Detailed information for compound 725655

Basic information

Technical information
  • TDR Targets ID: 725655
  • Name: [3-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl] ace tate
  • MW: 280.278 | Formula: C16H12N2O3
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1cccc(c1)c1onc(n1)c1ccccc1
  • InChi: 1S/C16H12N2O3/c1-11(19)20-14-9-5-8-13(10-14)16-17-15(18-21-16)12-6-3-2-4-7-12/h2-10H,1H3
  • InChiKey: ZCESOCQEANKEBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid [3-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl] ester
  • [3-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl] ethanoate
  • STK337392
  • ZINC04841465

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.3304 0.5706
Brugia malayi GH02984p 0.0396 0.5767 0.7313
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0296 0.1649
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0172 0.0093
Trypanosoma brucei PAB1-binding protein , putative 0.0128 0.1618 0.1565
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0114 0.1398 0.134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.0907 0.0841
Loa Loa (eye worm) hypothetical protein 0.0044 0.0313 0.03
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0591 0.0519
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0309 0.0233
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0526 0.0863
Schistosoma mansoni zinc finger protein 0.003 0.01 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Echinococcus granulosus sodium:myo inositol cotransporter 0.0044 0.0313 0.0492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.1259 0.2448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0035 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0309 0.0457
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0044 0.0313 0.0492
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Onchocerca volvulus 0.0105 0.1259 0.1467
Trypanosoma brucei ISWI complex protein 0.003 0.01 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.1259 0.2142
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2839 0.4896
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Echinococcus granulosus solute carrier family 5 0.0044 0.0313 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0172 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0467 0.0759
Brugia malayi Glycosyl hydrolases family 31 protein 0.0192 0.2605 0.3247
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0309 0.0294
Schistosoma mansoni flap endonuclease-1 0.0026 0.0038 0.0012
Loa Loa (eye worm) hypothetical protein 0.0096 0.1129 0.1349
Loa Loa (eye worm) hypothetical protein 0.0363 0.5255 0.6656
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Loa Loa (eye worm) hypothetical protein 0.0091 0.105 0.1248
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0318 0.0501
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0467 0.0759
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0296 0.0438
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0535 0.2958
Schistosoma mansoni inositol transporter 0.0044 0.0313 0.0492
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.2764 0.4765
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.3847
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0153 0.0212
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0153 0.0212
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0306 0.4371 0.7567
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.3304 0.4145
Loa Loa (eye worm) RNA binding protein 0.0207 0.2839 0.3548
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0093 0.1082 0.1019
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Trichomonas vaginalis esterase, putative 0.0105 0.1259 0.1862
Schistosoma mansoni bromodomain containing protein 0.0131 0.1664 0.2846
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0296 0.1402
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0907 0.5374
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0314 0.4499 0.4495
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0309 0.0233
Echinococcus multilocularis solute carrier family 5 0.0044 0.0313 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0172 0.0254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0723 0.1206
Mycobacterium tuberculosis Conserved protein 0.0105 0.1259 0.1232
Brugia malayi TAR-binding protein 0.0207 0.2839 0.3548
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.0907 0.1527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0309 0.0457
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.5162 0.5169
Schistosoma mansoni alpha-glucosidase 0.0165 0.2192 0.3768
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0296 0.1649
Mycobacterium ulcerans beta-lactamase 0.0105 0.1259 0.2448
Leishmania major cathepsin L-like protease 0.0062 0.0591 0.0519
Plasmodium vivax hypothetical protein, conserved 0.0105 0.1259 0.7667
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.105 0.1777
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2839 0.4896
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0591 0.0519
Brugia malayi mbt repeat family protein 0.0047 0.0366 0.0367
Brugia malayi Latrophilin receptor protein 2 0.0168 0.2238 0.2775
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1259 0.1862
Loa Loa (eye worm) hypothetical protein 0.0075 0.0797 0.0921
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0044 0.0313 0.0492
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0296 0.0438
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0296 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.289 0.4274
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0296 0.0462
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0526 0.0863
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0044 0.0313 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.1555 0.2658
