Detailed information for compound 72301

Basic information

Technical information
  • TDR Targets ID: 72301
  • Name: 2-(3-methoxyphenyl)-5,7-dimethyl-1H-1,8-napht hyridin-4-one
  • MW: 280.321 | Formula: C17H16N2O2
  • H donors: 1 H acceptors: 3 LogP: 3.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1cc(O)c2c(n1)nc(cc2C)C
  • InChi: 1S/C17H16N2O2/c1-10-7-11(2)18-17-16(10)15(20)9-14(19-17)12-5-4-6-13(8-12)21-3/h4-9H,1-3H3,(H,18,19,20)
  • InChiKey: YKYNUSIUKQDIRP-UHFFFAOYSA-N  


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Synonyms

  • NCI60_026477
  • NSC674679

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Tubulin alpha chain Starlite/ChEMBL References
Bos taurus Tubulin beta chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 40.1 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin alpha chain   451 aa 439 aa 39.2 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin alpha chain   451 aa 437 aa 39.4 %
Leishmania mexicana beta tubulin Tubulin alpha chain   451 aa 434 aa 42.4 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Brugia malayi Tubulin beta-1 chain Tubulin alpha chain   451 aa 434 aa 39.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Dictyostelium discoideum beta tubulin Tubulin alpha chain   451 aa 443 aa 40.4 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 434 aa 40.1 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 39.4 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Loa Loa (eye worm) BEN-1 protein Tubulin alpha chain   451 aa 434 aa 41.5 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.6 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 435 aa 40.9 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin gamma chain, putative 0.0041 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.6136 0.5463
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Echinococcus granulosus tubulin alpha chain 0.0033 0.6136 0.5463
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Brugia malayi tubulin alpha chain - mouse 0.0033 0.6136 0.5463
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0041 1 1
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha chain 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha chain 0.0033 0.6136 0.5463
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Toxoplasma gondii beta-1 tubulin, putative 0.0041 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0041 1 1
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Loa Loa (eye worm) alpha-tubulin 0.0033 0.6136 0.6136
Plasmodium falciparum tubulin beta chain 0.0041 1 1
Loa Loa (eye worm) BEN-1 protein 0.0041 1 1
Trypanosoma brucei alpha tubulin 0.0033 0.6136 0.5463
Schistosoma mansoni alpha tubulin 0.0033 0.6136 0.5463
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 1 1
Brugia malayi Tubulin alpha-2 chain 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.6136 0.6136
Echinococcus granulosus tubulin subunit TubB 0.0033 0.6136 0.5463
Schistosoma mansoni alpha tubulin 0.0033 0.6136 0.5463
Schistosoma mansoni tubulin subunit alpha 0.0033 0.6136 0.5463
Schistosoma mansoni tubulin subunit alpha 0.0033 0.6136 0.5463
Leishmania major beta tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.6136 0.6136
Echinococcus granulosus tubulin subunit beta 0.0041 1 1
Echinococcus multilocularis beta tubulin 0.0041 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0023 0.1484 0.1484
Trichomonas vaginalis tubulin beta chain, putative 0.0041 1 1
Brugia malayi Tubulin alpha chain 0.0033 0.6136 0.5463
Loa Loa (eye worm) tubulin beta-1 chain 0.0041 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0041 1 1
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Plasmodium falciparum alpha tubulin 2 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.6136 0.6136
Leishmania major beta tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0033 0.6136 0.5463
Brugia malayi alpha-tubulin 0.0033 0.6136 0.5463
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Giardia lamblia Alpha-tubulin 0.0033 0.6136 0.5463
Toxoplasma gondii alpha tubulin TUBA1 0.0033 0.6136 0.5463
Echinococcus multilocularis beta tubulin 0.0041 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 1 1
Plasmodium vivax tubulin beta chain, putative 0.0041 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0023 0.1427 0.1427
Trypanosoma brucei beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin alpha chain 0.0033 0.6136 0.5463
Echinococcus multilocularis tubulin alpha chain 0.0033 0.6136 0.5463
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.6136 0.5463
Echinococcus granulosus Tubulin beta 2C chain 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Giardia lamblia Beta tubulin 0.0041 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0023 0.1427 0.1427
