Detailed information for compound 724373

Basic information

Technical information
  • TDR Targets ID: 724373
  • Name: N-(2-fluorophenyl)-2-[(4-methoxy-3-methylphen yl)sulfonyl-(phenylmethyl)amino]acetamide
  • MW: 442.503 | Formula: C23H23FN2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.9 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)S(=O)(=O)N(CC(=O)Nc1ccccc1F)Cc1ccccc1
  • InChi: 1S/C23H23FN2O4S/c1-17-14-19(12-13-22(17)30-2)31(28,29)26(15-18-8-4-3-5-9-18)16-23(27)25-21-11-7-6-10-20(21)24/h3-14H,15-16H2,1-2H3,(H,25,27)
  • InChiKey: RLWFOWLDPADNHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluorophenyl)-2-[(4-methoxy-3-methyl-phenyl)sulfonyl-(phenylmethyl)amino]acetamide
  • 2-[benzyl-(4-methoxy-3-methyl-phenyl)sulfonyl-amino]-N-(2-fluorophenyl)acetamide
  • N-(2-fluorophenyl)-2-[(4-methoxy-3-methyl-phenyl)sulfonyl-(phenylmethyl)amino]ethanamide
  • ZINC01076287

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4793 0.5002
Schistosoma mansoni ap endonuclease 0.0022 0.02 0.02
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0832 0.9582 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0311 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0241 0.0452
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.02 0.0642
Onchocerca volvulus 0.0025 0.0241 0.1031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.02 0.0857
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0241 0.0452
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0053 0.0566 0.2433
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0241 0.1031
Schistosoma mansoni cript-related 0.0004 0.0002 0.0002
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0241 0.0499
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.02 0.0415
Echinococcus granulosus thioredoxin glutathione reductase 0.0273 0.3115 0.6498
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0241 0.0772
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0566 0.1067
Schistosoma mansoni cpg binding protein 0.0029 0.0291 0.0291
Plasmodium falciparum thioredoxin reductase 0.0272 0.3096 1
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0241 0.1031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0094 0.1041 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0241 0.048
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0241 0.0452
Mycobacterium ulcerans hypothetical protein 0.0053 0.0566 0.4345
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0056 0.0177
Leishmania major hypothetical protein, conserved 0.0025 0.0241 0.0452
Loa Loa (eye worm) thioredoxin reductase 0.0272 0.3096 1
Echinococcus granulosus cpg binding protein 0.0031 0.0311 0.0645
Leishmania major hypothetical protein, conserved 0.0025 0.0241 0.0452
Loa Loa (eye worm) glutathione reductase 0.0272 0.3096 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0241 0.0452
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0036 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0241 0.0499
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0241 0.1031
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0241 0.0772
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0094 0.1041 0.1041
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0689 0.7926 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0241 0.0772
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0094 0.1041 0.3359
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0241 0.0772
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0241 0.1031
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0241 0.0452
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0241 0.0772
Trypanosoma brucei trypanothione reductase 0.0272 0.3096 0.5857
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0291 0.0936
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0241 0.0249
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0241 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.1041 0.1967
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.1041 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0094 0.1041 0.1967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0241 0.048
Brugia malayi Thioredoxin reductase 0.0272 0.3096 1
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.02 0.0251
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0053 0.0566 0.4345
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0241 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0241 0.048
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0004 0.0002 0.0002
Echinococcus granulosus citrate lyase subunit beta protein 0.0053 0.0566 0.1177
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.1041 0.1967
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0752 0.2424
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0241 0.0452
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0241 0.1031
Schistosoma mansoni glutamate synthase 0.0025 0.0241 0.0241
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.062 0.7126 0.899
Toxoplasma gondii NADPH-glutathione reductase 0.0094 0.1041 0.3359
Brugia malayi glutamate synthase 0.0025 0.0241 0.0772
Onchocerca volvulus Serine\/threonine kinase homolog 0.0205 0.232 1
Trypanosoma cruzi hypothetical protein, conserved 0.0461 0.5286 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0241 0.0772
Plasmodium falciparum thioredoxin reductase 0.0094 0.1041 0.3359
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0241 0.0452
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0241 0.048
Mycobacterium tuberculosis Probable reductase 0.062 0.7126 0.899
Toxoplasma gondii thioredoxin reductase 0.0272 0.3096 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0241 0.0302
