Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0374 | 0.4083 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0374 | 0.4083 | 0.5 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0163 | 0 | 0.5 |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0163 | 0 | 0.5 |
Onchocerca volvulus | 0.0163 | 0 | 0.5 | |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0374 | 0.4083 | 0.5 |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0163 | 0 | 0.5 |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0163 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0374 | 0.4083 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.068 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0374 | 0.4083 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0374 | 0.4083 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0374 | 0.4083 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0374 | 0.4083 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0374 | 0.4083 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.