Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | thymidylate synthase | 0.0616 | 0.1191 | 0.1159 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0083 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0262 | 0.0464 | 0.043 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0318 | 0.0318 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0083 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.0036 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0036 | 0.0036 |
Brugia malayi | RNA binding protein | 0.007 | 0.007 | 0.007 |
Brugia malayi | beta-lactamase family protein | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.0134 | 0.0098 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.007 | 0.007 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0243 | 0.0426 | 0.0426 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.007 | 0.0034 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0083 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.008 | 0.0092 | 0.1124 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0036 | 0.0036 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0318 | 0.0283 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0292 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.007 | 0.007 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0034 | 0.0034 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.0134 | 0.0098 |
Echinococcus granulosus | geminin | 0.0191 | 0.0318 | 0.0283 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0101 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0616 | 0.1191 | 0.111 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0083 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.008 | 0.0092 | 0.0092 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4906 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.007 | 0.007 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0036 | 0.0036 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.021 | 0.1502 |
Brugia malayi | hypothetical protein | 0.0293 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0083 | 0.0047 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0083 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.021 | 0.021 |
Loa Loa (eye worm) | beta-lactamase | 0.008 | 0.0092 | 0.0092 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.008 | 0.0092 | 0.1124 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0083 | 0.0083 |
Toxoplasma gondii | ABC1 family protein | 0.008 | 0.0092 | 0.0104 |
Brugia malayi | beta-lactamase family protein | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0262 | 0.0464 | 0.043 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.008 | 0.0092 | 0.1124 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2647 | 0.5361 | 1 |
Brugia malayi | hypothetical protein | 0.0138 | 0.021 | 0.021 |
Brugia malayi | Dihydrofolate reductase | 0.4906 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.007 | 0.007 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.007 | 0.007 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0101 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0034 | 0.0034 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0293 | 0.0528 | 0.0924 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.008 | 0.0092 | 0.1124 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4906 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.007 | 0.007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.0134 | 0.0098 |
Onchocerca volvulus | 0.008 | 0.0092 | 0.048 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | thymidylate synthase | 0.0616 | 0.1191 | 0.1191 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0514 | 0.0982 | 0.0898 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.008 | 0.0092 | 0.0055 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.007 | 0.007 |
Echinococcus granulosus | thymidylate synthase | 0.0616 | 0.1191 | 0.1159 |
Brugia malayi | follicle stimulating hormone receptor | 0.0243 | 0.0426 | 0.0426 |
Echinococcus granulosus | dihydrofolate reductase | 0.4906 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.021 | 0.021 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2647 | 0.5361 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0036 | 0.0036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0293 | 0.0528 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0101 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0036 | 0.0036 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.008 | 0.0092 | 0.0092 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0134 | 0.0134 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.008 | 0.0092 | 0.1124 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0034 | 0.0034 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0129 | 0.0192 | 0.0292 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0134 | 0.0134 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0898 | 0.1771 | 0.1741 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2647 | 0.5361 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.021 | 0.1502 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.007 | 0.0034 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.1191 | 0.1191 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0036 | 0.0036 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.008 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.008 | 0.0092 | 0.0055 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4906 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4906 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.008 | 0.0092 | 0.0104 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.0134 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0293 | 0.0528 | 0.0441 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2647 | 0.5361 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 0.007 | 0.007 |
Mycobacterium ulcerans | thymidylate synthase | 0.0616 | 0.1191 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4906 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0616 | 0.1191 | 0.111 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0192 |
Onchocerca volvulus | 0.0616 | 0.1191 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0101 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0129 | 0.0192 | 0.0192 |
Onchocerca volvulus | 0.008 | 0.0092 | 0.048 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4906 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0129 | 0.0192 | 0.0156 |
Trypanosoma brucei | hypothetical protein, conserved | 0.008 | 0.0092 | 0.0104 |
Brugia malayi | beta-lactamase | 0.008 | 0.0092 | 0.0092 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2647 | 0.5361 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.0134 | 0.0134 |
Schistosoma mansoni | dihydrofolate reductase | 0.4906 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0083 | 0.0083 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2647 | 0.5361 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0129 | 0.0192 | 0.0156 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0083 | 0.0083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.008 | 0.0092 | 0.0104 |
Onchocerca volvulus | 0.008 | 0.0092 | 0.048 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.007 | 0.007 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0092 | 0.0104 |
Brugia malayi | hypothetical protein | 0.0262 | 0.0464 | 0.0464 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.008 | 0.0092 | 0.1124 |
Brugia malayi | thymidylate synthase | 0.0616 | 0.1191 | 0.1191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.