Detailed information for compound 725319

Basic information

Technical information
  • TDR Targets ID: 725319
  • Name: 1-(3-methoxypropyl)-3-[(4-morpholin-4-ylpheny l)amino]pyrrolidine-2,5-dione
  • MW: 347.409 | Formula: C18H25N3O4
  • H donors: 1 H acceptors: 2 LogP: 0.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCN1C(=O)CC(C1=O)Nc1ccc(cc1)N1CCOCC1
  • InChi: 1S/C18H25N3O4/c1-24-10-2-7-21-17(22)13-16(18(21)23)19-14-3-5-15(6-4-14)20-8-11-25-12-9-20/h3-6,16,19H,2,7-13H2,1H3
  • InChiKey: PVRPXJFMBDDJMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(3-methoxypropyl)-3-[(4-morpholinophenyl)amino]pyrrolidine-2,5-dione
  • 1-(3-methoxypropyl)-3-[(4-morpholinophenyl)amino]pyrrolidine-2,5-quinone
  • ST5404504

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.06 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0278 0.016
Schistosoma mansoni hypothetical protein 0.0171 0.552 0.5518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.086 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0923 0.0813
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0923 0.1031
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.069 0.0577
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0145 0.0087
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0059 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.0327
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.069 0.179
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0923 0.2413
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Brugia malayi nuclear hormone receptor 0.002 0.0059 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.6712 0.6672
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0195 0.0076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.012 0.0061
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0923 0.2793
Echinococcus granulosus FTZ F1 alpha 0.0042 0.086 0.0955
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0145 0.0129
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0414 0.3665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.086 0.0805
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0923 0.2521
Schistosoma mansoni hypothetical protein 0.0144 0.4536 0.4524
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.086 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Echinococcus granulosus lamin 0.0027 0.033 0.0323
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.012 0.0073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.086 0.0955
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0384 0.8971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.086 0.0955
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3306 0.3224
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0145 0.0102
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3306 0.9574
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0384 0.8971
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0923 0.2413
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.086 0.0846
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0145 0.0087
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.3306 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.033 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3306 0.3224
Brugia malayi 6-phosphofructokinase 0.011 0.3306 0.3295
Brugia malayi intermediate filament protein 0.0027 0.033 0.0315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.086 0.0955
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.086 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0923 0.0813
Schistosoma mansoni hypothetical protein 0.0171 0.552 0.5518
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0086
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0923 0.2793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0414 0.0298
Brugia malayi TAR-binding protein 0.0128 0.3989 0.398
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.4536 0.4528
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Echinococcus granulosus intermediate filament protein 0.0027 0.033 0.0323
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.3306 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1747 0.1735
Brugia malayi conserved hypotetical protein 0.002 0.0059 0.0044
Brugia malayi nuclear hormone receptor 0.0042 0.086 0.0846
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.3306 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.086 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.086 0.0846
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.086 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.086 0.0846
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.086 0.0809
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.086 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0197 0.0078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.086 0.0955
Schistosoma mansoni ap endonuclease 0.0021 0.012 0.0062
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.021 0.694 0.6922
Schistosoma mansoni hypothetical protein 0.0113 0.3448 0.3424
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.069 1
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.3306 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.086 0.0809
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.069 0.179
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.086 0.0846
Echinococcus multilocularis geminin 0.0171 0.552 0.5518
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0252 0.8441 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.086 0.0846
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.069 0.0638
Brugia malayi phosphofructokinase 0.011 0.3306 0.3295
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.086 0.0809
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.086 0.0846
Echinococcus granulosus lamin dm0 0.0027 0.033 0.0323
Brugia malayi nuclear receptor NHR-88 0.002 0.0059 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1747 0.2014
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0923 0.2521
Schistosoma mansoni hypothetical protein 0.0066 0.1747 0.1706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0197 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0384 0.0829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0278 0.016
Schistosoma mansoni nuclear hormone receptor 0.0042 0.086 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.086 0.0846
