TDR Targets

Basic information

Technical information

TDR Targets ID: 721025
Name: [2-[2-(4-ethylpiperazin-1-yl)ethoxy]phenyl]me thanol
MW: 264.363 | Formula: C15H24N2O2
H donors: 1 H acceptors: 1 LogP: 1.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)CCOc1ccccc1CO
InChi: 1S/C15H24N2O2/c1-2-16-7-9-17(10-8-16)11-12-19-15-6-4-3-5-14(15)13-18/h3-6,18H,2,7-13H2,1H3
InChiKey: UCMHTEBPVPLGNN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-[2-(4-ethyl-1-piperazinyl)ethoxy]phenyl]methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0367	0.0567
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0063	0.1449	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0263	0.0561
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0063	0.1449	0.1434
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0518	0.0501
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1425	0.22
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0142	0.5
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0984	0.0968
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0142	0.0285
Echinococcus granulosus	GPCR family 2	0.0032	0.0518	0.0501
Echinococcus granulosus	lamin dm0	0.0027	0.0367	0.035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Echinococcus multilocularis	musashi	0.0027	0.0367	0.035
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0546	0.1212
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0263	0.0561
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0089	0.0163
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0367	0.035
Loa Loa (eye worm)	inositol-1	0.0036	0.066	0.1018
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0142	0.0285
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0501
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0263	0.0561
Brugia malayi	TAR-binding protein	0.0062	0.1425	0.22
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0161	0.4374	0.675
Echinococcus granulosus	intermediate filament protein	0.0027	0.0367	0.035
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.1449	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0142	0.0285
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0263	0.0561
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0018	0.0028
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0142	0.0124
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0061	0.0099
Echinococcus multilocularis	lamin	0.0027	0.0367	0.035
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.066	0.1473
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1425	0.141
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0546	0.1212
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0518	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0367	0.0567
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1425	0.141
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.066	0.1473
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1425	0.141
Brugia malayi	hypothetical protein	0.0232	0.648	1
Leishmania major	dihydroorotate dehydrogenase	0.0161	0.4374	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0518	0.0799
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0161	0.4374	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.0142	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0263	0.0405
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0518	0.0501
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0161	0.4374	1
Echinococcus granulosus	lamin	0.0027	0.0367	0.035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0061	0.0099
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0161	0.4374	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.066	0.3958
Schistosoma mansoni	inositol monophosphatase	0.0036	0.066	0.0643
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0063	0.1449	0.1434
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.066	0.1473
Loa Loa (eye worm)	hypothetical protein	0.01	0.2553	0.394
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.2553	0.394
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0142	0.0219
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1425	0.141
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0263	0.0405
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1425	0.141
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0137
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0161	0.4374	1
Onchocerca volvulus		0.0027	0.0367	0.1454
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0142	0.0285
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.066	0.1473
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1425	0.22
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0142	0.0124
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0018	0.0028
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0518	0.0799
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0501
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0161	0.4374	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0142	0.0124
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.648	0.6473
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0161	0.4374	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1425	0.22
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0142	0.0124
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1425	0.22
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0501
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0142	0.0285
Schistosoma mansoni	hypothetical protein	0.035	1	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0984	0.0968
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0142	0.0285
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0263	0.0561
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0061	0.0099
Schistosoma mansoni	lamin	0.0027	0.0367	0.035
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1425	0.141
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0263	0.0405
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0263	0.0561
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0161	0.4374	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.1449	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0263	0.0405
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0263	0.0561
Echinococcus multilocularis	geminin	0.035	1	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0161	0.4374	0.4364
Brugia malayi	cytochrome P450	0.0015	0.0018	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0353	0.0545
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0263	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0137
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.1449	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.1449	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0263	0.0921
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0018	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0142	0.0219
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0263	0.0561
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0142	0.0124
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0263	0.0561
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.066	0.1473
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.066	0.3958
Schistosoma mansoni	inositol monophosphatase	0.0036	0.066	0.0643
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0142	0.0124
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0142	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0137
Echinococcus multilocularis	lamin dm0	0.0027	0.0367	0.035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0061	0.0099
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1611	0.2487
Schistosoma mansoni	hypothetical protein	0.0032	0.0518	0.0501
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.066	0.3958
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0137
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0063	0.1449	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0263	0.0561
Trypanosoma brucei	unspecified product	0.0019	0.0142	0.0285
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0089	0.0163
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0089	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0161	0.4374	1
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0018	0.0028
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.1449	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0137
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.066	0.3958
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Echinococcus granulosus	dna polymerase eta	0.0019	0.0142	0.0124
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0263	0.0405
Schistosoma mansoni	hypothetical protein	0.035	1	1
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.066	0.0643
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0984	0.1519
Brugia malayi	intermediate filament protein	0.0027	0.0367	0.0567
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0367	0.0567
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0518	0.0501
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0063	0.1449	0.3286
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0063	0.1449	0.1434
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0263	0.0561
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0161	0.4374	0.675
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.648	0.6473
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0161	0.4374	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0063	0.1449	0.1434
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0263	0.0561
Schistosoma mansoni	hypothetical protein	0.0068	0.1611	0.1596
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0263	0.0405
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0263	0.0921
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0142	0.0124
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0263	0.0561
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0263	0.0921
Onchocerca volvulus		0.0047	0.0984	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0518	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0518	0.0799
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.066	0.1473
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0142	0.0219
Onchocerca volvulus		0.0027	0.0367	0.1454
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0263	0.0561
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0367	0.0567
Brugia malayi	Zinc finger, C2H2 type family protein	0.0063	0.1449	0.2237
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0018	0.0028
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0142	0.0285
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0142	0.0124
Loa Loa (eye worm)	cytochrome P450	0.0015	0.0018	0.0028
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0018	0.0028
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.066	0.0643
Schistosoma mansoni	lamin	0.0027	0.0367	0.035
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0142	0.0285
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0161	0.4374	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1611	0.2487
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0142	0.0219
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.2553	0.394
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.2553	0.394
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0018	0.0028
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0142	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0232	0.648	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0518	0.0501
Brugia malayi	Inositol-1	0.0036	0.066	0.1018
Brugia malayi	RNA binding protein	0.0062	0.1425	0.22
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1425	0.141
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0142	0.0285
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0161	0.4374	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0018	0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 721025