Detailed information for compound 722625

Basic information

Technical information
  • TDR Targets ID: 722625
  • Name: N-(1,3-benzodioxol-5-yl)-2-[(4-bromo-3-methyl phenyl)-methylsulfonylamino]acetamide
  • MW: 441.296 | Formula: C17H17BrN2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)C)c1ccc(c(c1)C)Br)Nc1ccc2c(c1)OCO2
  • InChi: 1S/C17H17BrN2O5S/c1-11-7-13(4-5-14(11)18)20(26(2,22)23)9-17(21)19-12-3-6-15-16(8-12)25-10-24-15/h3-8H,9-10H2,1-2H3,(H,19,21)
  • InChiKey: ODVCJCQIQPLQTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,3-benzodioxol-5-yl)-2-[(4-bromo-3-methyl-phenyl)-methylsulfonyl-amino]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[(4-bromo-3-methyl-phenyl)-mesyl-amino]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[(4-bromo-3-methyl-phenyl)-methylsulfonyl-amino]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.1109 0.5645
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.0932
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.036 0.0932
Schistosoma mansoni rab6-interacting 0.0046 0.0419 0.0419
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.003 0.003
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.036 0.1212
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0445 0.1152
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0203 0.2388 0.2364
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0732 0.0732
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0182 0.2491
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Onchocerca volvulus 0.0097 0.1062 0.3081
Loa Loa (eye worm) apoptosis regulator protein 0.0097 0.1057 0.2737
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.1229 0.1202
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.036 0.0932
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0098 0.0098
Giardia lamblia DINP protein human, muc B family 0.0041 0.036 0.0869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0098 0.0255
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.036 0.036
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.036 0.1725
Loa Loa (eye worm) glutaminase 0.032 0.3864 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0144 0.165 0.3707
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2903 0.7513
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0732 0.2465
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.074 0.0711
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Echinococcus granulosus RUN 0.0046 0.0419 0.0389
Trichomonas vaginalis glutaminase, putative 0.032 0.3864 0.9323
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.074 0.1914
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1152
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0319 0.0346
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0098 0.0068
Loa Loa (eye worm) MBCTL1 0.0055 0.0529 0.1369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0098 0.0255
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0402 0.0373
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0529 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0097 0.1057 0.103
Schistosoma mansoni hypothetical protein 0.033 0.399 0.399
Plasmodium vivax glutathione reductase, putative 0.0044 0.0395 0.9435
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.125 0.6075
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0199 0.0669
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0445 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0098 0.0255
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.194 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0098 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0512 0.0483
Brugia malayi steroid hormone receptor 0.0021 0.0098 0.0255
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0187 0.0484
Schistosoma mansoni lipoxygenase 0.0119 0.1343 0.1343
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0098 0.0098
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0732 0.3674
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.2971 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0512 0.0512
Brugia malayi glutathione reductase 0.0044 0.0395 0.1023
Giardia lamblia Fructose-bisphosphate aldolase 0.0342 0.4142 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0031 0.0104
Onchocerca volvulus 0.0028 0.0187 0.0406
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0732 0.0704
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0187 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.2971 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Brugia malayi nuclear receptor NHR-88 0.0021 0.0098 0.0255
Schistosoma mansoni hypothetical protein 0.0046 0.0419 0.0419
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0031 0.0104
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0419 0.0389
Echinococcus granulosus dna polymerase kappa 0.0041 0.036 0.0331
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0445 0.1194
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.5535 0.5522
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0098 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0445 0.0416
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0098 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0198 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Brugia malayi Pre-SET motif family protein 0.0035 0.0278 0.0718
Brugia malayi nuclear hormone receptor 0.0021 0.0098 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0098 0.0255
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0031 0.0001
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0199 0.0669
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0098 0.0068
Leishmania major trypanothione reductase 0.0044 0.0395 0.133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0527 0.1205
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0187 0.082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0182 0.4355
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0144 0.165 0.5555
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0322 0.3895 0.3877
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0097 0.1057 0.1057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0732 0.1895
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Trypanosoma brucei polo-like protein kinase 0.011 0.1229 0.4137
Brugia malayi Pre-SET motif family protein 0.0243 0.2903 0.7513
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0167 0.194 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.074 0.3713
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0182 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.1062 0.275
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0098 0.0098
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.165 0.5555
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0031 0.0003
Mycobacterium ulcerans hypothetical protein 0.0028 0.0187 0.0484
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1624 0.1624
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0098 0.0255
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0732 0.1895
Treponema pallidum fructose-bisphosphate aldolase 0.0342 0.4142 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0098 0.0255
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.4142 1
Plasmodium vivax SET domain protein, putative 0.0035 0.0278 0.663
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0098 0.0068
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1229 0.4137
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.003 0.0102
Mycobacterium tuberculosis Probable reductase 0.0101 0.1109 0.5645
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0395 0.9435
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.5535 0.5522
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.074 0.074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0098 0.0255
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0732 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0098 0.0255
Brugia malayi hypothetical protein 0.0046 0.0419 0.1084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Loa Loa (eye worm) hypothetical protein 0.0097 0.1057 0.2737
Schistosoma mansoni hypothetical protein 0.0097 0.1057 0.1057
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.036 0.0331
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0363 0.496
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0527 0.1205
Schistosoma mansoni kinase 0.0056 0.0545 0.0545
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0363 0.496
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0718
Echinococcus granulosus geminin 0.033 0.399 0.3971
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0419 0.0389
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0099 0.2361
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0031 0.0424
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0031 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.0807 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.1109 0.5645
Schistosoma mansoni apoptosis regulator bax 0.0097 0.1057 0.1057
Loa Loa (eye worm) glutaminase 2 0.032 0.3864 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0098 0.0068
