Detailed information for compound 725491

Basic information

Technical information
  • TDR Targets ID: 725491
  • Name: 1-[3-(2,4-dimethyl-6-prop-2-enylphenoxy)propy l]-4-methylpiperazine
  • MW: 302.454 | Formula: C19H30N2O
  • H donors: 0 H acceptors: 0 LogP: 3.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCc1cc(C)cc(c1OCCCN1CCN(CC1)C)C
  • InChi: 1S/C19H30N2O/c1-5-7-18-15-16(2)14-17(3)19(18)22-13-6-8-21-11-9-20(4)10-12-21/h5,14-15H,1,6-13H2,2-4H3
  • InChiKey: LTRVTBWSFZJKEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-(2-allyl-4,6-dimethyl-phenoxy)propyl]-4-methyl-piperazine
  • 1-[3-(2-allyl-4,6-dimethylphenoxy)propyl]-4-methylpiperazine
  • 1-[3-(2,4-dimethyl-6-prop-2-enyl-phenoxy)propyl]-4-methyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0025 0.0039 0.0069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0191 0.1077 1
Trichomonas vaginalis esterase, putative 0.0157 0.086 0.1502
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0103 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Echinococcus granulosus intermediate filament protein 0.0057 0.0238 0.0217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0181 0.1014 0.1063
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.1434 0.1401
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0072 0.0127
Schistosoma mansoni lamin 0.0057 0.0238 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0077 0.0041
Brugia malayi MH2 domain containing protein 0.0506 0.305 0.5384
Toxoplasma gondii aldehyde dehydrogenase 0.0191 0.1077 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0097 0.017
Brugia malayi beta-lactamase family protein 0.0157 0.086 0.1518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0572 0.3462 0.6111
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.014 0.147
Onchocerca volvulus 0.0057 0.0238 0.1425
Loa Loa (eye worm) hypothetical protein 0.0248 0.1434 0.2531
Brugia malayi RNA recognition motif domain containing protein 0.0462 0.2772 0.4893
Loa Loa (eye worm) hypothetical protein 0.0924 0.5666 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0197 0.0348
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0206 0.2039
Loa Loa (eye worm) hypothetical protein 0.0391 0.2329 0.411
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0097 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Echinococcus granulosus lamin 0.0057 0.0238 0.0217
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0063
Schistosoma mansoni smad 0.0035 0.0097 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0025 0.0039 0.0273
Onchocerca volvulus 0.0157 0.086 0.5875
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Brugia malayi MH2 domain containing protein 0.0035 0.0097 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1077 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0125 0.5
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2772 0.298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.014 0.0184
Loa Loa (eye worm) calcium channel 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0103 0.0181
Loa Loa (eye worm) ion channel NompC 0.0025 0.0039 0.0069
Mycobacterium leprae Probable lipase LipE 0.0157 0.086 1
Brugia malayi cation channel family protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0103 0.0117
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1437 0.2556
Trypanosoma brucei glucosidase, putative 0.0036 0.0103 0.1029
Entamoeba histolytica hypothetical protein 0.0193 0.1091 1
Mycobacterium leprae conserved hypothetical protein 0.0157 0.086 1
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.0039 0.0000000089573
Mycobacterium ulcerans lipase LipD 0.0157 0.086 0.7721
Brugia malayi Smad1 0.0035 0.0097 0.017
Brugia malayi Transient-receptor-potential like protein 0.0025 0.0039 0.0069
Brugia malayi ion channel NompC 0.0025 0.0039 0.0069
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0125 0.0094
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.1434 0.1521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0206 0.0306
Echinococcus granulosus lamin dm0 0.0057 0.0238 0.0217
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0103 0.0064
Onchocerca volvulus 0.0107 0.0551 0.3665
Onchocerca volvulus 0.0093 0.046 0.3011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0125 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1077 1
Brugia malayi hypothetical protein 0.0025 0.0039 0.0069
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0103 0.0181
Loa Loa (eye worm) voltage-dependent calcium channel 0.0025 0.0039 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0159 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.086 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0053 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0025 0.0039 0.0069
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0025 0.0039 0.0069
Onchocerca volvulus 0.0157 0.086 0.5875
Echinococcus multilocularis GPCR, family 2 0.0181 0.1014 0.0979
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0025 0.0039 0.0273
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0103 0.0117
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.086 0.1502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0075 0.0066
Onchocerca volvulus 0.0249 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Schistosoma mansoni hypothetical protein 0.0181 0.1014 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0053 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Mycobacterium tuberculosis Conserved protein 0.0157 0.086 0.1259
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0462 0.2772 0.4893
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0551 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.014 0.0184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0572 0.3462 0.6111
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0025 0.0039 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0092 0.0097
Echinococcus multilocularis Smad4 0.0035 0.0097 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Schistosoma mansoni transient receptor potential channel 0.0025 0.0039 0.0000000089573
Brugia malayi olfactory channel protein osm-9 0.0025 0.0039 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0103 0.0778
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) RNA binding protein 0.0462 0.2772 0.4893
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0103 0.0117
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) TAR-binding protein 0.0462 0.2772 0.4893
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0882 0.0846
Loa Loa (eye worm) voltage-gated potassium channel 0.0025 0.0039 0.0069
Schistosoma mansoni hypothetical protein 0.0181 0.1014 0.1063
Entamoeba histolytica hypothetical protein 0.0193 0.1091 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.014 0.0974
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0305 0.3239
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0206 0.1613
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0125 0.0832
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0191 0.1077 0.1618
