Detailed information for compound 72262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 749.032 | Formula: C48H64N2O5
  • H donors: 3 H acceptors: 4 LogP: 8.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC/C(=C\C=C\[C@]1(C)[C@@H](O)CC[C@]2([C@H]1CCC1[C@]2(C)c2n3[C@@H](C(=C)C)C(=O)c4c3c(c2C1)cc1c4[C@@H](O)C2C1=CC(OC2(C)C)(C)C)C)/C(=O)NC(C)(C)C
  • InChi: 1S/C48H64N2O5/c1-14-26(42(54)49-43(4,5)6)16-15-20-46(11)32-18-17-27-22-30-29-23-28-31-24-44(7,8)55-45(9,10)36(31)39(52)34(28)35-38(29)50(37(25(2)3)40(35)53)41(30)48(27,13)47(32,12)21-19-33(46)51/h15-16,20,23-24,27,32-33,36-37,39,51-52H,2,14,17-19,21-22H2,1,3-13H3,(H,49,54)/b20-15+,26-16+/t27?,32-,33-,36?,37-,39+,46-,47-,48+/m0/s1
  • InChiKey: PDBSNWUGOFFJBM-LMGZOLSRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0017 0.0016
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1487 0.1869 0.1868
Giardia lamblia DINP protein human, muc B family 0.0043 0.0017 0.0045
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.5111
Schistosoma mansoni cathepsin C 0.0521 0.0631 0.0644
Leishmania major cathepsin L-like protease 0.2248 0.2846 0.2904
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Brugia malayi beta-lactamase 0.0038 0.0011 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1868
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Loa Loa (eye worm) histone methyltransferase 0.0097 0.0087 0.0136
Echinococcus multilocularis cathepsin L 0.0521 0.0631 0.0642
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0216 0.024 0.0243
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Onchocerca volvulus 0.2248 0.2846 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.0046 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.0631 0.0629
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0053 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.2138 0.2705 0.2759
Echinococcus multilocularis Smad4 0.0051 0.0028 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Loa Loa (eye worm) hypothetical protein 0.024 0.0271 0.0442
Giardia lamblia Cathepsin B precursor 0.0521 0.0631 0.1801
Loa Loa (eye worm) hypothetical protein 0.021 0.0233 0.0379
Brugia malayi glutathione reductase 0.0088 0.0075 0.0125
Brugia malayi Pre-SET motif family protein 0.0134 0.0135 0.0224
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0066 0.0047 0.0079
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Brugia malayi cathepsin B-like cysteine proteinase 0.4322 0.5505 0.9142
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0123 0.0125
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Echinococcus granulosus cathepsin l cysteine peptidase 0.2248 0.2846 0.2904
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0738 0.0909 0.2482
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0521 0.0631 0.0644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0036 0.0036
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0521 0.0631 0.1722
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0293 0.0338 0.0346
Loa Loa (eye worm) hypothetical protein 0.44 0.5606 0.9308
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0011 0.0023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0017 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0141 0.0143
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0738 0.0909 0.2482
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Toxoplasma gondii preprocathepsin c precursor, putative 0.0738 0.0909 0.1152
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0216 0.024 0.0618
Onchocerca volvulus 0.2248 0.2846 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.1487 0.1869 0.5111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0068 0.0049 0.0047
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0068 0.0049 0.0047
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1868
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0101 0.0102
Entamoeba histolytica acetyltransferase, GNAT family 0.0128 0.0126 0.0419
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2755 0.3495 0.3567
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0009 0.0007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0017 0.0016
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.7668 0.9797 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.1487 0.1869 0.1907
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Plasmodium falciparum plasmepsin IV 0.0284 0.0327 0.089
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.0382 0.0389
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0011 0.001
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0077 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0284 0.0327 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0193 0.0191
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0216 0.024 1
Brugia malayi PHD-finger family protein 0.0046 0.0022 0.0036
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0067 0.0049 0.0048
Mycobacterium tuberculosis Conserved protein 0.0038 0.0011 0.0023
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0056 0.0035 0.0058
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0201 0.022 0.0566
Trypanosoma cruzi cruzipain precursor, putative 0.2848 0.3616 0.3689
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0017 0.0015
Giardia lamblia Cysteine protease 0.0521 0.0631 0.1801
Onchocerca volvulus 0.0521 0.0631 0.2187
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Brugia malayi Latrophilin receptor protein 2 0.0293 0.0338 0.0562
Toxoplasma gondii calcium binding egf domain-containing protein 0.0056 0.0035 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0079 0.0064 0.0063
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4322 0.5505 0.5619
Toxoplasma gondii thioredoxin reductase 0.0088 0.0075 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0023 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.2248 0.2846 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0161 0.0163
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0216 0.024 0.0243
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0284 0.0327 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0009
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0065 0.0046 0.0114
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.021 0.0233 0.0379
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1908
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.4607 0.5871 0.5992
Plasmodium falciparum phd finger protein, putative 0.0089 0.0077 0.0206
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.2891 0.367 0.3745
Echinococcus granulosus cathepsin L 0.1231 0.1542 0.1572
Giardia lamblia Hypothetical protein 0.0888 0.1102 0.3148
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0077 0.0098
Echinococcus multilocularis cathepsin b 0.4322 0.5505 0.5619
Toxoplasma gondii GAF domain-containing protein 0.288 0.3656 0.4633
Leishmania major cathepsin L-like protease 0.2848 0.3616 0.3689
Brugia malayi CXXC zinc finger family protein 0.0298 0.0345 0.0572
Echinococcus multilocularis cpg binding protein 0.0315 0.0366 0.0372
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0028 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0494 0.0596 0.0608
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0017 0.0018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.4366 0.5562 0.5562
Giardia lamblia Cathepsin B precursor 0.1697 0.2138 0.6116
Schistosoma mansoni hypothetical protein 0.3029 0.3847 0.3927
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1487 0.1869 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0097 0.0087 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.1487 0.1869 0.1908
Toxoplasma gondii aspartyl protease ASP1 0.0284 0.0327 0.0415
Schistosoma mansoni smad1 5 8 and 0.0051 0.0028 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0123 0.0125
Brugia malayi F/Y-rich N-terminus family protein 0.0125 0.0123 0.0204
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1697 0.2138 0.2183
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.0199 0.0323
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0045 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.1231 0.1542 0.1572
Brugia malayi beta-lactamase family protein 0.0038 0.0011 0.0018
Brugia malayi Pax transcription factor protein 2 0.024 0.0271 0.045
