Detailed information for compound 721505

Basic information

Technical information
  • TDR Targets ID: 721505
  • Name: N-(2-chlorophenyl)-4-[3-(3-methoxyphenyl)-1,2 ,4-oxadiazol-5-yl]butanamide
  • MW: 371.818 | Formula: C19H18ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 3.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1noc(n1)CCCC(=O)Nc1ccccc1Cl
  • InChi: 1S/C19H18ClN3O3/c1-25-14-7-4-6-13(12-14)19-22-18(26-23-19)11-5-10-17(24)21-16-9-3-2-8-15(16)20/h2-4,6-9,12H,5,10-11H2,1H3,(H,21,24)
  • InChiKey: UKVUGKDDYYAYBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chlorophenyl)-4-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]butyramide
  • ZINC04821322

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Schistosoma mansoni potassium channel beta 0.0059 0.0994 0.262
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0204 0.3793 0.3108
Brugia malayi Fibulin-1 precursor 0.0009 0.0017 0.0044
Onchocerca volvulus 0.0204 0.3793 1
Trypanosoma brucei aldo-keto reductase, putative 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase 0.0204 0.3793 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Entamoeba histolytica aldose reductase, putative 0.0204 0.3793 0.3108
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Plasmodium falciparum aldo-keto reductase, putative 0.0059 0.0994 0.5
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0059 0.0994 0.2587
Echinococcus multilocularis aldehyde reductase 0.0145 0.2651 0.6977
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Toxoplasma gondii aldose reductase, putative 0.0204 0.3793 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0059 0.0994 0.5
Echinococcus granulosus voltage gated potassium channel subunit 0.0059 0.0994 0.2587
Onchocerca volvulus 0.0204 0.3793 1
Brugia malayi NADH-dependent xylose reductase 0.0059 0.0994 0.262
Loa Loa (eye worm) oxidoreductase 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Loa Loa (eye worm) AStacin protease 0.0016 0.0171 0.045
Loa Loa (eye worm) oxidoreductase 0.0204 0.3793 1
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0017 0.0044
Onchocerca volvulus 0.0204 0.3793 1
Plasmodium vivax aldehyde reductase, putative 0.0059 0.0994 0.5
Echinococcus granulosus aldehyde reductase 0.0145 0.2651 0.6977
Echinococcus granulosus Tolloid protein 1 0.0026 0.0362 0.0914
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0525 1 1
Schistosoma mansoni pol-related 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.0362 0.0954
Echinococcus multilocularis aldo keto reductase 0.0204 0.3793 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0158
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Plasmodium falciparum aldehyde reductase, putative 0.0059 0.0994 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0204 0.3793 0.3108
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0059 0.0994 0.262
Leishmania major prostaglandin f synthase, putative 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Toxoplasma gondii aldo-keto reductase 0.0059 0.0994 0.2587
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0044
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0059 0.0994 0.2587
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0204 0.3793 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0059 0.0994 0.2587
Giardia lamblia Aldose reductase 0.0204 0.3793 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0204 0.3793 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0059 0.0994 0.2587
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0204 0.3793 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Loa Loa (eye worm) oxidoreductase 0.0204 0.3793 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0204 0.3793 0.3108
Echinococcus multilocularis Tolloid protein 1 0.0026 0.0362 0.0914
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Trypanosoma cruzi aldo-keto reductase 0.0204 0.3793 1
Giardia lamblia Aldose reductase 0.0204 0.3793 0.5
Entamoeba histolytica aldose reductase, putative 0.0204 0.3793 0.3108
Leishmania major aldo-keto reductase-like protein 0.0204 0.3793 1
Onchocerca volvulus 0.0059 0.0994 0.262
Mycobacterium leprae Conserved hypothetical protein 0.0145 0.2651 0.5922
Trichomonas vaginalis aldo/keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus multilocularis aldo keto reductase 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase 0.0204 0.3793 1
Onchocerca volvulus 0.0204 0.3793 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0341 0.0899
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0059 0.0994 0.262
Entamoeba histolytica aldose reductase, putative 0.0204 0.3793 0.3108
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.0362 0.0954
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase 0.0204 0.3793 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase 0.0204 0.3793 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Trichomonas vaginalis aldo/keto reductase, putative 0.0204 0.3793 0.3108
Echinococcus granulosus hypothetical protein 0.0204 0.3793 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0009 0.0017 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Trichomonas vaginalis aldo/keto reductase, putative 0.0204 0.3793 0.3108
Onchocerca volvulus 0.0204 0.3793 1
Onchocerca volvulus 0.0204 0.3793 1
Mycobacterium ulcerans oxidoreductase 0.0204 0.3793 1
Loa Loa (eye worm) oxidoreductase 0.0204 0.3793 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.3793 0.3108
Loa Loa (eye worm) oxidoreductase 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Schistosoma mansoni aldo-keto reductase 0.0204 0.3793 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0204 0.3793 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0204 0.3793 1
Trypanosoma brucei prostaglandin f synthase 0.0204 0.3793 1
Schistosoma mansoni aldo-keto reductase 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0204 0.3793 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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