Echinococcus granulosus microtubule associated protein 2 0.1491 0.9209 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0125 0.1052
Mycobacterium tuberculosis Conserved protein 0.0157 0.086 0.1259
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0193 0.1091 0.1148
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0214 0.2133
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0191 0.1077 0.1132
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.086 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0077 0.0041
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0882 0.1557
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.086 0.1502
Echinococcus multilocularis smad 0.0035 0.0097 0.0058
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0077 0.0364
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Onchocerca volvulus 0.0157 0.086 0.5875
Mycobacterium tuberculosis Conserved protein 0.0157 0.086 0.1259
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0125 0.1296
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0305 0.3239
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0125 0.0158
Loa Loa (eye worm) beta-lactamase 0.0157 0.086 0.1518
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.0039 0.0000000082463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0206 0.0306
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0069 0.0033
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0206 0.2256
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0135
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0305 0.3239
Loa Loa (eye worm) ryanodine receptor 0.0025 0.0039 0.0069
Echinococcus granulosus tumor protein p63 0.0732 0.4462 0.4823
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.086 0.0895
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0025 0.0039 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.014 0.1231
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0025 0.0039 0.0069
Brugia malayi MH2 domain containing protein 0.0035 0.0097 0.017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0077 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0193 0.1091 0.1148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0572 0.3462 0.6111
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0181 0.1014 0.0979
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.086 0.1502
Brugia malayi cation channel family protein 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Brugia malayi Pre-SET motif family protein 0.0218 0.1248 0.2202
Echinococcus granulosus GPCR family 2 0.0181 0.1014 0.1063
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0103 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0103 0.0117
Mycobacterium ulcerans hypothetical protein 0.0157 0.086 0.7721
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0238 0.042
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0025 0.0039 0.0069
Schistosoma mansoni hypothetical protein 0.0181 0.1014 0.1063
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0206 0.0168
Brugia malayi beta-lactamase 0.0157 0.086 0.1518
Loa Loa (eye worm) hypothetical protein 0.0056 0.0232 0.0409
Echinococcus multilocularis microtubule associated protein 2 0.1491 0.9209 0.9206
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.0039 0.0000000089573
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0206 0.0183
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0206 0.2256
Echinococcus multilocularis lamin dm0 0.0057 0.0238 0.02
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0077 0.0041
Giardia lamblia GTOR 0.0052 0.0206 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0157 0.086 0.1259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0075 0.0066
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0882 0.0919
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0882 0.1557
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1077 1
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0462 0.2772 0.2744
Loa Loa (eye worm) voltage-gated calcium channel 0.0025 0.0039 0.0069
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0157 0.086 0.1259
Trypanosoma brucei hypothetical protein, conserved 0.0157 0.086 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0157 0.086 0.1259
Schistosoma mansoni hypothetical protein 0.0346 0.2049 0.2192
Schistosoma mansoni hypothetical protein 0.0346 0.2049 0.2192
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0103 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Echinococcus granulosus beta LACTamase domain containing family member 0.0157 0.086 0.0895
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0882 0.0846
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0025 0.0039 0.0069
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0025 0.0039 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0077 0.0041
Echinococcus granulosus smad 0.0035 0.0097 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0238 0.042
Mycobacterium ulcerans esterase/lipase LipP 0.0157 0.086 0.7721
Mycobacterium tuberculosis Probable lipase LipD 0.0157 0.086 0.1259
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.086 0.1502
Loa Loa (eye worm) voltage-gated potassium channel 0.0025 0.0039 0.0069
Brugia malayi Pre-SET motif family protein 0.0031 0.0077 0.0135
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.0039 0.0000000082463
Loa Loa (eye worm) transcription factor SMAD2 0.0506 0.305 0.5384
Schistosoma mansoni transient receptor potential channel 0.0025 0.0039 0.0000000089573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0206 0.0364
Schistosoma mansoni survival motor neuron protein 0.0051 0.0197 0.0173
Leishmania major cathepsin L-like protease 0.0068 0.0305 0.2562
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0924 0.5666 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0125 0.0158
Brugia malayi Latrophilin receptor protein 2 0.0181 0.1014 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.014 0.0184
Schistosoma mansoni hypothetical protein 0.0193 0.1091 0.1148
Brugia malayi TAR-binding protein 0.0462 0.2772 0.4893
Onchocerca volvulus 0.0057 0.0238 0.1425
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0125 0.0228
Loa Loa (eye worm) hypothetical protein 0.0181 0.1014 0.1789
Onchocerca volvulus 0.0051 0.0197 0.1134
Brugia malayi intermediate filament protein 0.0057 0.0238 0.042
Loa Loa (eye worm) hypothetical protein 0.0572 0.3462 0.6111
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2772 0.298
Schistosoma mansoni microtubule-associated protein tau 0.1491 0.9209 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0157 0.086 0.1518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.014 0.0184
Echinococcus granulosus Smad4 0.0035 0.0097 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0103 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2772 0.298
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0035 0.0222
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0103 0.0117
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0206 0.1048
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0025 0.0039 0.0069