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0395 0.1023
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0031 0.0741
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0363 0.8673
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.036 0.08
Brugia malayi Thioredoxin reductase 0.0044 0.0395 0.1023
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0098 0.0135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0512 0.1324
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0363 0.0808
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.1229 0.3181
Onchocerca volvulus 0.0046 0.0419 0.1114
Brugia malayi ecdysteroid receptor 0.0021 0.0098 0.0255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0098 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0098 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.036 0.1212
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.036 0.0449
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.036 0.0331
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0031 0.0104
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0031 0.0104
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0419 1
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0732 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0445 0.0416
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0097 0.1057 0.103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0098 0.0255
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0098 0.0068
Echinococcus granulosus transcription factor Dp 1 0.0083 0.0887 0.0859
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.1062 0.1035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.036 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0098 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0098 0.0255
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0144 0.165 0.1625
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0445 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0187 0.0484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0512 0.0512
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0199 0.0514
Plasmodium falciparum glutathione reductase 0.0044 0.0395 0.9435
Echinococcus multilocularis citrate lyase subunit beta protein 0.0029 0.0199 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0256
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.036 0.1212
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0031 0.008
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0445 0.0445
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0097 0.1057 0.103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0256
Brugia malayi photoreceptor-specific nuclear receptor 0.0297 0.3575 0.9252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0098 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.036 0.0932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0512 0.0512
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0187 0.0012
Brugia malayi Doublecortin family protein 0.0046 0.0419 0.1084
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0278 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.223 0.2206
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.003 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0261 0.0232
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0031 0.0424
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.036 0.036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0182 0.0795
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0182 0.2491
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0187 0.0484
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.1229 0.4137
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Echinococcus multilocularis transcription factor Dp 1 0.0083 0.0887 0.0859
Loa Loa (eye worm) hypothetical protein 0.0046 0.0419 0.1084
Trypanosoma brucei trypanothione reductase 0.0044 0.0395 0.133
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.5535 0.5522
Schistosoma mansoni polycystin 1-related 0.0046 0.0419 0.0419
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0363 0.0334
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0187 0.0484
Trypanosoma brucei hypothetical protein, conserved 0.0249 0.2971 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.074 0.0711
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.1109 0.5269
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0529 0.05
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0203 0.2388 0.2364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0098 0.0255
Mycobacterium tuberculosis Conserved protein 0.0029 0.0199 0.0881
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0445 0.0445
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0098 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.036 0.1212
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0031 0.0104
Onchocerca volvulus 0.0035 0.0278 0.0683
Echinococcus granulosus citrate lyase subunit beta protein 0.0029 0.0199 0.0169
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.036 0.1212
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0529 0.05
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0099 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0363 0.0808
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0319 0.7628
Echinococcus granulosus neuropeptide s receptor 0.0453 0.5535 0.5522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1574 0.1548
Schistosoma mansoni hypothetical protein 0.0097 0.1057 0.1057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.003 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.1109 0.5645
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Schistosoma mansoni DNA polymerase eta 0.0041 0.036 0.036
Brugia malayi glutaminase DH11.1 0.032 0.3864 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0182 0.0472
Echinococcus multilocularis dna polymerase kappa 0.0041 0.036 0.0331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0031 0.0741
Onchocerca volvulus 0.0277 0.3326 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0029 0.0199 0.0514
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0182 0.4355
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0419 0.0389
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0099 0.4483
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.165 0.5555
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0098 0.0135
Loa Loa (eye worm) hypothetical protein 0.0046 0.0419 0.1084
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0198 0.0666
Leishmania major DNA polymerase eta, putative 0.0041 0.036 0.1212
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0187 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0187 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0098 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0098 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0198 0.0666
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.223 0.2206
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.003 0.0727
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0284
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0144 0.165 0.1625
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.036 0.1212
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0097 0.1057 0.103
Brugia malayi mbt repeat family protein 0.0048 0.0445 0.1152
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0098 0.0255
Mycobacterium ulcerans hypothetical protein 0.0029 0.0199 0.0514
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Loa Loa (eye worm) hypothetical protein 0.0297 0.3575 0.9252
Brugia malayi hypothetical protein 0.0046 0.0419 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0098 0.0255
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0322 0.3895 0.3877
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.003 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0187 0.0012
Schistosoma mansoni coup transcription factor 0.0021 0.0098 0.0098
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1229 0.4137
Schistosoma mansoni loxhd1 0.0046 0.0419 0.0419
Schistosoma mansoni rab6-interacting 0.0046 0.0419 0.0419
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0182 0.0368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0098 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0512 0.0483
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.003 0.0416
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0098 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.003 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0187 0.063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0278
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.036 0.0932
Brugia malayi Isocitrate dehydrogenase 0.0015 0.003 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0098 0.0255
Loa Loa (eye worm) hypothetical protein 0.0097 0.1062 0.275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0278 0.0248
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.165 0.5555
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0512 0.0483
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0419 0.0389