Toxoplasma gondii PAN domain-containing protein 0.0944 0.1174 0.1488
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.2339 0.2963 0.3023
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2755 0.3495 0.3567
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0243
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.4725 0.6022 1
Brugia malayi Papain family cysteine protease containing protein 0.0521 0.0631 0.1048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0022 0.0028
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0075 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Brugia malayi Pepsin A precursor 0.0284 0.0327 0.0543
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0079 0.0064 0.0063
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1697 0.2138 0.2181
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0139 0.0141 0.0382
Trypanosoma cruzi cysteine peptidase, putative 0.2848 0.3616 0.3689
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1868
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0017 0.0016
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.0344 0.0564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0238
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0045 0.0045
Onchocerca volvulus 0.1538 0.1935 0.6787
Onchocerca volvulus 0.2248 0.2846 1
Trichomonas vaginalis rotamase, putative 0.0065 0.0045 0.0044
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.4788 0.6103 0.6103
Mycobacterium ulcerans hypothetical protein 0.0038 0.0011 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Brugia malayi Calcitonin receptor-like protein seb-1 0.0926 0.1151 0.1911
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2248 0.2846 0.2904
Brugia malayi RNA, U transporter 1 0.0079 0.0064 0.0107
Mycobacterium ulcerans hypothetical protein 0.0172 0.0184 0.0472
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0142 0.0144 0.0146
Entamoeba histolytica hypothetical protein 0.0521 0.0631 0.2196
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.7668 0.9797 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0134 0.0135 0.0138
Echinococcus granulosus kinesin family 1 0.102 0.1271 0.1296
Trypanosoma cruzi major cysteine proteinase, putative 0.0521 0.0631 0.0642
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0022 0.002
Schistosoma mansoni hypothetical protein 0.0297 0.0344 0.0351
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0017 0.0018
Echinococcus granulosus cathepsin b 0.4322 0.5505 0.5619
Plasmodium falciparum serine repeat antigen 8 0.0521 0.0631 0.1722
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0011 0.0011
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1908
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0011 0.0023
Plasmodium vivax aspartyl protease, putative 0.0284 0.0327 0.089
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2755 0.3495 0.3568
Leishmania major cathepsin L-like protease 0.2848 0.3616 0.3689
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1487 0.1869 0.1908
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Schistosoma mansoni hypothetical protein 0.0162 0.0171 0.0174
Loa Loa (eye worm) hypothetical protein 0.312 0.3964 0.658
Loa Loa (eye worm) hypothetical protein 0.1538 0.1935 0.3208
Trichomonas vaginalis esterase, putative 0.0038 0.0011 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0075 0.0075
Schistosoma mansoni cathepsin s 0.071 0.0874 0.0892
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0017 0.0016
Echinococcus granulosus cathepsin l1 0.1538 0.1935 0.1974
Loa Loa (eye worm) PAN domain-containing protein 0.0061 0.0041 0.006
Leishmania major hypothetical protein, conserved 0.0888 0.1102 0.1123
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0011 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.1231 0.1542 0.5405
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0128 0.0127 0.0202
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.2339 0.2963 0.3023
Schistosoma mansoni cathepsin F (C01 family) 0.1538 0.1935 0.1975
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0494 0.0596 0.0982
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0102 0.0274
Mycobacterium ulcerans beta-lactamase 0.0038 0.0011 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2248 0.2846 0.7784
Loa Loa (eye worm) hypothetical protein 0.1697 0.2139 0.3547
Echinococcus granulosus snurportin 1 0.0297 0.0344 0.0349
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0028 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0102 0.0102
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0162 0.0171 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0046 0.0045
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Brugia malayi latrophilin 2 splice variant baaae 0.0633 0.0775 0.1286
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0216 0.024 0.0243
Brugia malayi isocitrate dehydrogenase 0.0065 0.0046 0.0076
Brugia malayi hypothetical protein 0.0284 0.0327 0.0543
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0077 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0223 0.0249 0.0641
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0037 0.0036
Plasmodium vivax aspartyl protease, putative 0.0284 0.0327 0.089
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0011 0.0023
Schistosoma mansoni hypothetical protein 0.0049 0.0025 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2248 0.2846 0.2845
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0521 0.0631 0.2196
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0011 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0166 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.288 0.3656 0.3655
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0216 0.024 0.0399
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.0046 0.0047
Toxoplasma gondii hypothetical protein 0.288 0.3656 0.4633
Schistosoma mansoni cpg binding protein 0.0298 0.0345 0.0352
Leishmania major cysteine peptidase A (CPA) 0.2248 0.2846 0.2904
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1268 0.1589 0.162
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1697 0.2138 0.2181
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0036 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0017 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0023 0.0024
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0002 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.1231 0.1542 0.5405
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.1487 0.1869 0.1907
Loa Loa (eye worm) cysteine protease 0.2248 0.2846 0.4722
Plasmodium falciparum plasmepsin III 0.0284 0.0327 0.089
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0216 0.024 0.0243
Giardia lamblia Cathepsin B precursor 0.0521 0.0631 0.1801
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Schistosoma mansoni smad 0.0051 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Echinococcus multilocularis geminin 0.1815 0.229 0.2336
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.0144 0.0232
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Giardia lamblia Hypothetical protein 0.1487 0.1869 0.5345
Toxoplasma gondii PAN domain-containing protein 0.0061 0.0041 0.0051
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0181 0.0601
Plasmodium falciparum serine repeat antigen 5 0.0521 0.0631 0.1722
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0036 0.0061
Loa Loa (eye worm) hypothetical protein 0.071 0.0874 0.1444
Loa Loa (eye worm) transcription factor SMAD2 0.0751 0.0925 0.153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1538 0.1935 0.1934
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0161 0.0165
Onchocerca volvulus Huntingtin homolog 0.0128 0.0127 0.0408
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0056 0.0035 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0755 0.0931 0.093
Echinococcus multilocularis smad 0.0051 0.0028 0.0027
Plasmodium vivax SET domain protein, putative 0.0134 0.0135 0.0364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Loa Loa (eye worm) hypothetical protein 0.2755 0.3495 0.5801
Brugia malayi hypothetical protein 0.44 0.5606 0.9308
Trichomonas vaginalis bromodomain-containing protein, putative 0.0139 0.0141 0.014
Schistosoma mansoni cathepsin D (A01 family) 0.0284 0.0327 0.0334
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.161 0.2027 0.2068