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0059 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3306 0.3224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.086 0.0846
Brugia malayi 6-phosphofructokinase 0.011 0.3306 0.3295
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.086 0.1276
Schistosoma mansoni hypothetical protein 0.0066 0.1747 0.1706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1011 0.0962
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.069 0.0577
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0384 0.4631
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0384 0.8971
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.086 0.0809
Brugia malayi RNA binding protein 0.0128 0.3989 0.398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.3989 0.3954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1747 0.1735
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Loa Loa (eye worm) hypothetical protein 0.0066 0.1747 0.1698
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.012 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.06 0.0486
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0369 0.0252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1747 0.1706
Echinococcus multilocularis tar DNA binding protein 0.0128 0.3989 0.3971
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3306 0.3224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1747 0.1706
Loa Loa (eye worm) intermediate filament protein 0.0027 0.033 0.0273
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0374 0.0317
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.086 0.0805
Echinococcus granulosus geminin 0.0171 0.552 0.6515
Brugia malayi hypothetical protein 0.002 0.0059 0.0044
Brugia malayi Nuclear hormone receptor E75 0.002 0.0059 0.0044
Brugia malayi MH2 domain containing protein 0.012 0.3674 0.3664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0195 0.0076
Entamoeba histolytica hypothetical protein 0.0113 0.3448 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.06 0.0486
Brugia malayi Inositol-1 0.0037 0.069 0.0676
Brugia malayi Cytochrome P450 family protein 0.0028 0.0374 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3989 0.3971
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0923 0.0873
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.086 0.0809
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Schistosoma mansoni lamin 0.0027 0.033 0.0274
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0601 0.1511
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.3306 0.3266
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.3306 0.328
Schistosoma mansoni thyroid hormone receptor 0.0293 0.9957 1
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.086 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0403 0.0287
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.3306 0.3266
Brugia malayi ecdysteroid receptor 0.0042 0.086 0.0846
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.069 0.0753
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.086 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0197 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3674 0.3637
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.3448 0.3424
Echinococcus multilocularis lamin dm0 0.0027 0.033 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.086 0.0846
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.069 0.179
Schistosoma mansoni hypothetical protein 0.0066 0.1747 0.1706
Schistosoma mansoni lamin 0.0027 0.033 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.086 0.0805
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.086 0.0809
Schistosoma mansoni coup transcription factor 0.0042 0.086 0.0809
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.694 0.6935
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1011 0.0958
Brugia malayi nuclear receptor NHR-67 0.002 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.033 0.0273
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.086 0.0846
Loa Loa (eye worm) RNA binding protein 0.0128 0.3989 0.3954
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.086 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Brugia malayi ecdysone receptor 0.002 0.0059 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.012 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0923 0.0869
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3989 0.3971
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0414 0.0885
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0923 0.0909
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3674 0.3637
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0414 1
Giardia lamblia GTOR 0.0044 0.0923 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0145 0.0086
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0091 0.0275
Schistosoma mansoni 6-phosphofructokinase 0.011 0.3306 0.328
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1747 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0197 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1011 0.0962
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0414 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.086 0.1276
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0414 0.5162
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.086 0.1276
Echinococcus granulosus 6 phosphofructokinase 0.011 0.3306 0.3874
Loa Loa (eye worm) inositol-1 0.0037 0.069 0.0635
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0414 0.5162
Brugia malayi nuclear receptor RXR 0.002 0.0059 0.0044
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0923 0.2521
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.086 0.0809
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.069 0.179
Onchocerca volvulus 0.0027 0.033 0.0432
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.3448 0.3424
Onchocerca volvulus 0.0042 0.086 0.1276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.086 0.0809
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.069 0.1714
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.6712 0.6672
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Schistosoma mansoni hypothetical protein 0.0252 0.8441 0.8469
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3989 0.3971
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.086 0.0846
