Detailed information for compound 722186

Basic information

Technical information
  • TDR Targets ID: 722186
  • Name: 1-[2-(4-fluorophenyl)ethyl]-3-(2-methoxy-5-me thylphenyl)urea
  • MW: 302.343 | Formula: C17H19FN2O2
  • H donors: 2 H acceptors: 1 LogP: 3.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)NCCc1ccc(cc1)F)C
  • InChi: 1S/C17H19FN2O2/c1-12-3-8-16(22-2)15(11-12)20-17(21)19-10-9-13-4-6-14(18)7-5-13/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21)
  • InChiKey: DDQAUMBWWPNAOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-fluorophenyl)ethyl]-3-(2-methoxy-5-methyl-phenyl)urea
  • ZINC00609294
  • IVK/1635527

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0042 0.0238 0.0238
Schistosoma mansoni thyroid hormone receptor 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Onchocerca volvulus 0.0088 0.0608 0.5665
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1064 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0013 0.0016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0282 0.037
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0213 0.0202
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0062 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1425 0.1415
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0213 0.1914
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.017 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0062 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1425 0.1415
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0213 0.1914
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0359 0.2829
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Onchocerca volvulus 0.002 0.0062 0.0484
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0282 0.2578
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0282 0.2546
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0062 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Schistosoma mansoni cpg binding protein 0.0093 0.0648 0.0648
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0213 0.0213
Brugia malayi steroid hormone receptor 0.002 0.0062 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Schistosoma mansoni tar DNA-binding protein 0.0457 0.3587 0.3587
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0013 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0062 0.0106
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0062 0.0484
Brugia malayi Importin beta-1 subunit 0.0057 0.0359 0.0974
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0206 0.158
Schistosoma mansoni hypothetical protein 0.1252 1 1
Brugia malayi RNA binding protein 0.0457 0.3587 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0206 0.1847
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1425 0.1425
Loa Loa (eye worm) hypothetical protein 0.0048 0.0282 0.0564
Plasmodium vivax importin-beta 2, putative 0.0057 0.0359 0.3307
Echinococcus multilocularis cpg binding protein 0.0093 0.0648 0.0638
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0062 0.0062
Schistosoma mansoni apoferritin-2 0.0017 0.0036 0.0036
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0074 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0185 0.1655
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0059 0.0455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.1064 0.2189
Brugia malayi CXXC zinc finger family protein 0.0088 0.0608 0.1668
Onchocerca volvulus 0.0145 0.1064 1
Entamoeba histolytica hypothetical protein 0.0046 0.0272 0.2449
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0238 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0062 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1425 0.3954
Brugia malayi RNA recognition motif domain containing protein 0.0457 0.3587 1
Entamoeba histolytica Ran family GTPase 0.0042 0.0238 0.2125
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1064 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0206 0.1847
Schistosoma mansoni hypothetical protein 0.0345 0.2683 0.2683
Schistosoma mansoni ran 0.0042 0.0238 0.0238
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0118 0.0222
Entamoeba histolytica hypothetical protein 0.0146 0.1077 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0206 0.0195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.017 0.0216
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.1064 0.1054
Schistosoma mansoni hypothetical protein 0.061 0.482 0.482
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0282 0.2578
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0206 0.0544
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0213 0.1914
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Schistosoma mansoni tar DNA-binding protein 0.0457 0.3587 0.3587
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0213 0.1891
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0213 0.0213
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0238 0.2151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0213 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0062 0.0106
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0213 0.1914
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0923 0.7345 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0282 0.2578
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0213 0.0563
Loa Loa (eye worm) beta-lactamase 0.0145 0.1064 0.2189
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0013 0.0016
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0238 0.2151
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.1064 0.1435
Brugia malayi nuclear receptor NHR-88 0.002 0.0062 0.0143
Echinococcus multilocularis ferritin 0.0017 0.0036 0.0025
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.1064 0.1435
Schistosoma mansoni ferritin light chain 0.0017 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.0093 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0036 0.0185 0.0362
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0194
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.1283 0.3557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1425 0.1415
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0282 0.2578
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0282 0.0759
Plasmodium falciparum importin beta, putative 0.0057 0.0359 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0036 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1425 0.1415
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0062 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1064 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0062 0.0051
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.1064 0.1435
Mycobacterium ulcerans lipase LipD 0.0145 0.1064 1
Onchocerca volvulus 0.0048 0.0282 0.2578
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Entamoeba histolytica hypothetical protein 0.0146 0.1077 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0062 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0282 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1425 0.1425
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0013 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0062 0.0143
Schistosoma mansoni alpha-glucosidase 0.0148 0.109 0.109