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0238
Schistosoma mansoni myst-related protein 0.0035 0.0008 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.1231 0.1542 0.256
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0284 0.0327 0.0332
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1487 0.1869 0.1868
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0216 0.024 0.0653
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0017 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0011 0.0009
Echinococcus multilocularis peregrin 0.0101 0.0092 0.0092
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0293 0.0338 0.0344
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0888 0.1102 0.1823
Loa Loa (eye worm) hypothetical protein 0.071 0.0874 0.1444
Echinococcus granulosus cpg binding protein 0.0315 0.0366 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0011 0.0009
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0216 0.024 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0017 0.0015
Echinococcus multilocularis GPCR, family 2 0.0293 0.0338 0.0344
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0021 0.002
Plasmodium vivax aspartyl protease, putative 0.0284 0.0327 0.089
Schistosoma mansoni eyes absent homolog 0.01 0.0091 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0017 0.0029
Leishmania major DNA polymerase eta, putative 0.0043 0.0017 0.0016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0028 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0521 0.0631 0.0629
Echinococcus granulosus mixed lineage leukemia protein mll 0.0079 0.0064 0.0063
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0521 0.0631 0.2196
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.1538 0.1935 0.3208
Schistosoma mansoni kinesin eg-5 0.0133 0.0133 0.0135
Loa Loa (eye worm) hypothetical protein 0.0284 0.0327 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.0135 0.0138
Trypanosoma brucei PAB1-binding protein , putative 0.0109 0.0102 0.0104
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0142 0.0144 0.0143
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0011 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2248 0.2846 0.4722
Schistosoma mansoni rotamase 0.0066 0.0047 0.0048
Giardia lamblia Cathepsin L-like protease 0.0521 0.0631 0.1801
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0066 0.0047 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0755 0.0931 0.093
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.0046 0.0045
Schistosoma mansoni egf-like domain protein 0.0056 0.0035 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0494 0.0596 0.0607
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0284 0.0327 0.0536
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.0049 0.0081
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.4366 0.5562 0.5562
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0494 0.0596 0.0607
Plasmodium falciparum plasmepsin VII 0.0284 0.0327 0.089
Giardia lamblia Encystation-specific protease 0.0603 0.0736 0.2102
Giardia lamblia Cathepsin B precursor 0.0521 0.0631 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0142 0.0144 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.2848 0.3616 0.3689
Schistosoma mansoni hypothetical protein 0.0089 0.0077 0.0079
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0037 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0077 0.0098
Echinococcus multilocularis cathepsin L cysteine protease 0.2248 0.2846 0.2904
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.0046 0.0045
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.0144 0.0147
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.0382 0.0389
Loa Loa (eye worm) hypothetical protein 0.01 0.0091 0.0144
Entamoeba histolytica kinesin, putative 0.0133 0.0133 0.044
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0755 0.0931 0.1539
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0017 0.0016
Plasmodium vivax vivapain-2 0.2248 0.2846 0.7784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0494 0.0596 0.0608
Schistosoma mansoni ap endonuclease 0.0058 0.0036 0.0037
Onchocerca volvulus 0.0061 0.0041 0.0105
Echinococcus granulosus dna polymerase kappa 0.0043 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.6181 0.789 0.789
Onchocerca volvulus 0.0284 0.0327 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1697 0.2138 0.2137
Loa Loa (eye worm) PAN domain-containing protein 0.0061 0.0041 0.006
Schistosoma mansoni cpg binding protein 0.0315 0.0366 0.0374
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.1487 0.1869 0.1868
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0738 0.0909 0.2596
Brugia malayi Cathepsin L-like precursor 0.1538 0.1935 0.3213
Entamoeba histolytica cysteine proteinase, putative 0.1538 0.1935 0.679
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0139 0.0141 0.014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0036 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1682 0.212 0.2162
Plasmodium vivax phosphodiesterase gamma, putative 0.1487 0.1869 0.5111
Toxoplasma gondii hypothetical protein 0.0053 0.003 0.0038
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.0144 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0028 0.0039
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.0122 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0036 0.1459
Echinococcus granulosus histone lysine methyltransferase setb 0.0134 0.0135 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1645 0.2073 0.2071
Onchocerca volvulus Alhambra homolog 0.0089 0.0077 0.0234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0046 0.0045
Onchocerca volvulus 0.0284 0.0327 0.1116
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Plasmodium vivax serine-repeat antigen (SERA) 0.0521 0.0631 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0216 0.024 0.0819
Echinococcus granulosus microtubule associated protein 2 0.2263 0.2864 0.2923
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0243
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0216 0.024 0.0245
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0521 0.0631 0.1722
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0037 0.0046
Brugia malayi cathepsin L-like cysteine proteinase 0.0521 0.0631 0.1048
Toxoplasma gondii exonuclease III APE 0.0058 0.0036 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Mycobacterium tuberculosis Probable reductase 0.0201 0.022 0.0566
Trypanosoma cruzi cysteine peptidase, putative 0.2848 0.3616 0.3689
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0292 0.0338 0.0343
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0011 0.0023
Trypanosoma brucei cAMP-specific phosphodiesterase 0.7668 0.9797 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0049 0.0048
Loa Loa (eye worm) glutathione reductase 0.0088 0.0075 0.0118
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0017 0.0016
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0075 0.0058 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.2248 0.2846 0.2905
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0216 0.024 0.0243
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0037 0.0053
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Toxoplasma gondii microneme protein MIC17A 0.0061 0.0041 0.0051
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.7668 0.9797 0.9797
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0216 0.024 1
Brugia malayi Bromodomain containing protein 0.0101 0.0092 0.0153
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0017 0.0016
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.0046 0.0047
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0216 0.024 0.0304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0293 0.0338 0.0344
Entamoeba histolytica cysteine protease, putative 0.2248 0.2846 1
Trypanosoma brucei trypanothione reductase 0.0088 0.0075 0.0077
Trypanosoma cruzi major cysteine proteinase, putative 0.1121 0.14 0.1428
Giardia lamblia Cathepsin B precursor 0.0521 0.0631 0.1801
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0216 0.024 0.0243
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0149 0.0154 0.0248
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0216 0.024 0.0243
