Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0162 | 0.2119 | 0.3506 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0302 | 0.443 | 0.4366 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0594 | 0.0839 |
Schistosoma mansoni | alpha-glucosidase | 0.0161 | 0.2096 | 0.3465 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0316 | 0.0354 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.487 | 0.8312 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1378 | 0.221 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0043 | 0.0132 | 0.0032 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0678 | 0.1163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1776 | 0.2905 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0637 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0678 | 0.0988 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2735 | 0.4582 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.2826 | 0.6412 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0594 | 0.0486 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.0912 | 0.0807 |
Loa Loa (eye worm) | beta-lactamase | 0.007 | 0.0594 | 0.0839 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0594 | 0.1017 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1037 | 0.1614 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0316 | 0.2745 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.009 | 0.0912 | 0.0807 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.008 | 0.0752 | 0.0646 |
Onchocerca volvulus | 0.0108 | 0.122 | 0.3436 | |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1378 | 0.221 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0118 | 0.1378 | 0.2362 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.008 | 0.0752 | 0.036 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0043 | 0.0132 | 0.0181 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.2828 | 0.4744 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0316 | 0.0541 |
Onchocerca volvulus | 0.007 | 0.0594 | 0.1459 | |
Schistosoma mansoni | inositol transporter | 0.0043 | 0.0132 | 0.0032 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0043 | 0.0132 | 0.0032 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0678 | 0.8851 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.008 | 0.0752 | 0.0646 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0594 | 0.1017 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0386 | 0.5836 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0316 | 0.0205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.008 | 0.0752 | 0.1116 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0316 | 0.0205 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.3298 | 0.7527 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0118 | 0.1378 | 0.221 |
Toxoplasma gondii | exonuclease III APE | 0.008 | 0.0752 | 0.6279 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0043 | 0.0132 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1378 | 0.221 |
Brugia malayi | hypothetical protein | 0.0097 | 0.1037 | 0.1777 |
Brugia malayi | RNA binding protein | 0.02 | 0.2735 | 0.4687 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0195 | 0.2653 | 0.7961 |
Trypanosoma brucei | hypothetical protein, conserved | 0.007 | 0.0594 | 0.0486 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.2826 | 0.6412 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0132 | 0.0032 |
Toxoplasma gondii | hypothetical protein | 0.0103 | 0.113 | 1 |
Schistosoma mansoni | ap endonuclease | 0.008 | 0.0752 | 0.1116 |
Schistosoma mansoni | inositol transporter | 0.0043 | 0.0132 | 0.0032 |
Mycobacterium ulcerans | hypothetical protein | 0.0336 | 0.4995 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.007 | 0.0594 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.008 | 0.0752 | 0.1116 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0594 | 0.1135 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0043 | 0.0132 | 0.0032 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0118 | 0.1378 | 0.221 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0678 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0187 | 0.2528 | 0.422 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0316 | 0.0205 |
Echinococcus multilocularis | tar DNA binding protein | 0.02 | 0.2735 | 0.4582 |
Onchocerca volvulus | 0.007 | 0.0594 | 0.1459 | |
Schistosoma mansoni | hypothetical protein | 0.0254 | 0.3646 | 0.6172 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0043 | 0.0132 | 0.0032 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.2828 | 0.4846 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.007 | 0.0594 | 0.0839 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.007 | 0.0594 | 0.0839 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.008 | 0.0752 | 0.0251 |
Onchocerca volvulus | 0.007 | 0.0594 | 0.1459 | |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0297 | 0.4344 | 0.7444 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0162 | 0.2119 | 0.3632 |
Echinococcus granulosus | GPCR family 2 | 0.0118 | 0.1378 | 0.221 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0048 | 0.0217 | 0.0245 |
Trichomonas vaginalis | ap endonuclease, putative | 0.008 | 0.0752 | 0.1509 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0316 | 0.2745 |
Onchocerca volvulus | 0.0048 | 0.0222 | 0.0284 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0222 | 0.0189 |
Schistosoma mansoni | eyes absent homolog | 0.0097 | 0.1037 | 0.1614 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0637 | 1 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0048 | 0.0217 | 0.0245 |
Loa Loa (eye worm) | TAR-binding protein | 0.02 | 0.2735 | 0.4582 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0187 | 0.2528 | 0.422 |
Trichomonas vaginalis | ap endonuclease, putative | 0.008 | 0.0752 | 0.1509 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0678 | 0.8851 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1776 | 0.2905 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0316 | 0.0205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0678 | 0.0988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1776 | 0.2905 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1037 | 0.1614 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.02 | 0.2735 | 0.4582 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.009 | 0.0912 | 0.0807 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2735 | 0.4582 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.007 | 0.0594 | 0.1017 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0187 | 0.2528 | 0.422 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.008 | 0.0752 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.008 | 0.0752 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.02 | 0.2735 | 0.4582 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0297 | 0.4344 | 0.7393 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.008 | 0.0752 | 0.0646 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0043 | 0.0132 | 0.0032 |
