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0236 0.0586
Schistosoma mansoni hypothetical protein 0.0065 0.0236 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Brugia malayi jmjC domain containing protein 0.0038 0.0118 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0136 0.0305
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0039 0.0039
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0038 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0091
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0024 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0575 0.1535
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0415 0.0415
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Toxoplasma gondii cathepsin CPL 0.0018 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0243 0.1042 0.2768
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1042 0.1042
Loa Loa (eye worm) dUTP diphosphatase 0.0834 0.3714 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0038 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Leishmania major cathepsin L-like protease 0.0067 0.0249 0.8101
Echinococcus multilocularis dUTP pyrophosphatase 0.0834 0.3714 0.3714
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0194
Echinococcus granulosus chromobox protein 1 0.0076 0.0287 0.0287
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0039 0.002
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0834 0.3714 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0302 0.0755
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0039 0.002
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0038 0.0038
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0289 0.1253 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.06 0.0582
Brugia malayi ecdysteroid receptor 0.0021 0.0039 0.0091
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0024 0.0214
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0544 0.2405 0.6453
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0159
Echinococcus granulosus cathepsin l1 0.0018 0.0024 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0088 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0039 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0236 0.0236
Leishmania major DNA polymerase kappa, putative 0.0021 0.0038 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.06 0.1573
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.005
Brugia malayi hypothetical protein 0.0243 0.1042 0.2795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0249 0.817
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0091 0.0091
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0038 0.0992
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0559 0.0541
Onchocerca volvulus 0.0018 0.0024 0.0214
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0053
Echinococcus granulosus dUTP pyrophosphatase 0.0834 0.3714 0.3714
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0024 0.0024
Echinococcus multilocularis cysteine protease 0.0018 0.0024 0.0024
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0024 0.0024
Brugia malayi TAR-binding protein 0.0136 0.0559 0.1492
Plasmodium vivax SET domain protein, putative 0.0033 0.0091 0.0194
Schistosoma mansoni microtubule-associated protein tau 0.2224 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0617 0.1649
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0086 0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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