TDR Targets

Basic information

Technical information

TDR Targets ID: 722677
Name: 2-[(2-methanesulfonamidobenzoyl)amino]-N-(1-p henylethyl)benzamide
MW: 437.511 | Formula: C23H23N3O4S
H donors: 3 H acceptors: 4 LogP: 4 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C)NC(c1ccccc1)C
InChi: 1S/C23H23N3O4S/c1-16(17-10-4-3-5-11-17)24-22(27)18-12-6-8-14-20(18)25-23(28)19-13-7-9-15-21(19)26-31(2,29)30/h3-16,26H,1-2H3,(H,24,27)(H,25,28)
InChiKey: KYPMJLPHIJGLIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[(2-methanesulfonamidophenyl)-oxomethyl]amino]-N-(1-phenylethyl)benzamide
2-[[2-(methylsulfonylamino)phenyl]carbonylamino]-N-(1-phenylethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0369	0.2331
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0488	0.046
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0397	0.0495
Echinococcus multilocularis	GPCR, family 2	0.0032	0.08	0.0998
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.4028	0.6813
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1488	0.2518
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0397	0.0672
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0369	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.002	0.0397	0.0495
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0029	0.0049
Schistosoma mansoni	hypothetical protein	0.0176	0.5911	1
Onchocerca volvulus		0.002	0.0397	0.0971
Schistosoma mansoni	neurotransmitter gated ion channel	0.0009	0.0009	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.001	0.0042	0.0053
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0369	0.2331
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.1488	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0032	0.08	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.08	0.0998
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0009	0.0009	0.0011
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0283	0.5
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0397	0.0495
Echinococcus granulosus	mitogen activated protein kinase 15	0.001	0.0029	0.0036
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0397	0.0495
Echinococcus multilocularis	nAChR subunit	0.0011	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0397	0.0495
Onchocerca volvulus	Huntingtin homolog	0.0122	0.4001	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0938	0.1169
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0369	0.0341
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.08	0.0998
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.002	0.0397	0.0495
Brugia malayi	hypothetical protein	0.0236	0.8023	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0283	0.746
Brugia malayi	cyclin-dependent kinase 9	0.0053	0.1547	0.1928
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0042	0.0072
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1255	0.1564
Onchocerca volvulus		0.002	0.0397	0.0971
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0011
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0369	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0009	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0488	0.046
Brugia malayi	MAP kinase sur-1	0.0051	0.1488	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.1129	0.1103
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0009	0.0009	0.0011
Echinococcus multilocularis	geminin	0.0176	0.5911	0.7368
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.4563	0.4547
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0009	0.0009	0.0011
Echinococcus granulosus	GPCR family 2	0.0032	0.08	0.0998
Entamoeba histolytica	protein kinase domain containing protein	0.001	0.0029	0.0187
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.1488	0.1464
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0907	0.1534
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	1	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.08	0.0998
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0938	0.1169
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0488	0.3151
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0283	0.0352
Brugia malayi	TAR-binding protein	0.0123	0.4028	0.502
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.1054	0.1783
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0855	0.5661
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	1	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0009	0.0009	0.0011
Entamoeba histolytica	hypothetical protein	0.0035	0.0907	0.5862
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0488	0.0424
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0397	0.0495
Onchocerca volvulus		0.002	0.0397	0.0971
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0488	0.0489
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0397	0.0672
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0369	1
Schistosoma mansoni	ap endonuclease	0.002	0.0369	0.0624
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.4028	0.6813
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.5115	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0009	0.0009	0.0011
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.1488	1
Brugia malayi	Cell division protein kinase 2	0.001	0.0029	0.0036
Schistosoma mansoni	acetylcholine receptor-related	0.0009	0.0009	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0488	0.0424
Echinococcus granulosus	geminin	0.0176	0.5911	0.7368
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.3227	0.4022
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0488	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Brugia malayi	Cation transporter family protein	0.002	0.0397	0.0495
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.1547	0.2617
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.002	0.0397	0.0495
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0369	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0369	0.2331
Schistosoma mansoni	hypothetical protein	0.0048	0.138	0.2334
Loa Loa (eye worm)	hypothetical protein	0.0236	0.8023	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0488	0.0424
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.001	0.0029	0.0036
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.3227	0.4022
Entamoeba histolytica	cell division protein kinase 2, putative	0.001	0.0029	0.0187
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0397	0.0495
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0488	0.0424
Loa Loa (eye worm)	acetylcholine receptor protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Schistosoma mansoni	neurotransmitter gated ion channel	0.0011	0.0065	0.011