Plasmodium vivax | hypothetical protein, conserved | 0.007 | 0.0594 | 0.704 |
Schistosoma mansoni | alpha-glucosidase | 0.0161 | 0.2096 | 0.3465 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.0113 | 0.0194 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0254 | 0.3646 | 0.6247 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.007 | 0.0594 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0594 | 0.0486 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0151 | 0.0591 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0118 | 0.1378 | 0.221 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.008 | 0.0752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0109 | 0.1237 | 0.1136 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.008 | 0.0752 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.1776 | 0.2905 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0678 | 0.8851 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0678 | 0.0988 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.0217 | 0.102 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0302 | 0.443 | 0.4366 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.008 | 0.0752 | 0.1116 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0043 | 0.0132 | 0.0032 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.045 | 0.6893 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0386 | 0.5836 | 1 |
Brugia malayi | GH02984p | 0.0386 | 0.5836 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.5836 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0043 | 0.0132 | 0.0032 |
Schistosoma mansoni | sodium/solute symporter | 0.0043 | 0.0132 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1378 | 0.221 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0594 | 0.0839 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0118 | 0.1378 | 0.221 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0316 | 0.1849 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.009 | 0.0912 | 0.0807 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.1776 | 0.2905 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.1776 | 0.3042 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0372 | 0.5599 | 0.9594 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0222 | 0.0189 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0187 | 0.2528 | 0.4332 |
Brugia malayi | beta-lactamase | 0.007 | 0.0594 | 0.1017 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.3646 | 0.6172 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0302 | 0.443 | 0.4366 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.1776 | 0.2905 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.008 | 0.0752 | 0.1116 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.0217 | 0.0181 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.1776 | 0.2905 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2735 | 0.4582 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.0217 | 0.102 |
Echinococcus multilocularis | GPCR, family 2 | 0.0118 | 0.1378 | 0.221 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.2044 | 0.3373 |
Brugia malayi | Sodium:solute symporter family protein | 0.0043 | 0.0132 | 0.0226 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0162 | 0.2119 | 0.3506 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0594 | 0.1135 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0316 | 0.1993 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2735 | 0.4582 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.1776 | 0.2905 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0678 | 0.8851 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2735 | 0.4582 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0594 | 0.0839 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0594 | 0.1135 |
Trichomonas vaginalis | esterase, putative | 0.007 | 0.0594 | 0.1135 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0118 | 0.1378 | 0.2362 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0594 | 0.1135 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0372 | 0.5599 | 0.9586 |
Toxoplasma gondii | ABC1 family protein | 0.007 | 0.0594 | 0.4723 |
Echinococcus granulosus | solute carrier family 5 | 0.0043 | 0.0132 | 0.0032 |
Brugia malayi | RNA recognition motif domain containing protein | 0.02 | 0.2735 | 0.4687 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0386 | 0.5836 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.008 | 0.0752 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Brugia malayi | TAR-binding protein | 0.02 | 0.2735 | 0.4687 |
Loa Loa (eye worm) | RNA binding protein | 0.02 | 0.2735 | 0.4582 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.2653 | 0.6002 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0594 | 0.1135 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.008 | 0.0752 | 0.1288 |
Loa Loa (eye worm) | acetyltransferase | 0.0162 | 0.2119 | 0.3506 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0594 | 0.0486 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.487 | 0.8312 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0372 | 0.5599 | 0.9594 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0336 | 0.4995 | 0.6987 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.008 | 0.0752 | 0.0646 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.008 | 0.0752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.5599 | 0.9586 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0637 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.007 | 0.0594 | 0.0839 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0297 | 0.4344 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1378 | 0.221 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0118 | 0.1378 | 0.221 |
Onchocerca volvulus | 0.0233 | 0.3298 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0187 | 0.2528 | 0.422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.