Detailed information for compound 721291

Basic information

Technical information
  • TDR Targets ID: 721291
  • Name: N-[(3-bromo-5-ethoxy-4-prop-2-enoxyphenyl)met hyl]-3-morpholin-4-ylpropan-1-amine
  • MW: 413.349 | Formula: C19H29BrN2O3
  • H donors: 1 H acceptors: 0 LogP: 2.96 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1c(Br)cc(cc1OCC)CNCCCN1CCOCC1
  • InChi: 1S/C19H29BrN2O3/c1-3-10-25-19-17(20)13-16(14-18(19)24-4-2)15-21-6-5-7-22-8-11-23-12-9-22/h3,13-14,21H,1,4-12,15H2,2H3
  • InChiKey: AVADRRLRZGBMPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-allyloxy-3-bromo-5-ethoxy-phenyl)methyl]-3-morpholino-propan-1-amine
  • N-[(4-allyloxy-3-bromo-5-ethoxyphenyl)methyl]-3-morpholinopropan-1-amine
  • (4-allyloxy-3-bromo-5-ethoxy-benzyl)-(3-morpholinopropyl)amine
  • N-[(3-bromo-5-ethoxy-4-prop-2-enoxy-phenyl)methyl]-3-morpholin-4-yl-propan-1-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0034 0.0333 0.028
Brugia malayi MH2 domain containing protein 0.0015 0.0055 0.0076
Echinococcus multilocularis peregrin 0.003 0.0277 0.0245
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0383
Loa Loa (eye worm) hypothetical protein 0.0051 0.0585 0.081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0448 0.3187
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0448 0.3187
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.2215 0.3069
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0449 0.3193
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.2616 0.3624
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0922 0.1216
Echinococcus multilocularis Smad4 0.0034 0.0333 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Trypanosoma brucei trypanothione reductase 0.0054 0.063 0.4684
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0449 0.3193
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.1461 0.2023
Entamoeba histolytica hypothetical protein 0.0075 0.0944 0.7259
Echinococcus granulosus Smad4 0.0034 0.0333 0.0301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.2108 0.292
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2941 0.2902
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0585 0.081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0253 0.0351
Echinococcus granulosus intermediate filament protein 0.0028 0.025 0.0218
Mycobacterium tuberculosis Conserved protein 0.0074 0.0922 0.1216
Loa Loa (eye worm) hypothetical protein 0.011 0.1461 0.2023
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1278 0.123
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.063 0.4684
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0333 0.0301
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0449 0.3193
Loa Loa (eye worm) MH2 domain-containing protein 0.0501 0.7219 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.2949 0.4085
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0448 0.3187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.2108 0.2064
Brugia malayi Thioredoxin reductase 0.0054 0.063 0.0873
Echinococcus multilocularis tar DNA binding protein 0.0211 0.2941 0.2918
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0449 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0107 0.0387
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0055 0.0076
Brugia malayi jmjC domain containing protein 0.0099 0.1293 0.1792
Echinococcus multilocularis cpg binding protein 0.003 0.0277 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0922 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.9472
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0333 0.0462
Brugia malayi MH1 domain containing protein 0.0019 0.0108 0.015
Mycobacterium tuberculosis Conserved protein 0.0074 0.0922 0.1216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0728 0.0676
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0449 0.4194
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0879 0.9472
Mycobacterium ulcerans hypothetical protein 0.0074 0.0922 1
Brugia malayi Smad1 0.0034 0.0333 0.0462
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1278 0.1249
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0449 0.0417
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0107 0.0387
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1278 1
Brugia malayi hypothetical protein 0.0075 0.0944 0.1308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0028 0.025 0.0347
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0922 0.0872
Brugia malayi MH1 domain containing protein 0.0034 0.0333 0.0462
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0055 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Onchocerca volvulus 0.0074 0.0922 0.2996
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1656 0.2312
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0395 0.0363
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0081 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0107 0.0075
Toxoplasma gondii ABC1 family protein 0.0074 0.0922 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.2108 0.2082
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0395 0.0547
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0034 0.0047
Brugia malayi glutathione reductase 0.0054 0.063 0.0873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.2108 0.2064
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0547 0.3995
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0395 0.0342
Brugia malayi MH1 domain containing protein 0.0019 0.0108 0.015
Plasmodium vivax hypothetical protein, conserved 0.003 0.0277 0.2988
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0107 0.5
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0452 0.042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0448 0.0621
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0879 0.0849
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.1656 0.7827
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1278 1
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2941 0.2902
Brugia malayi MH2 domain containing protein 0.0034 0.0333 0.0462
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0034 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0107 0.1679
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0448 0.3187
Schistosoma mansoni microtubule-associated protein tau 0.0689 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1293 0.1265
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0922 0.1216
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0448 0.3187
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0922 0.1216
Brugia malayi TAR-binding protein 0.0211 0.2941 0.4074
Schistosoma mansoni lamin 0.0028 0.025 0.0197
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0922 0.7078
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0448 0.3187
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2941 0.2902
Brugia malayi beta-lactamase family protein 0.0074 0.0922 0.1277
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1278 0.1249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0107 0.1679
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.2108 0.2082
Plasmodium falciparum glutathione reductase 0.0019 0.0107 0.1679
