Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0325 | 0.9892 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0142 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0406 | 0.0327 |
Echinococcus granulosus | thymidylate synthase | 0.0325 | 0.9892 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0142 | 0.0059 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0585 | 0.0504 |
Loa Loa (eye worm) | thymidylate synthase | 0.0325 | 0.9892 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0585 | 0.051 |
Mycobacterium ulcerans | oxidoreductase | 0.0023 | 0.059 | 0.0509 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1768 | 0.1787 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0325 | 0.9892 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0023 | 0.059 | 0.0515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1768 | 0.1787 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Onchocerca volvulus | 0.0023 | 0.059 | 0.0515 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0377 | 0.0326 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0783 | 0.0792 |
Mycobacterium ulcerans | thymidylate synthase | 0.0325 | 0.9892 | 0.9891 |
Onchocerca volvulus | 0.0023 | 0.0585 | 0.051 | |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0783 | 0.0712 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0585 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0085 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0585 | 0.051 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0734 | 0.0662 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0023 | 0.059 | 0.0515 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0023 | 0.059 | 0.0515 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0585 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0585 | 0.051 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0023 | 0.059 | 0.0515 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1768 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0406 | 0.0327 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0585 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0155 | 0.4642 | 0.4662 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0023 | 0.059 | 0.0515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1768 | 0.1787 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0783 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.059 | 0.0515 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0585 | 0.051 |
Onchocerca volvulus | 0.0325 | 0.9892 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0585 | 0.0538 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0585 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Brugia malayi | hypothetical protein | 0.0155 | 0.4642 | 0.4646 |
Brugia malayi | SWIRM domain containing protein | 0.0023 | 0.059 | 0.0515 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0142 | 0.0059 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0085 | 0.0029 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0585 | 0.051 |
Mycobacterium ulcerans | dehydrogenase | 0.0023 | 0.059 | 0.0509 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0406 | 0.0356 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0325 | 0.9892 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Brugia malayi | thymidylate synthase | 0.0325 | 0.9892 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1768 | 0.1787 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0085 | 0.0029 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1768 | 0.1716 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0585 | 0.0504 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0585 | 0.051 |
Leishmania major | UDP-galactopyranose mutase | 0.0023 | 0.059 | 0.0515 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.009 | 0.0091 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0406 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0585 | 0.051 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0155 | 0.4642 | 0.4646 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0783 | 0.0792 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0377 | 0.0326 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.4642 | 0.9459 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0377 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0085 | 0.0029 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1768 | 0.1716 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0023 | 0.059 | 0.0596 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0734 | 0.0742 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0734 | 0.0662 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0023 | 0.059 | 0.0515 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0585 | 0.0538 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.059 | 0.0596 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0023 | 0.059 | 0.0515 |
Mycobacterium ulcerans | monoamine oxidase | 0.0023 | 0.059 | 0.0509 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0085 | 0.0028 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0023 | 0.059 | 0.0515 |
Onchocerca volvulus | 0.0028 | 0.0734 | 0.0662 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0585 | 0.0504 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0085 | 0.0086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1768 | 0.1787 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0085 | 0.0029 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1768 | 0.1716 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.059 | 0.0543 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0085 | 0.0029 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1768 | 0.1716 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0139 | 0.0055 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0023 | 0.059 | 0.0596 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1768 | 0.1716 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0377 | 0.0326 |
Echinococcus multilocularis | 0.0023 | 0.059 | 0.0515 | |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0023 | 0.059 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1768 | 0.1716 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.059 | 0.0515 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.009 | 0.0005 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0085 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0406 | 0.0327 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0023 | 0.059 | 0.0509 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.009 | 0.0005 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0325 | 0.9892 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0023 | 0.059 | 0.0543 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0085 | 0.0029 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0023 | 0.059 | 0.0515 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0406 | 0.0327 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0085 | 0.0029 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1768 | 0.1716 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0585 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0085 | 0.0028 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.059 | 0.0515 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0585 | 0.051 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0023 | 0.059 | 0.0515 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1501 | 0.1444 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0585 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0406 | 0.0327 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0325 | 0.9892 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0085 | 0.0029 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.009 | 0.0005 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.059 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0406 | 0.0327 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0406 | 0.0327 |
Brugia malayi | hypothetical protein | 0.0023 | 0.059 | 0.0515 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0023 | 0.059 | 0.0515 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0585 | 0.051 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0023 | 0.059 | 0.0515 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0585 | 0.051 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0585 | 0.0504 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0306 | 0.9287 | 0.9385 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0585 | 0.051 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0163 | 0.4903 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0.0642 | 0.0568 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.009 | 0.0005 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.1695 | 0.1714 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0085 | 0.0029 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0585 | 0.0504 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.059 | 0.0515 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0329 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.