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0664 0.991 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0366 0.0367
Toxoplasma gondii exonuclease III APE 0.0082 0.0907 0.5374
Entamoeba histolytica hypothetical protein 0.0113 0.1388 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.105 0.1777
Trypanosoma brucei glucosidase, putative 0.0043 0.0296 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.1259 0.1199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Schistosoma mansoni inositol transporter 0.0044 0.0313 0.0492
Schistosoma mansoni hypothetical protein 0.004 0.0261 0.04
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0296 0.0462
Brugia malayi latrophilin 2 splice variant baaae 0.0363 0.5255 0.6656
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0366 0.0583
Schistosoma mansoni zinc finger protein 0.0046 0.0343 0.0544
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0894 0.9848
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0093 0.1082 0.1019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0137 0.0368
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.3847
Mycobacterium leprae conserved hypothetical protein 0.0105 0.1259 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0366 0.0583
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.108 0.1597
Brugia malayi PHD-finger family protein 0.0056 0.0504 0.0545
Schistosoma mansoni hypothetical protein 0.0167 0.222 0.3817
Loa Loa (eye worm) TAR-binding protein 0.0207 0.2839 0.3548
Echinococcus multilocularis geminin 0.0167 0.222 0.3817
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.1259 0.1199
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.0907 1
Onchocerca volvulus 0.0105 0.1259 0.1467
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0467 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2839 0.4896
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0192 0.2605 0.3247
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0314 0.4499 0.4495
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.3847
Echinococcus multilocularis zinc finger protein 0.0046 0.0343 0.0544
Echinococcus multilocularis high affinity choline transporter 1 0.0396 0.5767 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.1259 0.2142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.3304 0.5706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0035 0.0051
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0467 0.0759
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.1618 0.1565
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.0907 0.0841
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0467 0.0759
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0309 0.0484
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.108 0.6501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0172 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0296 0.0438
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0261 0.0232
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.5162 0.5169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.1259 0.2142
Brugia malayi acetyltransferase, GNAT family protein 0.0306 0.4371 0.5519
Onchocerca volvulus Glucosylceramidase homolog 0.02 0.2724 0.3738
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Brugia malayi beta-lactamase family protein 0.0105 0.1259 0.1516
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0296 0.0438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0531 0.7856 1
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.108 0.1597
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.3304 0.5706
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0366 0.0583
Schistosoma mansoni hypothetical protein 0.003 0.01 0.0119
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0044 0.0313 0.0492
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0366 0.0583
Mycobacterium tuberculosis Conserved protein 0.0105 0.1259 0.1232
Echinococcus granulosus geminin 0.0167 0.222 0.3817
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.2839 0.3548
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0894 0.6225
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0306 0.4371 0.7567
Loa Loa (eye worm) hypothetical protein 0.0396 0.5767 0.7313
Leishmania major cathepsin L-like protease 0.0062 0.0591 0.0519
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0044 0.0313 0.1516
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0591 0.0519
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0172 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.289 0.4274
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.1259 0.1516
Loa Loa (eye worm) hypothetical protein 0.0047 0.0366 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0088 0.013
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0309 0.0233
Mycobacterium tuberculosis Conserved protein 0.0105 0.1259 0.1232
Echinococcus multilocularis lysosomal alpha glucosidase 0.0192 0.2605 0.4488
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0366 0.0583
Brugia malayi Bromodomain containing protein 0.0154 0.2018 0.2491
Echinococcus multilocularis tar DNA binding protein 0.0207 0.2839 0.4896
Brugia malayi Bromodomain containing protein 0.0082 0.0909 0.1065
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0296 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0314 0.4499 0.4495
Leishmania major cathepsin L-like protease 0.0062 0.0591 0.0519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0531 0.7856 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0168 0.2238 0.2775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Echinococcus granulosus sodium:glucose cotransporter 0.0044 0.0313 0.0492
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0467 0.0759
Onchocerca volvulus 0.0058 0.0535 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0211 0.0312
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.1259 0.1232
