Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0012 | 0.0055 | 0.0052 |
Brugia malayi | ecdysteroid receptor | 0.0022 | 0.0299 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0498 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0055 | 0.0135 |
Brugia malayi | tailless protein | 0.0011 | 0.0025 | 0.0066 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0684 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.0299 | 0.0777 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0299 | 0.0297 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1303 | 0.1281 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.0299 | 0.0275 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0011 | 0.0025 | 0.0059 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0299 | 0.0777 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0299 | 0.0777 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.0299 | 0.0275 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0.0299 | 0.1299 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0299 | 0.0297 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0011 | 0.0025 | 0.0066 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.0299 | 0.0275 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0011 | 0.0025 | 0.0023 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0015 | 0.0117 | 0.0304 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0011 | 0.0025 | 0.0059 |
Schistosoma mansoni | thyroid hormone receptor | 0.0162 | 0.3529 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0055 | 0.0135 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0011 | 0.0025 | 0.0066 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0299 | 0.0777 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0684 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0011 | 0.0025 | 0.0059 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0011 | 0.0025 | 0.0023 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0299 | 0.0777 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.0299 | 0.0275 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0299 | 0.0771 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0011 | 0.0025 | 0.0023 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0299 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.0299 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0299 | 0.0275 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0025 | 0.0023 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0299 | 0.0777 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0684 | 0.177 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.3011 | 0.2993 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0055 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0055 | 0.0029 |
Brugia malayi | nuclear receptor NHR-67 | 0.0011 | 0.0025 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0011 | 0.0025 | 0.0023 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0299 | 0.0297 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.0299 | 0.0771 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0.0684 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0299 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0055 | 0.0135 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0684 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0055 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0011 | 0.0025 | 0.0023 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0684 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0011 | 0.0025 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.0684 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0011 | 0.0025 | 0.0023 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0684 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0025 | 0.0066 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0442 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.0299 | 0.0275 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | nuclear receptor RXR | 0.0012 | 0.0055 | 0.0142 |
Onchocerca volvulus | 0.0031 | 0.0498 | 0.2242 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0299 | 0.0777 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.0299 | 0.0297 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.0299 | 0.0771 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0299 | 0.0275 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.0299 | 0.0275 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0498 | 0.0474 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0498 | 0.1288 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.0299 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.0299 | 0.0297 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0.0299 | 0.1299 |
Brugia malayi | ecdysone receptor | 0.0011 | 0.0025 | 0.0066 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0.0684 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0539 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0055 | 0.0135 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.0684 | 0.0681 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0055 | 0.0142 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0684 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0011 | 0.0025 | 0.0066 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0025 | 0.0066 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.0299 | 0.0777 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0299 | 0.0771 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0299 | 0.0777 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0025 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.0684 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0684 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0011 | 0.0025 | 0.0023 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.3851 | 0.385 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.3851 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.3851 | 0.385 |
Schistosoma mansoni | thyroid hormone receptor | 0.0162 | 0.3529 | 0.3513 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.0299 | 0.0777 |
Onchocerca volvulus | 0.0022 | 0.0299 | 0.1299 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.0299 | 0.0777 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0684 | 0.1776 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0025 | 0.0066 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0055 | 0.0142 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.0299 | 0.0275 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0299 | 0.0297 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0299 | 0.0297 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.3285 | 0.3267 |
Brugia malayi | conserved hypotetical protein | 0.0011 | 0.0025 | 0.0066 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0299 | 0.0777 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0299 | 0.0777 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0011 | 0.0025 | 0.0059 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0011 | 0.0025 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.0299 | 0.0777 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0011 | 0.0025 | 0.0066 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0684 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0539 | 0.0515 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.0684 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0015 | 0.0117 | 0.0435 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0684 | 0.066 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0299 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0299 | 0.0777 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.0299 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0011 | 0.0025 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0299 | 0.0771 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0055 | 0.0142 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0.0299 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0299 | 0.0297 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0539 | 0.0537 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0011 | 0.0025 | 0.0066 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0011 | 0.0025 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.014 | 0.3011 | 0.3009 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0684 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0299 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0025 | 0.0059 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0299 | 0.0771 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.3851 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0299 | 0.0771 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0012 | 0.0055 | 0.0029 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0539 | 0.0515 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0162 | 0.3529 | 0.3527 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0684 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0299 | 0.0777 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0011 | 0.0025 | 0.0023 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.3851 | 0.385 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0299 | 0.0297 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0299 | 0.0777 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0684 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.0299 | 0.0777 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0012 | 0.0055 | 0.0052 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0025 | 0.0023 |
Onchocerca volvulus | 0.0102 | 0.2135 | 1 | |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.3285 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0117 | 0.0297 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0012 | 0.0055 | 0.0135 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.014 | 0.3011 | 0.3009 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.