Detailed information for compound 725619

Basic information

Technical information
  • TDR Targets ID: 725619
  • Name: 5-(diethylsulfamoyl)-2-methyl-N-(1,3-thiazol- 2-yl)benzamide
  • MW: 353.46 | Formula: C15H19N3O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(c(c1)C(=O)Nc1nccs1)C)CC
  • InChi: 1S/C15H19N3O3S2/c1-4-18(5-2)23(20,21)12-7-6-11(3)13(10-12)14(19)17-15-16-8-9-22-15/h6-10H,4-5H2,1-3H3,(H,16,17,19)
  • InChiKey: ARZFBFSZCABSES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(diethylsulfamoyl)-2-methyl-N-thiazol-2-yl-benzamide
  • 5-(diethylsulfamoyl)-2-methyl-N-(2-thiazolyl)benzamide
  • ZINC04841720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0872 0.3058
Schistosoma mansoni transient receptor potential channel 0.0094 0.0749 0.1604
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0872 0.3058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0051 0.0178
Trypanosoma brucei C-8 sterol isomerase, putative 0.075 0.7743 0.7742
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0184 0.0645
Onchocerca volvulus 0.0105 0.0872 0.3961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0212 0.2014 0.2989
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0119 0.0113
Brugia malayi Bromodomain containing protein 0.0122 0.1045 0.1343
Schistosoma mansoni ferritin light chain 0.0026 0.0023 0.0036
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0411 0.0603
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0372 0.3717 0.4796
Loa Loa (eye worm) MBCTL1 0.0057 0.0355 0.0451
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0152 0.0668
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0058 0.0077
Toxoplasma gondii thioredoxin reductase 0.0038 0.015 0.1036
Schistosoma mansoni hypothetical protein 0.0046 0.0236 0.0497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0119 0.1018 0.1308
Giardia lamblia GTOR 0.0044 0.0213 0.2052
Loa Loa (eye worm) TAR-binding protein 0.0271 0.2634 0.3397
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0281 0.0356
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0119 0.1018 0.7782
Brugia malayi exodeoxyribonuclease III family protein 0.0119 0.1018 0.1308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0671 0.6906 0.8917
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.3717 0.5525
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0872 0.0867
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2194 0.7691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0182 0.0639
Brugia malayi Thioredoxin reductase 0.0038 0.015 0.0187
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.1707 0.2199
Loa Loa (eye worm) hypothetical protein 0.0129 0.1123 0.1444
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0304 0.2992 0.4445
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0135 0.1191 0.1186
Schistosoma mansoni hypothetical protein 0.0212 0.2014 0.4332
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.0356
Echinococcus multilocularis tar DNA binding protein 0.0271 0.2634 0.3913
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0281 0.0594
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0383 0.3835 0.4949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0024 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Leishmania major trypanothione reductase 0.0038 0.015 0.0145
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0119 0.1018 0.1507
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Schistosoma mansoni inositol transporter 0.0042 0.0195 0.0409
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0184 0.0265
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0406 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0213 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0603 0.5905
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0024 0.0006 0.002
Plasmodium vivax glutathione reductase, putative 0.0038 0.015 0.143
Echinococcus multilocularis chromobox protein 1 0.0067 0.0467 0.0687
Loa Loa (eye worm) glutathione reductase 0.0038 0.015 0.0187
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0184 0.0645
Echinococcus granulosus histone acetyltransferase KAT2B 0.0094 0.0756 0.1117
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0213 0.0309
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0749 0.1107
Onchocerca volvulus 0.004 0.0175 0.0774
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0024 0.0006 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.1895 0.6644
Schistosoma mansoni ap endonuclease 0.0119 0.1018 0.2183
Entamoeba histolytica hypothetical protein 0.0146 0.1306 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0184 0.1276
Schistosoma mansoni hypothetical protein 0.0046 0.0242 0.051
Schistosoma mansoni apoferritin-2 0.0026 0.0023 0.0036
Entamoeba histolytica hypothetical protein 0.0146 0.1306 1
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0766 0.1099
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0766 0.1099
Toxoplasma gondii ABC1 family protein 0.0105 0.0872 0.6202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Brugia malayi PHD-finger family protein 0.0082 0.0619 0.0793
Mycobacterium ulcerans hypothetical protein 0.0105 0.0872 0.1658
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0119 0.1018 0.1013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0212 0.2014 0.2989
Schistosoma mansoni hypothetical protein 0.0459 0.4641 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1707 0.2533
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.1306 0.1936
Schistosoma mansoni chromobox protein 0.0067 0.0467 0.0995
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0119 0.1018 0.1013
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.0195 0.0282
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0872 0.112