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0011	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0488	0.0608
Schistosoma mansoni	hypothetical protein	0.0035	0.0907	0.1534
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0009	0.0009	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0488	0.046
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2104	0.2622
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1255	0.2123
Echinococcus granulosus	cyclin dependent kinase 9	0.0053	0.1547	0.1928
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0011
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.1488	0.1855
Loa Loa (eye worm)	RNA binding protein	0.0123	0.4028	0.502
Schistosoma mansoni	hypothetical protein	0.0032	0.08	0.1354
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0011
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0488	0.3151
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.08	0.0998
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0369	0.046
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0397	0.0495
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0938	0.1169
Trypanosoma brucei	protein kinase, putative	0.006	0.1811	0.1787
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0369	0.0341
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0397	0.0495
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0369	0.0341
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.002	0.0397	0.0672
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.1129	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0488	0.0608
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.2104	0.2622
Echinococcus multilocularis	cyclin dependent kinase 9	0.0053	0.1547	0.1928
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.4028	0.6813
Brugia malayi	Cation transporter family protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0771	0.0962
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.1488	0.1464
Echinococcus multilocularis	tar DNA binding protein	0.0123	0.4028	0.502
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.002	0.0397	0.0495
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.002	0.0397	0.0495
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1255	0.1564
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0488	0.0424
Entamoeba histolytica	hypothetical protein	0.0035	0.0907	0.5862
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0123	0.4028	0.502
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0488	0.0424
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.08	0.0998
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0369	0.046
Schistosoma mansoni	kinase	0.0053	0.1547	0.2617
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1488	1
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0938	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0122	0.4001	0.4987
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.001	0.0042	0.0053
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0283	0.0068
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0011
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0397	0.0495
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.002	0.0397	0.0495
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0011	0.0065	0.0081
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0488	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0369	0.0179
Echinococcus granulosus	tar DNA binding protein	0.0123	0.4028	0.502
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.138	0.1719
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1255	0.2123
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0283	0.0352
Toxoplasma gondii	hypothetical protein	0.0047	0.1342	0.8695
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1255	0.1564
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Onchocerca volvulus		0.0023	0.0488	0.1198
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.1488	0.1855
Echinococcus granulosus	nAChR subunit	0.0011	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.01	0.3227	0.4022
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.001	0.0029	0.0036
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Brugia malayi	Protein kinase domain containing protein	0.001	0.0029	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Brugia malayi	excitatory GABA receptor EXP-1A	0.002	0.0397	0.0495
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0369	0.0341
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.001	0.0042	0.0053
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Schistosoma mansoni	hypothetical protein	0.0032	0.08	0.1354
Schistosoma mansoni	hypothetical protein	0.0032	0.08	0.1354
Schistosoma mansoni	ap endonuclease	0.002	0.0369	0.0624
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.1488	0.1464
Mycobacterium ulcerans	hypothetical protein	0.0154	0.5115	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0009	0.0009	0.0011
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.002	0.0397	0.0495
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0397	0.0672
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1255	0.2123
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.3227	0.4022
Entamoeba histolytica	hypothetical protein	0.0011	0.0065	0.042
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0011	0.0065	0.011
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Schistosoma mansoni	nAChR subunit	0.0009	0.0009	0.0016
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.4028	0.6813
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.002	0.0397	0.0672
Schistosoma mansoni	serine/threonine kinase	0.001	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0488	0.0489
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0488	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0011	0.0065	0.0081
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.002	0.0397	0.0495
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0292	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0283	0.0352
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0397	0.0495
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.001	0.0029	0.0036
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.002	0.0397	0.0672
Schistosoma mansoni	hypothetical protein	0.0032	0.08	0.1354
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1488	0.1464
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0009	0.0009	0.0011
Schistosoma mansoni	protein kinase	0.001	0.0029	0.0049
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0369	0.046
Echinococcus multilocularis	voltage gated potassium channel	0.001	0.0042	0.0053
