Detailed information for compound 724129

Basic information

Technical information
  • TDR Targets ID: 724129
  • Name: 2-[(4-chlorophenyl)sulfonyl-(2-methylphenyl)a mino]-N-(3,4-dimethylphenyl)acetamide
  • MW: 442.958 | Formula: C23H23ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)Cl)c1ccccc1C)Nc1ccc(c(c1)C)C
  • InChi: 1S/C23H23ClN2O3S/c1-16-8-11-20(14-18(16)3)25-23(27)15-26(22-7-5-4-6-17(22)2)30(28,29)21-12-9-19(24)10-13-21/h4-14H,15H2,1-3H3,(H,25,27)
  • InChiKey: BLKWUVDLUFHZQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-chlorophenyl)sulfonyl-(2-methylphenyl)amino]-N-(3,4-dimethylphenyl)ethanamide
  • ZINC01072588

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1013 0.5
Schistosoma mansoni hypothetical protein 0.0054 0.1692 0.2377
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0079 0.2685 0.2685
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0201 0.7531 0.7531
Onchocerca volvulus 0.0037 0.1013 0.1279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0079 0.2685 0.2685
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.2685 1
Onchocerca volvulus 0.0019 0.0302 0.0327
Schistosoma mansoni nuclear hormone receptor 0.0021 0.039 0.0549
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.1184 0.5
Brugia malayi Cathepsin L-like precursor 0.0012 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Leishmania major cathepsin L-like protease 0.0071 0.2379 0.8715
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.039 0.039
Echinococcus granulosus cathepsin l1 0.0019 0.0302 0.0302
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.26 0.26
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0433 0.0433
Brugia malayi nuclear receptor NHR-88 0.0021 0.039 0.039
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Entamoeba histolytica hypothetical protein 0.0077 0.26 0.9678
Loa Loa (eye worm) fibroinase 0.0019 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.039 0.039
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.7531 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0433 0.0433
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.4768 0.4768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Loa Loa (eye worm) beta-lactamase 0.0037 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0302 0.0302
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.039 0.039
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0302 0.0327
Loa Loa (eye worm) ctsf protein 0.0019 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1013 0.3638
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0058 0.0081
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.039 0.0549
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.039 0.039
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.1776 0.6186
Onchocerca volvulus 0.0019 0.0302 0.0327
Onchocerca volvulus 0.0022 0.0433 0.0502
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1013 0.3638
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.039 0.039
Schistosoma mansoni ap endonuclease 0.0041 0.1184 0.1663
Onchocerca volvulus 0.0054 0.1692 0.2187
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0302 0.0424
Echinococcus multilocularis ubiquitin specific protease 41 0.0079 0.2685 0.2685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.2379 0.8715
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Brugia malayi Cathepsin L-like precursor 0.0012 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.2379 0.8715
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.039 0.039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.1184 0.1184
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.039 0.039
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0079 0.2685 0.2685
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.1184 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.2685 0.2685
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.1184 0.1184
Echinococcus multilocularis geminin 0.0191 0.7117 0.7117
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.039 0.039
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.039 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1013 0.1424
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.2685 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.039 0.039
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0302 0.0302
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.039 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.1184 0.4287
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1013 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.039 0.039
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.039 0.0549
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.039 0.039
Entamoeba histolytica hypothetical protein 0.0077 0.26 0.9678
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.2685 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Leishmania major cathepsin L-like protease 0.0071 0.2379 0.8715
Onchocerca volvulus 0.0019 0.0302 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.039 0.039
Brugia malayi ecdysteroid receptor 0.0021 0.039 0.039
Schistosoma mansoni rab6-interacting 0.0022 0.0433 0.0608
Schistosoma mansoni thyroid hormone receptor 0.0021 0.039 0.0549
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0079 0.2685 0.2685
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0058 0.0058
Brugia malayi cathepsin L-like precursor 0.0012 0.0058 0.0058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.26 0.26
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.1184 0.3701
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.039 0.0549
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Schistosoma mansoni rab6-interacting 0.0022 0.0433 0.0608
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0302 0.0302
Leishmania major cathepsin L-like protease 0.0071 0.2379 0.8715
Onchocerca volvulus 0.0019 0.0302 0.0327
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1013 0.1013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Echinococcus granulosus survival motor neuron protein 1 0.0263 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0302 0.093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Entamoeba histolytica hypothetical protein 0.0077 0.26 0.9678
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.039 0.039
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.1184 0.4287
Schistosoma mansoni loxhd1 0.0022 0.0433 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Schistosoma mansoni lipoxygenase 0.0131 0.4768 0.67
Trichomonas vaginalis esterase, putative 0.0037 0.1013 0.3638
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0433 0.0433
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0302 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Echinococcus multilocularis cysteine protease 0.0019 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) cysteine protease 0.0019 0.0302 0.0302
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.2685 1
Toxoplasma gondii exonuclease III APE 0.0041 0.1184 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1013 0.3638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1692 0.1692
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.1184 0.4287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.1184 0.102
