Detailed information for compound 725617

Basic information

Technical information
  • TDR Targets ID: 725617
  • Name: 4-[2-(2-bromo-4-chloro-6-methylphenoxy)ethyl] morpholine
  • MW: 334.637 | Formula: C13H17BrClNO2
  • H donors: 0 H acceptors: 0 LogP: 3.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(C)c(c(c1)Br)OCCN1CCOCC1
  • InChi: 1S/C13H17BrClNO2/c1-10-8-11(15)9-12(14)13(10)18-7-4-16-2-5-17-6-3-16/h8-9H,2-7H2,1H3
  • InChiKey: CVMVDUGHXROGNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(2-bromo-4-chloro-6-methyl-phenoxy)ethyl]morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0163 0.313 0.3248
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0729 0.0789
Brugia malayi acetyltransferase, GNAT family protein 0.0448 0.9242 0.9592
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0135 0.2525 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Onchocerca volvulus 0.0076 0.1247 0.2512
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0769 0.0832
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0753 0.1206
Trypanosoma cruzi ISWI complex protein 0.0031 0.0291 0.0465
Leishmania major DNA polymerase kappa, putative 0.0021 0.0063 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0319 0.6467 0.6712
Trypanosoma cruzi ISWI complex protein 0.0031 0.0291 0.0465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.5783 0.6518
Echinococcus granulosus tumor protein p63 0.0352 0.7179 0.8091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis bromodomain-containing protein, putative 0.0135 0.2525 0.5087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0769 0.0798
Schistosoma mansoni bromodomain containing protein 0.002 0.0043 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.5783 0.6002
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.063 0.0653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.043 0.0687
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0447 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0448
Schistosoma mansoni transient receptor potential channel 0.0097 0.1709 0.1849
Entamoeba histolytica hypothetical protein 0.0115 0.2085 0.9529
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.1247 0.4009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.1247 0.1247
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.1247 0.1406
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0166 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Onchocerca volvulus 0.0249 0.4963 1
Schistosoma mansoni hypothetical protein 0.0148 0.2791 0.302
Giardia lamblia Histone acetyltransferase GCN5 0.012 0.2188 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0447 0.09
Entamoeba histolytica acetyltransferase, GNAT family 0.012 0.2188 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0447 0.1806
Mycobacterium leprae conserved hypothetical protein 0.0076 0.1247 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0447 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Brugia malayi MH2 domain containing protein 0.012 0.2188 0.2271
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0166 0.0335
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Brugia malayi mbt repeat family protein 0.0047 0.063 0.0653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0047 0.0627 0.0651
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.4139
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Brugia malayi Pre-SET motif family protein 0.0219 0.4315 0.4478
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1247 0.1997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Loa Loa (eye worm) hypothetical protein 0.0467 0.9635 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.104 0.1126
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.2757 0.4375
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0063 0.0071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.2085 0.2256
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.104 0.1173
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0399 0.0449
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.104 0.1126
Loa Loa (eye worm) hypothetical protein 0.0061 0.0933 0.0968
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4315 0.4478
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.104 0.1126
Mycobacterium ulcerans hypothetical protein 0.0076 0.1247 0.4009
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0063 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.5783 0.6518
Schistosoma mansoni transient receptor potential channel 0.0064 0.1003 0.1085
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0447 0.1436
Schistosoma mansoni transient receptor potential channel 0.0064 0.1003 0.1085
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0636 0.0955
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0447 0.0463
Schistosoma mansoni zinc finger protein 0.0031 0.0291 0.0315
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0063 0.0065
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0135 0.2525 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0148 0.2791 0.3146
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.1247 0.1247
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0554 0.0887
Trichomonas vaginalis esterase, putative 0.0076 0.1247 0.2513
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0447 0.1768
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0166 0.0656
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0636 0.1018
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0724 0.1159
Loa Loa (eye worm) MBCTL1 0.0053 0.0769 0.0798
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.5783 0.6002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0367 0.0397
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.4601 0.4775
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.1247 0.1247
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.1247 0.1247
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1247 0.2513
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0296 0.1171
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0636 0.0955
Schistosoma mansoni hypothetical protein 0.0293 0.591 0.6394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0063 0.0068
Brugia malayi mbt repeat family protein 0.0047 0.063 0.0653
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0467 0.9635 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0724 0.3307
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0554 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Onchocerca volvulus 0.0047 0.063 0.1268
Onchocerca volvulus 0.0076 0.1247 0.2512
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0399 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0296 0.032
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.1247 0.1247
Brugia malayi PHD-finger family protein 0.0062 0.0943 0.0979
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.1061 0.1698
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0447 0.065
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.3757 0.4065
Loa Loa (eye worm) beta-lactamase 0.0076 0.1247 0.1294
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0724 0.2866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0063 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.5783 0.6257