Trichomonas vaginalis esterase, putative 0.0145 0.1064 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.1064 0.1435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0062 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0062 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.1064 0.1054
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0104 0.0887
Mycobacterium ulcerans hypothetical protein 0.0145 0.1064 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0062 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0185 0.0362
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.653 0.6526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.1403 0.1403
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.017 0.0216
Schistosoma mansoni thyroid hormone receptor 0.002 0.0062 0.0062
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.1064 0.1435
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0013 0.0016
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0062 0.0143
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0282 0.2546
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.1283 0.1273
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0206 0.1847
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0062 0.0143
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0059 0.0455
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.1064 1
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0933 0.1918
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0272 0.2479
Mycobacterium tuberculosis Conserved protein 0.0145 0.1064 0.1435
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0282 0.2578
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0213 0.1914
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0213 0.1914
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0062 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1064 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0062 0.0143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0062 0.0051
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0238 0.0633
Loa Loa (eye worm) hypothetical protein 0.0048 0.0282 0.0564
Loa Loa (eye worm) TAR-binding protein 0.0457 0.3587 0.7436
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0213 0.0202
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.1064 0.1435
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0074 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0282 0.2578
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.1064 0.1435
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0062 0.0051
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0206 0.1847
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0238 0.6504
Loa Loa (eye worm) RNA binding protein 0.0457 0.3587 0.7436
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.482 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.1064 0.2944
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0062 0.0143
Leishmania major GTP-binding protein, putative 0.0042 0.0238 0.2151
Trichomonas vaginalis helicase, putative 0.002 0.0059 0.0455
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.1077 0.1077
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0282 0.2578
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0206 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0062 0.0106
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0238 0.0227
Schistosoma mansoni ferritin 0.0017 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0062 0.0143
Leishmania major hypothetical protein, conserved 0.0145 0.1064 1
Onchocerca volvulus 0.0145 0.1064 1
Schistosoma mansoni tar DNA-binding protein 0.0457 0.3587 0.3587
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0213 0.0202
Loa Loa (eye worm) hypothetical protein 0.0036 0.0185 0.0362
Mycobacterium leprae conserved hypothetical protein 0.0145 0.1064 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1425 0.294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0062 0.0106
Echinococcus granulosus ferritin 0.0017 0.0036 0.0025
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0238 0.184
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0036 0.0034
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0206 0.1847
Echinococcus granulosus expressed protein 0.0017 0.0036 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0062 0.0143
Loa Loa (eye worm) hypothetical protein 0.0057 0.0359 0.0724
Entamoeba histolytica hypothetical protein 0.0146 0.1077 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0146 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0185 0.0362
Schistosoma mansoni importin beta-1 0.0057 0.0359 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0282 0.0759
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0206 0.1847
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0013 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0104 0.2681
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1064 0.1064
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0206 0.1825
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0282 0.2578
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0074 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0282 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Mycobacterium tuberculosis Conserved protein 0.0145 0.1064 0.1435
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0104 0.0887
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1064 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1064 1
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0036 0.5
Schistosoma mansoni ferritin 0.0017 0.0036 0.0036
Echinococcus multilocularis expressed protein 0.0017 0.0036 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0062 0.0051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0608 0.124
Brugia malayi ecdysteroid receptor 0.002 0.0062 0.0143
Echinococcus granulosus importin subunit beta 1 0.0057 0.0359 0.0349
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.1077 0.1067
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0104 0.0887
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1283 0.1273
Leishmania major hypothetical protein, conserved 0.0026 0.0104 0.0887
Trichomonas vaginalis ferritin, putative 0.0017 0.0036 0.024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0013 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0062 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0359 0.3307
Trichomonas vaginalis ran, putative 0.0042 0.0238 0.2151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.1283 0.2645
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0213 0.0202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0118 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0059 0.0455
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0062 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0062 0.0051
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0062 0.0051
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0238 0.2151
Schistosoma mansoni ferritin light chain 0.0017 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0062 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1425 0.1425
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0206 0.0195
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0206 0.1847
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0013 0.0016