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0241 0.1031
Plasmodium falciparum glutathione reductase 0.0272 0.3096 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0115
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0241 0.048
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0241 0.1031
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0053 0.0566 0.4345
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0094 0.1041 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0094 0.1041 0.3359
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0241 0.0499
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0205 0.232 0.7491
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0241 0.1031
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.02 0.0207
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.1041 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0241 0.0772
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0241 0.1031
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0036 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0094 0.1041 0.3359
Leishmania major hypothetical protein, conserved 0.0025 0.0241 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Schistosoma mansoni synaptojanin 0.0004 0.0002 0.0002
Giardia lamblia Kinase, PLK 0.0205 0.232 1
Brugia malayi glutathione reductase 0.0272 0.3096 1
Giardia lamblia Glutamate synthase 0.0025 0.0241 0.1031
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0689 0.7926 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0241 0.0499
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0094 0.1041 0.1085
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.02 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.1041 0.1967
Trichomonas vaginalis glutathione reductase, putative 0.0094 0.1041 0.4484
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0028 0.0115
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0241 0.0772
Mycobacterium tuberculosis Putative ferredoxin reductase 0.062 0.7126 0.899
Giardia lamblia NADH oxidase lateral transfer candidate 0.0094 0.1041 0.4484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0241 0.0772
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0241 0.1031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.02 0.0642
Schistosoma mansoni cpg binding protein 0.0031 0.0311 0.0311
Brugia malayi serine/threonine-protein kinase plk-2 0.0205 0.232 0.7491
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0028 0.0115
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0241 0.0302
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0241 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.232 0.232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Plasmodium vivax thioredoxin reductase, putative 0.0272 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0241 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0094 0.1041 1
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0241 0.0772
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0241 0.0772
Trypanosoma cruzi hypothetical protein, conserved 0.0461 0.5286 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0672 0.0672
Leishmania major NADH dehydrogenase, putative 0.0025 0.0241 0.0452
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0241 0.1031
Echinococcus multilocularis glutamate synthase 0.0025 0.0241 0.0249
Schistosoma mansoni ap endonuclease 0.0022 0.02 0.02
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.232 0.4387
Schistosoma mansoni neutral sphingomyelinase 0.0004 0.0002 0.0002
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0241 0.048
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0241 0.0241
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.062 0.7126 0.899
Echinococcus multilocularis thioredoxin glutathione reductase 0.0273 0.3115 0.325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1124 0.4841
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0241 0.0302
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.232 0.4387
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0241 0.048
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0053 0.0566 0.0712
Treponema pallidum oxidoreductase 0.0025 0.0241 0.2299
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0205 0.232 0.4387
Brugia malayi CXXC zinc finger family protein 0.0029 0.0291 0.0936
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0036 0.0071
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0241 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0241 0.0452
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0241 0.048
Schistosoma mansoni glutamate synthase 0.0025 0.0241 0.0241
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0094 0.1041 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.02 0.0857
Giardia lamblia Thioredoxin reductase 0.0025 0.0241 0.1031
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0241 0.1031
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0241 0.0452
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0241 0.1031
Schistosoma mansoni cpg binding protein 0.0031 0.0311 0.0311
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.02 0.1911
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.02 0.0642
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0595 0.1919
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0094 0.1041 0.1967
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0094 0.1041 0.217
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.02 0.0376
Mycobacterium ulcerans dehydrogenase 0.0025 0.0241 0.048
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0094 0.1041 0.3359
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1124 0.4841
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0566 0.1067