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0448 0.9242 1
Brugia malayi Latrophilin receptor protein 2 0.0148 0.2791 0.2896
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0447 0.0715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.2085 0.2256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0447 0.204
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0063 0.0203
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Echinococcus multilocularis zinc finger protein 0.0051 0.0711 0.0769
Onchocerca volvulus 0.0076 0.1247 0.2512
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1003 0.113
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.1709 0.1849
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.6245 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.063 0.071
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.1247 0.4009
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0724 0.3307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.3826 0.397
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1247 0.1349
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0636 0.2905
Mycobacterium ulcerans hypothetical protein 0.0163 0.3111 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.5783 0.6257
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.043 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0135 0.2525 0.5087
Echinococcus granulosus histone acetyltransferase KAT2B 0.0431 0.8872 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1003 0.1085
Leishmania major hypothetical protein, conserved 0.0051 0.0724 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0148 0.2791 0.3146
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0063 0.0203
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1191 0.1343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0607 0.0657
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2188 0.2271
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.063 0.1268
Echinococcus granulosus dna polymerase eta 0.0021 0.0063 0.0071
Entamoeba histolytica hypothetical protein 0.0115 0.2085 0.9529
Plasmodium vivax SET domain protein, putative 0.0031 0.0296 0.1171
Toxoplasma gondii hypothetical protein 0.005 0.0691 0.2736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0467 0.9635 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.3826 0.397
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0148 0.2791 0.2896
Loa Loa (eye worm) hypothetical protein 0.0097 0.1709 0.1773
Toxoplasma gondii exonuclease III APE 0.0038 0.0447 0.1768
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.043 0.0687
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2188 0.2271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.3111 0.3111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0271 0.0306
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0447 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1247 0.2513
Trypanosoma brucei unspecified product 0.0021 0.0063 0.0031
Trichomonas vaginalis set domain proteins, putative 0.0249 0.4963 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Schistosoma mansoni hypothetical protein 0.0148 0.2791 0.302
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0524 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0063 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0135 0.2525 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.1247 0.1294
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0065
Loa Loa (eye worm) hypothetical protein 0.0066 0.104 0.1079
Loa Loa (eye worm) hypothetical protein 0.0052 0.0729 0.0756
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0554 0.0823
Plasmodium falciparum flap endonuclease 1 0.0025 0.0166 0.0757
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.1639 0.1774
Plasmodium falciparum histone acetyltransferase GCN5 0.012 0.2188 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.1247 0.1247
Brugia malayi TAR-binding protein 0.0196 0.3826 0.397
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0636 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Loa Loa (eye worm) hypothetical protein 0.0098 0.1718 0.1782
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0063 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.4139
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0607 0.0684
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.063 0.0681
Loa Loa (eye worm) latrophilin receptor protein 2 0.0148 0.2791 0.2896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0607 0.0657
Echinococcus granulosus dna polymerase kappa 0.0021 0.0063 0.0071
Entamoeba histolytica hypothetical protein 0.0115 0.2085 0.9529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0303 0.061
Schistosoma mansoni hypothetical protein 0.0023 0.0117 0.0126
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0063 0.01
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0636 0.0688
Loa Loa (eye worm) hypothetical protein 0.0078 0.1298 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0758 0.1213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.5783 0.6257
Brugia malayi follicle stimulating hormone receptor 0.0232 0.4601 0.4775
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0769 0.0832
Schistosoma mansoni DNA polymerase eta 0.0021 0.0063 0.0068
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0769 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Schistosoma mansoni hypothetical protein 0.0042 0.0524 0.0567
Echinococcus granulosus flap endonuclease 1 0.0025 0.0166 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.1247 0.1941
Brugia malayi beta-lactamase family protein 0.0076 0.1247 0.1294
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0447 0.0463
Echinococcus granulosus GPCR family 2 0.0148 0.2791 0.3146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0636 0.2905
Brugia malayi hypothetical protein 0.0033 0.0334 0.0346
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0117 0.0132
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0724 0.2866
Loa Loa (eye worm) acetyltransferase 0.0448 0.9242 0.9592
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.6245 1
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.4139
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0769 0.0832
Schistosoma mansoni hypothetical protein 0.0319 0.6467 0.6998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.2757 0.4414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0636 0.066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0367 0.0414
Brugia malayi Bromodomain containing protein 0.0089 0.1528 0.1585
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0 0.0001
Echinococcus multilocularis dna polymerase eta 0.0021 0.0063 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0148 0.2791 0.302
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.6245 1
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0447 0.204
Schistosoma mansoni ap endonuclease 0.0038 0.0447 0.0483
Brugia malayi RNA binding protein 0.0196 0.3826 0.397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0399 0.0431
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.1709 0.1926