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0156 0.0223
Brugia malayi beta-lactamase family protein 0.0105 0.0872 0.112
Loa Loa (eye worm) acetyltransferase 0.0304 0.2992 0.3859
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0119 0.1018 0.1507
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0291 0.2852 0.3679
Schistosoma mansoni high-affinity choline transporter 0.0379 0.3791 0.8166
Brugia malayi Latrophilin receptor protein 2 0.0212 0.2014 0.2595
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0135 0.1191 0.1186
Mycobacterium tuberculosis Conserved protein 0.0105 0.0872 0.1253
Loa Loa (eye worm) hypothetical protein 0.0379 0.3791 0.4892
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0467 0.1638
Loa Loa (eye worm) hypothetical protein 0.008 0.06 0.0768
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0184 0.0645
Trypanosoma cruzi ISWI complex protein 0.0046 0.0236 0.0231
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0184 0.0178
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0664 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0175 0.0365
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0872 0.1253
Brugia malayi RNA recognition motif domain containing protein 0.0271 0.2634 0.3397
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.0892 0.132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0292 0.0426
Loa Loa (eye worm) hypothetical protein 0.0042 0.0195 0.0245
Plasmodium falciparum glutathione reductase 0.0038 0.015 0.143
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.1306 0.2806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Toxoplasma gondii hypothetical protein 0.0155 0.1403 1
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0872 0.0867
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1015 0.1304
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0023 0.0167
Entamoeba histolytica hypothetical protein 0.0146 0.1306 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0184 0.0645
Echinococcus granulosus endonuclease exonuclease phosphatase 0.022 0.21 0.3118
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0847 0.8314
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0872 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0507 0.5149 0.7436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0213 0.0748
Onchocerca volvulus 0.0042 0.0195 0.0867
Loa Loa (eye worm) hypothetical protein 0.0671 0.6906 0.8917
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0281 0.1259
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0094 0.0756 0.5372
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0121 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0415
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0467 0.0596
Schistosoma mansoni cellular tumor antigen P53 0.0096 0.077 0.1649
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0872 0.1253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.1306 0.1936
Loa Loa (eye worm) hypothetical protein 0.0103 0.0847 0.1088
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0024 0.0006 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0872 0.129
Trypanosoma cruzi C-8 sterol isomerase, putative 0.075 0.7743 0.7742
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0112
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0411 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0024 0.0084
Trypanosoma brucei ISWI complex protein 0.0046 0.0236 0.0231
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0281 0.0594
Loa Loa (eye worm) hypothetical protein 0.0092 0.0732 0.0939
Echinococcus granulosus GPCR family 2 0.0212 0.2014 0.2989
Loa Loa (eye worm) hypothetical protein 0.0057 0.0355 0.0451
Brugia malayi hypothetical protein 0.0092 0.0732 0.0939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0213 0.0748
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0182 0.0639
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0664 0.0952
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0872 0.1869
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0281 0.041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0872 0.1253
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0189
Echinococcus granulosus chromobox protein 1 0.0067 0.0467 0.0687
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0408 0.0402
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0184 0.0645
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0872 0.3058
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0119 0.0113
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0603 0.5905
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.3717 0.5525
Onchocerca volvulus Glucosylceramidase homolog 0.0191 0.1785 0.8134
Mycobacterium tuberculosis Conserved protein 0.0105 0.0872 0.1253
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.015 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0872 0.0867
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0184 0.1371
Schistosoma mansoni ferritin 0.0026 0.0023 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0872 0.112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0135 0.1191 0.1186
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0962 1 1
Trypanosoma brucei glucosidase, putative 0.0041 0.0184 0.0178
Toxoplasma gondii exonuclease III APE 0.0119 0.1018 0.7244
Brugia malayi RNA binding protein 0.0271 0.2634 0.3397
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0213 0.0208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0119 0.1018 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0034 0.012
Schistosoma mansoni zinc finger protein 0.0046 0.0236 0.0497
Echinococcus granulosus fetal alzheimer antigen falz 0.0067 0.0467 0.0686
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.015 0.143