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0053 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0053 0.0133
Brugia malayi Eukaryotic aspartyl protease family protein 0.0284 0.0327 0.0543
Toxoplasma gondii aspartyl protease ASP3 0.0284 0.0327 0.0415
Plasmodium falciparum thioredoxin reductase 0.0088 0.0075 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0926 0.1151 0.1911
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0022 0.002
Schistosoma mansoni Smad4 0.0051 0.0028 0.0029
Schistosoma mansoni hypothetical protein 0.005 0.0027 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.6181 0.789 0.789
Plasmodium falciparum serine repeat antigen 7 0.0521 0.0631 0.1722
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0139 0.0141 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0017 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Plasmodium falciparum phosphodiesterase gamma, putative 0.1487 0.1869 0.5111
Plasmodium vivax vivapain-1 0.1231 0.1542 0.4215
Brugia malayi hypothetical protein 0.0888 0.1102 0.1829
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0053 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.1487 0.1869 0.1908
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Loa Loa (eye worm) hypothetical protein 0.0284 0.0327 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0633 0.0775 0.128
Entamoeba histolytica hypothetical protein 0.0162 0.0171 0.0575
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0037 0.0037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0036 0.009
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.3038 0.3859 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Echinococcus granulosus laminin 0.0056 0.0035 0.0034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0474 0.057 0.0582
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0021
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0046 0.0058
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0603 0.0736 0.201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.071 0.0874 0.1444
Entamoeba histolytica hypothetical protein 0.0162 0.0171 0.0575
Schistosoma mansoni hypothetical protein 0.0293 0.0338 0.0346
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Brugia malayi MAP kinase sur-1 0.0058 0.0037 0.0061
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0521 0.0631 0.1801
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0159 0.0166 0.0168
Trichomonas vaginalis set domain proteins, putative 0.1021 0.1271 0.127
Echinococcus multilocularis dnaJ subfamily B 0.3029 0.3847 0.3926
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0036 0.0036
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0521 0.0631 0.0644
Schistosoma mansoni transcription factor LCR-F1 0.0162 0.0171 0.0174
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0521 0.0631 0.1722
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.4366 0.5562 0.5562
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2755 0.3495 0.3567
Trypanosoma cruzi cysteine peptidase, putative 0.1231 0.1542 0.1572
Brugia malayi Cathepsin L-like cysteine proteinase 0.1538 0.1935 0.3213
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0284 0.0327 0.0536
Mycobacterium tuberculosis Conserved protein 0.0038 0.0011 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0637 0.0779 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Giardia lamblia Cysteine protease 0.0521 0.0631 0.1801
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0216 0.024 0.0819
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1268 0.1589 0.2638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0494 0.0596 0.0989
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0738 0.0909 0.0927
Giardia lamblia Histone acetyltransferase GCN5 0.0128 0.0126 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0521 0.0631 0.0629
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0002 0.0002
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.3038 0.3859 1
Entamoeba histolytica cysteine proteinase 2 0.1231 0.1542 0.5405
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2248 0.2846 0.2904
Brugia malayi aspartic protease BmAsp-1, identical 0.0284 0.0327 0.0543
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0017 0.0016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0011 0.0023
Giardia lamblia Cathepsin B precursor 0.1697 0.2138 0.6116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1487 0.1869 0.1908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0053 0.0054
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.44 0.5606 0.5722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Trichomonas vaginalis conserved hypothetical protein 0.1487 0.1869 0.1868
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Leishmania major cAMP-specific phosphodiesterase, putative 0.1487 0.1869 0.1907
Schistosoma mansoni smad1 5 8 and 0.0051 0.0028 0.0029
Schistosoma mansoni hypothetical protein 0.1815 0.229 0.2338
Schistosoma mansoni hypothetical protein 0.0293 0.0338 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Toxoplasma gondii ABC1 family protein 0.0038 0.0011 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.0382 0.039
Echinococcus granulosus geminin 0.1815 0.229 0.2336
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.44 0.5606 0.5605
Leishmania major hypothetical protein, conserved 0.1487 0.1869 0.1907
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0056 0.0035 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0003 0.0001
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1682 0.212 0.2162
Toxoplasma gondii PAN domain-containing protein 0.0061 0.0041 0.0051
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0521 0.0631 0.0644
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0037 0.0035
Plasmodium vivax plasmepsin V, putative 0.0284 0.0327 0.089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1682 0.212 0.2687
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0521 0.0631 0.0644
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0036 0.01
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.0144 0.0146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0521 0.0631 0.0644
Echinococcus granulosus expressed protein 0.0066 0.0047 0.0047
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0075 0.0058 0.0131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4322 0.5505 0.5619
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0102 0.0102
Echinococcus granulosus GPCR family 2 0.0293 0.0338 0.0344
Loa Loa (eye worm) hypothetical protein 0.0926 0.1151 0.1904
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0474 0.057 0.0581
Toxoplasma gondii cathepsin CPL 0.2248 0.2846 0.3607
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0216 0.024 0.0819
Brugia malayi cathepsin L-like precursor 0.1538 0.1935 0.3213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0293 0.0338 0.0555
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0142 0.0144 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0293 0.0338 0.0344
Onchocerca volvulus 0.0061 0.0041 0.0105
Loa Loa (eye worm) pax transcription factor protein 2 0.024 0.0271 0.0442
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0017 0.0041
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0028 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0036 0.1459
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0216 0.024 0.0245
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.5111
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0046 0.0045
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0247 0.0279 0.0456
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.0046 0.0045
Echinococcus granulosus dnaJ subfamily B 0.3029 0.3847 0.3926
Loa Loa (eye worm) hypothetical protein 0.4146 0.5279 0.8765
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2755 0.3495 1
Schistosoma mansoni cathepsin S (C01 family) 0.0521 0.0631 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0037 0.0037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0134 0.0135 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0011 0.0025
Echinococcus granulosus cathepsin L 0.0521 0.0631 0.0642
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0284 0.0327 0.0332
Plasmodium falciparum serine repeat antigen 2 0.0521 0.0631 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Toxoplasma gondii microneme protein, putative 0.0061 0.0041 0.0051
