Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0133 | 0.5104 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0055 | 0.1615 | 0.3164 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.1615 | 0.3164 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.1615 | 0.1615 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.1955 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.1955 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.0837 | 0.1639 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.1615 | 0.3164 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0837 | 0.0837 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.1615 | 0.3164 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 0.5104 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.1615 | 0.3164 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.0837 | 0.0837 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.0837 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1615 | 0.1615 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 0.5104 | 1 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.1615 | 0.1615 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0837 | 0.1639 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.1615 | 0.6955 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.1955 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0133 | 0.5104 | 0.5104 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.1615 | 0.3164 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.5104 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0243 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.5104 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.0837 | 0.1639 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.1615 | 0.3164 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0133 | 0.5104 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0837 | 0.1639 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.0837 | 0.5 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.0837 | 0.1639 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.5104 | 0.5104 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.5104 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0837 | 0.1639 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0062 | 0.1955 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0837 | 0.1639 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.5104 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.1615 | 0.3164 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.1615 | 0.3164 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.7 uM | Antiviral activity against rhinoviral-1B serotype in a plaque inhibition assay using monolayers of M-HeLa cells | ChEMBL. | 2547069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.