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.1184 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0433 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.039 0.039
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0079 0.2685 0.2685
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0302 0.093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0079 0.2685 0.3772
Echinococcus granulosus RUN 0.0022 0.0433 0.0433
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.039 0.039
Schistosoma mansoni ap endonuclease 0.0041 0.1184 0.1663
Entamoeba histolytica hypothetical protein 0.0077 0.26 0.9678
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0433 0.0433
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Schistosoma mansoni thyroid hormone receptor 0.0021 0.039 0.0549
Brugia malayi beta-lactamase family protein 0.0037 0.1013 0.1013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Brugia malayi beta-lactamase 0.0037 0.1013 0.1013
Echinococcus granulosus ubiquitin specific protease 41 0.0079 0.2685 0.2685
Onchocerca volvulus 0.0022 0.0433 0.0502
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.1184 0.1184
Schistosoma mansoni coup transcription factor 0.0021 0.039 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0302 0.0327
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Brugia malayi Doublecortin family protein 0.0022 0.0433 0.0433
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1013 0.8067
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.1184 0.3701
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0302 0.0302
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0302 0.0302
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0022 0.0433 0.0608
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0079 0.2685 0.3772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.1184 0.3701
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0433 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.26 0.3653
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0433 0.0433
Brugia malayi beta-lactamase family protein 0.0037 0.1013 0.1013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Entamoeba histolytica cysteine protease, putative 0.0019 0.0302 0.093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.1184 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.039 0.039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.039 0.039
Brugia malayi hypothetical protein 0.0022 0.0433 0.0433
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.039 0.0549
Onchocerca volvulus 0.0021 0.039 0.0445
Echinococcus granulosus geminin 0.0191 0.7117 0.7117
Brugia malayi hypothetical protein 0.0077 0.26 0.26
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.039 0.039
Schistosoma mansoni survival motor neuron protein 0.0054 0.1692 0.2377
Schistosoma mansoni hypothetical protein 0.0077 0.26 0.3653
Echinococcus multilocularis RUN 0.0022 0.0433 0.0433
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.8829 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.039 0.039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.1184 0.1184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.039 0.039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.039 0.0549
Onchocerca volvulus 0.0019 0.0302 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0433 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.039 0.039
Brugia malayi Cathepsin L-like precursor 0.0019 0.0302 0.0302
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.039 0.0549
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0433 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1013 0.2985
Mycobacterium leprae Probable lipase LipE 0.0037 0.1013 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1013 0.3638
Echinococcus multilocularis survival motor neuron protein 1 0.0263 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.039 0.039
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.2685 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0302 0.093
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.4768 0.4768
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.2685 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.039 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.039 0.039
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.039 0.039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.039 0.039
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.2379 0.8715
Toxoplasma gondii ABC1 family protein 0.0037 0.1013 0.8067
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0302 0.0424
Schistosoma mansoni hypothetical protein 0.0191 0.7117 1
Schistosoma mansoni lipoxygenase 0.0092 0.3202 0.4499
Leishmania major hypothetical protein, conserved 0.0037 0.1013 0.2985
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.2134 0.769
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0433 0.0433
Brugia malayi hypothetical protein 0.0022 0.0433 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.039 0.039
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0263 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.1013 0.1013
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1013 0.2985
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.039 0.039
Onchocerca volvulus 0.0037 0.1013 0.1279
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0079 0.2685 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.039 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0302 0.093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.039 0.039
Brugia malayi steroid hormone receptor 0.0021 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0302 0.0302
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.1184 0.5
Onchocerca volvulus 0.0019 0.0302 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.2379 0.8168
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0302 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0021 0.039 0.039
Brugia malayi N-terminal motif family protein 0.0201 0.7531 0.7531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.039 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1013 0.1424
Brugia malayi nuclear hormone receptor 0.0021 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0191 0.7117 1
Echinococcus multilocularis cysteine protease 0.0019 0.0302 0.0302
Onchocerca volvulus 0.0019 0.0302 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0302 0.093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.039 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.039 0.039
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.1184 0.0218
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0079 0.2685 1
Onchocerca volvulus 0.0037 0.1013 0.1279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.039 0.039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.039 0.039
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0433 0.1488
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1013 0.1013
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1013 0.3638
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.039
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.2379 0.8715
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.039 0.0445
Echinococcus granulosus cathepsin l1 0.0012 0.0058 0.0058
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0302 0.0302

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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