Onchocerca volvulus 0.0061 0.0041 0.0105
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0216 0.024 0.0243
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0738 0.0909 0.2482
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.4607 0.5871 0.5992
Schistosoma mansoni cathepsin D (A01 family) 0.0284 0.0327 0.0334
Trypanosoma cruzi cysteine peptidase, putative 0.071 0.0874 0.089
Loa Loa (eye worm) PAN domain-containing protein 0.0061 0.0041 0.006
Brugia malayi Cathepsin L-like precursor 0.1538 0.1935 0.3213
Entamoeba histolytica cysteine proteinase 1, putative 0.1231 0.1542 0.5405
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0053 0.0133
Plasmodium vivax aspartyl proteinase, putative 0.0284 0.0327 0.089
Plasmodium falciparum serine repeat antigen 3 0.0521 0.0631 0.1722
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.161 0.2027 0.2069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.0135 0.0138
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Trypanosoma cruzi cysteine protease, putative 0.1231 0.1542 0.1572
Onchocerca volvulus Huntingtin homolog 0.0128 0.0127 0.0408
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Giardia lamblia Kinesin-5 0.0133 0.0133 0.0374
Brugia malayi cathepsin Z-like cysteine proteinase 0.0755 0.0931 0.1546
Onchocerca volvulus 0.0298 0.0345 0.1178
Leishmania major hypothetical protein, conserved 0.0038 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0159 0.0166 0.0168
Plasmodium falciparum histone acetyltransferase GCN5 0.0128 0.0126 0.0341
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0216 0.024 0.0245
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0017 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0521 0.0631 0.0644
Echinococcus multilocularis cysteine protease 0.2248 0.2846 0.2904
Toxoplasma gondii microneme protein MIC17B 0.0061 0.0041 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0075 0.0202
Onchocerca volvulus 0.2248 0.2846 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Brugia malayi Pre-SET motif family protein 0.0897 0.1114 0.1849
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0193 0.0191
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0139 0.0141 0.0179
Loa Loa (eye worm) Smad1 0.0051 0.0028 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0022 0.0022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0017 0.0016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0134 0.0135 0.0136
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4322 0.5505 0.5619
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.071 0.0874 0.1451
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1682 0.212 0.2687
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0243
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0025 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0065 0.0046 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Loa Loa (eye worm) beta-lactamase 0.0038 0.0011 0.001
Loa Loa (eye worm) acetyltransferase 0.0474 0.057 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1231 0.1542 0.154
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.4788 0.6103 0.6103
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0067 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0109 0.0102 0.0161
Onchocerca volvulus 0.0061 0.0041 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0011 0.0011
Brugia malayi hypothetical protein 0.0284 0.0327 0.0543
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2248 0.2846 0.4722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Entamoeba histolytica hypothetical protein 0.0162 0.0171 0.0575
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0037 0.0036
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0028 0.0027
Plasmodium vivax glutathione reductase, putative 0.0088 0.0075 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0037 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0017 0.0018
Leishmania major cathepsin L-like protease 0.2248 0.2846 0.2904
Brugia malayi Cathepsin L-like precursor 0.2248 0.2846 0.4726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Schistosoma mansoni myst-related protein 0.0035 0.0008 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4322 0.5505 0.5619
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0128 0.0127 0.0202
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0009
Plasmodium vivax plasmepsin IV, putative 0.0284 0.0327 0.089
Brugia malayi acetyltransferase, GNAT family protein 0.0474 0.057 0.0947
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.0296 0.0483
Brugia malayi beta-lactamase family protein 0.0038 0.0011 0.0018
Brugia malayi Cytochrome P450 family protein 0.0033 0.0005 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0061 0.0041 0.0051
Echinococcus multilocularis cathepsin L 0.1231 0.1542 0.1572
Onchocerca volvulus 0.0444 0.0531 0.1836
Trichomonas vaginalis rotamase, putative 0.0066 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0153 0.0159 0.0256
Entamoeba histolytica cysteine proteinase, putative 0.2248 0.2846 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Brugia malayi Papain family cysteine protease containing protein 0.0521 0.0631 0.1048
Trichomonas vaginalis hypothetical protein 0.0036 0.0009 0.0007
Loa Loa (eye worm) aspartyl protease 6 0.0284 0.0327 0.0536
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0097 0.0087 0.0087
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0102 0.0274
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1682 0.212 0.5796
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0603 0.0736 0.201
Onchocerca volvulus Cathepsin F homolog 0.2248 0.2846 1
Leishmania major cathepsin L-like protease 0.2848 0.3616 0.3689
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0056 0.0035 0.005
Brugia malayi hypothetical protein 0.0247 0.0279 0.0463
Onchocerca volvulus 0.0061 0.0041 0.0105
Toxoplasma gondii PAN domain-containing protein 0.0061 0.0041 0.0051
Onchocerca volvulus Arrow homolog 0.0056 0.0035 0.0085
Trypanosoma cruzi UNC119 0.0888 0.1102 0.1123
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0036 0.0037
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.1268 0.1589 0.2632
Brugia malayi MH2 domain containing protein 0.0751 0.0925 0.1537
Plasmodium falciparum phosphodiesterase delta, putative 0.1487 0.1869 0.5111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Toxoplasma gondii PAN domain-containing protein 0.0944 0.1174 0.1488
Echinococcus multilocularis snurportin 1 0.0297 0.0344 0.0349
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0079 0.0064 0.0063
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0021 0.002
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0284 0.0327 0.0415
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.0046 0.0121
Echinococcus multilocularis cathepsin L cysteine protease 0.2248 0.2846 0.2904
Trypanosoma cruzi cysteine peptidase, putative 0.2248 0.2846 0.2904
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2755 0.3495 0.443
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Brugia malayi hypothetical protein 0.0109 0.0102 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0581 0.0707 0.0897
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.7668 0.9797 0.9797
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.4146 0.5279 0.8766
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0216 0.024 0.0304
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1697 0.2139 0.2184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0036 0.0035
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Plasmodium falciparum glutathione reductase 0.0088 0.0075 0.0202
Schistosoma mansoni cathepsin B (C01 family) 0.0521 0.0631 0.0644
Leishmania major DNA polymerase kappa, putative 0.0043 0.0017 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0755 0.0931 0.093
Plasmodium falciparum plasmepsin I 0.0284 0.0327 0.089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0521 0.0631 0.104
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2755 0.3495 0.3567
Echinococcus granulosus cysteine protease 0.1231 0.1542 0.1572
Mycobacterium tuberculosis Probable oxidoreductase 0.0223 0.0249 0.0641
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0047 0.0023 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0017 0.0018