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0107 0.1147
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0055 0.0022
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2616 0.2592
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0371 0.0339
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0277 0.208
Schistosoma mansoni hypothetical protein 0.003 0.0277 0.0223
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.063 0.0781
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0107 0.1147
Brugia malayi jmjC domain containing protein 0.0038 0.0395 0.0547
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0448 0.4184
Toxoplasma gondii thioredoxin reductase 0.0054 0.063 0.6422
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.063 0.0873
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0107 0.0149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0922 0.0872
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0055 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2941 0.2902
Loa Loa (eye worm) nuclear factor I 0.0019 0.0108 0.015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0449 1
Brugia malayi intermediate filament protein 0.0028 0.025 0.0347
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0449 0.2919
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0107 0.0387
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0879 0.0829
Onchocerca volvulus 0.0028 0.025 0.0676
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0448 0.3187
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.186 0.2616
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0448 0.3187
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1278 0.177
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0922 0.7078
Trypanosoma brucei polo-like protein kinase 0.0098 0.1278 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0395 0.0342
Loa Loa (eye worm) Smad1 0.0034 0.0333 0.0462
Giardia lamblia PHD finger protein 15 0.003 0.0277 0.1448
Plasmodium falciparum phd finger protein, putative 0.003 0.0277 0.4374
Brugia malayi N-terminal motif family protein 0.0211 0.2949 0.4085
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.186 0.2616
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Echinococcus multilocularis musashi 0.0028 0.025 0.0218
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0922 1
Onchocerca volvulus 0.0109 0.1441 0.4791
Schistosoma mansoni hypothetical protein 0.0051 0.0585 0.0533
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1656 0.2312
Toxoplasma gondii exonuclease III APE 0.0042 0.0449 0.4194
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Loa Loa (eye worm) beta-lactamase 0.0074 0.0922 0.1277
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0449 0.051
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0879 0.6725
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0333 0.028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0922 0.1216
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0944 0.0914
Schistosoma mansoni cpg binding protein 0.0029 0.0253 0.0199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Onchocerca volvulus 0.0074 0.0922 0.2996
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0922 0.1216
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0922 0.7078
Echinococcus granulosus lamin 0.0028 0.025 0.0218
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.063 0.06
Leishmania major trypanothione reductase 0.0054 0.063 0.4684
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0277 0.0245
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.063 0.6832
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0448 0.3187
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2616 0.2592
Schistosoma mansoni alpha-glucosidase 0.0163 0.2228 0.2185
Loa Loa (eye worm) RNA binding protein 0.0211 0.2941 0.4074
Loa Loa (eye worm) glutathione reductase 0.0054 0.063 0.0873
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0449 0.0417
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0449 0.0622
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0107 0.0387
Loa Loa (eye worm) TAR-binding protein 0.0211 0.2941 0.4074
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0107 0.0387
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1656 0.2312
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0448 0.3187
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.6807 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0449 0.3193
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1278 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0879 0.0849
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0449 0.3193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0448 0.3187
Schistosoma mansoni hypothetical protein 0.0051 0.0585 0.0533
Echinococcus multilocularis lamin 0.0028 0.025 0.0218
Loa Loa (eye worm) hypothetical protein 0.0052 0.0596 0.0826
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0585 0.0554
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0922 0.0892
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0107 0.0387
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0922 1
Schistosoma mansoni hypothetical protein 0.0051 0.0585 0.0533
Brugia malayi MH2 domain containing protein 0.0501 0.7219 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0585 0.0554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0585 0.0554
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0922 0.7078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0449 0.3193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0333 0.0301
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.2108 0.292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.2215 0.3069
Brugia malayi beta-lactamase 0.0074 0.0922 0.1277
Brugia malayi CXXC zinc finger family protein 0.0029 0.0253 0.0351
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0055 0.0076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.006 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0993 0.0943
Entamoeba histolytica hypothetical protein 0.0075 0.0944 0.7259
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Onchocerca volvulus Alhambra homolog 0.003 0.0277 0.0767
Entamoeba histolytica hypothetical protein 0.0075 0.0944 0.7259
Onchocerca volvulus 0.0029 0.0253 0.0685
Mycobacterium ulcerans beta-lactamase 0.0074 0.0922 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0922 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0055 0.0076
Schistosoma mansoni alpha-glucosidase 0.0163 0.2228 0.2185
Plasmodium falciparum thioredoxin reductase 0.0019 0.0107 0.1679
Schistosoma mansoni Smad4 0.0034 0.0333 0.028
Mycobacterium tuberculosis Conserved protein 0.0074 0.0922 0.1216
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0585 0.081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0922 0.1277
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0243 0.0336
Giardia lamblia Kinase, PLK 0.0098 0.1278 1
Trypanosoma brucei glucosidase, putative 0.0042 0.0448 0.3187
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0277 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0107 0.0387
