Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0504 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0197 | 0.3783 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0504 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.2721 | 0.2721 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0197 | 0.3783 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0504 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0504 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0197 | 0.3783 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0197 | 0.3783 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0504 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0504 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0504 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0504 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.2721 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0504 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0197 | 0.3783 | 0.3783 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0504 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0504 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.2721 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0504 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0504 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0504 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0197 | 0.3783 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.