Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1618 | 0.1618 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.6285 | 0.6285 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.6101 | 0.6101 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.09 | 0.09 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.6285 | 0.6285 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.6285 | 0.6285 |
Onchocerca volvulus | 0.0027 | 0.6285 | 1 | |
Echinococcus multilocularis | musashi | 0.0027 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1084 | 0.1084 |
Schistosoma mansoni | lamin | 0.0027 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.09 | 0.09 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.6285 | 0.6285 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.8557 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.1618 | 0.1618 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.6285 | 0.6285 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.8557 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.6285 | 0.6285 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.6285 | 0.6285 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.6285 | 0.6285 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.6285 | 0.6285 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 0.6285 | 0.6285 |
Onchocerca volvulus | 0.0027 | 0.6285 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.6285 | 0.6285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.