Schistosoma mansoni nocturnin 0.0004 0.0002 0.0002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0241 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Leishmania major hypothetical protein, conserved 0.0461 0.5286 1
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0241 0.048
Mycobacterium ulcerans monoxygenase 0.0025 0.0241 0.048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0241 0.0302
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.062 0.7126 0.8958
Trypanosoma brucei polo-like protein kinase 0.0205 0.232 0.4387
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0241 0.048
Mycobacterium tuberculosis Probable oxidoreductase 0.0689 0.7926 1
Schistosoma mansoni hypothetical protein 0.0418 0.4793 0.4793
Toxoplasma gondii selenide, water dikinase 0.0025 0.0241 0.0772
Leishmania major trypanothione reductase 0.0272 0.3096 0.5857
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0241 0.0452
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0241 0.0452
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0241 0.0249
Trichomonas vaginalis helicase, putative 0.0007 0.0028 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0055 0.0173
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.02 0.0376
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0094 0.1041 0.1967
Schistosoma mansoni kinase 0.0104 0.1155 0.1155
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0241 0.0452
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0241 0.0772
Mycobacterium ulcerans hypothetical protein 0.0053 0.0566 0.4345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.02 0.0376
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0241 0.0452
Plasmodium vivax glutathione reductase, putative 0.0272 0.3096 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0205 0.232 0.242
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0241 0.0772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0241 0.0249
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0094 0.1041 0.1967
Schistosoma mansoni synaptojanin 0.0004 0.0002 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.1041 0.1967
Echinococcus multilocularis citrate lyase subunit beta protein 0.0053 0.0566 0.0589
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.02 0.0857
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0241 0.048
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0053 0.0566 0.4345
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0241 0.0772
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0241 0.1031
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0566 0.1067
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0241 0.0499
Schistosoma mansoni carbon catabolite repressor protein 0.0004 0.0002 0.0002
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0241 0.0452
Mycobacterium ulcerans hypothetical protein 0.0025 0.0241 0.048
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0241 0.0452
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0241 0.0772
Mycobacterium tuberculosis Probable dehydrogenase 0.062 0.7126 0.899
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.1041 0.1967
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0241 0.048
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0241 0.0249
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0205 0.232 0.4838
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.062 0.7126 0.899
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0115
Toxoplasma gondii exonuclease III APE 0.0022 0.02 0.0642
Schistosoma mansoni glutamate synthase 0.0025 0.0241 0.0241
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0094 0.1041 0.3359
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0752 0.2424
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Treponema pallidum NADH oxidase 0.0094 0.1041 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0241 0.0302
Entamoeba histolytica serine/threonine protein kinase, putative 0.0205 0.232 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0094 0.1041 0.3359
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0241 0.1031
Trypanosoma brucei hypothetical protein, conserved 0.0461 0.5286 1
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0025 0.0241 0.048
Onchocerca volvulus 0.0029 0.0291 0.125
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0272 0.3096 0.3905
Mycobacterium tuberculosis Conserved protein 0.0053 0.0566 0.0712
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0241 0.0302
Treponema pallidum thioredoxin reductase (trxB) 0.0025 0.0241 0.2299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0036 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0241 0.1031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.02 0.0376
Trypanosoma cruzi trypanothione reductase, putative 0.0272 0.3096 0.5857
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.1041 0.1967
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.02 0.0642
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4793 1
Trichomonas vaginalis mercuric reductase, putative 0.0094 0.1041 0.4484
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.232 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0241 0.0772
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0241 0.0452
Schistosoma mansoni hypothetical protein 0.0025 0.0241 0.0241
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0094 0.1041 0.1312
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0241 0.0452
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0689 0.7926 1
Echinococcus granulosus glutamate synthase 0.0025 0.0241 0.0499
Plasmodium falciparum glutathione reductase 0.0094 0.1041 0.3359

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.