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0673 0.6922 1
Echinococcus multilocularis tumor protein p63 0.0654 0.6723 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1897 0.2445
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0213 0.0268
Schistosoma mansoni alpha-glucosidase 0.0158 0.1434 0.3082
Schistosoma mansoni tar DNA-binding protein 0.0271 0.2634 0.5671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0415
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0355 0.052
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0847 0.0842
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0847 0.0842
Loa Loa (eye worm) hypothetical protein 0.0096 0.077 0.0988
Schistosoma mansoni alpha glucosidase 0.0041 0.0184 0.0385
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0119 0.1018 1
Brugia malayi GH02984p 0.0379 0.3791 0.4892
Schistosoma mansoni inositol transporter 0.0042 0.0195 0.0409
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0671 0.6906 0.8917
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0872 0.3058
Schistosoma mansoni ferritin 0.0026 0.0023 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0872 0.1658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0455 0.4601 0.4598
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0006 0.002
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.0195 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1506 0.1501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0094
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0962 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Trichomonas vaginalis ap endonuclease, putative 0.0119 0.1018 0.3568
Loa Loa (eye worm) hypothetical protein 0.0094 0.0749 0.0961
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0847 0.8314
Leishmania major hypothetical protein, conserved 0.0103 0.0847 0.0842
Treponema pallidum exodeoxyribonuclease (exoA) 0.0119 0.1018 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0267 0.0261
Leishmania major C-8 sterol isomerase-like protein 0.075 0.7743 0.7742
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0184 0.0265
Mycobacterium tuberculosis Conserved protein 0.0105 0.0872 0.1253
Echinococcus granulosus ferritin 0.0026 0.0023 0.0025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.0892 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0061 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0212 0.2014 0.2595
Mycobacterium ulcerans lipase LipD 0.0105 0.0872 0.1658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3717 0.8005
Loa Loa (eye worm) hypothetical protein 0.0212 0.2014 0.2595
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0121 0.0172
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0455 0.4601 0.4598
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0213 0.1597
Onchocerca volvulus 0.005 0.0281 0.1259
Schistosoma mansoni ferritin 0.0026 0.0023 0.0036
Brugia malayi beta-lactamase 0.0105 0.0872 0.112
Schistosoma mansoni hypothetical protein 0.0212 0.2014 0.4332
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0213 0.0208
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0749 0.1604
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0271 0.2634 0.3397
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.015 0.0187
Plasmodium falciparum thioredoxin reductase 0.0038 0.015 0.143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0872 0.129
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0185 0.1726 0.2561
Leishmania major cathepsin L-like protease 0.0062 0.0408 0.0402
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0184 0.023
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0355 0.052
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0664 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0152 0.0532
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0408 0.0402
Schistosoma mansoni apoferritin-2 0.0026 0.0023 0.0036
Schistosoma mansoni ferritin 0.0026 0.0023 0.0036
Schistosoma mansoni bromodomain containing protein 0.0196 0.184 0.3956
Leishmania major cathepsin L-like protease 0.0062 0.0408 0.0402
Brugia malayi Bromodomain containing protein 0.0231 0.2212 0.2852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0212 0.2014 0.2989
Onchocerca volvulus 0.0106 0.0882 0.4004
Echinococcus granulosus chromobox protein 1 0.0067 0.0467 0.0687
Echinococcus multilocularis high affinity choline transporter 1 0.0379 0.3791 0.5635
Echinococcus multilocularis solute carrier family 5 0.0042 0.0195 0.0282
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.0195 0.1358
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0094 0.0756 0.7415
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0119 0.1018 0.1942
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0185 0.1726 0.2561
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0872 0.1253
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0156 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0271 0.2634 0.5671
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0152 0.0532
Echinococcus multilocularis chromobox protein 1 0.0067 0.0467 0.0687
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.1707 0.2533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0872 0.1869
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0292 0.0426
Echinococcus multilocularis zinc finger protein 0.0066 0.045 0.0661
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0766 0.8748
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0291 0.2852 0.3679
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0184 0.0645
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0067 0.0467 0.0994
Brugia malayi hypothetical protein 0.0146 0.1306 0.1681
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0119 0.1018 1
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0024 0.0006 0.002