Schistosoma mansoni hypothetical protein 0.0097 0.1057 0.1057
Loa Loa (eye worm) acetyltransferase 0.0142 0.1624 0.4203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0256
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.1062 0.1035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0278 0.3791
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0284
Onchocerca volvulus 0.0046 0.0419 0.1114
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0199 0.0514
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.1109 0.5645
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0029 0.0199 0.0408
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0031 0.0001
Schistosoma mansoni glutaminase 0.032 0.3864 0.3864
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0512 0.0483
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1229 0.2914
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.125 0.6387
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.036 0.1725
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0098 0.0068
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0098 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0732 0.0732
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0098 0.0098
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0031 0.0104
Echinococcus multilocularis geminin 0.033 0.399 0.3971
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0031 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0098 0.0255
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0031 0.0075
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0529 0.1369
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Plasmodium falciparum thioredoxin reductase 0.0044 0.0395 0.9435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0732 0.1895
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0187 0.0484
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0395 0.133
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0445 0.0416
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.1229 0.1202
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0098 0.0068
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0402 0.0373
Echinococcus granulosus dna polymerase eta 0.0041 0.036 0.0331
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0199 0.0669
Trypanosoma brucei unspecified product 0.0029 0.0198 0.0666
Leishmania major hypothetical protein, conserved 0.0249 0.2971 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0187 0.0027
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0144 0.165 0.4271
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0099 0.2361
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.003 0.0102
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0529 0.05
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0098 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0187 0.082
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0031 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0278 0.0248
Schistosoma mansoni microtubule-associated protein tau 0.0807 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0031 0.0104
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.074 0.1914
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.036 0.1212
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0187 0.0484
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0319 0.0771
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.003 0.0079
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.036 0.1212
Onchocerca volvulus 0.0048 0.0445 0.1194
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0419 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0182 0.0614
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.003 0.0416
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0097 0.1057 0.2737
Schistosoma mansoni hypothetical protein 0.033 0.399 0.399
Plasmodium falciparum glutathione reductase 0.0015 0.0031 0.0741
Loa Loa (eye worm) hypothetical protein 0.0055 0.0529 0.1369
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1229 0.1229
Trypanosoma brucei unspecified product 0.0029 0.0198 0.0666
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.036 0.1212
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.003 0.0727
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1624 0.4203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0284
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0395 0.1909
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0029 0.0199 0.0881
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0098 0.0255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0098 0.0068
Mycobacterium ulcerans glutaminase 0.032 0.3864 1
Toxoplasma gondii thioredoxin reductase 0.0044 0.0395 0.5396
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0031 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0187 0.0484
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.1062 0.1062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0512 0.1324
Schistosoma mansoni lipoxygenase 0.0203 0.2388 0.2388
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0419 0.0389
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0182 0.0614
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0031 0.0031
Echinococcus multilocularis RUN 0.0046 0.0419 0.0389
Trypanosoma brucei unspecified product 0.0041 0.036 0.1212
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0144 0.165 0.165
Echinococcus multilocularis dna polymerase eta 0.0041 0.036 0.0331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0098 0.0068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0187 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0278
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0182 1
Leishmania major DNA polymerase kappa, putative 0.0041 0.036 0.1212
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.125 0.6387
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.194 0.5023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0031 0.008
Schistosoma mansoni hypothetical protein 0.0293 0.3528 0.3528
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0098 0.0098
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.1109 0.5645
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0098 0.0135
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.125 0.6387
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0284
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.1229 0.2643
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0031 0.0741
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.1229 0.359
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0278 0.0248
Onchocerca volvulus 0.0021 0.0098 0.0135
Mycobacterium ulcerans hypothetical protein 0.0029 0.0199 0.0514
Loa Loa (eye worm) glutathione reductase 0.0044 0.0395 0.1023
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.1229 0.3181
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0419 0.0389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.4142 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0098 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0098 0.0255
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0031 0.0104
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0626 0.162
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0182 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0098 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0098 0.0068
Plasmodium falciparum thioredoxin reductase 0.0015 0.0031 0.0741
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0419 0.1084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0256
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0187 0.0484
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0187 0.0484
Trichomonas vaginalis set domain proteins, putative 0.0277 0.3326 0.8016
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1624 0.1598
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0529 0.05
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0099 0.0358
Brugia malayi mbt repeat family protein 0.0048 0.0445 0.1152
Giardia lamblia Kinase, PLK 0.011 0.1229 0.2967
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0484
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.074 0.249
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.036 0.08
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.074 0.1914
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0098 0.0255
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0098 0.0068
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0098 0.0255
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.4142 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0144 0.165 0.4271
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0255
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.036 0.1212
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.036 0.1212
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0098 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0187 0.063
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0031 0.0104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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