Schistosoma mansoni alpha-glucosidase 0.0138 0.0742 0.0767
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0077 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0103 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0125 0.0832
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0103 0.0615
Brugia malayi voltage-dependent calcium channel 0.0025 0.0039 0.0069
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0077 0.0038
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Leishmania major hypothetical protein, conserved 0.0157 0.086 0.7911
Schistosoma mansoni hypothetical protein 0.0391 0.2329 0.2497
Schistosoma mansoni alpha-glucosidase 0.0138 0.0742 0.0767
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0094
Echinococcus granulosus tar DNA binding protein 0.0462 0.2772 0.298
Schistosoma mansoni hypothetical protein 0.0051 0.0197 0.0173
Loa Loa (eye worm) hypothetical protein 0.0107 0.0551 0.0973
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0181 0.1014 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0181 0.1014 0.1789
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0157 0.086 0.1518
Loa Loa (eye worm) Smad1 0.0035 0.0097 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0082
Schistosoma mansoni lamin 0.0057 0.0238 0.0217
Toxoplasma gondii ABC1 family protein 0.0157 0.086 0.7911
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0206 0.1613
Echinococcus multilocularis geminin 0.0346 0.2049 0.2018
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0025 0.0039 0.0069
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0097 0.0058
Brugia malayi Inositol-1 0.0039 0.0125 0.0221
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0206 0.0364
Brugia malayi RNA binding protein 0.0462 0.2772 0.4893
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0097 0.0063
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0206 0.0183
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.1077 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0123 0.0154
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0206 0.2039
Echinococcus multilocularis tumor protein p63 0.0732 0.4462 0.4441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0181 0.1014 0.0979
Echinococcus multilocularis beta LACTamase domain containing family member 0.0157 0.086 0.0824
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0103 0.0615
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.0039 0.0000000089573
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0268 0.279
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0125 0.1052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0193 0.1091 0.1057
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0025 0.0039 0.0069
Brugia malayi hypothetical protein 0.0193 0.1091 0.1926
Brugia malayi beta-lactamase family protein 0.0157 0.086 0.1518
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0097 0.0063
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0039 0.0069
Loa Loa (eye worm) inositol-1 0.0039 0.0125 0.0221
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0025 0.0039 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0238 0.042
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0039 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0073 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2772 0.298
Schistosoma mansoni inositol monophosphatase 0.0039 0.0125 0.0094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0238 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0073 0.0063
Mycobacterium tuberculosis Probable hydrolase 0.0157 0.086 0.1259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0103 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0506 0.305 0.5384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0206 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.086 0.1502
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0305 0.3239
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0025 0.0039 0.0069
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0125 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Entamoeba histolytica hypothetical protein 0.0193 0.1091 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0072 0.0127
Echinococcus multilocularis musashi 0.0057 0.0238 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0099 0.011
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.1077 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0899 0.5507 1
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2772 0.298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0305 0.3423
Plasmodium vivax hypothetical protein, conserved 0.0157 0.086 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.086 0.1518
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0025 0.0039 0.0069
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0097 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.014 0.0184
Brugia malayi hypothetical protein 0.0248 0.1434 0.2531
Leishmania major cathepsin L-like protease 0.0068 0.0305 0.2562
Brugia malayi MH1 domain containing protein 0.0035 0.0097 0.017
Mycobacterium ulcerans beta-lactamase 0.0157 0.086 0.7721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0056 0.0032
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0123 0.0809
Echinococcus granulosus geminin 0.0346 0.2049 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0075 0.0066
Echinococcus multilocularis lamin 0.0057 0.0238 0.02
Schistosoma mansoni smad1 5 8 and 0.0035 0.0097 0.0063
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0191 0.1077 0.1042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Schistosoma mansoni intermediate filament proteins 0.0057 0.0238 0.0217
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0206 0.1048
Leishmania major cathepsin L-like protease 0.0068 0.0305 0.2562
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0181 0.1014 0.1063
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0097 0.017
Brugia malayi Cyclic-nucleotide gated cation channel 0.0025 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0391 0.2329 0.411
Mycobacterium tuberculosis Probable lipase LipE 0.0157 0.086 0.1259
Onchocerca volvulus 0.0031 0.0077 0.027
Entamoeba histolytica hypothetical protein 0.0193 0.1091 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0069
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1 0.6138 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0125 0.0094
Mycobacterium tuberculosis Probable esterase LipL 0.0157 0.086 0.1259
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.0039 0.0000000082463
Schistosoma mansoni alpha glucosidase 0.0036 0.0103 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.086 0.0895
Brugia malayi MH1 domain containing protein 0.0035 0.0097 0.017
Schistosoma mansoni Smad4 0.0035 0.0097 0.0063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0157 0.086 0.7721
Schistosoma mansoni hypothetical protein 0.0181 0.1014 0.1063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1248 0.2202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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