Echinococcus granulosus beta tubulin 0.0041 1 1
Giardia lamblia Beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin subunit beta 0.0041 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Loa Loa (eye worm) hypothetical protein 0.0023 0.1427 0.1427
Echinococcus multilocularis tubulin subunit TubB 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha chain 0.0033 0.6136 0.5463
Toxoplasma gondii beta tubulin 0.0041 1 1
Trypanosoma brucei beta tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.0033 0.6136 0.5463
Trypanosoma cruzi beta tubulin, putative 0.0041 1 1
Echinococcus granulosus beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.6136 0.5463
Schistosoma mansoni alpha tubulin 0.0033 0.6136 0.5463
Trypanosoma brucei alpha tubulin 0.0033 0.6136 0.5463
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.1484 0.1484
Echinococcus granulosus peroxisome assembly protein 26 0.0033 0.6136 0.5463
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 1 1
Trypanosoma brucei alpha tubulin 0.0033 0.6136 0.5463
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.6136 0.6136
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.6136 0.6136
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0023 0.1427 0.1427
Schistosoma mansoni tubulin subunit alpha 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Leishmania major beta tubulin 0.0041 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Brugia malayi Tubulin alpha-2 chain 0.0033 0.6136 0.5463
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin, putative 0.0041 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.6136 0.5463
Loa Loa (eye worm) hypothetical protein 0.0033 0.6136 0.6136
Echinococcus multilocularis tubulin alpha chain 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin alpha chain 0.0033 0.6136 0.5463
Leishmania major beta tubulin 0.0041 1 1
Trypanosoma brucei beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.6136 0.5463
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Echinococcus multilocularis tubulin alpha chain 0.0033 0.6136 0.5463
Leishmania major beta tubulin 0.0041 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 1 1
Echinococcus multilocularis hypothetical protein 0.0033 0.6136 0.5463
Loa Loa (eye worm) tubulin alpha-2 chain 0.0033 0.6136 0.6136
Echinococcus granulosus Tubulin beta 2C chain 0.0041 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0041 1 1
Entamoeba histolytica tubulin family protein 0.0041 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.6136 0.5463
Trypanosoma cruzi alpha tubulin, putative 0.0033 0.6136 0.5463
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Echinococcus granulosus Tubulin beta 2C chain 0.0041 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Leishmania major beta tubulin 0.0041 1 1
Giardia lamblia Alpha-tubulin 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.1484 0.1484
Giardia lamblia Beta tubulin 0.0041 1 1
Loa Loa (eye worm) beta-tubulin 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Loa Loa (eye worm) tubulin beta chain 0.0041 1 1
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Loa Loa (eye worm) alpha-tubulin 0.0033 0.6136 0.6136
Echinococcus granulosus alpha tubulin 0.0033 0.6136 0.5463
Plasmodium falciparum alpha tubulin 1 0.0033 0.6136 0.5463
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.6136 0.5463
Brugia malayi tubulin alpha-2 chain 0.0033 0.6136 0.5463
Echinococcus granulosus tubulin beta 4A class IVa 0.0041 1 1
Brugia malayi beta-tubulin, identical 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0041 1 1
Entamoeba histolytica tubulin family protein 0.0041 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Trypanosoma brucei beta tubulin 0.0041 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0041 1 1
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0041 1 1
Leishmania major beta tubulin 0.0041 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0023 0.1427 0.1427
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Leishmania major beta tubulin 0.0041 1 1
Echinococcus multilocularis tubulin alpha chain 0.0033 0.6136 0.5463
Entamoeba histolytica tubulin alpha chain, putative 0.0033 0.6136 0.5463
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.6136 0.6136
Leishmania major beta tubulin 0.0041 1 1
Loa Loa (eye worm) BEN-1 protein 0.0041 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.6136 0.5463
Echinococcus multilocularis peroxisome assembly protein 26 0.0033 0.6136 0.5463
Toxoplasma gondii beta-tubulin, putative 0.0041 1 1
Schistosoma mansoni tubulin subunit beta 0.0041 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.1484 0.1484
Leishmania major alpha tubulin 0.0033 0.6136 0.5463
Trypanosoma brucei alpha tubulin 0.0033 0.6136 0.5463