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0488	0.0424
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0009	0.0009	0.0016
Loa Loa (eye worm)	GABA receptor subunit	0.0011	0.0065	0.0081
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1255	0.1564
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0488	0.0424
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0397	0.0495
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.1488	0.1855
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0369	0.2386
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.002	0.0397	0.0495
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.4028	0.6813
Brugia malayi	hypothetical protein	0.0035	0.0907	0.113
Brugia malayi	cyclin-dependent kinase 7 homolog	0.001	0.0029	0.0036
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0042	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Onchocerca volvulus		0.002	0.0397	0.0971
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.1488	0.1464
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.002	0.0397	0.0495
Brugia malayi	RNA recognition motif domain containing protein	0.0123	0.4028	0.502
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0009	0.0011
Onchocerca volvulus		0.0011	0.0065	0.014
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0397	0.0495
Echinococcus multilocularis	cyclin dependent kinase 9	0.0062	0.187	0.2331
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0397	0.0495
Echinococcus granulosus	serine:threonine protein kinase NLK	0.001	0.0029	0.0036
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0855	0.5661
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1488	0.1464
Onchocerca volvulus		0.002	0.0397	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.002	0.0397	0.0495
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0907	0.113
Echinococcus granulosus	nAChR subunit	0.002	0.0397	0.0495
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0.1547	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0011	0.0065	0.011
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.001	0.0029	0.0036
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0397	0.0495
Schistosoma mansoni	hypothetical protein	0.0176	0.5911	1
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Onchocerca volvulus		0.0048	0.138	0.3433
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Brugia malayi	RNA binding protein	0.0123	0.4028	0.502
Brugia malayi	hypothetical protein	0.0122	0.4001	0.4987
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0397	0.0495
Schistosoma mansoni	survival motor neuron protein	0.0048	0.138	0.2334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0009	0.0011
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.1446	0.1421
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.001	0.0029	0.0036
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.002	0.0397	0.0495
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0283	0.746
Echinococcus granulosus	voltage gated potassium channel	0.001	0.0042	0.0053
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0488	0.5
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0053	0.1547	0.1928
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.08	0.0998
Echinococcus multilocularis	nAChR subunit	0.002	0.0397	0.0495
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.4563	0.4547
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0283	0.0352
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.002	0.0397	0.0495
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1255	0.1564
Loa Loa (eye worm)	TAR-binding protein	0.0123	0.4028	0.502
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.1129	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0488	0.0608
Onchocerca volvulus		0.002	0.0397	0.0971
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.1488	0.1855
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0907	0.113
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0369	0.0246
Entamoeba histolytica	hypothetical protein	0.0035	0.0907	0.5862
Onchocerca volvulus		0.0011	0.0065	0.014
Echinococcus granulosus	cyclin dependent kinase 9	0.0062	0.187	0.2331
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0488	0.3151
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.1054	0.1783
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0397	0.0495
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.08	0.0998
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.001	0.0042	0.0053
Schistosoma mansoni	hypothetical protein	0.0069	0.2104	0.3559
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.002	0.0397	0.0495
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0488	0.0608
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0009	0.0009	0.0011
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.002	0.0397	0.0495
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0397	0.0495
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.8023	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0011
Loa Loa (eye worm)	LGC-31 protein	0.002	0.0397	0.0495
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.002	0.0397	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0283	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0397	0.0495
Onchocerca volvulus	Putative nachr subunit	0.002	0.0397	0.0971
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.1129	0.1103
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.8023	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0369	0.046
Schistosoma mansoni	neurotransmitter gated ion channel	0.0009	0.0009	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0122	0.4001	0.4987
Entamoeba histolytica	hypothetical protein	0.0035	0.0907	0.5862
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1488	1
Brugia malayi	Cation transporter family protein	0.002	0.0397	0.0495
Loa Loa (eye worm)	haspin protein kinase	0.001	0.0029	0.0036
Loa Loa (eye worm)	hypothetical protein	0.002	0.0397	0.0495
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.1488	0.1464
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0011	0.0065	0.0081
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0009	0.0009	0.0011
Schistosoma mansoni	nAChR subunit	0.0009	0.0009	0.0016
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0397	0.0495
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1255	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0081
Schistosoma mansoni	nAChR subunit	0.002	0.0397	0.0672
Onchocerca volvulus	Huntingtin homolog	0.0122	0.4001	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.4563	0.4547

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 722677