Trypanosoma brucei ISWI complex protein 0.0031 0.0003 0.0003
Plasmodium vivax kinesin-5 0.0133 0.0133 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0108 0.0101 0.0103
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0053 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0047 0.0046
Brugia malayi hypothetical protein 0.0444 0.0531 0.0882
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.0382 0.0389
Giardia lamblia PHD finger protein 15 0.0089 0.0077 0.0216
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.027 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0755 0.0931 0.093
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Echinococcus granulosus cathepsin l1 0.2248 0.2846 0.2904
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0201 0.022 0.0566
Echinococcus multilocularis dna polymerase eta 0.0043 0.0017 0.0016
Giardia lamblia hypothetical protein 0.1487 0.1869 0.5345
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Echinococcus granulosus cathepsin b 0.4322 0.5505 0.5619
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0011 0.0009
Echinococcus granulosus cathepsin L cysteine protease 0.1231 0.1542 0.1572
Toxoplasma gondii hypothetical protein 0.6181 0.789 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1231 0.1542 0.154
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0279 0.0283
Toxoplasma gondii hypothetical protein 0.0061 0.0041 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Onchocerca volvulus 0.2248 0.2846 1
Schistosoma mansoni smad1 5 8 and 0.0051 0.0028 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Brugia malayi MH2 domain containing protein 0.0051 0.0028 0.0047
Leishmania major hypothetical protein, conserved 0.0109 0.0102 0.0102
Plasmodium falciparum plasmepsin V 0.0284 0.0327 0.089
Plasmodium vivax unspecified product 0.071 0.0874 0.2386
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0009
Brugia malayi MH1 domain containing protein 0.0051 0.0028 0.0047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1231 0.1542 0.1574
Schistosoma mansoni hypothetical protein 0.0293 0.0338 0.0346
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.7668 0.9797 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Loa Loa (eye worm) PDE1B protein 0.2891 0.367 0.6091
Brugia malayi cathepsin F-like cysteine proteinase 0.0521 0.0631 0.1048
Plasmodium falciparum cysteine proteinase falcipain 1 0.1231 0.1542 0.4215
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0159 0.0166 0.0169
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.005
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Loa Loa (eye worm) MH2 domain-containing protein 0.0751 0.0925 0.153
Loa Loa (eye worm) hypothetical protein 0.071 0.0874 0.1444
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.2891 0.367 0.3746
Toxoplasma gondii cathepsin CPC1 0.0738 0.0909 0.1152
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0223 0.0249 0.0641
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1231 0.1542 0.1574
Plasmodium vivax ataxin-2 like protein, putative 0.0109 0.0102 0.0274
Onchocerca volvulus 0.005 0.0027 0.0058
Brugia malayi Papain family cysteine protease containing protein 0.2248 0.2846 0.4726
Brugia malayi hypothetical protein 0.007 0.0052 0.0087
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0521 0.0631 0.1722
Echinococcus multilocularis expressed protein 0.0066 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Loa Loa (eye worm) cathepsin B 0.1697 0.2138 0.3546
Echinococcus multilocularis fibrillin 1 0.0056 0.0035 0.0034
Trypanosoma brucei cAMP-specific phosphodiesterase 0.7668 0.9797 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0011 0.0023
Onchocerca volvulus 0.0061 0.0041 0.0105
Brugia malayi MH1 domain containing protein 0.0051 0.0028 0.0047
Onchocerca volvulus 0.0061 0.0041 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Plasmodium falciparum plasmepsin IX 0.0284 0.0327 0.089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0017 0.0016
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.7668 0.9797 1
Giardia lamblia Cathepsin B precursor 0.0755 0.0931 0.266
Echinococcus granulosus Smad4 0.0051 0.0028 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0201 0.022 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0011 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.2248 0.2846 0.2905
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0521 0.0631 0.1722
Echinococcus multilocularis microtubule associated protein 2 0.2263 0.2864 0.2923
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0216 0.024 0.0682
Schistosoma mansoni memapsin-2 (A01 family) 0.659 0.8415 0.8589
Leishmania major cathepsin L-like protease 0.2248 0.2846 0.2904
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Toxoplasma gondii PAN/Apple domain-containing protein 0.0061 0.0041 0.0051
Plasmodium vivax serine-repeat antigen (SERA) 0.0521 0.0631 0.1722
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0046 0.0045
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0603 0.0736 0.2102
Echinococcus multilocularis cathepsin b 0.4322 0.5505 0.5619
Brugia malayi hypothetical protein 0.0162 0.0171 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0017 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.0046 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Schistosoma mansoni jumonji domain containing protein 0.0232 0.026 0.0266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.0046 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0521 0.0631 0.1048
Plasmodium vivax vivapain-3 0.1231 0.1542 0.4215
Schistosoma mansoni cpg binding protein 0.0315 0.0366 0.0374
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1697 0.2139 0.3547
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0603 0.0736 0.2102
Loa Loa (eye worm) hypothetical protein 0.01 0.0091 0.0144
Entamoeba histolytica cysteine proteinase, putative 0.1231 0.1542 0.5405
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.4725 0.6022 0.6147
Toxoplasma gondii cathepsin B 0.1697 0.2138 0.271
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0053 0.0052
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0216 0.024 1
Onchocerca volvulus Cathepsin L homolog 0.2248 0.2846 1
Echinococcus granulosus peregrin 0.0101 0.0092 0.0092
Brugia malayi Thioredoxin reductase 0.0088 0.0075 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0017 0.0016
Loa Loa (eye worm) PAN domain-containing protein 0.0061 0.0041 0.006
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0216 0.024 0.0653
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0159 0.0166 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.0631 0.0629
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0243
Loa Loa (eye worm) hypothetical protein 0.0521 0.0631 0.104
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0017 0.0044
Schistosoma mansoni survival motor neuron protein 0.005 0.0027 0.0028
Echinococcus granulosus dna polymerase eta 0.0043 0.0017 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Plasmodium falciparum zinc finger protein, putative 0.0035 0.0008 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0036 0.0035
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0011 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0017 0.0018
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Toxoplasma gondii LsmAD domain-containing protein 0.0109 0.0102 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0293 0.0338 0.0344
Brugia malayi hypothetical protein 0.01 0.0091 0.0152
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0045 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0298 0.0345 0.0565
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0292 0.0338 0.0343
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0494 0.0596 0.0607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0075 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0003 0.0001
Plasmodium vivax vivapain-2 0.2248 0.2846 0.7784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0521 0.0631 0.0644
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0036 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0201 0.022 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0028 0.0029
Brugia malayi hypothetical protein 0.0128 0.0127 0.021