Echinococcus granulosus tumor protein p63 0.0654 0.6723 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.0195 0.0282
Onchocerca volvulus 0.003 0.0065 0.0271
Brugia malayi Heterochromatin protein 1 0.0067 0.0467 0.0596
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0847 0.6023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0119 0.1018 0.1013
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0467 0.1638
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0213 0.0208
Trichomonas vaginalis Phospholipase C precursor, putative 0.0024 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.075 0.7743 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0213 0.0448
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0872 0.1253
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0408 0.0402
Brugia malayi hypothetical protein 0.0066 0.0458 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.06 0.1282
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0119 0.0113
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.06 0.0885
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0119 0.1018 0.1463
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0304 0.2992 0.6442
Leishmania major cathepsin L-like protease 0.0062 0.0408 0.0402
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.015 0.0209
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0847 0.8314
Loa Loa (eye worm) hypothetical protein 0.0135 0.1183 0.1522
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0292 0.0618
Schistosoma mansoni hypothetical protein 0.0327 0.3236 0.6969
Mycobacterium ulcerans beta-lactamase 0.0105 0.0872 0.1658
Echinococcus multilocularis GPCR, family 2 0.0212 0.2014 0.2989
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0184 0.0645
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0242 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.06 0.0885
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0355 0.052
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0872 0.1253
Schistosoma mansoni tar DNA-binding protein 0.0271 0.2634 0.5671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Echinococcus granulosus solute carrier family 5 0.0042 0.0195 0.0282
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0716 0.1057
Mycobacterium ulcerans hypothetical protein 0.0507 0.5149 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0023 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3717 0.8005
Brugia malayi ERG2 and Sigma1 receptor like protein 0.075 0.7743 1
Brugia malayi Pre-SET motif family protein 0.0201 0.1897 0.2445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0664 0.0952
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0281 0.041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.3717 0.5525
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0182 0.0807
Onchocerca volvulus 0.0096 0.077 0.3495
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1707 0.2533
Echinococcus granulosus tar DNA binding protein 0.0271 0.2634 0.3913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0094
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0411 0.0603
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0872 0.8562
Trichomonas vaginalis esterase, putative 0.0105 0.0872 0.3058
Brugia malayi latrophilin 2 splice variant baaae 0.0459 0.4641 0.5991
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0212 0.2014 0.2595
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1015 0.1304
Echinococcus multilocularis expressed protein 0.0026 0.0023 0.0025
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0184 0.023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0213 0.0309
Brugia malayi glutathione reductase 0.0038 0.015 0.0187
Trichomonas vaginalis ferritin, putative 0.0026 0.0023 0.0079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0212 0.2014 0.2989
Schistosoma mansoni hypothetical protein 0.0212 0.2014 0.4332
Schistosoma mansoni zinc finger protein 0.0066 0.045 0.0958
Brugia malayi Sodium:solute symporter family protein 0.0042 0.0195 0.0245
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0058 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2852 1
Onchocerca volvulus 0.0229 0.2194 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.0195 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3717 0.8005
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.022 0.21 0.3118
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1785 0.6259
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.0195 0.0282
Loa Loa (eye worm) bromodomain containing protein 0.006 0.0389 0.0495
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0006 0.002
Echinococcus granulosus zinc finger protein 0.0066 0.045 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.06 0.1282
Brugia malayi mbt repeat family protein 0.005 0.0281 0.0356
Loa Loa (eye worm) hypothetical protein 0.0092 0.0732 0.0939
Schistosoma mansoni chromobox protein 0.0067 0.0467 0.0995
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0184 0.0645
Mycobacterium tuberculosis Probable reductase 0.0086 0.0664 0.0952
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0213 0.0208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0046 0.0061
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0355 0.0753
Schistosoma mansoni hypothetical protein 0.0146 0.1306 0.2806
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0184 0.0645
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0094 0.0756 0.2651
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0135 0.1191 0.1186
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.0195 0.0282
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0213 0.0208
Echinococcus granulosus histone acetyltransferase KAT2B 0.0289 0.2828 0.4201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0671 0.6906 0.8917