Loa Loa (eye worm) hypothetical protein 0.0531 0.7856 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0502 0.0821
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0285 0.0264
Brugia malayi beta-lactamase 0.0105 0.1259 0.1516
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0907 0.1341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0535 0.0879
Schistosoma mansoni alpha glucosidase 0.0043 0.0296 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1388 0.2366
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.0907 1
Schistosoma mansoni hypothetical protein 0.0303 0.4321 0.748
Echinococcus granulosus sodium:glucose cotransporter 2 0.0044 0.0313 0.0492
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0168 0.2238 0.3847
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516
Loa Loa (eye worm) hypothetical protein 0.0183 0.2461 0.3062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0318 0.0501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0296 0.0438
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0296 0.0438
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0366 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.3304 0.5706
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.1259 0.2448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0531 0.7856 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.0907 0.1063
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.1259 0.1232
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.1618 0.1565
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.1259 0.1232
Echinococcus granulosus GPCR family 2 0.0168 0.2238 0.3847
Loa Loa (eye worm) acetyltransferase 0.0306 0.4371 0.5519
Plasmodium vivax SET domain protein, putative 0.0058 0.0535 0.2958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0057
Echinococcus granulosus zinc finger protein 0.0046 0.0343 0.0544
Loa Loa (eye worm) hypothetical protein 0.0087 0.0982 0.116
Loa Loa (eye worm) hypothetical protein 0.0054 0.0467 0.0497
Brugia malayi hypothetical protein 0.0096 0.1129 0.1349
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.1259 0.1232
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0309 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0172 0.0254
Leishmania major hypothetical protein, conserved 0.0128 0.1618 0.1565
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.1618 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0153 0.0212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0309 0.0294
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0366 0.0081
Leishmania major hypothetical protein, conserved 0.0105 0.1259 0.1199
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.1259 0.1232
Echinococcus granulosus tar DNA binding protein 0.0207 0.2839 0.4896
Trichomonas vaginalis ferritin, putative 0.0025 0.0031 0.0046
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0591 0.0519
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0309 0.1748
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.0907 0.0841
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0082 0.0907 0.1745
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0535 0.0879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Trichomonas vaginalis set domain proteins, putative 0.0461 0.6762 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0309 0.0484
Echinococcus granulosus high affinity choline transporter 1 0.0396 0.5767 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0309 0.1748
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.108 0.6501
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.2764 0.4765
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.0907 0.6321
Toxoplasma gondii LsmAD domain-containing protein 0.0128 0.1618 1
Brugia malayi beta-lactamase family protein 0.0105 0.1259 0.1516
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.1082 0.1019
Entamoeba histolytica hypothetical protein 0.0113 0.1388 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.5897 0.7481
Brugia malayi hypothetical protein 0.0083 0.0916 0.1075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.5162 0.6535
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1259 0.1862
Leishmania major hypothetical protein, conserved 0.003 0.01 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.0907 0.1527
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.0907 0.1063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.0907 0.0878
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0907 0.5374
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516
Loa Loa (eye worm) beta-lactamase 0.0105 0.1259 0.1516
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0894 0.5293
Schistosoma mansoni ap endonuclease 0.0082 0.0907 0.1527
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0168 0.2238 0.3847
Loa Loa (eye worm) hypothetical protein 0.0168 0.2238 0.2775
Loa Loa (eye worm) hypothetical protein 0.0138 0.1774 0.2178
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0664 0.991 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0172 0.0093
Mycobacterium ulcerans hypothetical protein 0.0105 0.1259 0.2448
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.5162 0.5169
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0387 0.0312
Entamoeba histolytica hypothetical protein 0.0113 0.1388 1
Leishmania major mitochondrial DNA polymerase beta 0.0664 0.991 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.1555 0.2658
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.105 0.1777
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0168 0.2238 0.3847
Loa Loa (eye worm) latrophilin receptor protein 2 0.0168 0.2238 0.2775
Mycobacterium ulcerans lipase LipD 0.0105 0.1259 0.2448
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.008 0.0119
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0318 0.0501
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2839 0.4896
