Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0337 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.0436 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0234 | 0.0168 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0321 | 0.0882 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0234 | 0.0168 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0067 | 0.0092 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0067 | 0.0175 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.6841 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0181 | 0.7687 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.9203 |
Entamoeba histolytica | recQ family DNA helicase | 0.0005 | 0.0004 | 0.0241 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.0436 | 0.0632 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0234 | 0.0168 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0457 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.1274 | 0.1215 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0115 | 0.0048 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0175 |
Echinococcus multilocularis | geminin | 0.0167 | 0.3594 | 0.3551 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0979 | 0.1347 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0175 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0169 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.037 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.0436 | 0.0545 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0115 | 0.0071 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.25 | 0.365 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0235 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0234 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2642 | 0.3858 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1274 | 0.3538 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0235 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3594 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0235 | 0.4699 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.25 | 0.365 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1274 | 0.3538 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.0436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0234 | 0.0336 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0115 | 0.4422 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0169 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0234 | 0.0168 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.1274 | 0.1858 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0169 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0634 | 0.0837 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0234 | 0.0168 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.1274 | 0.1215 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0115 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0115 | 0.0162 |
Brugia malayi | RNA binding protein | 0.0063 | 0.1274 | 0.1782 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0234 | 0.064 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0235 | 0.9061 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0169 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.1274 | 0.1858 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0235 | 0.0169 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.0436 | 0.0372 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0169 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0115 | 0.0162 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0235 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0979 | 0.1347 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3594 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0979 | 0.1426 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.6841 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0314 | 0.6841 | 0.6819 |
Brugia malayi | Muscleblind-like protein | 0.0314 | 0.6841 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0314 | 0.6841 | 0.6819 |
Echinococcus multilocularis | muscleblind protein | 0.0314 | 0.6841 | 0.6819 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0234 | 0.0168 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0234 | 0.0247 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0115 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0634 | 0.0922 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1274 | 0.3538 |
Schistosoma mansoni | smad | 0.0008 | 0.0067 | 0.0175 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0115 | 0.0048 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0235 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.9203 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0067 | 0.0092 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0642 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0234 | 0.0336 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0255 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.3594 | 0.3551 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0979 | 0.1426 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0115 | 0.4422 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0115 | 0.0048 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.0004 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0235 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0457 | 1 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0181 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0234 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0634 | 0.1755 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.1274 | 0.1782 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0259 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.0436 | 0.0372 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1274 | 0.3538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1274 | 0.3538 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0234 | 0.064 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.25 | 0.3591 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0235 | 0.0247 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0175 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0235 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0067 | 0.0092 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0115 | 0.0308 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0115 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0115 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0234 | 0.064 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0067 | 0.0175 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.1274 | 0.1782 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.1274 | 0.1858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.