Schistosoma mansoni tar DNA-binding protein 0.0271 0.2634 0.5671
Schistosoma mansoni transient receptor potential channel 0.0062 0.0411 0.0874
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.3717 0.5525
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0872 0.1253
Schistosoma mansoni hypothetical protein 0.0212 0.2014 0.4332
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0184 0.0178
Trichomonas vaginalis ap endonuclease, putative 0.0119 0.1018 0.3568
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0355 0.052
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0281 0.041
Schistosoma mansoni eyes absent homolog 0.0092 0.0732 0.1567
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0184 0.1371
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0106
Schistosoma mansoni sodium/solute symporter 0.0042 0.0195 0.0409
Schistosoma mansoni transient receptor potential channel 0.0062 0.0411 0.0874
Trypanosoma brucei trypanothione reductase 0.0038 0.015 0.0145
Onchocerca volvulus 0.0105 0.0872 0.3961
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0962 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0716 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0034 0.012
Entamoeba histolytica hypothetical protein 0.0146 0.1306 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0067 0.0467 0.0686
Plasmodium vivax SET domain protein, putative 0.0029 0.0058 0.0514
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0355 0.0451
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0351 0.0345
Loa Loa (eye worm) RNA binding protein 0.0271 0.2634 0.3397
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0213 0.0268
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0094 0.0636
Loa Loa (eye worm) hypothetical protein 0.0059 0.0377 0.048
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0119 0.1018 1
Leishmania major hypothetical protein, conserved 0.0046 0.0236 0.0231
Trichomonas vaginalis bromodomain-containing protein, putative 0.0094 0.0756 0.2651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Schistosoma mansoni ferritin light chain 0.0026 0.0023 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.1895 0.6644
Leishmania major hypothetical protein, conserved 0.0105 0.0872 0.0867
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0749 0.1107
Brugia malayi beta-lactamase family protein 0.0105 0.0872 0.112
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.0195 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0408 0.0402
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0024 0.0006 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0372 0.3717 0.4796
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0213 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0146 0.051
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0242 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0415
Loa Loa (eye worm) hypothetical protein 0.0459 0.4641 0.5991
Echinococcus multilocularis ferritin 0.0026 0.0023 0.0025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0664 0.0952
Brugia malayi MH2 domain containing protein 0.0119 0.1015 0.1304
Schistosoma mansoni hypothetical protein 0.0062 0.0406 0.0863
Brugia malayi Pre-SET motif family protein 0.0029 0.0058 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0847 0.0842
Schistosoma mansoni ap endonuclease 0.0119 0.1018 0.2183
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0872 0.3058
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0281 0.041
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0281 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0415
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0872 0.1658
Brugia malayi TAR-binding protein 0.0271 0.2634 0.3397
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0766 0.1099
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0213 0.1597
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0094 0.0756 0.5372
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0184 0.0178
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0411 0.0603
Echinococcus granulosus high affinity choline transporter 1 0.0379 0.3791 0.5635
Trypanosoma cruzi ISWI complex protein 0.0046 0.0236 0.0231
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0292 0.0618
Schistosoma mansoni alpha-glucosidase 0.0158 0.1434 0.3082
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0023 0.0024
Brugia malayi hypothetical protein 0.0103 0.0847 0.1088
Mycobacterium leprae Probable lipase LipE 0.0105 0.0872 1
Brugia malayi acetyltransferase, GNAT family protein 0.0304 0.2992 0.3859
Loa Loa (eye worm) hypothetical protein 0.0114 0.097 0.1246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0408 0.0402
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0119 0.1018 0.1013
Loa Loa (eye worm) hypothetical protein 0.0211 0.1999 0.2576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0603 0.4595
Loa Loa (eye worm) hypothetical protein 0.0105 0.0872 0.112
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0121 0.0172
Brugia malayi chromobox protein homolog 3 0.0038 0.0152 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0271 0.2634 0.5671
Loa Loa (eye worm) beta-lactamase 0.0105 0.0872 0.112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0664 0.7547
Onchocerca volvulus 0.0105 0.0872 0.3961
Echinococcus granulosus expressed protein 0.0026 0.0023 0.0025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.1707 0.2199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0331
Brugia malayi mbt repeat family protein 0.005 0.0281 0.0356
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0455 0.4601 0.4598

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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