Loa Loa (eye worm) hypothetical protein 0.2659 0.3373 0.5597
Brugia malayi cathepsin L precursor 0.0521 0.0631 0.1048
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0223 0.0249 0.0653
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0521 0.0631 0.0629
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0161 0.0163
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0216 0.024 0.0245
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.0144 0.0146
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0017 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1231 0.1542 0.1574
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.0184 0.0472
Trypanosoma brucei cysteine peptidase C (CPC) 0.1697 0.2138 0.2183
Plasmodium falciparum kinesin-5 0.0133 0.0133 0.0358
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0521 0.0631 0.0629
Plasmodium falciparum plasmepsin X 0.0284 0.0327 0.089
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0123 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1487 0.1869 0.3104
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0017 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0293 0.0338 0.0562
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.7668 0.9797 1
Trichomonas vaginalis conserved hypothetical protein 0.1487 0.1869 0.1868
Trichomonas vaginalis conserved hypothetical protein 0.0521 0.0631 0.0629
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0521 0.0631 0.1722
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.5111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.0631 0.0629
Toxoplasma gondii calcium binding egf domain-containing protein 0.0056 0.0035 0.0044
Schistosoma mansoni microtubule-associated protein tau 0.2263 0.2864 0.2924
Onchocerca volvulus Cathepsin L homolog 0.2248 0.2846 1
Giardia lamblia Cysteine protease 0.0521 0.0631 0.1801
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0926 0.1151 0.1904
Onchocerca volvulus 0.2248 0.2846 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0655 0.0803 0.0802
Echinococcus granulosus smad 0.0051 0.0028 0.0027
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.7668 0.9797 1
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0017 0.0016
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.7668 0.9797 0.9797
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0521 0.0631 0.1048
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.4788 0.6103 0.623
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1487 0.1869 0.1908
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7827 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0521 0.0631 0.0629
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0037 0.0035
Plasmodium falciparum cysteine proteinase falcipain 3 0.2248 0.2846 0.7784
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Plasmodium falciparum serine repeat antigen 4 0.0521 0.0631 0.1722
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1682 0.212 0.2162
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0142 0.0144 0.0232
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0002 0.0002
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0045 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Leishmania major trypanothione reductase 0.0088 0.0075 0.0075
Plasmodium falciparum serine repeat antigen 6 0.0521 0.0631 0.1722
Onchocerca volvulus 0.0061 0.0041 0.0105
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0521 0.0631 0.0644
Onchocerca volvulus 0.0134 0.0135 0.0438
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0216 0.024 0.0243
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.4607 0.5871 0.9749
Plasmodium falciparum serine repeat antigen 9 0.0521 0.0631 0.1722
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Brugia malayi jmjC domain containing protein 0.0125 0.0123 0.0204
Loa Loa (eye worm) ctsf protein 0.2248 0.2846 0.4722
Loa Loa (eye worm) hypothetical protein 0.0444 0.0531 0.0875
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0036 0.009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0022 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Onchocerca volvulus 0.0061 0.0041 0.0105
Giardia lamblia Cysteine protease 0.0521 0.0631 0.1801
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0049 0.0048
Leishmania major cathepsin L-like protease 0.2248 0.2846 0.2904
Echinococcus granulosus Tolloid protein 1 0.0056 0.0035 0.0034
Brugia malayi Calcium binding EGF domain containing protein 0.0056 0.0035 0.0058
Echinococcus multilocularis cysteine protease 0.2248 0.2846 0.2904
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0017 0.0016
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0046 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Echinococcus granulosus lysine specific demethylase 5A 0.0125 0.0123 0.0124
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0011 0.0023
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0017 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.7827 1 1
Trichomonas vaginalis conserved hypothetical protein 0.6181 0.789 0.789
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.0144 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Brugia malayi PHD-finger family protein 0.0089 0.0077 0.0128
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0061 0.0041 0.0051
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0216 0.024 0.0245
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0279 0.0283
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0149 0.0154 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0003 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2248 0.2846 0.7784
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0521 0.0631 0.104
Brugia malayi Smad1 0.0051 0.0028 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2848 0.3616 0.3691
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0046 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Brugia malayi cathepsin Z-like cysteine proteinase 0.0755 0.0931 0.1546
Trichomonas vaginalis helicase, putative 0.0068 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0292 0.0338 0.0561
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0002 0.0002
Plasmodium falciparum plasmepsin VI 0.0284 0.0327 0.089
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0076 0.0076
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Trypanosoma cruzi cruzipain precursor, putative 0.071 0.0874 0.089
Plasmodium vivax aspartyl proteinase, putative 0.0284 0.0327 0.089
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0142 0.0144 0.0146
Onchocerca volvulus 0.0061 0.0041 0.0105
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0017 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0017 0.0016
Plasmodium falciparum plasmepsin VIII, putative 0.0284 0.0327 0.089
Onchocerca volvulus 0.1021 0.1271 0.4446
Toxoplasma gondii microneme protein MIC4 0.0061 0.0041 0.0051
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.2891 0.367 0.6094
Trypanosoma cruzi UNC119 0.0888 0.1102 0.1123
Echinococcus granulosus histone acetyltransferase KAT2B 0.0461 0.0553 0.0563
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0494 0.0596 0.0607
Toxoplasma gondii cathepsin CPC2 0.0603 0.0736 0.0933
Toxoplasma gondii kinesin motor domain-containing protein 0.0133 0.0133 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0296 0.0294
Plasmodium vivax unspecified product 0.1231 0.1542 0.4215
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0037 0.0036
Mycobacterium ulcerans putative regulatory protein 0.288 0.3656 0.9473
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.2891 0.367 0.3745
Loa Loa (eye worm) hypothetical protein 0.2248 0.2846 0.4722
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1268 0.1589 0.162
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0076 0.0076
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.0296 0.0491
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0053 0.0067
Toxoplasma gondii aspartyl protease 0.0284 0.0327 0.0415
Loa Loa (eye worm) hypothetical protein 0.0293 0.0338 0.0555
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0897 0.1114 0.1843
Entamoeba histolytica hypothetical protein 0.0162 0.0171 0.0575
Toxoplasma gondii hypothetical protein 0.288 0.3656 0.4633
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0053 0.0133
Trypanosoma brucei unspecified product 0.0043 0.0017 0.0018
