Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.1618 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0195 | 0.0378 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0195 | 0.0378 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0195 | 0.0378 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0195 | 0.0378 | 0.0766 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.1618 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0195 | 0.0378 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0832 | 0.4685 | 0.9489 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0195 | 0.0378 | 0.0766 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0869 | 0.4938 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0869 | 0.4938 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.1618 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0911 | 0.5221 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0195 | 0.0378 | 0.0766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 5 | Ratio between poly-dAdT and poly-dGdC binding | ChEMBL. | 8510102 |
Tm (binding) | = 9.4 degrees C | Thermal denaturation in alternating poly(dG-dC)-poly(dG-dC) homopolymer (GC) | ChEMBL. | 8510102 |
Tm (binding) | = 22.4 degrees C | Thermal denaturation in sonicated calf thymus DNA (CT DNA) | ChEMBL. | 8510102 |
Tm (binding) | = 42.7 degrees C | Thermal denaturation in alternating poly(dA-dT)poly(dA-dT) homopolymer (AT) | ChEMBL. | 8510102 |
Tm (binding) | = 45.3 degrees C | Thermal denaturation in sonicated poly(dA)-poly(dT) homopolymer (AT) | ChEMBL. | 8510102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.