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0309 0.0233
Plasmodium vivax ataxin-2 like protein, putative 0.0128 0.1618 1
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.3847
Loa Loa (eye worm) MBCTL1 0.0054 0.0467 0.0497
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0296 0.0219
Onchocerca volvulus 0.0461 0.6762 1
Schistosoma mansoni high-affinity choline transporter 0.0396 0.5767 1
Entamoeba histolytica hypothetical protein 0.0113 0.1388 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0296 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2839 0.4896
Loa Loa (eye worm) hypothetical protein 0.0357 0.5162 0.6535
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.3304 0.4145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0309 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0296 0.0438
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.3304 0.5706
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0304 0.4342 0.5481
Echinococcus granulosus lysosomal alpha glucosidase 0.0192 0.2605 0.4488
Brugia malayi hypothetical protein 0.0113 0.1388 0.1682
Schistosoma mansoni alpha-glucosidase 0.0165 0.2192 0.3768
Schistosoma mansoni hypothetical protein 0.0113 0.1388 0.2366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0057
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0508 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Brugia malayi mbt repeat family protein 0.0047 0.0366 0.0367
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0296 0.0277
Echinococcus granulosus flap endonuclease 1 0.0029 0.008 0.0086
Brugia malayi Sodium:solute symporter family protein 0.0044 0.0313 0.03
Loa Loa (eye worm) hypothetical protein 0.0091 0.104 0.1234
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.1259 0.1862
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0153 0.0212
Onchocerca volvulus 0.0047 0.0366 0.0081
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0304 0.4342 0.5481
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0309 0.0233
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1388 0.2366
Schistosoma mansoni sodium/solute symporter 0.0044 0.0313 0.0492
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.1259 0.2142
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0073 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0664 0.991 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.1082 0.1019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0723 0.1206
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.1259 0.1516
Loa Loa (eye worm) hypothetical protein 0.0096 0.1129 0.1349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.3304 0.5706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0057
Brugia malayi RNA binding protein 0.0207 0.2839 0.3548
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0366 0.0583
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.1259 0.1232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.105 0.1777
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1259 0.1862
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.108 0.6501
Brugia malayi Pre-SET motif family protein 0.0405 0.5897 0.7481
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Toxoplasma gondii hypothetical protein 0.0107 0.1294 0.7894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0172 0.0254
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.2839 0.3548
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0309 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0296 0.0219
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.1259 0.1862
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.108 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0137 0.0202
Schistosoma mansoni hypothetical protein 0.0057 0.0526 0.0863
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.1259 0.1199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.1259 0.1232
Brugia malayi hypothetical protein 0.0128 0.1618 0.1978
Schistosoma mansoni hypothetical protein 0.0363 0.5255 0.9109
Schistosoma mansoni hypothetical protein 0.0167 0.222 0.3817
Echinococcus multilocularis lysosomal alpha glucosidase 0.0192 0.2605 0.4488
Onchocerca volvulus 0.0105 0.1259 0.1467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0535 0.0879
Mycobacterium tuberculosis Conserved hypothetical protein 0.035 0.5048 0.5033
Brugia malayi Pre-SET motif family protein 0.0058 0.0535 0.0585
Mycobacterium ulcerans hypothetical protein 0.035 0.5048 1
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2724 0.4029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1388 0.2366
Mycobacterium leprae Probable lipase LipE 0.0105 0.1259 1
Trichomonas vaginalis glucosylceramidase, putative 0.0304 0.4342 0.6421
Onchocerca volvulus 0.0111 0.1354 0.1614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.3304 0.5706
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0168 0.2238 0.3847
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0296 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0907 0.1341
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0082 0.0907 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0293 0.4169 0.7215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0591 0.0519
Toxoplasma gondii ABC1 family protein 0.0105 0.1259 0.7667
Schistosoma mansoni eyes absent homolog 0.0096 0.1129 0.1914
Schistosoma mansoni ap endonuclease 0.0082 0.0907 0.1527
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.0907 0.0841
Echinococcus multilocularis GPCR, family 2 0.0168 0.2238 0.3847
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.1618 1
Echinococcus multilocularis flap endonuclease 1 0.0029 0.008 0.0086
Loa Loa (eye worm) hypothetical protein 0.0128 0.1618 0.1978
Giardia lamblia GTOR 0.0043 0.0309 0.2766
Loa Loa (eye worm) hypothetical protein 0.0105 0.1259 0.1516

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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