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0448 0.0417
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.2616 0.3624
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0277 0.208
Schistosoma mansoni kinase 0.005 0.0566 0.0514
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0922 0.7078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.2108 0.2064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0585 0.081
Brugia malayi beta-lactamase family protein 0.0074 0.0922 0.1277
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0347
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0922 0.1216
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0107 0.0387
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0448 0.3187
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.025 0.0347
Schistosoma mansoni smad 0.0034 0.0333 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.9472
Brugia malayi MH2 domain containing protein 0.0034 0.0333 0.0462
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0107 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0689 1 1
Schistosoma mansoni ap endonuclease 0.0042 0.0449 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0922 0.7078
Echinococcus granulosus smad 0.0034 0.0333 0.0301
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0105 0.0146
Echinococcus multilocularis smad 0.0034 0.0333 0.0301
Echinococcus granulosus tar DNA binding protein 0.0211 0.2941 0.2918
Loa Loa (eye worm) hypothetical protein 0.0162 0.2215 0.3069
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0922 0.7078
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0922 0.1216
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.2941 0.4074
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0448 0.3187
Schistosoma mansoni intermediate filament proteins 0.0028 0.025 0.0197
Brugia malayi MH1 domain containing protein 0.0034 0.0333 0.0462
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0449 0.486
Echinococcus multilocularis lamin dm0 0.0028 0.025 0.0218
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0055 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0333 0.0301
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0752 0.1042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0879 0.1152
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0547 0.3995
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0922 0.7078
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2941 0.2902
Echinococcus granulosus GPCR family 2 0.0051 0.0585 0.0554
Schistosoma mansoni ap endonuclease 0.0042 0.0449 0.0396
Leishmania major hypothetical protein, conserved 0.0074 0.0922 0.7078
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0277 0.0383
Schistosoma mansoni hypothetical protein 0.011 0.1461 0.1414
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0277 0.0245
Brugia malayi RNA binding protein 0.0211 0.2941 0.4074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.2941 0.4074
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0448 0.0417
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0083
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.063 0.06
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.025 0.0347
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1656 0.2312
Plasmodium falciparum glutathione reductase 0.0054 0.063 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.006 0.0018
Schistosoma mansoni smad1 5 8 and 0.0034 0.0333 0.028
Entamoeba histolytica hypothetical protein 0.0075 0.0944 0.7259
Plasmodium falciparum thioredoxin reductase 0.0054 0.063 1
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0449 0.0622
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1293 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1278 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.2949 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0448 0.0621
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0585 0.0554
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0055 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.2616 0.2592
Schistosoma mansoni cpg binding protein 0.003 0.0277 0.0224
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0449 0.7113
Mycobacterium tuberculosis Probable reductase 0.0124 0.1656 0.2312
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0452 0.042
Echinococcus granulosus cpg binding protein 0.003 0.0277 0.0245
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0055 0.0076
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.186 0.2616
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0922 0.0892
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0922 0.1277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.2215 0.3069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0107 0.0387
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1656 0.2312
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0107 0.0075
Echinococcus granulosus lamin dm0 0.0028 0.025 0.0218
Brugia malayi PHD-finger family protein 0.003 0.0277 0.0383
Brugia malayi Bromodomain containing protein 0.003 0.0277 0.0383
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0944 0.0894
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.186 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1278 0.4225
Onchocerca volvulus 0.0074 0.0922 0.2996
Echinococcus granulosus peregrin 0.003 0.0277 0.0245
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0333 0.0462
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0107 0.0387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0944 0.0914
Schistosoma mansoni alpha glucosidase 0.0042 0.0448 0.0395
Loa Loa (eye worm) transcription factor SMAD2 0.0501 0.7219 1
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0879 0.0829
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0333 0.0301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.2108 0.2082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.2108 0.2082
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0449 0.3193
Schistosoma mansoni lamin 0.0028 0.025 0.0197
Trichomonas vaginalis esterase, putative 0.0074 0.0922 0.7078
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0107 0.0387
Loa Loa (eye worm) hypothetical protein 0.0074 0.0922 0.1277
Schistosoma mansoni hypothetical protein 0.0075 0.0944 0.0894
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0632 0.6438
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0448 0.3187
Schistosoma mansoni smad1 5 8 and 0.0034 0.0333 0.028
Echinococcus multilocularis GPCR, family 2 0.0051 0.0585 0.0554
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1278 0.177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.9472
Schistosoma mansoni cpg binding protein 0.003 0.0277 0.0224
Onchocerca volvulus 0.0028 0.025 0.0676
Plasmodium vivax glutathione reductase, putative 0.0054 0.063 0.6832
Schistosoma mansoni hypothetical protein 0.0051 0.0585 0.0533
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0107 0.0387
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1278 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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