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.063 0.0681
Onchocerca volvulus 0.0031 0.0296 0.0595
Schistosoma mansoni bromodomain containing protein 0.014 0.2618 0.2833
Brugia malayi hypothetical protein 0.0115 0.2085 0.2164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Schistosoma mansoni hypothetical protein 0.0148 0.2791 0.302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0724 0.0751
Brugia malayi beta-lactamase family protein 0.0076 0.1247 0.1294
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1247 0.1997
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0636 0.0717
Leishmania major DNA polymerase eta, putative 0.0021 0.0063 0.01
Toxoplasma gondii ABC1 family protein 0.0076 0.1247 0.4939
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.1247 0.1294
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0769 0.0798
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0063 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.063 0.0681
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0315
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0447 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0296 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Loa Loa (eye worm) RNA binding protein 0.0196 0.3826 0.397
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1003 0.113
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.063 0.0681
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0296 0.032
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.4139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Schistosoma mansoni flap endonuclease-1 0.0023 0.0114 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Brugia malayi Pre-SET motif family protein 0.0031 0.0296 0.0307
Plasmodium vivax hypothetical protein, conserved 0.0076 0.1247 0.4939
Mycobacterium ulcerans beta-lactamase 0.0076 0.1247 0.4009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0166 0.0656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.1247 0.1349
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.3757 0.4234
Giardia lamblia GTOR 0.0047 0.0636 0.2696
Schistosoma mansoni zinc finger protein 0.0051 0.0711 0.0769
Schistosoma mansoni hypothetical protein 0.0115 0.2085 0.2256
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0467 0.9635 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0636 0.1018
Schistosoma mansoni hypothetical protein 0.0148 0.2791 0.302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0117 0.0126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.2462 0.2664
Loa Loa (eye worm) hypothetical protein 0.0033 0.0329 0.0341
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0063 0.0063
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.6245 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0636 0.066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0936 0.1499
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0724 0.1097
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Echinococcus multilocularis tar DNA binding protein 0.0196 0.3826 0.4139
Echinococcus granulosus cathepsin l1 0.0018 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0148 0.2791 0.302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0281 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0724 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0488 0.0983
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0447 0.0715
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0166 0.0172
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.063 0.0681
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0063 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.5783 0.6257
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0102 0.0094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0636 0.1018
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0166 0.0757
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0063 0.0127
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0376 0.149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0367 0.0397
Loa Loa (eye worm) hypothetical protein 0.0144 0.271 0.2812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0448
Loa Loa (eye worm) TAR-binding protein 0.0196 0.3826 0.397
Onchocerca volvulus 0.0052 0.0729 0.1468
Loa Loa (eye worm) hypothetical protein 0.0319 0.6467 0.6712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.5783 0.6257
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.1247 0.1247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0367 0.0397
Echinococcus multilocularis tumor protein p63 0.0352 0.7179 0.7767
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.4139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0447 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0447 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0063 0.0068
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.063 0.071
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.2757 0.4414
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0636 0.0688
Echinococcus granulosus tar DNA binding protein 0.0196 0.3826 0.4312
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0063 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.1709 0.1849
Echinococcus granulosus histone acetyltransferase KAT2B 0.0135 0.2525 0.2846
Mycobacterium ulcerans lipase LipD 0.0076 0.1247 0.4009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0447 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0769 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1003 0.1085
Leishmania major hypothetical protein, conserved 0.0031 0.0291 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma brucei ISWI complex protein 0.0031 0.0291 0.0398
Brugia malayi hypothetical protein 0.0051 0.0724 0.0751
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1294
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1191 0.1289
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0166 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.2085 0.235
Brugia malayi Flap endonuclease-1 0.0025 0.0166 0.0172
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0448 0.9242 1
Entamoeba histolytica hypothetical protein 0.0115 0.2085 0.9529
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Schistosoma mansoni ap endonuclease 0.0038 0.0447 0.0483
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0554 0.0887
Mycobacterium leprae Probable lipase LipE 0.0076 0.1247 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.1639 0.1848
Loa Loa (eye worm) hypothetical protein 0.0047 0.063 0.0653
Brugia malayi beta-lactamase 0.0076 0.1247 0.1294
Echinococcus granulosus zinc finger protein 0.0051 0.0711 0.0801
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Loa Loa (eye worm) hypothetical protein 0.0094 0.1634 0.1696
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1247 0.1349
Echinococcus multilocularis GPCR, family 2 0.0148 0.2791 0.302
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2791 0.2896
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.2462 0.2775
Loa Loa (eye worm) hypothetical protein 0.0036 0.0399 0.0413
Leishmania major hypothetical protein, conserved 0.0076 0.1247 0.1997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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