Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.326 | 0.326 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.3912 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.3912 | 0.3912 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.3912 | 0.3912 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.326 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.326 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.326 | 0.326 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.3912 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.326 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6896 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.326 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3912 | 0.3912 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.326 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.326 | 0.326 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.3912 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.326 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.326 | 0.326 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.3912 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.3912 | 0.5672 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.3912 | 0.3912 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6896 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6896 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.