Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0268 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0268 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0268 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0573 | 0.2585 | 0.2585 |
Plasmodium falciparum | cysteine repeat modular protein 2 | 0.0268 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 3 | 0.0268 | 0 | 0.5 |
Entamoeba histolytica | cysteine-rich surface protein, putative | 0.0268 | 0 | 0.5 |
Brugia malayi | ephrin receptor 1 precursor | 0.0543 | 0.2331 | 0.2788 |
Toxoplasma gondii | GCC2 and GCC3 domain-containing protein | 0.0268 | 0 | 0.5 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.1406 | 0.9657 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0268 | 0 | 0.5 |
Onchocerca volvulus | 0.1125 | 0.7276 | 0.8199 | |
Entamoeba histolytica | protein kinase, putative | 0.0268 | 0 | 0.5 |
Schistosoma mansoni | ephrin receptor | 0.1138 | 0.7381 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0268 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0268 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0268 | 0 | 0.5 |
Giardia lamblia | CEGP1 protein | 0.0268 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0268 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 2, putative | 0.0268 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1314 | 0.8874 | 1 |
Plasmodium vivax | cysteine repeat modular protein 3, putative | 0.0268 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.12 | 0.7905 | 0.7905 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1253 | 0.8362 | 0.8362 |
Plasmodium falciparum | conserved protein, unknown function | 0.0268 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.1253 | 0.8362 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 4 | 0.0268 | 0 | 0.5 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.1406 | 0.9657 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0268 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1125 | 0.7276 | 0.7276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.03 uM | Ability to inhibit cytopathogenicity of thymidine kinase-deficient (TK-) strain of Varicella zoster virus (YS/R) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 1.03 uM | Ability to inhibit cytopathogenicity of thymidine kinase-deficient (TK-) strain of Varicella zoster virus (YS/R) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 3.98 uM | Anticancer activity carried out in vitro against human T-lymphocyte CEM/0 | ChEMBL. | 11356110 |
IC50 (functional) | = 4.4 uM | Ability to inhibit cytopathogenicity of thymidine kinase-positive(TK+) strain of Varicella zoster virus (YS) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 4.4 uM | Ability to inhibit cytopathogenicity of thymidine kinase-positive(TK+) strain of Varicella zoster virus (YS) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 5.81 uM | Anticancer activity carried out in vitro against murine leukemia L1210 | ChEMBL. | 11356110 |
IC50 (functional) | = 5.81 uM | Anticancer activity carried out in vitro against murine leukemia L1210 | ChEMBL. | 11356110 |
IC50 (functional) | = 6.49 uM | Anticancer activity carried out in vitro against murine leukemia P388 | ChEMBL. | 11356110 |
IC50 (functional) | = 6.49 uM | Anticancer activity carried out in vitro against murine leukemia P388 | ChEMBL. | 11356110 |
IC50 (functional) | = 7.35 uM | Anticancer activity carried out in vitro against human T-lymphocyte Molt4/C8 | ChEMBL. | 11356110 |
IC50 (functional) | = 9.83 uM | Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (KOS) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 9.83 uM | Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (KOS) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 14.82 uM | Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (G) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 14.82 uM | Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (G) in HeLa cell culture | ChEMBL. | 11356110 |
IC50 (functional) | = 15.43 uM | Anticancer activity carried out in vitro against breast carcinoma MCF-7 | ChEMBL. | 11356110 |
IC50 (functional) | = 15.43 uM | Anticancer activity carried out in vitro against breast carcinoma MCF-7 | ChEMBL. | 11356110 |
IC50 (functional) | = 19.32 uM | Concentration required to cause microscopically visible change or disruption in about 50% of cell sheet of HeLa cells | ChEMBL. | 11356110 |
IC50 (functional) | = 19.32 uM | Concentration required to cause microscopically visible change or disruption in about 50% of cell sheet of HeLa cells | ChEMBL. | 11356110 |
Inhibition (binding) | = 37.61 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 100 microM | ChEMBL. | 11356110 |
Inhibition (binding) | = 37.61 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 100 microM | ChEMBL. | 11356110 |
Inhibition (binding) | = 71.2299999999999 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 10.0 microM | ChEMBL. | 11356110 |
Inhibition (binding) | = 71.23 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 10.0 microM | ChEMBL. | 11356110 |
Inhibition (binding) | = 91.03 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 1.0 microM | ChEMBL. | 11356110 |
Inhibition (binding) | = 91.03 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 1.0 microM | ChEMBL. | 11356110 |
Inhibition (binding) | > 99 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 0.1 microM | ChEMBL. | 11356110 |
Inhibition (binding) | > 99 % | Inhibitory activity against purified Bovine liver S-adenosylhomocysteine hydrolase at 0.1 microM | ChEMBL. | 11356110 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 11356110 | |
Homo sapiens | ChEMBL23 | 11356110 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.