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0036 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0104 0.0887
Onchocerca volvulus 0.0099 0.0699 0.6535
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0062 0.0143
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0206 0.1847
Schistosoma mansoni hypothetical protein 0.0345 0.2683 0.2683
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0185 0.0238
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0062 0.0143
Brugia malayi hypothetical protein 0.0016 0.0031 0.0057
Mycobacterium ulcerans beta-lactamase 0.0145 0.1064 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0062 0.0062
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0036 0.024
Leishmania major importin beta-1 subunit, putative 0.0046 0.0272 0.2479
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0457 0.3587 0.7436
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0238 0.2151
Brugia malayi nuclear hormone receptor 0.002 0.0062 0.0143
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0062 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0238 0.0471
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0062 0.0051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0074 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0933 0.1918
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0013 0.0016
Toxoplasma gondii ABC1 family protein 0.0145 0.1064 0.8553
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0185 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0062 0.0051
Schistosoma mansoni ferritin 0.0017 0.0036 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0206 0.1847
Echinococcus granulosus tar DNA binding protein 0.0457 0.3587 0.358
Echinococcus granulosus snurportin 1 0.061 0.482 0.4814
Schistosoma mansoni tar DNA-binding protein 0.0457 0.3587 0.3587
Brugia malayi RNA, U transporter 1 0.0163 0.1209 0.3351
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0206 0.1847
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0238 0.0227
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0282 0.2578
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0282 0.2546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0062 0.0143
Brugia malayi beta-lactamase family protein 0.0145 0.1064 0.2944
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Trypanosoma brucei glucosidase, putative 0.0038 0.0206 0.1847
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0272 0.2479
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0272 0.2479
Schistosoma mansoni nuclear hormone receptor 0.002 0.0062 0.0062
Onchocerca volvulus 0.0145 0.1064 1
Echinococcus multilocularis snurportin 1 0.061 0.482 0.4814
Schistosoma mansoni ferritin 0.0017 0.0036 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0282 0.2578
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0062 0.0062
Schistosoma mansoni alpha glucosidase 0.0038 0.0206 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0213 0.0202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0062 0.0051
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0104 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0145 0.1064 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0118 0.0107
Schistosoma mansoni alpha-glucosidase 0.0148 0.109 0.109
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0013 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0013 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1064 1
Brugia malayi beta-lactamase 0.0145 0.1064 0.2944
Echinococcus multilocularis tar DNA binding protein 0.0457 0.3587 0.358
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.1077 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0062 0.0143
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0062 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0059 0.0455
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.1064 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0282 0.2578
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0213 0.0202
Brugia malayi hypothetical protein 0.0146 0.1077 0.2981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0062 0.0106
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.1064 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0185 0.0362
Mycobacterium ulcerans hypothetical protein 0.0048 0.0282 0.2578
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0185 0.5005
Brugia malayi MH2 domain containing protein 0.0128 0.0933 0.2579
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0359 0.3307
Mycobacterium leprae Probable lipase LipE 0.0145 0.1064 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0106
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0062 0.0484
Schistosoma mansoni cpg binding protein 0.0088 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0213 0.1914
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0206 0.1847
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0282 0.2578
Entamoeba histolytica hypothetical protein 0.0146 0.1077 1
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1064 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0036 0.5
Mycobacterium tuberculosis Conserved protein 0.0145 0.1064 0.1435
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0062 0.0062
Brugia malayi TAR-binding protein 0.0457 0.3587 1
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0013 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0104 0.2681
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0013 0.0016
Brugia malayi beta-lactamase family protein 0.0145 0.1064 0.2944
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0206 0.1847
Echinococcus multilocularis dnaJ subfamily B 0.1252 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.017 0.0216
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0206 0.1825
Schistosoma mansoni tar DNA-binding protein 0.0457 0.3587 0.3587
Loa Loa (eye worm) hypothetical protein 0.0048 0.0282 0.0564
Echinococcus granulosus cpg binding protein 0.0093 0.0648 0.0638
Echinococcus granulosus geminin 0.0345 0.2683 0.2675
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0062 0.0062
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0359 0.0349
Schistosoma mansoni coup transcription factor 0.002 0.0062 0.0062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0062 0.0051
Loa Loa (eye worm) hypothetical protein 0.0145 0.1064 0.2189
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0062 0.0106
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1283 0.1273
Echinococcus multilocularis geminin 0.0345 0.2683 0.2675
Schistosoma mansoni apoferritin-2 0.0017 0.0036 0.0036
Brugia malayi hypothetical protein 0.0026 0.0104 0.0261
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0036 0.024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0062 0.0062
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0185 0.1655
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0062 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0062 0.0143
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0272 0.2479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0062 0.0106
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0115 0.029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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