Activities

Activity type Activity value Assay description Source Reference
Average LogGI50 (functional) = -6.19 Cytotoxic effect in human tumor cell lines, tested by the National Cancer Institute ChEMBL. 9216846
GI50 (functional) < -8 Concentration which reduced cell growth to 50 % of level against MDA-MB-435 breast cancer line ChEMBL. 9216846
GI50 (functional) < -8 Concentration which reduced cell growth to 50 % of level against MDA-N breast cancer line ChEMBL. 9216846
GI50 (functional) -7.174 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -6.77 Concentration which reduced cell growth to 50 % of U251 cancer line ChEMBL. 9216846
GI50 (functional) = -6.76 Concentration which reduced cell growth to 50 % of level against HL-60 (TB) leukemia cell line ChEMBL. 9216846
GI50 (functional) -6.741 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -6.6 Concentration which reduced cell growth to 50 % of level against OVCAR-3 ovarian cancer line ChEMBL. 9216846
GI50 (functional) -6.599 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -6.54 Concentration which reduced cell growth to 50 % of level against SK-MEL-5 melanoma cell line ChEMBL. 9216846
GI50 (functional) -6.522 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -6.51 Concentration which reduced cell growth to 50 % of level against PC-3 prostate cancer line ChEMBL. 9216846
GI50 (functional) = -6.39 Concentration which reduced cell growth to 50 % of level against HCT-116 colon cancer cell line ChEMBL. 9216846
GI50 (functional) = -6.38 Concentration which reduced cell growth to 50 % of level against SF-295 CNS cancer line ChEMBL. 9216846
GI50 (functional) = -6.36 Concentration which reduced cell growth to 50 % of level against 786-0 renal cancer line ChEMBL. 9216846
GI50 (functional) = -6.35 compound was tested for for concentration which reduced cell growth to 50 % of level against NCI-H460 non -small-cell lung cancer cell line ChEMBL. 9216846
GI50 (functional) -6.342 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.256 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.127 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.073 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.062 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.919 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.563 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 6.06 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972
IC50 (functional) = 0.88 uM Inhibition of bovine tubulin polymerization ChEMBL. 9216846
IC50 (functional) = 0.88 uM Inhibition of bovine tubulin polymerization ChEMBL. 9216846
Inhibition (functional) = 22 % Inhibition of colchicine binding and evaluated only when polymerization IC50 <=1 microM ChEMBL. 9216846
Inhibition (functional) = 22 % Inhibition of colchicine binding and evaluated only when polymerization IC50 <=1 microM ChEMBL. 9216846
Log GI50 (functional) < -8 Concentration which reduced cell growth to 50 % of level against MDA-MB-435 breast cancer line ChEMBL. 9216846
Log GI50 (functional) < -8 Concentration which reduced cell growth to 50 % of level against MDA-N breast cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.77 Concentration which reduced cell growth to 50 % of U251 cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.76 Concentration which reduced cell growth to 50 % of level against HL-60 (TB) leukemia cell line ChEMBL. 9216846
Log GI50 (functional) = -6.6 Concentration which reduced cell growth to 50 % of level against OVCAR-3 ovarian cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.54 Concentration which reduced cell growth to 50 % of level against SK-MEL-5 melanoma cell line ChEMBL. 9216846
Log GI50 (functional) = -6.51 Concentration which reduced cell growth to 50 % of level against PC-3 prostate cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.39 Concentration which reduced cell growth to 50 % of level against HCT-116 colon cancer cell line ChEMBL. 9216846
Log GI50 (functional) = -6.38 Concentration which reduced cell growth to 50 % of level against SF-295 CNS cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.36 Concentration which reduced cell growth to 50 % of level against 786-0 renal cancer line ChEMBL. 9216846
Log GI50 (functional) = -6.35 compound was tested for for concentration which reduced cell growth to 50 % of level against NCI-H460 non -small-cell lung cancer cell line ChEMBL. 9216846
Log IC50 (binding) = 6.06 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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