Echinococcus multilocularis laminin 0.0056 0.0035 0.0034
Mycobacterium ulcerans putative regulatory protein 0.288 0.3656 0.9473
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0238
Loa Loa (eye worm) kinesin-like protein KLP2 0.0133 0.0133 0.0212
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.161 0.2027 0.2068
Toxoplasma gondii microneme protein MIC17C 0.0061 0.0041 0.0051
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0077 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.1487 0.1869 0.1907
Schistosoma mansoni ap endonuclease 0.0058 0.0036 0.0037
Schistosoma mansoni DNA polymerase eta 0.0043 0.0017 0.0018
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0037 0.0036
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.1682 0.212 0.2162
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0037 0.0036
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0017 0.0018
Brugia malayi Fibulin-1 precursor 0.0056 0.0035 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1231 0.1542 0.1574
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0056 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.161 0.2027 0.5542
Brugia malayi cathepsin F-like cysteine proteinase 0.071 0.0874 0.1451
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Plasmodium falciparum plasmepsin II 0.0284 0.0327 0.089
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0046 0.0047
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1697 0.2139 0.3552
Brugia malayi Kinesin motor domain containing protein 0.0133 0.0133 0.022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0002 0.0003
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0037 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.012 0.0121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.1869 0.2369
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.288 0.3656 0.9473
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.161 0.2027 0.2569
Onchocerca volvulus Cathepsin L homolog 0.0521 0.0631 0.2187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0075 0.0058 0.0057
Echinococcus multilocularis kinesin family 1 0.102 0.1271 0.1296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0017 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1487 0.1869 0.1868
Plasmodium vivax hypothetical protein, conserved 0.288 0.3656 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0216 0.024 0.0245
Loa Loa (eye worm) fibroinase 0.2248 0.2846 0.4722
Leishmania major hypothetical protein, conserved 0.1487 0.1869 0.1907
Toxoplasma gondii subtilisin SUB12 0.0061 0.0041 0.0051
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0037 0.01
Schistosoma mansoni hypothetical protein 0.0888 0.1101 0.1124
Brugia malayi MH2 domain containing protein 0.0051 0.0028 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0162 0.0171 0.0173
Plasmodium falciparum serine repeat antigen 1 0.0521 0.0631 0.1722
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1487 0.1869 0.1868
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4322 0.5505 0.5619
Entamoeba histolytica cysteine proteinase, putative 0.1231 0.1542 0.5405
Loa Loa (eye worm) hypothetical protein 0.1538 0.1935 0.3208
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1231 0.1542 0.1572
Loa Loa (eye worm) hypothetical protein 0.4725 0.6022 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0077 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.0135 0.0138
Plasmodium vivax unspecified product 0.0521 0.0631 0.1722
Loa Loa (eye worm) hypothetical protein 0.021 0.0233 0.0379
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0017 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0077 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0036 0.0036
Plasmodium falciparum GAF domain-related protein, putative 0.288 0.3656 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0284 0.0327 0.0415
Trypanosoma brucei protein kinase, putative 0.0058 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1538 0.1935 0.1934
Trypanosoma cruzi cysteine proteinase, putative 0.1231 0.1542 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1231 0.1542 0.1574
Onchocerca volvulus 0.2248 0.2846 1
Brugia malayi Papain family cysteine protease containing protein 0.1231 0.1542 0.256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0011 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0017 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0011 0.0009
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0216 0.024 0.0238
Echinococcus multilocularis Tolloid protein 1 0.0056 0.0035 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0037 0.0035
Trypanosoma cruzi ISWI complex protein 0.0031 0.0003 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0201 0.022 0.0574
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0017 0.0016
Echinococcus granulosus jumonji domain containing protein 0.0124 0.0122 0.0123
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0045 0.0045
Giardia lamblia Hypothetical protein 0.0521 0.0631 0.1801
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.001
Giardia lamblia Cathepsin L-like protease 0.0521 0.0631 0.1801
Toxoplasma gondii hypothetical protein 0.0061 0.0041 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0017 0.0016
Entamoeba histolytica cysteine protease, putative 0.0521 0.0631 0.2196
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1487 0.1869 0.1908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0049 0.0047
Schistosoma mansoni hypothetical protein 0.1815 0.229 0.2338
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0521 0.0631 0.1722
Leishmania major cathepsin L-like protease 0.2248 0.2846 0.2904
Giardia lamblia Hypothetical protein 0.0521 0.0631 0.1801
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Brugia malayi fibroinase precursor 0.0521 0.0631 0.1048
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0738 0.0909 0.2482
Brugia malayi PAN domain containing protein 0.0061 0.0041 0.0067
Onchocerca volvulus 0.0061 0.0041 0.0105
Loa Loa (eye worm) hypothetical protein 0.0134 0.0135 0.0216
Onchocerca volvulus 0.024 0.0271 0.0918
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1682 0.212 0.2162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0494 0.0596 0.0608
Loa Loa (eye worm) hypothetical protein 0.0089 0.0077 0.012
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.7827 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Loa Loa (eye worm) PAN domain-containing protein 0.0061 0.0041 0.006
Mycobacterium tuberculosis Probable dehydrogenase 0.0201 0.022 0.0566
Giardia lamblia Cathepsin L precursor 0.0521 0.0631 0.1801
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1645 0.2073 0.2071
Trypanosoma brucei UNC119 0.0888 0.1102 0.1125
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.1682 0.212 0.2164
Schistosoma mansoni hypothetical protein 0.0633 0.0775 0.0791
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0025 0.0024
Echinococcus granulosus cathepsin L cysteine proteinase 0.2248 0.2846 0.2904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2248 0.2846 0.2845
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0134 0.0135 0.0171
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.7668 0.9797 0.9797
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.0327 0.0334
Mycobacterium leprae conserved hypothetical protein 0.288 0.3656 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0284 0.0327 0.0543
Plasmodium falciparum cGMP-specific phosphodiesterase 0.1487 0.1869 0.5111
Entamoeba histolytica cysteine protease, putative 0.1231 0.1542 0.5405
Loa Loa (eye worm) hypothetical protein 0.4322 0.5505 0.9141
Giardia lamblia Cathepsin B precursor 0.1697 0.2138 0.6116
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0049 0.0047
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0075 0.0058 0.0147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0017 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0181 0.0179
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0011 0.0009
Brugia malayi Cathepsin L-like precursor 0.071 0.0874 0.1451

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1 p.p.m. In vitro systemic flea efficacy using membrane feeding assay. ChEMBL. 12067553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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