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.069 0.2088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.06 0.0486
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0145 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1011 0.0997
Entamoeba histolytica hypothetical protein 0.0113 0.3448 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.3306 1
Brugia malayi steroid hormone receptor 0.0042 0.086 0.0846
Brugia malayi hypothetical protein 0.0022 0.0145 0.0129
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0414 1
Echinococcus granulosus tar DNA binding protein 0.0128 0.3989 0.4689
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.694 0.6935
Loa Loa (eye worm) hypothetical protein 0.0027 0.0312 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.086 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0288 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0086
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.086 0.0805
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0601 0.1511
Entamoeba histolytica hypothetical protein 0.0113 0.3448 1
Schistosoma mansoni hypothetical protein 0.0066 0.1747 0.1706
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0384 0.0829
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.6336 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.069 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1011 0.1136
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0414 1
Brugia malayi tailless protein 0.002 0.0059 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.086 0.0809
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.086 0.0955
Loa Loa (eye worm) hypothetical protein 0.0144 0.4536 0.4504
Brugia malayi hypothetical protein 0.0029 0.0384 0.0369
Onchocerca volvulus 0.0027 0.033 0.0432
Echinococcus multilocularis musashi 0.0027 0.033 0.0274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.086 0.0846
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0384 0.1162
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0923 0.2521
Echinococcus multilocularis GPCR, family 2 0.0066 0.1747 0.1706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0288 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.06 0.0486
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1011 0.1136
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0923 0.0873
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0059 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1011 0.0962
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0549 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.086 0.0805
Entamoeba histolytica hypothetical protein 0.0113 0.3448 1
Brugia malayi nuclear receptor NHR-88 0.0042 0.086 0.0846
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.3448 0.4043
Loa Loa (eye worm) phosphofructokinase 0.011 0.3306 0.3266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0195 0.0076
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Schistosoma mansoni intermediate filament proteins 0.0027 0.033 0.0274
Echinococcus multilocularis lamin 0.0027 0.033 0.0274
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.9957 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3989 0.3971
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3989 0.3971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0519 0.0403
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3306 0.9574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1011 0.0962
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.3306 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.0298
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0414 0.5162
Brugia malayi hypothetical protein 0.0022 0.0145 0.0129
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.086 0.0809
Schistosoma mansoni ap endonuclease 0.0021 0.012 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.0805
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.086 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0288 0.017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.086 0.0809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.086 0.0805
Echinococcus granulosus GPCR family 2 0.0066 0.1747 0.2014
Schistosoma mansoni thyroid hormone receptor 0.0293 0.9957 1
Brugia malayi hypothetical protein 0.002 0.0059 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.069 0.0577
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.033 0.0315
Leishmania major hypothetical protein, conserved 0.0029 0.0384 0.0829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.086 0.0805
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0414 0.5
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.012 0.0363
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0601 0.1819
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0414 0.0924
Schistosoma mansoni 6-phosphofructokinase 0.011 0.3306 0.328
Brugia malayi Nuclear hormone receptor E75 0.002 0.0059 0.0044
Loa Loa (eye worm) TAR-binding protein 0.0128 0.3989 0.3954
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1011 0.0962
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.6336 0.6291
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0145 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0923 0.0813
Schistosoma mansoni inositol monophosphatase 0.0037 0.069 0.0638
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0252 0.8441 0.8469
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.086 0.0955
Brugia malayi hypothetical protein 0.0113 0.3448 0.3437
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0519 0.6987
Trichomonas vaginalis glucosylceramidase, putative 0.0295 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1747 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0692 0.0579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.694 0.6922
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0414 1
Leishmania major ATP-dependent phosphofructokinase 0.011 0.3306 1
Brugia malayi nuclear receptor RXR 0.0022 0.0145 0.0129
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.086 0.0955
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.086 0.0809
Schistosoma mansoni inositol monophosphatase 0.0037 0.069 0.0638
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.3989 0.398
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3306 0.9574

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.